News

Leading CCRCB Specialist Lands Top Role
Professor Kevin Prise
Professor Kevin Prise
 

A leading cancer expert from Queen’s University who is pioneering improved approaches for treating cancer with radiotherapy is set to become the next Vice-President of an international research society.

Professor Kevin Prise, Deputy Director of the Centre for Cancer Research and Cell Biology (CCRCB) at Queen’s, has been chosen as Vice-President-Elect of the US Radiation Research Society. He was elected via a ballot of all Society Members.

Professor of Radiation Biology, Kevin leads the Radiation Biology Group at CCRCB which is working on improved approaches for treating cancer with radiotherapy.  Professor Prise, in collaboration with Professor Joe O’Sullivan, Clinical Director, and Professor Alan Hounsell, Clinical Physics Research Lead, plays a major role in the Prostate Cancer UK Movember Centre of Excellence at CCRCB which is researching new approaches for treating men who are likely to fail current treatments for prostate cancer.

Speaking about his appointment, Professor Prise said: “This is a rare privilege and exciting challenge, especially for a non-US member of the Society.

This role is a great opportunity to profile internationally the work we are doing at Queen’s and the Centre for Cancer Research and Cell Biology to improve outcomes for cancer patients.”

Professor Prise, living in Lisburn but originally from Aberdeen, will take up the position of Vice-President in September 2016 and will serve as President from September 2017.

 

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National award for Queen’s cancer researchers
The CRUK Accelerator launch meeting
The CRUK Accelerator launch meeting

Cancer experts from Queen’s University Belfast have received a major award exceeding £3.6M from Cancer Research UK aimed at developing a national digital pathology programme to assist and accelerate the delivery of Precision Medicine in the UK.

The CRUK Accelerator Award brings together a consortium of cancer pathologists, biologists and immunologists from the Belfast Cancer Research UK Centre, who will work in partnership with researchers from the Universities of Southampton, Manchester and Newcastle, University College London and the Institute of Cancer Research.

Already recognised as experts in identifying faulty genes and molecules in tumours, the Belfast team will now lead this nationwide research programme dedicated to expanding the application and use of digital pathology to quantify specific tumour markers. The programme will be supported using software from PathXL, a Queen’s University spin-out company which specialises in high resolution imaging of tumours and cloud-based digital pathology.

Queen’s Professor David Waugh, Director of the Centre for Cancer Centre and Cell Biology, said:  “The selection of this research programme submitted by the Belfast CRUK Centre is further proof that Queen’s cancer researchers are at the cutting edge of the latest innovations to improve outcomes for cancer patients across the world. Through this new research programme we will develop knowledge that can inform the targeted use of immunotherapeutic agents in cancer patients.”

“We are thrilled to receive this award and I congratulate my colleagues Professor Manuel Salto-Tellez and Professor Peter Hamilton, in leading this successful bid. It is further recognition of the powerful alliance that our Centre is forging with local and international industry to deliver new advances in cancer care.”

Queen’s University Belfast will also lead the education and training programme in pathology that underpins the national network.

Professors Salto-Tellez and Peter Hamilton, Professors of Molecular and Digital Pathology respectively at Queen’s University, added: “Traditionally, researchers have used standard slides to examine tissue cells under the microscope. However, in recent years our research at Queen’s has pioneered the way to exploit digital technology to revolutionize the way we look at tumours, enabling us to obtain a deeper understanding of the cancer and provide a more detailed diagnosis to clinicians, as well as better tools for our scientists."

Professor Hamilton said: “This award demonstrates how Belfast has been leading in digital biotechnology for cancer research and diagnostics.  This CRUK funding will allow Belfast and the wider UK team to accelerate cancer discovery using these novel technologies, promote their application in clinical practice and maintain Belfast CRUK Centre’s reputation as a world leader in digital molecular pathology."

Des Speed, CEO of PathXL, said: “We are delighted that this innovative research project is progressing to implementation, and are looking forward to working with all centres in the consortium.

“It is very exciting to be at the forefront of this UK-wide strategy for digital and molecular pathology in cancer, which has the potential to drive dramatic change. This award is further recognition that Northern Ireland is leading the way in developing digital pathology, and of the strength of the PathXL software platform.”

Researchers from each of the collaborating UK academic institutes met at Queen’s University on 19 and 20 August to launch this new initiative.

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Student of the Year 'strikes a chord'
First Trust Bank Student of the Year Laura Graham

The winner of the annual First Trust Bank Queen’s Student of the Year Award is Dental student Laura Graham from Portglenone, Co Antrim. Laura was chosen for her international academic success and for her role in student music.

The Award, which is presented by the Queen’s Graduates’ Association (QGA) with generous backing from First Trust Bank, is one of the highlights of Graduation Week. Now in its 17th year, it recognises exceptional students for excellence, achievement or service either to the University or to the wider community.

