Staff Profile




General Profile Information
Staff Name Professor Stuart Elborn
Job Title Dean, School of Medicine, Dentistry and Biomedical Sciences (JA)
Location H.S.B Block 10 MBC Site
Room Number 0G.016
School School of Medicine, Dentistry and Biomedical Sciences
Contact Details
Telephone +44 (0)28 9097 2764
E-mail s.elborn@qub.ac.uk
Research Keywords
Cystic Fibrosis Chest disease Clinical trials



Research Statement

My main focus is Cystic Fibrosis focused on understanding pathophysiology of infection and inflammation and the translation of new therapies into clinical practice. This programme of work is undertaken with laboratory and clinical collaborators in QUB. This includes a significant commitment from the NICRN (Respiratory Health) where I am PI on 6 current clinical trials. I have smaller programmes with others in COPD, bronchiectasis, lung cancer including  clinical trials.  My research is funded by grants from government agencies, charitable bodies, industry and money raised from clinical trials.  I have developed a clinical trials network for Respiratory Health funded by the Northern Ireland Research and Development Office.

 

In all my research I endeavour to bring scientists and clinicians together to promote inter-disciplinary research.  I have been successful in developing programmes of research across disciplines, hospitals and universities in Northern Ireland.  Some members in my group are now developing independent research programmes.  I am committed to capacity building in Respiratory Medicine and am mentor to two Careers Scientists funded by NIHR (Tunney and O'Kane), and a Walport Academic Clinical Lecturer (Magee).





Professional Qualifications

NHS Responsibilities

 

Special interests:      Cystic fibrosis

                                    Bronchiectasis

                                    Immune deficiency (Non-HIV)

 

 

Fully trained in General Internal Medicine (inc 1 year in Infectious Diseases) and Respiratory Medicine.  GMC No 2614977

 

 

 

 





Membership Of Other Societies / Professional Activities

SOCIETY MEMBERSHIP

 

Association of Physicians of UK and Ireland

Royal College of Physicians of London

Royal College of Physicians of Edinburgh

British Thoracic Society

Irish Thoracic Society

Ulster Society of Internal Medicine

Ulster Medical Society

European Cystic Fibrosis Society (President)

1942 Club

 

PEER REVIEW

 

•·      Associate Editor of Thorax from January 1999:  This involves reviewing over 50 manuscripts each year and deciding on publication.  I also commission editorials and reviews.

 

•·      Editorial Boards:  Ulster Medical Journal, International Journal of Respiratory Care.

 

•·      I review manuscripts for the following journals:

ADIS International

American Journal of Respiratory and Critical Care Medicine

Archives of Diseases of Childhood

Chest

Clinical Infectious Diseases

Clinical Nutrition

Frontiers in Bioscience

International Journal of Obesity

Journal of Biological Chemistry

Journal of Cystic Fibrosis

Journal of Clinical Microbiology

Journal of Infection

Journal of Paediatrics

Journal of Pathology

Pediatric Pulmonology

Pharmacy and Pharmacology

Respiratory Medicine

Thorax (Associate Editor)

 

•·      Chairman of the Research (RMAC) which is the grant awarding body of the Cystic Fibrosis Trust.  This involves a substantial amount of peer review work.

 

•·      Member of NICHSA Research Committee

 

•·      I have reviewed grants for the following research committees and charities:

The Cystic Fibrosis Trust

Canadian Cystic Fibrosis Foundation

Irish Cystic Fibrosis Association

Action Research

Medical Research Council

British Lung Foundation

Sparks

Welcome Trust

 

 

Visiting Professor (Health Sciences), The University of Ulster

Chairman of the Research  Advisory Committees of the Cystic Fibrosis Trust

President, European Cystic Fibrosis Society.

