The Ingram Group
Spectrum of Disease
The overarching focus of the Ingram group is investigating the lymphocytic response to bacterial respiratory infections, and the interplay between the adaptive and innate immune response. The work is divided into projects examine response to acute and chronic infection/inflammation and aims to address clinically relevant questions.
To date the work on acute responses has focused on Acute Lung Injury (ALI). Areas being investigated include role of Tregs in orchestrating the early inflammatory events during ALI and the source and role of IL-17 in ALI. The group also have projects investigating the role of Secretory leukocyte protease inhibitor (SLPI) in acute bacterial infection and the regulation of IL-22 production by Tregs during acute infection or ALI.
The work undertaken in chronic bacterial infection research relates predominantly to Cystic Fibrosis (CF), particularly Pseudomonas infection. Projects are on going to characterise the T cell response to Pseudomonas proteins in CF patients, in order to identify novel vaccine targets.