Speaking ahead of the presentation Mark McKeown, Manager of First Trust Bank University Road, said: “We have been supporting these important Awards since their inception and are very proud to be associated with such a stand-out event in the University calendar.

“Our endorsement recognises and celebrates the achievements of all those Queen's students who make such an invaluable contribution to life in Northern Ireland and beyond. This year’s Student of the Year – Laura Graham – is an inspirational role model for all students but especially those considering undertaking postgraduate research.”

While taking a year out from her Dentistry studies to complete an intercalated Master’s Degree of Research at the Centre for Cancer Research and Cell Biology (CCRCB), Laura focused on the role of p63 and BRCA1 in Oropharyngeal Cancer – genes which are linked to early-onset of breast and ovarian cancer. She was then selected to represent the Irish division at the International Association of Dental Research annual conference in Boston, Massachusetts in May where she won the Junior Researcher Hatton Award, the most prestigious student research prize in world dentistry.

In addition to a lead role in the St Vincent de Paul society at Queen’s, Laura was also actively involved in the student orchestra (where she played violin) and was a soprano in the Chamber Choir. Last year she received a Degree Plus award for time spent with the Choir.

Feargus McCauley, President of the QGA who delivered the Student of the Year citation, believes that the First Trust Awards are an acknowledgement of all that is best about Queen’s. He said: “With the recent opening of the Graduate School at Queen’s, the University is poised to be a powerhouse of postgraduate research.

“This year’s Student of the Year Award recognises the achievement and impact of a gifted researcher, an exemplary master’s student, and a person of great tenacity and commitment. Laura Graham richly deserves recognition this year.”

The Student of the Year receives a trophy and £500.

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Queen’s Researchers in £5 Million Programme to Improve Bowel Cancer Survival
Professor Mark Lawler
Professor Mark Lawler

Researchers at Queen’s University Belfast have launched a revolutionary personalised treatment programme to help improve bowel cancer survival rates.

The £5 million initiative aims to fundamentally change how we treat bowel cancer patients, both in the UK and around the world, by personalising their treatments and ensuring that each patient gets access to the most effective therapies. 

The S-CORT Consortium, jointly launched and funded by Medical Research Council (MRC) and Cancer Research UK (CRUK), will employ the latest state-of-the-art techniques to define the genetic make-up of bowel cancer cells, collected from over 2,000 patients from large clinical trials, and use the information to develop personalised care plans for individual cancer patients.

More than 41,500 people are diagnosed with bowel cancer each year in the UK. One of the consortium’s key aims is to allow the most effective therapies to be delivered to newly-diagnosed bowel cancer patients.

Professor Mark Lawler, Chair of Translational Cancer Genomics at Queen’s University Belfast’s Centre for Cancer Research and Cell Biology (CCRCB) and Queen’s lead on the programme, said: “This Precision Medicine approach, where we match the right patient to the right treatment, has the potential to revolutionise how we treat this deadly disease.  It will also allow us to spare patients the often debilitating side effects of ineffective therapies, thus improving their quality of life.”

Professor Patrick Johnston, Vice-Chancellor of Queen’s and a principal investigator of the S-CORT Consortium, said: “I am delighted that Queen’s researchers are playing such a prominent role in a UK-wide collaborative programme that has the potential to significantly improve the lives of bowel cancer patients.  This is further evidence of Queen’s University leading on world class research which will have a lasting impact around the globe.”

Head of the S-CORT Consortium, Professor Tim Maughan, based at the University of Oxford, said: “Bowel cancer survival has more than doubled in the last 40 years. But there is still a lot more work to do.  Recognising this challenge, we have brought together key partners to develop new ways to tailor treatment to the patients who will benefit the most, and make a significant difference to their chances of beating this common disease.”

Margaret Grayson, Chair of the Northern Ireland Cancer Research Consumer Forum, said:  “We are very excited to be an active part of this research programme that has a clear line of sight to us, the cancer patients.”

Craigavon based biotech company, Almac Diagnostics are a key partner in the initiative. Professor Richard Kennedy, McClay Professor of Experimental Medicine (CCRCB) at Queen’s and Vice-President and Medical Director of Almac Diagnostics, said: “We see the potential for industry and  academia to work together in partnership to develop new tests that will predict which patients will respond to different therapies.  This research has the potential not only to improve patient outcomes in Northern Ireland and across the UK, it also can contribute to the local economy.”

The announcement is made during Bowel Cancer Awareness month and represents a significant commitment from MRC and CRUK in developing a more personalised medicine strategy in this common cancer.