 

 

MD / PhD Examiner

 

-  University of Nottingham

-  National University of Ireland (UCD & Galway)

-  University of Cardiff

-  University of Dundee

-  Royal College of Surgeons, Ireland

-  University of Leicester

-  Monash University, Melbourne

-  University of Edinburgh

 

 

 

PRESENTATIONS TO SOCIETIES AND MEETINGS

 

 

I have presented at local, national and international meetings including the following:

 

American Heart Association

American Thoracic Society

Association of Physicians

British Association of Parenteral and Enteral Nutrition

British Thoracic Society

British Pharmacological Society

European Society for Clinical Investigation

European Cardiac Society

European Cystic Fibrosis Society

European Respiratory Society

Irish Cardiac Society

Irish Thoracic Society

Medical Research Society

North American Cystic Fibrosis Foundation

 

In the past year my group have presented papers at the following meetings:

 

American Thoracic Society

British Thoracic Society

European Respiratory Society

European Cystic Fibrosis Society

North American Cystic Fibrosis Foundation Conference

 

 

Invited Lectures

 

 

I have given a number of invited lectures at Universities in the UK in the past 5 years, including Imperial College, Cambridge, Nottingham, Cardiff, Manchester and Dublin.  I have given invited talks at National, European and North American Cystic Fibrosis Conferences, the British Thoracic Society and European Respiratory Society.

 





