Staff Profile


Publications
Edited Book(s)
TitlePublisherYear
Mechanisms of Pulmonary Innate Immunity Research Signpost 2008
Chapter(s)
TitleBook TitleYear
SLPI and elafin - multifunctional components of the respiratory tract Mechanisms of Pulmonary Innate Immunity 2008
Antiproteases Chronic Obstructive Pulmonary Disease Cellular and Molecular Mechanisms 2005
Surrogate markers of lung destruction LAM and other diseases of smooth muscle 1999
Journal(s)
TitleJournal NameYear
The prevalence of alpha-1 antitrypsin deficiency in Ireland Respiratory Research Vol 12:91  DOI   2011
The Effect of Liposome Encapsulation on the Pharmacokinetics of Recombinant Secretory Leukocyte Protease Inhibitor (rSLPI) Therapy after Local Delivery to a Guinea Pig Asthma Model Pharmaceutical Research Vol 28 (9) (2233-2245)  DOI   2011
Altered Toll-like Receptor 2-mediated Endotoxin Tolerance Is Related to Diminished Interferon beta Production Journal of Biological Chemistry Vol 286 (34) (29492-29500)  DOI   2011
Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis Journal of Cystic Fibrosis Vol epub ahead of print (29492-29500)  2011
Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases. Biological Chemistry Vol in press (000-000)  DOI 2010
Biologic protease inhibitors as novel therapeutic agents. Biochimie Vol in press (000-000)  DOI 2010
Antiproteases as therapeutics to target inflammation in cystic fibrosis. The open respiratory medicine journal Vol 4 (20-31)  DOI 2010
Impaired Immune Tolerance to Porphyromonas gingivalis Lipopolysaccharide Promotes Neutrophil Migration and Decreased Apoptosis. Infection and Immunity Vol 78(10) (4151-4156)  DOI   2010
Decreased Levels of Secretory Leucoprotease Inhibitor in the Pseudomonas-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation Journal of Immunology Vol 183 (8148-8156)  DOI   2009
Neutrophil Elastase Increases Airway Epithelial Nonheme Iron Levels CTS-CLINICAL AND TRANSLATIONAL SCIENCE Vol 2 (333-339)  DOI   2009
Anti-apoptotic effects of Z alpha-1 antitrypsin in human bronchial epithelial cells. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Vol in press (000-000)  DOI 2009
Neutrophil elastase increases airway epithelial nonheme iron levels. CTS-CLINICAL AND TRANSLATIONAL SCIENCE Vol 2(5) (333-339)  DOI 2009
Alpha-1-antitrypsin deficiencey: A conformational disease associated with lung and liver manifestations Journal of Inherited Metabolic Disease Vol 31(1) (21-34)  2008
Alpha-one antitrypsin aerosolized augmentation abrogates neutrophil elastase induced expression of Cathepsin B and Matrix Metalloprotease 2 in vivo and in vitro Thorax Vol 63 (621-626)  DOI   2008
Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway The Journal of biological chemistry Vol 283 (31736-31744)  DOI   2008
Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis The Journal of biological chemistry Vol 283 (32377-32385)  DOI   2008
Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation Journal of Microencapsulation Vol 26 (521-526)  2008
Alpha-1-antitrypsin deficiency: current concepts Lung Vol 185(4) (191-201)  2007
Innate host defense functions of secretory leucoprotease inhibitor Experimental Lung Research Vol 33(10) (485-491)  2007
Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor Cellular Microbiology Vol 9(3) (670-679)  2007
The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses Biochemical Society Transactions Vol 35 (273-276)  2007
Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression Journal of Immunology Vol 178 (5871-5878)  2007
Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of bad Hepatology Vol 46(2) (496-503)  2007
The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the cystic fibrosis pathogen Burkholderia cepacia complex when cultured planktonically or as biofilms Journal of Antimicrobial Chemotherapy Vol 60(3) (546-554)  2007
Secretory leucocyte protease inhibitor inhibits interferon gamma-induced cathepsin s expression Journal of Biological Chemistry Vol 282(46) (33389-33395)  2007
Elafin prevents lipopolysaccharide-induced AP-1 and NF-kB activation via an effect on the ubiquitin-proteasome pathway Journal of Biological Chemistry Vol 281(46) (34730-34735)  DOI   2006
Antimicrobial proteins and polypeptides in pulmonary innate defense Respiratory Research Vol 7 (29-29)  2006
Matrix metalloproteinases 2 and 9 in human atherosclerotic and non-atherosclerotic cerebral aneurysms European Neurology Vol 10 (1098-1105)  2006