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Queen’s Leads International Research Programme in Precision Cancer Medicine
Members of the Precision Cancer Medicine Programme

Queen’s University Belfast is leading a major new international initiative into modern cancer care medicine which was announced in Washington D.C.

Researchers from Queen’s University’s world-class Centre for Cancer Research and Cell Biology (CCRCB) in partnership with researchers at the National Cancer Institute (NCI) in Washington are working together to deliver a £2.5M 4 year PhD programme in Precision Cancer Medicine.

Precision Cancer Medicine  utilises our increased biological understanding of  cancer to drive a more selective approach, ensuring patients receive therapeutically effective treatment based on their genetic make-up, while avoiding treatment-related side effects. CCRCB has established an innovative Academia-Industry-Healthcare Precision Cancer Medicine  pipeline that is delivering new diagnostics and new therapies for cancer patients.   

The innovative Doctoral Training Programme in Precision Cancer Medicine will initially provide 12 Queen’s students with an unrivalled opportunity to perform cutting edge research at a world renowned cancer institution, positioning them as future leaders in an area that is revolutionising how we deliver 21st century medicine to cancer patients.

Vice-Chancellor of Queen’s University Belfast, Professor Patrick Johnston said: "It is extremely exciting to be announcing this initiative here in Washington. It provides significant opportunities for students to be exposed to state-of-the-art technologies and receive quality mentorship from researchers both at the NCI and at Queen’s and it is further evidence of how Queen’s researchers are continuing to advance knowledge and change lives at a global level."

Dr Stephen Chanock, Chief, Division of Cancer Epidemiology and Genetics, NCI said: "We welcome this opportunity for Northern Ireland students to come to the National Institutes of Health. They will join with fellow graduate students from many parts of the world in an academic milieu that will encourage research excellence."  

In this Doctoral Training Programme, PhD students will not only acquire specialist research skills, but will also be exposed to entrepreneurship, innovation and leadership training, as part of a collaboration between the School of Medicine, Dentistry and Biomedical Sciences,  the Queen’s University Management School and the William J Clinton Leadership Institute at Queen’s.

"This cross faculty, interdisciplinary PhD Programme is an excellent example of the type of modern postgraduate degree that we are now offering to students attending Queen’s." said Professor Margaret Topping, Dean of Queen’s Graduate School.

Professor David Waugh, Director, CCRCB said: "Doctoral training is a key component of our Precision Cancer Medicine Programme. Partnering with researchers at the NCI not only enhances the student experience, but also provides significant opportunities for future research collaborations with CCRCB scientists."

Professor Mark Lawler, Associate Director of Postgraduate Studies at CCRCB and chief architect of the programme said: "This vibrant Doctoral Training Programme actively encourages excellence with impact, delivering a cadre of innovative, business-aware and socially responsible scientists who will compete successfully in the evolving global research and bio-industry communities. It provides Northern Ireland students with a “once-in-a-lifetime opportunity” to further their careers at a world famous cancer institution and deliver research with global impact."

For Further Information Please contact Professor Mark Lawler Associate Director of Postgraduate Studies, CCRCB and Director of the Doctoral Training programme in Precision Cancer Medicine.

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CCRCB Open Day - Saturday 9 May 2015
CCRCB Building

Find out how we are curing cancer in Belfast at our free Open Day.  This is a unique opportunity for you to meet the researchers, go behind the scenes in our labs, and find out more about cancer research.    

Come along and experience our local cancer research brought to life by the researchers themselves. See how researchers in Belfast are working together to discover and pioneer new cancer treatments.

There will be interactive activities suitable for all ages including children (* Please note due to health and safety regulations, young adults and children will need to be supervised by a responsible adult at all times in the Centre.)

Date – Saturday 9 May 2015
Time: 11am – 3pm
Venue – Centre for Cancer Research and Cell Biology, Queen’s University Belfast

Please visit the CCRCB Open Day page for more information and registration details. 

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CCRCB Researchers in BBC Documentary
Image from the Truth about Cancer documentary

Our cancer researchers have featured in a BBC One documentary on The Truth About Cancer, presented by Stephen Nolan. The researchers spoke about their work and the advances in modern science which are giving cancer patients a higher rate of survival.

If you missed it, you can watch the documentary here.

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Queen's Vice Chancellor Receives Prestigious Accolade
Queen's Vice Chancellor receives accolade

Vice-Chancellor of Queen’s University Belfast, Professor Patrick Johnston, has been awarded an Honorary Fellowship of the Royal College of Surgeons in Ireland (RSCI).

Founded in 1784, the RSCI is a world renowned medical institution, providing extensive education and training in the healthcare professions for students in Ireland.

The award, the highest distinction the RSCI bestows, was presented to Professor Johnston in recognition of his contribution to cancer research. A globally-recognised cancer specialist over the last 20 years, Professor Johnston, from Derry, has also led the development of a world-leading Institute of Health Sciences at Queen’s University.

