Staff Profile




General Profile Information
Staff Name Professor Danny McAuley
Job Title Clinical Professor (Cons) (JA)
Location H.S.B Block 10 MBC Site
Room Number 0G.002A
School School of Medicine, Dentistry and Biomedical Sciences
Contact Details
Telephone +44 (0)28 9097 5876
E-mail d.f.mcauley@qub.ac.uk
Interests

Prof Danny McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast.

He is Co-Director of Research for the Intensive Care Society and Chair of the Irish Critical Care Trials Group. His major research area is acute lung injury.





Research Statement
 

Current research interests

My major interest is acute lung injury (ALI). My research strategy in ALI is to investigate potential novel therapeutic agents in ALI in vitro, in vivo in a human LPS model of ALI and in phase 2 clinical trials to inform subsequent phase 3 clinical trials. My roles as the UK Intensive Care Society Co-Director of Research, the Irish Critical Care Trials group Chair and the NICRN (Critical Care) clinical lead, mean I am well placed to develop the novel therapeutic targets into phase 3 clinical trials. I am currently investigating the role of statins and keratinocyte growth factor in vitro, in the in vivo human LPS model and in early phase clinical trials in the prevention and treatment of ALI.

I am currently investigating elafin and SLPI in vitro with a view to developing these agents as potential therapeutic agents for ALI.

I am also interested in ion channel function in the clearance of pulmonary oedema in ALI as well as the pathophysiological role of matrix metalloproteinases (MMPs), oncostatin M and receptor for advanced glycation endproducts (RAGE) in ALI.

My other research interests are vascular reactivity in critical illness, nosocomial MRSA and fungal infection, acute kidney injury, delirium in critical illness and interventions in patients undergoing major vascular surgery to avoid pulmonary complications.





Professional Qualifications

Membership of Learned Societies

Ulster Medical Society

Association of Physicians of Great Britain & Ireland

British Thoracic Society

American Thoracic Society

Intensive Care Society of Ireland

Intensive Care Society

European Society of Intensive Care Medicine





Membership Of Other Societies / Professional Activities

Professional Activities 

Member of editorial board for The Open Critical Care Medicine Journal 2008-

Review papers for Thorax, Critical Care Medicine, Chest, American Journal of Respiratory and Critical Care Medicine, Intensive Care Medicine, American Journal of Physiology: Lung Cellular and Molecular Physiology, Quarterly Journal of Medicine and PLoS Medicine

Expert reviewer for MRC, National Institute for Health Research (NIHR) and Scottish Chief Scientist Office Biochemical and Therapeutic Research committee research grants

NIHR Health Technology Assessment (HTA) programme College of Experts 2009-

NIHR Efficacy and Mechanism Evaluation (EME) (MRC funded) programme College of Experts 2009-

Review abstracts for the British Thoracic Society Scientific meeting 2006-

Medical advisor for the study of medical admissions into adult general intensive care units undertaken by the National Confidential Enquiry for Patient Outcome and Death (NCEPOD).

Member of Data Monitoring and Ethics Committees for 2 ICORG multi-centre clinical trials

Positions of responsibility

Co-Director of Research UK Intensive Care Society                                            2009-

Chair of the Irish Critical Care Clinical Trials group                                              2009

Member of UKCRN / NIHR Specialty Group for Critical Care 2008-

Intensive Care Society Research Committee                                                      2008-

Clinical lead Northern Ireland Clinical Research Network for Critical Care                2007-

UK and Ireland Acute Lung Injury group (co-founder)                                        2007-

Vice-Chair of the Irish Critical Care Clinical Trials group                                      2006-2009

Deputy Director of Research UK Intensive Care Society                                     2008-2009

Invited lectures

I have given over 20 national (UK and Ireland) and 8 international invited presentations, with a further 6 international invited presentations pending.

8th World Congress on Trauma, Shock, Inflammation and Sepsis. March 2010.

            Simvastatin in the treatment of pulmonary Inflammation and acute lung injury

30th International Symposium on Intensive Care and Emergency Medicine. March 2010.

            What we need before a phase III trial - Clinical trials under the spotlight

            Human models to test novel therapies

            Keratinocyte growth factor in ARDS: New therapeutic options

            Statins in ARDS: New therapeutic options

UK Intensive Care Society. Dec 2009

            Identifying new treatments for ALI.