Publications
Chapter(s)
TitleBook TitleYear
Non respiratory manifestations of cystic fibrosis Respiratory Medicine 2002
Clincial experience with resistant patients Resistance concerns in cystic fibrosis 2000
Substrate utilisation during exercise in chronic cardiac failure Heart failure: Mechanisms and Management 1991
Journal(s)
TitleJournal NameYear
A CFTR Potentiator in Patients with Cystic Fibrosis and the G551D Mutation New England Journal of Medicine Vol 365 (1663-1672)    2011
Drug and light delivery strategies for photodynamic antimicrobial chemotherapy (PACT) of pulmonary pathogens: A pilot study Photodiagnosis and Photodynamic Therapy Vol 8 (1-6)  2011
A randomized clinical trial of hydroxymethylglutaryl-CoA reductase inhibition for acute lung injury (The HARP study) American Journal of Respiratory and Critical Care Medicine Vol 183 (620-626)  DOI   2011
A20 Regulation of NF-{kappa}B: Perspectives for Inflammatory Lung Disease. American Journal of Respiratory Cell and Molecular Biology Vol in press (620-626)  DOI   2011
Use of culture and molecular analysis to determine the effect of antibiotic treatment on microbial community diversity and abundance during exacerbation in patients with cystic fibrosis. Thorax Vol ONLINE (620-626)  DOI   2011
Incidence and risk factors for pulmonary exacerbation treatment failures in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa Chest Vol in press (620-626)  2011
Molecular characterization and phylogenetic analysis of quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and parE gene loci in viridans group streptococci isolated from adult patients with cystic fibrosis J Antimicrob Chemother. Vol 66 (478-486)    2011
Raman microscopy in the diagnosis and prognosis of surgically resected nonsmall cell lung cancer JOURNAL OF BIOMEDICAL OPTICS Vol 15 (478-486)  DOI   2010
Comparison of techniques to examine the diversity of fungi in adult patients with cystic fibrosis Medical Mycology Vol 48 (166-176)  DOI   2010
Association of airway cathepsin B and S with inflammation in cystic fibrosis. Pediatric Pulmonology Vol 45(9) (860-868)  DOI 2010
Newer Antibacterial agents and their potential role in cystic fibrosis pulmonary exacerbation management Journal of Antimicrobial Chemotherapy Vol 68 (1853-1861)  2010
Optimal airway antimicrobial therapy for cystic fibrosis: the role of inhaled aztreonam lysine Expert opinion on pharmacotherapy Vol 11 (1371-1385)  2010
Pseudomonas aeruginosa cystic fibrosis isolates of similar RAPD genotype exhibit diversity in biofilm forming ability in vitro. BMC Microbiology Vol 10 (38-1385)  DOI 2010
Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury Critical Care Medicine Vol 38 (114-120)  DOI   2010
Decreased Levels of Secretory Leucoprotease Inhibitor in the Pseudomonas-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation Journal of Immunology Vol 183 (8148-8156)  DOI   2009
Molecular characterization of macrolide resistance determinants [erm(B) and mef(A)] in Streptococcus pneumoniae and viridans group streptococci (VGS) isolated from adult patients with cystic fibrosis (CF) Journal of Antimicrobial Chemotherapy Vol 64 (501-506)  DOI   2009
Clinical phenotype of cystic fibrosis patients with the G551D mutation QJM-AN INTERNATIONAL JOURNAL OF MEDICINE Vol 102 (793-798)  DOI   2009
Implementation of European standards of care for cystic fibrosis - provision of care Journal of Cystic Fibrosis Vol 8 (348-355)  DOI   2009
Implementation of European standards of care for cystic fibrosis - Control and treatment of infection Journal of Cystic Fibrosis Vol 8 (211-217)  DOI   2009
Validity and reliability of cardiorespiratory measurements recorded by the LifeShirt during exercise tests Respiratory Physiology and Neurobiology Vol 167 (162-167)  DOI   2009
Isolation of Burkholderia cenocepacia and Burkholderia vietnamiensis from human sewage Int J Environ Health Res Vol 19(2) (157-162)  2009
EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates and cystic fibrosis pulmonary disease severity Physiol Genomics Vol 0 (0-0)  2009
EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collabortion European Respiratory Journal Vol 34 (793-798)  2009
Molecular epidemiology of Pseudomonas aeruginosa in adult patients with cystic fibrosis in Northern Ireland British Journal of Biomedical Science Vol 65 (1) (18-21)  2008
High levels of Epstein-Barr virus in COPD European Respiratory Journal Vol 31(6) (1221-1226)  2008
Non-tuberculous mycobacterial infection in adult patients with cystic fibrosis: comparison of three decontamination methods Br J Biomed Sci Vol 65(1) (28-30)  2008
Development of selective media for the isolation of yeasts and filamentous fungi from the sputum of adult patients with cystic fibrosis (CF) Journal of Cystic Fibrosis Vol 7 (566-572)  DOI   2008
Temocillin in cystic fibrosis: A retrospective pilot study Journal of Cystic Fibrosis Vol 7 (551-554)  DOI   2008
