'FROM DISCOVERY TO RECOVERY'
Prof Danny McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast.
He is Co-Director of Research for the Intensive Care Society and Chair of the Irish Critical Care Trials Group. His major research area is acute lung injury.
Current research interests
My major interest is acute lung injury (ALI). My research strategy in ALI is to investigate potential novel therapeutic agents in ALI in vitro, in vivo in a human LPS model of ALI and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. My roles as the UK Intensive Care Society Co-Director of Research, the Irish Critical Care Trials group Chair and the NICRN (Critical Care) clinical lead, mean I am well placed to develop the novel therapeutic targets into phase 3 clinical trials. I am currently investigating the role of statins and keratinocyte growth factor in vitro, in the in vivo human LPS model and in early phase clinical trials in the prevention and treatment of ALI.
I am currently investigating elafin and SLPI in vitro with a view to developing these agents as potential therapeutic agents for ALI.
I am also interested in ion channel function in the clearance of pulmonary oedema in ALI as well as the pathophysiological role of matrix metalloproteinases (MMPs), oncostatin M and receptor for advanced glycation endproducts (RAGE) in ALI.
My other research interests are vascular reactivity in critical illness, nosocomial MRSA and fungal infection, acute kidney injury, delirium in critical illness and interventions in patients undergoing major vascular surgery to avoid pulmonary complications.
Membership of Learned Societies
Ulster Medical Society
Association of Physicians of Great Britain & Ireland
British Thoracic Society
American Thoracic Society
Intensive Care Society of Ireland
Intensive Care Society
European Society of Intensive Care Medicine
Member of editorial board for The Open Critical Care Medicine Journal 2008-
Review papers for Thorax, Critical Care Medicine, Chest, American Journal of Respiratory and Critical Care Medicine, Intensive Care Medicine, American Journal of Physiology: Lung Cellular and Molecular Physiology, Quarterly Journal of Medicine and PLoS Medicine
Expert reviewer for MRC, National Institute for Health Research (NIHR) and Scottish Chief Scientist Office Biochemical and Therapeutic Research committee research grants
NIHR Health Technology Assessment (HTA) programme College of Experts 2009-
NIHR Efficacy and Mechanism Evaluation (EME) (MRC funded) programme College of Experts 2009-
Review abstracts for the British Thoracic Society Scientific meeting 2006-
Medical advisor for the study of medical admissions into adult general intensive care units undertaken by the National Confidential Enquiry for Patient Outcome and Death (NCEPOD).
Member of Data Monitoring and Ethics Committees for 2 ICORG multi-centre clinical trials
Positions of responsibility
Co-Director of Research UK Intensive Care Society 2009-
Chair of the Irish Critical Care Clinical Trials group 2009
Member of UKCRN / NIHR Specialty Group for Critical Care 2008-
Intensive Care Society Research Committee 2008-
Clinical lead Northern Ireland Clinical Research Network for Critical Care 2007-
UK and Ireland Acute Lung Injury group (co-founder) 2007-
Vice-Chair of the Irish Critical Care Clinical Trials group 2006-2009
Deputy Director of Research UK Intensive Care Society 2008-2009
I have given over 20 national (UK and Ireland) and 8 international invited presentations, with a further 6 international invited presentations pending.
8th World Congress on Trauma, Shock, Inflammation and Sepsis. March 2010.
Simvastatin in the treatment of pulmonary Inflammation and acute lung injury
30th International Symposium on Intensive Care and Emergency Medicine. March 2010.
What we need before a phase III trial - Clinical trials under the spotlight
Human models to test novel therapies
Keratinocyte growth factor in ARDS: New therapeutic options
Statins in ARDS: New therapeutic options
UK Intensive Care Society. Dec 2009
Identifying new treatments for ALI.
British Thoracic Society. Dec 2009
Human models of lung inflammation.
British Burns Association Annual Conference April 2009
Recent advances in respiratory care in ICU
Irish Congress of Anaesthesia May 2008
Statins; Emerging indications.
College of Emergency Medicine annual scientific conference May 2008
Assessment of the critically ill.
ICS acute lung injury seminar November 2007
Emerging pharmacological treatments.
9th Current controversies in anaesthesia and peri-operative medicine. October 2007
Update on acute lung injury.
Intensive Care Society of Ireland. June 2007.
Basic research relevant to novel therapies for ARDS.
Scottish Intensive Care Society of Ireland. June 2007.
Emerging therapies for treatment of ARDS.
27th International Symposium on Intensive Care and Emergency Medicine. March 2007.
Beta-adrenergic agonists in ARDS revisited
Helping endothelial cells
Intensive Care Society of Ireland. Nov 2006.
Use of data from the Irish Clinical Trials Group audit to inform design of clinical trials
Adjunctive therapy in the management of ARDS.
8th Current controversies in anaesthesia and peri-operative medicine. Sept 2006
Beta-adrenergic agonists as a potential adjunctive therapy in acute lung injury.
ARDS : an integrated approach to mechanisms and management. June 2006.
ARDS - an acute injury to the endothelium and epithelium.
Trauma Care 2006. May 2006.
British Association of Critical Care Nurses. Feb 2006.
UK Intensive Care Society. Dec 2005
Beta-adrenergic agonists in the management of ARDS.
British Thoracic Society. Dec 2005
Adjuncts to mechanical ventilation.
Intensive Care Society of Ireland. Nov 2005.
Pro Con debate "An Irish Clinical Trials Group?"
Intensive Care Society of Ireland. June 2005.
Novel therapies for ARDS"
24th International Symposium on Intensive Care and Emergency Medicine. March 2004.
Relative immunosuppression - role of neutrophils
Compliance as a predictor of outcome in ARDS
Role of beta-adrenergic agonists in the management of ARDS
Effect of admission to intensive care on neuropsychological morbidity
UK Intensive Care Society Trainees Meeting. August 2002
Pro Con debate "There is no place for physicians in ICU"
Local Principle Investigator in multi-centre clinical trials
Fungal Infection Risk Evalution
Beta Agonist Lung Injury TrLal Prevention
Beta Agonist Lung Injury TrLal 2
Ongoing external research collaborations
Dr John Simpson (Edinburgh University) Monocyte depletion in acute neutrophil-mediated lung injury
Prof John Laffey (Galway University Hospitals) Matrix metalloproteinases (MMPs) in ventilator associated lung injury
Dr David Thickett and Dr Gavin Perkins (University of Brimingham and University of Warwick) RAGE in ALI, Vitamin D in ALI
Prof Michael Matthay (University of California, San Francisco) Protective role of KGF in acute lung injury