British Thoracic Society. Dec 2009

Human models of lung inflammation.

British Burns Association Annual Conference April 2009

Recent advances in respiratory care in ICU

Irish Congress of Anaesthesia May 2008

Statins; Emerging indications.

College of Emergency Medicine annual scientific conference May 2008

Assessment of the critically ill.

ICS acute lung injury seminar November 2007

Emerging pharmacological treatments.

9th Current controversies in anaesthesia and peri-operative medicine. October 2007

Update on acute lung injury.

Intensive Care Society of Ireland. June 2007.

Basic research relevant to novel therapies for ARDS.

Scottish Intensive Care Society of Ireland. June 2007.

Emerging therapies for treatment of ARDS.

27th International Symposium on Intensive Care and Emergency Medicine. March 2007.

            Endothelial injury

            Inhaled therapy

            Beta-adrenergic agonists in ARDS revisited

            Helping endothelial cells

Intensive Care Society of Ireland. Nov 2006.

Use of data from the Irish Clinical Trials Group audit to inform design of clinical trials

Adjunctive therapy in the management of ARDS.

8th Current controversies in anaesthesia and peri-operative medicine. Sept 2006

Beta-adrenergic agonists as a potential adjunctive therapy in acute lung injury.

ARDS : an integrated approach to mechanisms and management. June 2006.

ARDS - an acute injury to the endothelium and epithelium.

Trauma Care 2006. May 2006.

Nosocomial infection.

British Association of Critical Care Nurses. Feb 2006.

Non-invasive ventilation.

UK Intensive Care Society. Dec 2005

Beta-adrenergic agonists in the management of ARDS.

British Thoracic Society. Dec 2005

Adjuncts to mechanical ventilation.

Intensive Care Society of Ireland. Nov 2005.

Pro Con debate "An Irish Clinical Trials Group?"

Intensive Care Society of Ireland. June 2005.

Novel therapies for ARDS"

24th International Symposium on Intensive Care and Emergency Medicine. March 2004.

            Relative immunosuppression - role of neutrophils

            Compliance as a predictor of outcome in ARDS

            Role of beta-adrenergic agonists in the management of ARDS

            Effect of admission to intensive care on neuropsychological morbidity

UK Intensive Care Society Trainees Meeting. August 2002

Pro Con debate "There is no place for physicians in ICU"

 

Local Principle Investigator in multi-centre clinical trials

Fungal Infection Risk Evalution

Beta Agonist Lung Injury TrLal Prevention

Beta Agonist Lung Injury TrLal 2

Ongoing external research collaborations

Dr John Simpson (Edinburgh University) Monocyte depletion in acute neutrophil-mediated lung injury

Prof John Laffey (Galway University Hospitals) Matrix metalloproteinases (MMPs) in ventilator associated lung injury

Dr David Thickett and Dr Gavin Perkins (University of Brimingham and University of Warwick) RAGE in ALI, Vitamin D in ALI 

Prof Michael Matthay (University of California, San Francisco) Protective role of KGF in acute lung injury





