'FROM DISCOVERY TO RECOVERY'
I am currently investigating the expression and functional characteristics of novel ion channels located in the airways of asthmatic and cough patients. It is hoped this work will help identify novel targets for the treatment of acute and chronic cough. I have been a core contributor to one national (British Thoracic Society, 2006) and two international (European Respiratory Society, 2004 & 2007) guideline documents on cough which have pioneered the clinical and scientific approach to this field of respiratory medicine.
In collaboration with Wise (Johns Hopkins Hospital, Baltimore, USA) and John (Charite Hospital, Berlin, Germany) I have developed a new methodological approach to the reliable adjudication of cause-specific mortality in chronic obstructive pulmonary disease (COPD). This methodology has been utilised in the two largest clinical trials in COPD to date (TORCH & UPLIFT).
In 2008 I established the Premature Adult Lung Study (PALS) group, a multidisciplinary team currently undertaking a programme of research to comprehensively evaluate the impact of bronchopulmonary dysplasia (BPD) in adult life.