Publications

Chapter(s)
Title	Book Title	Year
Do non-ventilatory strategies for acute lung injury and the acute respiratory distress syndrome work?	Evidence-based practice of Critical Care	2010
Antioxidants for the treatment of endothelial dysfunction in critical illness	27th Yearbook of Intensive Care and Emergency Medicine	2007
Potential Mechanisms by which statins modulate the development of Acute Lung Injury	Yearbook of Intensive Care and Emergency Medicine	2007
Matrix metalloproteinases: a potential role in the pathogensis of ARDS	Yearbook of Intensive Care and Emergency Medicine	2004
Lung fluid balance and pulmonary edema in the acute respiratory distress syndrome: modulation by beta adrenergenic stimulation	24th Yearbook of Intensive Care and Emergency Medicine	2004
Ethical committees and application for ethical application	Key Topics in Clinical Research	2002
Audit	Key Topics in Clinical Research	2002
Introduction to the Research Process	Key Topics in Clinical Research	2002
Journal(s)
Title	Journal Name	Year
Effect of intravenous beta-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial	Lancet Vol 379 (229-235)  DOI	2012
Risk factors for acute organ failure in ICU patients with single organ (respiratory) dysfunction or failure: an international, prospective, cohort study	Critical Care Vol in press (229-235)	2012
A novel subpopulation of monocyte-like cells in the human lung after LPS inhalation.	The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Vol in press (229-235)  DOI	2012
A randomized clinical trial of hydroxymethylglutaryl-CoA reductase inhibition for acute lung injury (The HARP study)	American Journal of Respiratory and Critical Care Medicine Vol 183 (620-626)  DOI	2011
Decisional responsibility for mechanical ventilation and weaning: an international survey.	Critical Care Vol 15(6) (R295-626)  DOI	2011
C5a-mediated neutrophil phagocytic dysfunction is RhoA-dependent and predicts nosocomial infection in critically ill patients.	Blood Vol 117 No.19 (5178-5188)  DOI	2011
Nasal potential difference to detect Na+ channel dysfunction in acute lung injury	American Journal of Physiology - Lung Cellular and Molecular Physiology Vol 300 (3) (L305-L318)	2011
A national clinical scenario-based survey of clinicians' attitudes towards fresh frozen plasma transfusion for critically ill patients	Transfusion Medicine Vol 21 (2) (124-129)  DOI	2011
Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury	Respiratory Research Vol 12 (52-129)  DOI	2011
Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1)	JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION Vol 306 (1659-1668)  DOI	2011
Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo.	PLoS ONE Vol 6(10) (e26525-1668)  DOI	2011
Evolution of the inflammatory and fibroproliferative responses during resolution and repair following ventilator induced lung injury in the rat	Anesthesiology Vol in press (in press-in press)	2011
A national survey of the mangement of delirium in UK intensive care units	Quarterly Journal of Medicine Vol 103 (4) (243-251)  DOI	2010
Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury	Critical Care Medicine Vol 38 (114-120)  DOI	2010
Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation.	Respiratory Research Vol 11 (117-120)  DOI	2010
A potential role for keratinocyte growth factor and clarithromycin in the treatment of paraquat overdose.	QJM : monthly journal of the Association of Physicians Vol 103(8) (611-613)  DOI	2010
Impaired endothelium-dependent vasodilatation is a novel predictor of mortality in intensive care.	Critical Care Medicine Vol In press (00-00)  DOI	2010
The Swine Flu Triage (SwiFT) study: Development and ongoing refinement of a triage tool to provide regular information to guide immediate policy and practice for the use of critical care services during the H1N1 swine influenza pandemic.	Health technology assessment (Winchester, England) Vol 14(55) (337-496)  DOI	2010
The impact of a PCR assay for candidemia on antifungal drug prescribing in critical care: an interrupted time series pilot study.	The Journal of infection Vol 61(1) (81-85)  DOI	2010
A national survey of the UK management of coagulapthy in critical care	Transfusion Medicine Vol In press (00-00)	2010
Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers	American Journal of Respiratory and Critical Care Medicine Vol 179 (1107-1114)  DOI	2009
Routine delirium monitoring in a UK critical care unit	Critical Care Vol 13 (0-0)  DOI	2009
Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis	Thorax Vol 64 (156-161)  DOI	2009
Type XVIII collagen degradation products in acute lung injury	Critical Care Vol 13 (000-000)  DOI	2009
MMP expression and abnormal lung permeability are important determinants of outcome in IPF	European Respiratory Journal Vol 33 (77-84)  DOI	2009
Preliminary Results of a Prospective Randomized Trial of Restrictive Versus Standard Fluid Regime in Elective Open Abdominal Aortic Aneurysm Repair	Annals of Surgery Vol 250 (28-34)  DOI	2009
Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism	Thorax Vol 64 (976-982)  DOI	2009
Decreased Levels of Secretory Leucoprotease Inhibitor in the Pseudomonas-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation	Journal of Immunology Vol 183 (8148-8156)  DOI	2009
