Staff Profile




General Profile Information
Staff Name Dr Thamarai Schneiders
Job Title Lecturer
Location H.S.B Block 10 MBC Site
Room Number 03.019
School School of Medicine, Dentistry and Biomedical Sciences
Contact Details
Telephone +44 (0)28 9097 5831
E-mail t.schneiders@qub.ac.uk
Research Statement

My research interests focus on the role of intrinsic mechanisms in mediating antibiotic resistance in bacteria. In this regard we study the genetic regulation and phenotypic effects of transcriptional loci such as marRAB, ramA that control pleiotrophic phenotypes within bacteria. The key aim of our research is to ascertain the effects of these transcription factors in promoting the emergence and development of antibiotic resistance. Specifically we study the ramA locus in Enterobacteriaceae by using both transcriptomic and proteomic approaches in order to determine the effects of overexpression or deletion of these loci in multidrug resistance bacteria. However our research is not limited to the ramRA locus and we are actively pursuing the role of intrinsic mechanisms in other clinically relevant pathogens. We also collaborate externally with researchers in the UK, Germany, Pakistan.

 

We are continually looking to expand and invite any enquiries about our research or positions in the laboratory.





Professional Qualifications
  • British Society for Antimicrobial Chemotherapy-Conference Vice Chair-March 2011-Nov 2011
  • British Society for Antimicrobial Chemotherapy-Conference Chair-Nov 2011- Nov 2012




Membership Of Other Societies / Professional Activities

External Presentations

  • British Society for Antimicrobial Chemotherapy 2006, ARM Meeting, Birmingham (Invited Speaker) . “The regulation of the ramA locus and its role in antibiotic resistance”
  • 19th European Congress for Clinical Microbiology and Infectious Diseases, Helsinki, (2009).Transcriptional Profiling of K. pneumoniae genes controlled by the transcription factor, RamA. (Selected Oral Presentation).
  • 19th European Congress for Clinical Microbiology and Infectious Diseases, Helsinki, (2009). RamR, A Dual Regulator of Antibiotic Susceptibility and Biofilm Formation in Klebsiella pneumoniae Kp 342. (Selected Oral Presentation).
  • Queen’s University Belfast, Centre for Infection and Immunity 2009. The Regulation of the ramA Locus and Its Role in Antibiotic Resistance.
  • Institut fur Pharmazie, University of Hamburg, 2010. The RamA Locus; Its Regulation and Its Regulon in Klebsiella pneumoniae.
  • Queen’s University Belfast-Infection and Immunity, 2012. Elucidating the Molecular Basis of Chronic Cystic Fibrosis Biofilm Infections.
  • University of Massachusetts, Dartmouth, USA-November 2012

 

Journal and Abstract Peer Review

  •  Expert Reviewer for ESCMID Antimicrobial Resistance Group
    • Reviewing of conference abstracts in the area of Antimicrobial Chemotherapy for the annual ECCMID conferences.
    • Reviewer for Journal of Antimicrobial Chemotherapy, Antimicrobial Agents and Chemotherapy, Emerging Infectious Diseases, Journal of Clinical Microbiology, BMC Infectious Diseases

 

Grant Review

  •  Reviewer for BSAC, Wellcome Grants, Portugese Foundation for Science and Technology

 





Awards And Honours/major Prizes
  • MRC New Investigator Award (2007-2011)
  • ECCMID Travel Grant Programme (2009)
  • ESCMID New Investigator Grant (2010)
    • http://www.escmid.org/profession_career/awards_grants/research_grants/awardees_2011/
  • President's Fund for Research Visit (2011-2012)
  • QUB Staff Travel Grant (2012)

 





Publications
Authored Book(s)
TitlePublisherYear
Efflux pumps of Acinetobacter baumannii Springer Verlag 2008
The mar Regulon in Frontiers of Antibiotic Resistance ASM Press 2005
Journal(s)
TitleJournal NameYear
Identification of a novel prophage regulator in Escherichia coli controlling the expression of type III secretion. Molecular Microbiology Vol 83(1) (208-223)  DOI 2012
Characterisation of RarA, a Novel AraC-family Multidrug Resistance Regulator in Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy Vol 00 (208-223)  2012
Tigecycline resistance can occur independently of the ramA gene in Klebsiella pneumoniae Antimicrobial Agents and Chemotherapy Vol 00 (208-223)  2012
Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae International Journal of Antimicrobial Agents and Chemotherapy Vol 38 (1) (39-45)  DOI   2011
In Vivo Selection of a Missense Mutation in adeR and Conversion of the Novel blaOXA-164 into blaOXA-58 in Carbapenem-Resistant Acinetobacter baumannii Isolated From a Hospitalized Patient. Antimicrobial Agents and Chemotherapy Vol epub (39-45)  DOI 2010
Emergence of CTX-M Group 1-ESBL producing Klebsiella pneumonia from a tertiary care centre in Karachi, Pakistan. Journal of infection in developing countries Vol 4(8) (472-476)    2010
Tackling antibiotic resistance: a dose of common antisense? The Journal of antimicrobial chemotherapy Vol 63(2) (225-229)  DOI   2009
The marC gene of Escherichia coli is not involved in multiple antibiotic resistance. Antimicrobial Agents and Chemotherapy Vol 52(1) (382-383)  DOI 2008
MarA-mediated transcriptional repression of the rob promoter. The Journal of biological chemistry Vol 281(15) (10049-10055)  DOI 2006
The Escherichia coli transcriptional regulator MarA directly represses transcription of purA and hdeA. The Journal of biological chemistry Vol 279(10) (9037-9042)  DOI 2004
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore. Antimicrobial Agents and Chemotherapy Vol 47(9) (2831-2837)  2003
Moxifloxacin sensitivity of respiratory pathogens in the United Kingdom. Journal of chemotherapy (Florence, Italy) Vol 14(1) (19-24)  2002
Emergence of a carbapenem-resistant Klebsiella pneumoniae. Lancet Vol 350(9080) (783-24)  1997