'FROM DISCOVERY TO RECOVERY'
I am currently investigating the expression and functional characteristics of novel ion channels located in the airways of asthmatic and cough patients. It is hoped this work will help identify novel targets for the treatment of acute and chronic cough. I have been a core contributor to one national (British Thoracic Society, 2006) and two international (European Respiratory Society, 2004 & 2007) guideline documents on cough which have pioneered the clinical and scientific approach to this field of respiratory medicine.
In collaboration with Wise (Johns Hopkins Hospital, Baltimore, USA) and John (Charite Hospital, Berlin, Germany) I have developed a new methodological approach to the reliable adjudication of cause-specific mortality in chronic obstructive pulmonary disease (COPD). This methodology has been utilised in the two largest clinical trials in COPD to date (TORCH & UPLIFT).
In 2008 I established the Premature Adult Lung Study (PALS) group, a multidisciplinary team currently undertaking a programme of research to comprehensively evaluate the impact of bronchopulmonary dysplasia (BPD) in adult life.
As a recognised international leader in the field of cough I have served since 2006 as Co-Chair of the British Thoracic Society Cough Taskforce Guidelines Committee producing National guidelines in 2006 and have accepted the invitation to continue in this role for the 2016 Guideline update. In 2004 I was appointed member of the European Respiratory Society Cough Task Force Committee undertaking a central role in the writing of two cough guideline documents (2004 & 2007) and a recent 2014 position paper. In 2011 I was appointed Expert Member of the American College Chest Physicians Guideline Committee tasked with using an evidence-based systematic approach to create ‘living’ cough guidelines recently published in 2014.
In 2011 I was appointed to the International Technical Expert Panel of the Duke University Clinical Research Institute to participate in the design of the recently published Comparative Effectiveness Review of Assessment & Management of Cough.
Between 2010 and 2015 I served Editor-in-Chief for BMC Cough journal, Guest Editor for Pulmonary Pharmacology and Therapeutics and due to my large contribution to expert review in the field of cough was invited in 2014 to join the Editorial Board for Chest (Impact Factor: 7.5).
In 2014 my expertise in COPD clinical trial adverse event adjudication has been recognised in my appointment as an Expert Panellist on the Duke University/US FDA initiated Cardiac Safety Research Consortium and I have recently lectured at the American College of Cardiologists in Washington DC on cardiovascular safety in COPD clinical trials of bronchodilator therapy.
In 2014, I was appointed Chair of the Data Safety Monitoring Committee for the UK NIHR funded ARCHIE (The early use of Antibiotics for at Risk CHildren with InfluEnza in primary care) study).
I have been appointed Internal Examiner for 19 PhD or MD theses and External Examiner for 15 theses by Nationaland International Universities including Katholieke Universiteit Leuven, University of Sydney, University ofManchester, Kings College London, University of Salford and University of Leicester.
My clinical expertise in management of cough and the scientific contribution that my research has made to this field has been recognised internationally and is reflected in many invitations to deliver lectures including keynote presentations on cough management at meetings in USA (Milwaukee 2009, New York 2010, 2012, Washington 2014), South Korea (2009, 2014), China (2010, 2014, 2016), Europe (Copenhagen 2008, Barcelona 2010; Madrid 2010; Bologna, 2012, Cork 2014, Amsterdam 2015, Leuven 2016,Prague 2016).
Appointment to National/International Expert Advisory Panels
Peer nominated member of Association of Physicians of Great Britain and Ireland (elected 2011)
Co-Chairman British Thoracic Society (BTS) Cough Guideline Group (2005-present)
Panel Member of the European Respiratory Society (ERS) Cough Taskforce (2003-present)
Expert Member of American College of Chest Physicians (ACCP) Cough Guideline Committee (appointed 2011)
Member of International Technical Expert Panel of the Duke University Clinical Research Institute for the Comparative Effectiveness Review of Assessment & Management of Cough (appointed 2013)
Member representing Northern Ireland on UKCRN/NIHR Respiratory Specialty Group Committee. (Appointed 2008)
Member of Scientific Research Committee for Asthma UK (2012 – 2015)
Member of Scientific Research Committee for Northern Ireland Chest Heart & Stroke (2006-present)
My undergraduate and postgraduate students have won a number of national and international scientific prizes under my supervision:
Editorial Board membership
Joint Editor-in-Chief BMC Cough (appointed 2010)
Editorial Board member: Chest (appointed 2014)
Guest Editor: Pulmonary Pharmacology Therapeutics
Editorial Board member: Journal of Occupational Medicine and Toxicology.
Editorial Board member: Primary Care Respiratory Journal
European Research Council (ERC) Advanced Grant Reviewer 2015
Medical Research Council (MRC) – Expert Reviewer for Developmental Clinical Studies Board, Population and Systems Medical Board and Training Fellowships
NI Chest Heart & Stroke