Intensive care for the adult population in Ireland: a multicentre study of intensive care population demographics. The Irish Critical Care Trials Group	Critical Care Vol 12 (0-0)	2008
Predictors of mortality in acute lung injury during the era of lung protective ventilation	Thorax Vol 63 (994-998)  DOI	2008
A randomized controlled trial of tea tree oil (5%) body wash versus standard body wash to prevent colonization with methicillin-resistant Staphylococcus aureus (MRSA) in critically ill adults: research protocol	BMC Infectious Diseases Vol 8 (0-0)  DOI	2008
Acute lung injury and the acute respiratory distress syndrome in Ireland; a prospective audit of epidemiology and management	Critical Care Vol 12 (R30-R30)	2008
The effect of salbutamol on neutrophil recruitment and activation in ARDS	Thorax Vol 62 (36-42)	2007
Development of core competencies for an international training programme in intensive care medicine. The CoBaTrICE Collaboration	Intensive Care Medicine Vol 32 (1371-1383)	2006
New flow cytometric technique for the evaluation of circulating endothelial progenitor cell levels in various disease groups.	J Immunol Methods Vol 32 (1371-1383)  DOI	2006
Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.	Am J Physiol Lung Cell Mol Physiol Vol 32 (1371-1383)  DOI	2006
Role of nonbronchoscopic lavage for investigating alveolar inflammation and permeability in acute respiratory distress syndrome	Critical Care Medicine Vol 34 (57-64)	2006
Randomised controlled cross-over comparison of continuous positive airway pressure through the Hamilton Galileo ventilator with a Drager CF 800 device	Anaesthesia Vol 60 (72-76)	2005
VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema	European Respiratory Journal Vol 26 (101-105)	2005
Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury	Critical Care Medicine Vol 33 (181-188)	2005
Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury	Thorax Vol 60(2) (153-158)  DOI	2005
Safety and tolerability of nonbronchoscopic lavage in ARDS	Chest Vol 127 (1358-1363)	2005
The beta-agonist lung injury trial (BALTI) - a randomized placebo-controlled clinical trial	American Journal of Respiratory and Critical Care Medicine Vol 173(3) (281-287)  DOI	2005
Clinically relevant concentrations of beta(2)-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury	Critical Care Medicine Vol 32(7) (1470-1476)  DOI	2004
Discrepancies between clinical and postmortem diagnoses in critically ill patients: an observational study	Critical Care Vol 7 (R129-R132)	2003
Do changes in pulse oximeter oxygen saturation predict equivalent changes in arterial oxygen saturation?	Critical Care Vol 7 (R67-R71)	2003
Phagocyte priming as a prognostic indicator in the intensive care unit	Journal of Trauma-Injury Infection & Critical Care Vol 55 (1089-1094)	2003
What is the optimal duration of ventilation in the prone position in acute lung injury and acute respiratory distress syndrome?	Intensive Care Medicine Vol 28 (414-418)	2002
Individuals with cystic fibrosis do not display impaired endothelial function or evidence of oxidative damage in endothelial cells exposed to serum	Clinical Science (London) Vol 101 (507-513)	2001
The effects of oral methionine and homocystine on endothelial function	Heart Vol 85 (326-330)	2001
Hyperhomocysteinaemia in young adults is not associated with impaired endothelial function	Clinical Science (London) Vol 100 (67-72)	2001
Bradykinin infusion in chronic cardiac failure and the effects of captopril	European Journal of Heart Failure Vol 3 (671-677)	2001
The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia	BMC Cardiovascular Disorders Vol 1 (1-1)	2001
Vasoconstriction to endogenous endothelin-1 is impaired in patients with Type II diabetes mellitus	Clinical Science (London) Vol 99 (175-179)	2000
Vasoconstriction to endothelin-1 is blunted in non-insulin dependent diabetes: a dose-response study	Journal of Cardiovascular Pharmacology Vol 36 (203-208)	2000
No evidence of endothelial dysfunction in patients with Alzheimer's disease	Dementia and Geriatric Cognitive Disorders Vol 11 (197-201)	2000
Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation	Journal of Toxicology-Clinical Toxicology Vol 37 (435-440)	1999
Forearm reactive hyperaemia is not mediated by nitric oxide in heathy volunteers	British Journal of Clinical Pharmacology Vol 48 (457-459)	1999
Accuracy and precision of blood pressure determination with the Finapres: an overview using re-sampling statistics	Journal of Human Hypertension Vol 12 (403-409)	1998
Sources of inaccuracy in the use of the Hawksley Random-Zero Sphygmomanometer	Hypertension Vol 15 (1379-1384)	1997
Forearm endothelial dependent vascular responses are not mediated through the potassium-ATP channel	British Journal of Clinical Pharmacology Vol 44 (292-294)	1997
Reliability of blood pressure determination with the Finapres with altered physiological states or pharmacodynamic conditions	Clinical Autonomic Research Vol 7 (179-184)	1997
Other Output(s)
Title	Publication Type	Year
Infection control: helping hands. (Editorial) Practical Patient Care,	Internet publication	2008