Staff Profile


Publications
Chapter(s)
TitleBook TitleYear
Do non-ventilatory strategies for acute lung injury and the acute respiratory distress syndrome work? Evidence-based practice of Critical Care 2010
Antioxidants for the treatment of endothelial dysfunction in critical illness 27th Yearbook of Intensive Care and Emergency Medicine 2007
Potential Mechanisms by which statins modulate the development of Acute Lung Injury Yearbook of Intensive Care and Emergency Medicine 2007
Matrix metalloproteinases: a potential role in the pathogensis of ARDS Yearbook of Intensive Care and Emergency Medicine 2004
Lung fluid balance and pulmonary edema in the acute respiratory distress syndrome: modulation by beta adrenergenic stimulation 24th Yearbook of Intensive Care and Emergency Medicine 2004
Ethical committees and application for ethical application Key Topics in Clinical Research 2002
Audit Key Topics in Clinical Research 2002
Introduction to the Research Process Key Topics in Clinical Research 2002
Journal(s)
TitleJournal NameYear
Effect of intravenous beta-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial Lancet Vol 379 (229-235)  DOI   2012
Risk factors for acute organ failure in ICU patients with single organ (respiratory) dysfunction or failure: an international, prospective, cohort study Critical Care Vol in press (229-235)  2012
A novel subpopulation of monocyte-like cells in the human lung after LPS inhalation. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Vol in press (229-235)  DOI 2012
A randomized clinical trial of hydroxymethylglutaryl-CoA reductase inhibition for acute lung injury (The HARP study) American Journal of Respiratory and Critical Care Medicine Vol 183 (620-626)  DOI   2011
Decisional responsibility for mechanical ventilation and weaning: an international survey. Critical Care Vol 15(6) (R295-626)  DOI 2011
C5a-mediated neutrophil phagocytic dysfunction is RhoA-dependent and predicts nosocomial infection in critically ill patients. Blood Vol 117 No.19 (5178-5188)  DOI   2011
Nasal potential difference to detect Na+ channel dysfunction in acute lung injury American Journal of Physiology - Lung Cellular and Molecular Physiology Vol 300 (3) (L305-L318)    2011
A national clinical scenario-based survey of clinicians' attitudes towards fresh frozen plasma transfusion for critically ill patients Transfusion Medicine Vol 21 (2) (124-129)  DOI   2011
Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury Respiratory Research Vol 12 (52-129)  DOI   2011
Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1) JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION Vol 306 (1659-1668)  DOI   2011
Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo. PLoS ONE Vol 6(10) (e26525-1668)  DOI 2011
Evolution of the inflammatory and fibroproliferative responses during resolution and repair following ventilator induced lung injury in the rat Anesthesiology Vol in press (in press-in press)  2011
A national survey of the mangement of delirium in UK intensive care units Quarterly Journal of Medicine Vol 103 (4) (243-251)  DOI   2010
Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury Critical Care Medicine Vol 38 (114-120)  DOI   2010
Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation. Respiratory Research Vol 11 (117-120)  DOI 2010
A potential role for keratinocyte growth factor and clarithromycin in the treatment of paraquat overdose. QJM : monthly journal of the Association of Physicians Vol 103(8) (611-613)  DOI 2010
Impaired endothelium-dependent vasodilatation is a novel predictor of mortality in intensive care. Critical Care Medicine Vol In press (00-00)  DOI 2010
The Swine Flu Triage (SwiFT) study: Development and ongoing refinement of a triage tool to provide regular information to guide immediate policy and practice for the use of critical care services during the H1N1 swine influenza pandemic. Health technology assessment (Winchester, England) Vol 14(55) (337-496)  DOI 2010
The impact of a PCR assay for candidemia on antifungal drug prescribing in critical care: an interrupted time series pilot study. The Journal of infection Vol 61(1) (81-85)  DOI   2010
A national survey of the UK management of coagulapthy in critical care Transfusion Medicine Vol In press (00-00)  2010
Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers American Journal of Respiratory and Critical Care Medicine Vol 179 (1107-1114)  DOI   2009
Routine delirium monitoring in a UK critical care unit Critical Care Vol 13 (0-0)  DOI   2009
Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis Thorax Vol 64 (156-161)  DOI   2009
Type XVIII collagen degradation products in acute lung injury Critical Care Vol 13 (000-000)  DOI   2009
MMP expression and abnormal lung permeability are important determinants of outcome in IPF European Respiratory Journal Vol 33 (77-84)  DOI   2009
Preliminary Results of a Prospective Randomized Trial of Restrictive Versus Standard Fluid Regime in Elective Open Abdominal Aortic Aneurysm Repair Annals of Surgery Vol 250 (28-34)  DOI   2009
Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism Thorax Vol 64 (976-982)  DOI   2009
