Staff Profile

Research Statement

My research covers a broad range of interests from understanding basic mechanisms of inflammation regulation to evaluating indices of inflammation in in vivo biological samples. The setting of this research is the chronic infected lung particularly Cystic Fibrosis and Chronic Obstructive Pulmonary Disease (COPD) although my recent work has brought me into the area of Acute Lung Injury as well. I am interested in how the innate immune response is involved in regulating inflammation with particular emphasis on how antimicrobial proteins/peptides and proteases contribute to inflammatory responses in the lung. From the disease point of view, I am intrigued by how these inflammatory responses become dysregulated in the diseases outlined above. My research has been published in high-ranking journals including the Journal of Experimental Medicine, Journal of Immunology, Blood, Journal of Biological Chemistry and the American Journal of Respiratory and Critical Care Medicine. My research in the Respiratory/Pulmonary area has recently been recognized by the European Respiratory Society with the award of the Romain Pauwels Research award for outstanding contribution to respiratory medicine in 2008.