Copying letters to patients with cystic fibrosis (CF): Letter content and patient perceptions of benefit Journal of Cystic Fibrosis Vol 7 (511-514)  DOI   2008
Development of a novel PCR assay for the identification of the black yeast, Exophiala (Wangiella) dermatitidis from adult patients with cystic fibrosis (CF) Journal of Cystic Fibrosis Vol 7 (576-580)  DOI   2008
Does additional support by nurses enhance the effect of a brief smoking cessation intervention in people with moderate to severe chronic obstructive pulmonary disease? A randomised controlled trial International Journal of Nursing Studies Vol 45 (508-517)  DOI   2008
Cystic fibrosis and the isolation of Pseudomonas aeruginosa from horses Vet Res Vol 163(13) (399-400)  2008
Respiratory viral infection in exacerbations of COPDR Respiratory Medicine Vol 102(11) (1575-1579)  2008
Quality of life and inflammation in exacerbations of bronchiectasis Chronic Respiratory Disease Vol 5(3) (161-165)  2008
Pulmonary rehabilitation and follow-on services: a Northern Ireland survey Chronic Respiratory Disease Vol 5(3) (149-154)  2008
Detection of Anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis American Journal of Respiratory and Critical Care Medicine Vol 177 (995-1001)  DOI 2008
The use of Raman microscopy to determine and localize vitamin E in biological samples The FASEB Journal Vol 21(3) (766-776)  DOI   2007
The relationship of clinical and inflammatory markers to outcome in stable patients with cystic fibrosis. Pediatric Pulmonology Vol 42(3) (216-220)  DOI 2007
Delivery of photosensitisers and light through mucus: Investigations into the potential use of photodynamic therapy for treatment of Pseudomonas aeruginosa cystic fibrosis pulmonary infection Journal of Controlled Release Vol 117(2) (217-226)  DOI 2007
Bronchial epithelial cell growth regulation in fibroblast cocultures: the role of hepatocyte growth factor American Journal of Physiology - Lung Cellular and Molecular Physiology Vol 293(1) (L69-L76)  DOI 2007
Flight assessment in patients with respiratory disease:hypoxic challenge testing vs.predictive equations QJM : monthly journal of the Association of Physicians Vol 100 (361-367)  DOI 2007
Acute and latent adenovirus in COPD Respiratory Medicine Vol 101(10) (2084-2090)  2007
The effect of treatment of cystic fibrosis pulmonary exacerbations on airways and systemic inflammation Pediatric Pulmonology Vol 42 (729-735)    2007
Development of a genus-specific PCR assay for the molecular detection, confirmation and identification of Fusobacterium spp Br J Biomed Sci Vol 64(2) (74-77)  2007
Sputum antibiotic concentrations: implications for treatment of cystic fibrosis lung infection Pediatric Pulmonology Vol 42(11) (1008-1017)  2007
Effect of pH onthe antimicrobial susceptibility of planktonic and biofilm-grown clinical Pseudomonas aeruginosa isolates Br J Biomed Sci Vol 64(3) (101-104)  2007
Environmental persistence of Pseudomonas aeruginosa and Burkholderia multivorans in sea water: preliminary evidence of a viable but non-culturable state Br J Biomed Sci Vol 64(3) (129-131)  2007
Molecular detection and identification of Cryptosporidium species in lettuce employiing nested small-subunit rRNA PCR and direct automated sequencing Br J Biomed Sci Vol 64(3) (133-135)  2007
Predictors of mortality in adults with cystic fibrosis Pediatric Pulmonology Vol 42(6) (525-532)  2007
Glucocorticoids as an adjuvant treatment to intravenous antibiotics for cystic fibrosis pulmonary exacerbations: a UK survey Journal of Cystic Fibrosis Vol 6(4) (311-313)  2007
Occurrence of Cryptosporidium parvum and bacterial pathogens in faecal material in the red fox (Vulpes Vulpes) population Veterinary Research Communications Vol 31(5) (559-564)  2007
A systematic review of randomized controlled trials examining the short-term benefit of ambulatory oxygen in COPD Chest Vol 131(1) (278-285)  2007
Self-management in bronchiectasis: the patients' perspective European Respiratory Journal Vol 29(3) (541-547)  2007
Acapella versus 'usual airway clearance' during acute exacerbation in bronchiectasis: a randomised crossover trial Chronic Respiratory Disease Vol 4(2) (67-74)  2007
Airway clearance in the treatment of: A randomised trial of Acapella versus usual airways clearance during 'normal airway clearance' during pulmonary exacerbation in bronchiectasis Chronic Respiratory Disease Vol 4 (1-8)  2007
Frequency of cytokine gene promoter polymorphisms in the Northern Ireland Cystic Fibrosis population Journal of Cystic Fibrosis Vol 6 (363-365)  2007
Evidence for physical therapies (airway clearance and physical training) in cystic fibrosis: An overview of five Cochrane systematic reviews Respiratory Medicine Vol 100 (191-201)  2006
Antibiotic resistance and identification of uncommon Gram-negative bacteria isolated from sputum of adult patients with cystic fibrosis British Journal of Biomedical Science Vol 63 (22-25)  2006