Decreased Levels of Secretory Leucoprotease Inhibitor in the Pseudomonas-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation Journal of Immunology Vol 183 (8148-8156)  DOI   2009
Intensive care for the adult population in Ireland: a multicentre study of intensive care population demographics. The Irish Critical Care Trials Group Critical Care Vol 12 (0-0)  2008
Predictors of mortality in acute lung injury during the era of lung protective ventilation Thorax Vol 63 (994-998)  DOI   2008
A randomized controlled trial of tea tree oil (5%) body wash versus standard body wash to prevent colonization with methicillin-resistant Staphylococcus aureus (MRSA) in critically ill adults: research protocol BMC Infectious Diseases Vol 8 (0-0)  DOI   2008
Acute lung injury and the acute respiratory distress syndrome in Ireland; a prospective audit of epidemiology and management Critical Care Vol 12 (R30-R30)  2008
The effect of salbutamol on neutrophil recruitment and activation in ARDS Thorax Vol 62 (36-42)  2007
Development of core competencies for an international training programme in intensive care medicine. The CoBaTrICE Collaboration Intensive Care Medicine Vol 32 (1371-1383)  2006
New flow cytometric technique for the evaluation of circulating endothelial progenitor cell levels in various disease groups. J Immunol Methods Vol 32 (1371-1383)  DOI 2006
Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol Vol 32 (1371-1383)  DOI 2006
Role of nonbronchoscopic lavage for investigating alveolar inflammation and permeability in acute respiratory distress syndrome Critical Care Medicine Vol 34 (57-64)  2006
Randomised controlled cross-over comparison of continuous positive airway pressure through the Hamilton Galileo ventilator with a Drager CF 800 device Anaesthesia Vol 60 (72-76)  2005
VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema European Respiratory Journal Vol 26 (101-105)  2005
Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury Critical Care Medicine Vol 33 (181-188)  2005
Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury Thorax Vol 60(2) (153-158)  DOI 2005
Safety and tolerability of nonbronchoscopic lavage in ARDS Chest Vol 127 (1358-1363)  2005
The beta-agonist lung injury trial (BALTI) - a randomized placebo-controlled clinical trial American Journal of Respiratory and Critical Care Medicine Vol 173(3) (281-287)  DOI 2005
Clinically relevant concentrations of beta(2)-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury Critical Care Medicine Vol 32(7) (1470-1476)  DOI 2004
Discrepancies between clinical and postmortem diagnoses in critically ill patients: an observational study Critical Care Vol 7 (R129-R132)  2003
Do changes in pulse oximeter oxygen saturation predict equivalent changes in arterial oxygen saturation? Critical Care Vol 7 (R67-R71)  2003
Phagocyte priming as a prognostic indicator in the intensive care unit Journal of Trauma-Injury Infection & Critical Care Vol 55 (1089-1094)  2003
What is the optimal duration of ventilation in the prone position in acute lung injury and acute respiratory distress syndrome? Intensive Care Medicine Vol 28 (414-418)  2002
Individuals with cystic fibrosis do not display impaired endothelial function or evidence of oxidative damage in endothelial cells exposed to serum Clinical Science (London) Vol 101 (507-513)  2001
The effects of oral methionine and homocystine on endothelial function Heart Vol 85 (326-330)  2001
Hyperhomocysteinaemia in young adults is not associated with impaired endothelial function Clinical Science (London) Vol 100 (67-72)  2001
Bradykinin infusion in chronic cardiac failure and the effects of captopril European Journal of Heart Failure Vol 3 (671-677)  2001
The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia BMC Cardiovascular Disorders Vol 1 (1-1)  2001
Vasoconstriction to endogenous endothelin-1 is impaired in patients with Type II diabetes mellitus Clinical Science (London) Vol 99 (175-179)  2000
Vasoconstriction to endothelin-1 is blunted in non-insulin dependent diabetes: a dose-response study Journal of Cardiovascular Pharmacology Vol 36 (203-208)  2000
No evidence of endothelial dysfunction in patients with Alzheimer's disease Dementia and Geriatric Cognitive Disorders Vol 11 (197-201)  2000
Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation Journal of Toxicology-Clinical Toxicology Vol 37 (435-440)  1999
Forearm reactive hyperaemia is not mediated by nitric oxide in heathy volunteers British Journal of Clinical Pharmacology Vol 48 (457-459)  1999
Accuracy and precision of blood pressure determination with the Finapres: an overview using re-sampling statistics Journal of Human Hypertension Vol 12 (403-409)  1998
Sources of inaccuracy in the use of the Hawksley Random-Zero Sphygmomanometer Hypertension Vol 15 (1379-1384)  1997
Forearm endothelial dependent vascular responses are not mediated through the potassium-ATP channel British Journal of Clinical Pharmacology Vol 44 (292-294)  1997
Reliability of blood pressure determination with the Finapres with altered physiological states or pharmacodynamic conditions Clinical Autonomic Research Vol 7 (179-184)  1997
Other Output(s)
TitlePublication TypeYear
Infection control: helping hands. (Editorial) Practical Patient Care, Internet publication 2008