Publications
Chapter(s)
TitleBook TitleYear
Do non-ventilatory strategies for acute lung injury and the acute respiratory distress syndrome work? Evidence-based practice of Critical Care 2010
Antioxidants for the treatment of endothelial dysfunction in critical illness 27th Yearbook of Intensive Care and Emergency Medicine 2007
Potential Mechanisms by which statins modulate the development of Acute Lung Injury Yearbook of Intensive Care and Emergency Medicine 2007
Matrix metalloproteinases: a potential role in the pathogensis of ARDS Yearbook of Intensive Care and Emergency Medicine 2004
Lung fluid balance and pulmonary edema in the acute respiratory distress syndrome: modulation by beta adrenergenic stimulation 24th Yearbook of Intensive Care and Emergency Medicine 2004
Ethical committees and application for ethical application Key Topics in Clinical Research 2002
Audit Key Topics in Clinical Research 2002
Introduction to the Research Process Key Topics in Clinical Research 2002
Journal(s)
TitleJournal NameYear
Effect of intravenous beta-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial Lancet Vol 379 (229-235)  DOI   2012
Risk factors for acute organ failure in ICU patients with single organ (respiratory) dysfunction or failure: an international, prospective, cohort study Critical Care Vol in press (229-235)  2012
A novel subpopulation of monocyte-like cells in the human lung after LPS inhalation. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Vol in press (229-235)  DOI 2012
A randomized clinical trial of hydroxymethylglutaryl-CoA reductase inhibition for acute lung injury (The HARP study) American Journal of Respiratory and Critical Care Medicine Vol 183 (620-626)  DOI   2011
Decisional responsibility for mechanical ventilation and weaning: an international survey. Critical Care Vol 15(6) (R295-626)  DOI 2011
C5a-mediated neutrophil phagocytic dysfunction is RhoA-dependent and predicts nosocomial infection in critically ill patients. Blood Vol 117 No.19 (5178-5188)  DOI   2011
Nasal potential difference to detect Na+ channel dysfunction in acute lung injury American Journal of Physiology - Lung Cellular and Molecular Physiology Vol 300 (3) (L305-L318)    2011
A national clinical scenario-based survey of clinicians' attitudes towards fresh frozen plasma transfusion for critically ill patients Transfusion Medicine Vol 21 (2) (124-129)  DOI   2011
Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury Respiratory Research Vol 12 (52-129)  DOI   2011
Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1) JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION Vol 306 (1659-1668)  DOI   2011
Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo. PLoS ONE Vol 6(10) (e26525-1668)  DOI 2011
Evolution of the inflammatory and fibroproliferative responses during resolution and repair following ventilator induced lung injury in the rat Anesthesiology Vol in press (in press-in press)  2011
A national survey of the mangement of delirium in UK intensive care units Quarterly Journal of Medicine Vol 103 (4) (243-251)  DOI   2010
Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury Critical Care Medicine Vol 38 (114-120)  DOI   2010
Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation. Respiratory Research Vol 11 (117-120)  DOI 2010
A potential role for keratinocyte growth factor and clarithromycin in the treatment of paraquat overdose. QJM : monthly journal of the Association of Physicians Vol 103(8) (611-613)  DOI 2010
Impaired endothelium-dependent vasodilatation is a novel predictor of mortality in intensive care. Critical Care Medicine Vol In press (00-00)  DOI 2010
The Swine Flu Triage (SwiFT) study: Development and ongoing refinement of a triage tool to provide regular information to guide immediate policy and practice for the use of critical care services during the H1N1 swine influenza pandemic. Health technology assessment (Winchester, England) Vol 14(55) (337-496)  DOI 2010
The impact of a PCR assay for candidemia on antifungal drug prescribing in critical care: an interrupted time series pilot study. The Journal of infection Vol 61(1) (81-85)  DOI   2010
A national survey of the UK management of coagulapthy in critical care Transfusion Medicine Vol In press (00-00)  2010
Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers American Journal of Respiratory and Critical Care Medicine Vol 179 (1107-1114)  DOI   2009
Routine delirium monitoring in a UK critical care unit Critical Care Vol 13 (0-0)  DOI   2009
Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis Thorax Vol 64 (156-161)  DOI   2009
Type XVIII collagen degradation products in acute lung injury Critical Care Vol 13 (000-000)  DOI   2009
MMP expression and abnormal lung permeability are important determinants of outcome in IPF European Respiratory Journal Vol 33 (77-84)  DOI   2009
Preliminary Results of a Prospective Randomized Trial of Restrictive Versus Standard Fluid Regime in Elective Open Abdominal Aortic Aneurysm Repair Annals of Surgery Vol 250 (28-34)  DOI   2009
Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism Thorax Vol 64 (976-982)  DOI   2009