His research has resulted in a number of prestigious landmark publications, over 20 patents and almost £100 million in grants being secured from research and philanthropic bodies.

Professor Johnston was presented with the award by RCSI President, Declan J Magee, at a conferring ceremony at RCSI in Dublin, on February 7, 2015.

Commenting on the distinguished accolade, Professor Johnston said: “I am delighted to have received an Honorary Fellowship of the Royal College of Surgeons in Ireland. It is a privilege to have received this honour and to have had my contribution to cancer research recognised in this way.”

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CCRCB Building Sign

Bowel Cancer Breakthrough May Benefit Thousands of Patients

Researchers at Queen’s University have made a significant breakthrough that may benefit patients with bowel cancer. 

Dr Sandra van Schaeybroeck and her team have discovered how two genes cause bowel cancer cells to become resistant to treatments used against the disease. The research, which was funded by Cancer Research UK, was published this month in the prestigious international journal Cell Reports.

The activity of the two genes, called MEK and MET, was uncovered when the researchers looked at all the different pathways and interactions taking place in bowel cancer cells.

Dr van Schaeybroeck and her group found that these bowel cancers switch on a survival mechanism when they are treated with drugs that target faulty MEK genes. But when the researchers added drugs that also block the MET gene, the bowel cancer cells died.  The team are now testing a new approach to target these two genes in the most aggressive forms of bowel cancer in a European Commission funded clinical trial that is being led by Dr van Schaeybroeck.

Currently over 40,000 people are diagnosed with bowel cancer in the UK each year and over 16,000 patients die of the disease. More than half of patients develop the aggressive form of the disease which does not respond to standard therapy, the five year overall survival in this patient group is less than five per cent.

Study author Dr Sandra van Schaeybroeck, from the Centre for Cancer Research and Cell Biology (CCRCB) at Queen’s University, said: “We have discovered how two key genes contribute to aggressive bowel cancer. Understanding how they are involved in development of the disease has also primed the development of a potential new treatment approach for this disease.” 

Queen’s University Vice-Chancellor, Professor Patrick Johnston, said: “Understanding the genes that cause bowel cancer is a key focus of our research. Our discoveries in this deadly disease have identified a new route to clinical application for cancer patients.”

Professor David Waugh, Director of the CCRCB at Queen’s, said: “The publication of this research by Dr van Schaeybroeck and her team demonstrates our commitment to performing excellent science here in Belfast that can be directly translated to the clinic.”

The clinical trial, which is called MErCuRIC and is due to start in September, will deliver personalised medicine to Northern Irish patients and patients from other European countries. Overall, the pan European collaborative effort will involving 13 research/clinical teams from nine European countries.

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CCRCB Scientists’ Effort to Beat Blood Cancer Receives Funding Boost

Scientists at the Centre for Cancer Research and Cell Biology have been awarded a £126,000 grant by blood cancer charity Leukaemia & Lymphoma Research for research to improve treatments for blood cancer patients.

The two year research project will be led by Professor Ken Mills, Dr Kienan Savage, Professor Mary Frances McMullin and Dr Fabio Liberante. They will develop new treatments that are more effective at seeking out and destroying abnormal white blood cells.

The research will focus on a genetic fault found in patients with myelodysplastic syndrome (MDS). MDS is a group of blood disorders where the balance of healthy blood cells in the body is disrupted by the growth of ‘master’ cells. Patients with these types of disease are usually elderly and are often unable to cope with intensive treatment like chemotherapy.

Professor Mills said: “Several genetic abnormalities have been connected with MDS but we don’t know their role in the onset or progression of the disease. In particular a gene called SF3B1 is known to be mutated in the blood cells of around a third of patients with MDS. As many as 85% of patients with a type of MDS called refractory anaemia with ring sideroblasts (RARS) have the error. The ultimate aim of our research is to improve treatment for patients with MDS, particularly RARS, by identifying a specific drug that can target this SF3B1 mutation.”

The researchers will study this particular genetic fault and use cutting-edge genetic techniques to identify exactly how the mutated SF3B1 gene influences the development of MDS. They will look at how the abnormal SF3B1 affects the ability of the cell to repair damaged DNA, how this impairment influences disease progression, and whether it’s possible to block it with drugs.

Dr Matt Kaiser, Head of Research at Leukaemia & Lymphoma Research, said: “The majority of patients diagnosed with MDS are over the age of 60 and most are unable to cope with the current treatments available. This research shed light on how a genetic error in SF3B1 affects blood cell development and behaviour. Improving treatments and tailoring them to target specific rogue cells will enable a safer and more effective way of combating the disease for patients.”

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