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The School of Medicine, Dentistry and Biomedical Sciences
'FROM DISCOVERY TO RECOVERY'
Centre for Infection and Immunity
In This Section
Exchange protein directly activated by cAMP 1 (Epac1) is expressed in human neutrophils and mediates cAMP-dependent activation of the monomeric GTPase Rap1
Journal of Leukocyte Biology Vol 90 (741-749)
USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity
Journal of Biological Chemistry Vol 284 (9587-9595)
Beta2 integrins target Rap GTPases to the plasma membrane by means of degranulation.
Biochemical and Biophysical Research Communications Vol 376(4) (642-646)
Nitric Oxide Produced in Response to Engagement of beta 2 Integrins on Human Neutrophils Activates the Monomeric GTPases Rap1 and Rap2 and Promotes Adhesion
Journal of Biological Chemistry Vol 281(46) (35008-35020)
E3B1, a human homologue of the mouse gene product Abi-1, sensitizes activation of Rap1 in response to epidermal growth factor.
Experimental Cell Research Vol 310(2) (463-473)
Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils.
Biochemical and Biophysical Research Communications Vol 317(4) (1000-1005)
Fgr but not Syk tyrosine kinase is a target for beta2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils
The Biochemical Journal Vol 370(2) (687-694)
Down-regulation of Rac Activity during beta 2 Integrin-mediated Adhesion of Human Neutrophils
Journal of Biological Chemistry Vol 278(26) (24181-24188)
Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion.
International journal of cancer. Journal international du cancer Vol 103(3) (344-351)
Role of p190RhoGAP in beta2 Integrin Regulation of RhoA in Human Neutrophils
Journal of Immunology Vol 166 (10) (6311-6322)
Modification of adipocyte membrane adenylyl cyclase activity by NAD: evidence against NAD-induced endogenous ADP-ribosylation of Gsalpha protein.
Biochemical and Biophysical Research Communications Vol 270(1) (203-208)
BETA 2 integrin signaling in leukocytes.
Frontiers in bioscience : a journal and virtual library Vol 5 (D438-D451)
Cyclic AMP regulates G(omicronalpha) protein and mRNA levels by modulating the transcriptional rate of G(omicronalpha) gene.
Molecular and Cellular Endocrinology Vol 156(1-2) (35-43)
Cyclic AMP regulation of G(i alpha2) and G(i alpha3) mRNAs and proteins in astroglial cells.
Journal of Neurochemistry Vol 71(6) (2271-2277)
Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly. A disorder characterized by selective postreceptor insulin resistance.
The Journal of clinical investigation Vol 101(5) (1111-1120)
Expression of the putative inhibitor of the insulin receptor tyrosine kinase PC-1 in dermal fibroblasts from patients with syndromes of severe insulin resistance.
Clinical Endocrinology Vol 47(1) (65-70)
Sodium saccharin inhibits adenylyl cyclase activity in non-taste cells.
Cellular Signalling Vol 9(6) (431-438)
Two naturally occurring mutant insulin receptors phosphorylate insulin receptor substrate-1 (IRS-1) but fail to mediate the biological effects of insulin. Evidence that IRS-1 phosphorylation is not sufficient for normal insulin action.
The Journal of biological chemistry Vol 271(12) (7134-7140)
Effects of sodium saccharin diet on fat-cell lipolysis: evidence for increased function of the adenylyl cyclase catalyst.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity Vol 20(1) (15-20)
12-O-tetradecanoyl-phorbol-13-acetate (TPA) counteracts the cAMP up-regulation of the expression of the stimulatory guanine nucleotide binding protein (Gs alpha) and Gs alpha messenger RNA in cultured pig thyroid cells.
Molecular and Cellular Endocrinology Vol 99(2) (229-235)
Cyclic AMP regulation of messenger RNA level of the stimulatory GTP-binding protein Gs alpha. Isoproterenol, forskolin and 8-bromoadenosine 3':5'-cyclic monophosphate increase the level of Gs alpha mRNA in cultured astroglial cells.
European journal of biochemistry / FEBS Vol 219(1-2) (529-537)
Modification of the amounts of G proteins and of the activity of adenylyl cyclase in human benign thyroid tumours.
The Journal of endocrinology Vol 132(3) (477-485)
The effect of glycosyl inositol-phosphate on cAMP production in isolated rat fat-cells is transduced by a pertussis toxin sensitive G-protein.
FEBS Letters Vol 286(1-2) (105-109)
Alteration of the functional activity of Gs protein in thyrotropin-desensitized pig thyroid cells.
Molecular and Cellular Endocrinology Vol 75(2) (123-131)
Cyclic AMP regulation of Gs protein. Thyrotropin and forskolin increase the quantity of stimulatory guanine nucleotide-binding proteins in cultured thyroid follicles.
The Journal of biological chemistry Vol 265(32) (19942-19946)