Decreased Levels of Secretory Leucoprotease Inhibitor in the Pseudomonas-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation Journal of Immunology Vol 183 (8148-8156)  DOI   2009
Intensive care for the adult population in Ireland: a multicentre study of intensive care population demographics. The Irish Critical Care Trials Group Critical Care Vol 12 (0-0)  2008
Predictors of mortality in acute lung injury during the era of lung protective ventilation Thorax Vol 63 (994-998)  DOI   2008
A randomized controlled trial of tea tree oil (5%) body wash versus standard body wash to prevent colonization with methicillin-resistant Staphylococcus aureus (MRSA) in critically ill adults: research protocol BMC Infectious Diseases Vol 8 (0-0)  DOI   2008
Acute lung injury and the acute respiratory distress syndrome in Ireland; a prospective audit of epidemiology and management Critical Care Vol 12 (R30-R30)  2008
The effect of salbutamol on neutrophil recruitment and activation in ARDS Thorax Vol 62 (36-42)  2007
Development of core competencies for an international training programme in intensive care medicine. The CoBaTrICE Collaboration Intensive Care Medicine Vol 32 (1371-1383)  2006
New flow cytometric technique for the evaluation of circulating endothelial progenitor cell levels in various disease groups. J Immunol Methods Vol 32 (1371-1383)  DOI 2006
Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol Vol 32 (1371-1383)  DOI 2006
Role of nonbronchoscopic lavage for investigating alveolar inflammation and permeability in acute respiratory distress syndrome Critical Care Medicine Vol 34 (57-64)  2006
Randomised controlled cross-over comparison of continuous positive airway pressure through the Hamilton Galileo ventilator with a Drager CF 800 device Anaesthesia Vol 60 (72-76)  2005
VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema European Respiratory Journal Vol 26 (101-105)  2005
Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury Critical Care Medicine Vol 33 (181-188)  2005
Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury Thorax Vol 60(2) (153-158)  DOI 2005
Safety and tolerability of nonbronchoscopic lavage in ARDS Chest Vol 127 (1358-1363)  2005
The beta-agonist lung injury trial (BALTI) - a randomized placebo-controlled clinical trial American Journal of Respiratory and Critical Care Medicine Vol 173(3) (281-287)  DOI 2005
Clinically relevant concentrations of beta(2)-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury Critical Care Medicine Vol 32(7) (1470-1476)  DOI 2004
Discrepancies between clinical and postmortem diagnoses in critically ill patients: an observational study Critical Care Vol 7 (R129-R132)  2003
Do changes in pulse oximeter oxygen saturation predict equivalent changes in arterial oxygen saturation? Critical Care Vol 7 (R67-R71)  2003
Phagocyte priming as a prognostic indicator in the intensive care unit Journal of Trauma-Injury Infection & Critical Care Vol 55 (1089-1094)  2003
What is the optimal duration of ventilation in the prone position in acute lung injury and acute respiratory distress syndrome? Intensive Care Medicine Vol 28 (414-418)  2002
Individuals with cystic fibrosis do not display impaired endothelial function or evidence of oxidative damage in endothelial cells exposed to serum Clinical Science (London) Vol 101 (507-513)  2001
The effects of oral methionine and homocystine on endothelial function Heart Vol 85 (326-330)  2001
Hyperhomocysteinaemia in young adults is not associated with impaired endothelial function Clinical Science (London) Vol 100 (67-72)  2001
Bradykinin infusion in chronic cardiac failure and the effects of captopril European Journal of Heart Failure Vol 3 (671-677)  2001
The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia BMC Cardiovascular Disorders Vol 1 (1-1)  2001
Vasoconstriction to endogenous endothelin-1 is impaired in patients with Type II diabetes mellitus Clinical Science (London) Vol 99 (175-179)  2000
Vasoconstriction to endothelin-1 is blunted in non-insulin dependent diabetes: a dose-response study Journal of Cardiovascular Pharmacology Vol 36 (203-208)  2000
No evidence of endothelial dysfunction in patients with Alzheimer's disease Dementia and Geriatric Cognitive Disorders Vol 11 (197-201)  2000
Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation Journal of Toxicology-Clinical Toxicology Vol 37 (435-440)  1999
Forearm reactive hyperaemia is not mediated by nitric oxide in heathy volunteers British Journal of Clinical Pharmacology Vol 48 (457-459)  1999
Accuracy and precision of blood pressure determination with the Finapres: an overview using re-sampling statistics Journal of Human Hypertension Vol 12 (403-409)  1998
Sources of inaccuracy in the use of the Hawksley Random-Zero Sphygmomanometer Hypertension Vol 15 (1379-1384)  1997
Forearm endothelial dependent vascular responses are not mediated through the potassium-ATP channel British Journal of Clinical Pharmacology Vol 44 (292-294)  1997
Reliability of blood pressure determination with the Finapres with altered physiological states or pharmacodynamic conditions Clinical Autonomic Research Vol 7 (179-184)  1997
Other Output(s)
TitlePublication TypeYear
Infection control: helping hands. (Editorial) Practical Patient Care, Internet publication 2008