Secretory leucoprotease inhibitor binds to NF-{kappa}B binding sites in monocytes and inhibits p65 binding Journal of Experimental Medicine Vol 202(12) (1659-1668)  DOI   2005
Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease American Journal of Respiratory Critical Care Medicine Vol 171 (1070-1076)  2005
TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells Journal of Immunology Vol 174 (1638-1646)  2005
Endotoxin up-regulates interleukin-18: Potential role for gram-negative colonization in sarcoidosis American Journal of Respiratory and Critical Care Medicine Vol 172(10) (1299-1307)  2005
Respiratory epithelial cells require toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide Respiratory Research Vol 6 (116-116)  2005
Viral inhibition of IL-1 and neutrophil elastase-induced inflammatory response in bronchial epithelial cells Journal of Immunology Vol 175(11) (7594-7601)  2005
Interleukin-1, Neutrophil Elastase, and Lipopolysaccharide: Key Pro-Inflammatory Stimuli Regulating Inflammation in Cystic Fibrosis Current Respiratory Medicine Review Vol 1 (43-67)  2005
Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency Journal of Immunology Vol 172 (5722-5726)  2004
Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant Chest Vol 125 (1952-1957)  2004
Secretory leucoprotease inhibitor impairs toll-like receptor-2 and 4-mediated responses in monocytic cells Infection and Immunity Vol 72 (3684-3687)  2004
Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis Journal of Infectious Diseases Vol 190 (1245-1253)  2004
Inactivation of Human beta-Defensins 2 and 3 by Elastolytic Cathepsins Journal of Immunology Vol 171 (2) (931-937)    2003
Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4 FEBS Letters Vol 544(1-3) (129-132)  2003
Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells FEBS Letters Vol 546(2-3) (233-236)  2003
Anti-neutrophil elastase capacity is impaired in community acquired pneumonia Journal of Infectious Diseases Vol 188 (769-776)  2003
Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced Ikappa Balpha degradation without affecting phosphorylation or ubiquitination Journal of Biological Chemistry Vol 277(37) (33648-33653)  DOI   2002
Ambient pCO2 modulates intracellular pH, intracellular oxidant generation and interleukin-8 secretion in human neutrophils Journal of Leukocyte Biology Vol 71(4) (603-610)  2002
Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis Blood Vol 100 (3383-3391)  2002
TNFa converting enzyme: its role in community-acquired pheumonia Journal of Infectious Diseases Vol 186 (1790-1796)  2002
Anti-PR3 antibody activation of neutrophils can be inhibited by alpha 1 antitrypsin American Journal of Respiratory Cell and Molecular Biology Vol 24(6) (747-754)  2001
Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor Journal of Biological Chemistry Vol 276(36) (33345-33352)  2001
Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TAF-6 in human bronchial epithelium Journal of Biological Chemistry Vol 276(38) (35494-35499)  2001
Alpha-1 antitrypsin Deficiency: Biological Answers to Clinical Questions American Journal of Medical Sciences Vol 321 (33-41)  2001
Oxidation of either methionine 351 or Methionine 358 in alpha-1-Antitrypsin causes loss of anti-neutrophil elastase activity J. Biol. Chem Vol 275 (27258-27265)  2000
The role of interleukin-18 in CD4+ T lymphocyte activation in sarcoidosis Journal of Immunology Vol 165 (4718-4724)  2000
Abnormal regulation of cytosolic pH in neutrophils from cystic fibrosis patients American Journal of Physiology Vol 279(1) (L66-L74)  2000
Increased elastase release from neutrophils in cystic fibrosis in modulated by tumour necrosis fact alpha and interleukin-8 American Journal of Physiology Vol 278 (L33-L41)  2000
Regulated nucleear localisation of the yeast transcription factor Ace2p controls expression of chitinase (CTS1) in Saccharomyces cerevisiae Molecular Genetics and Genomics Vol 262(2) (275-282)  1999
Alpha 1-antitrypsin deficiency Irish Medical Journal Vol 92 (227-228)  1999
The role of dietary cholesterol in the regulation of postprandial apolipoprotein B48 levels in diabetes. Diabetic medicine : a journal of the British Diabetic Association Vol 14(12) (1051-1058)  DOI 1997
Effect of different carbon sources on heterologous expression levels in the yeast S. cerevisiae BJ2168. Biochemical Society Transactions Vol 22(1) (22S-22S)  1994
B-loop analogues of human epidermal growth factor; design, expression and properties. Biochemical Society Transactions Vol 22(1) (21S-21S)  1994