Symptoms suffered by life-limited children that cause anxiety to UK children’s hospice staff International Journal of Palliative Nursing Vol 12(6) (254-268)  2006
Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis American Journal of Respiratory and Critical Care Medicine Vol 173(12) (1356-1362)  DOI 2006
Staphylococcus aureus enterotoxins induce IL-8 secretion by human nasal epithelial cells Respiratory Research Vol 7 (115-126)  DOI 2006
Safety and efficacy of recombinant alpha(1)-antitrypsin therapy in cystic fibrosis. Pediatric Pulmonology Vol 41(2) (177-183)  DOI 2006
Bacterial contaminants in cosmetic products from a patient with cystic fibrosis Br J Biomed Sci Vol 63(3) (141-142)  2006
Managing bronchiectasis Practitioner Vol 250(1681) (194-200)  2006
Effect of reduced pH on inorganic polyphosphate accumulation by Burkholderia cepacia complex isolates Letters in Applied Microbiology Vol 42(6) (617-623)  DOI   2006
Association of improved pulmonary phenotype in Irish cystic fibrosis patients with a 3' enhancer polymorphism in alpha-1-antitrypsin Pediatric Pulmonology Vol 41 (584-591)  2006
Cystic fibrosis sputum stimulates CD18-independent neutrophil migration across endothelial cells. Experimental Lung Research Vol 31 (377-390)  2005
Neutrophil cell death, activation and bacterial infection in cystic fibrosis Thorax Vol 60(8) (659-664)  DOI 2005
Effect of cystic fibrosis exacerbations on neutrophil function International Immunopharmacology Vol 5(3) (601-608)  DOI 2005
Development of a rapid colorimetric time-kill assay for determining the in vitro activity of ceftazidime and tobramycin in combination against Pseudomonas aeruginosa Journal of Microbiological Methods Vol 61 (171-179)  2005
Physiotherapy involvment in non-invasive ventilation hospital services: A British Isles survey International Journal of Clinical Practice Vol 59 (453-456)  2005
Comparison of in vitro susceptibilities to levofloxacin and ciprofloxacin with Pseudomonas aeruginosa and Stenotrophomonas maltophilia isolated from cystic fibrosis patients in Northern Ireland British Journal of Biomedical Science Vol 62 (30-32)  2005
Cystic fibrosis genotype and bacterial infection: a possible connection British Journal of Biomedical Science Vol 62 (85-88)  2005
Effect of oxygen limitation on the in vitro antimicrobial susceptibility of clinical isolates of Pseudomonas aeruginos grown planktonically and as biofilms European Journal of Clinical Microbiology & Infectious Diseases Vol 24 (677-687)  2005
Microbial ecology of the cystic fibrosis lung: does microflora type influence microbial loading? British Journal of Biomedical Science Vol 62 (175-178)  2005
Airway clearance in bronchiectasis: a randomized crossover trial of active cycle of breathing techniques versus Acapella Respiration Vol 72 (239-242)  2005
Comparison of in vitro susceptibilities to levofloxacin and ciprofloxacin with pseudomonas aeruginosa and stenotrophomonas maltophilia isolated from cystic fibrosis patients in northern ireland British Journal of Biomedical Science Vol 72 (30-32)  2005
Role of physiotherapy in non-invasive ventilation for cystic fibrosis: A British Isle Survey International Journal Clincial Practice Vol 59 (453-456)  2005
Inflammatory related changes in bone mineral content in adults with cystic fibrosis. Thorax Vol 59(7) (613-617)  DOI 2004
Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis Thorax Vol 59(3) (231-236)  DOI 2004
Ribosomal DNA (16SrDNA), PCR identification of Saccharomorospora viridis associated with mushroom workers lung Compost Science and Utilisation Vol 12 (192-195)  2004
Detection of mycobacterial DNA from sputum of patients with cystic fibrosis Irish Journal of Medical Science Vol 173 (96-98)  2004
Molecular (PCR) detection of Pseudomonas spp. other an P-aeruginos directly from the sputum of adults and children with cystic fibrosis British Journal of Biomedical Science Vol 61 (147-149)  2004
Epidemiology of Burkholderia cepacia complex species recovered from cystic fibrosis patients: issues related to patient segregation Journal of Medical Microbiology Vol 53 (663-668)  2004
Employment of 16 S rDNA gene sequencing techniques to identify culturable environmental eubacteria in a tertiary referral hospital Journal of Hospital Infection Vol 57 (52-58)  2004
Inflammatory related changes in bone mineral content in adults with cystic fibrosis Thorax Vol 59(7) (613-617)  DOI 2004
Subjective benefit of inhaled therapies in patients with bronchiectasis: a questionnaire study International Journal of Clinical Practice Vol 58 (441-443)  2004
Clinical outcome of Burkholderia cepacia complex infection in cystic fibrosis patients Journal of Cystic Fibrosis Vol 3 (93-98)  2004
Infection control and the signficance of sputum and other respiratory secretions from adult patients with cystic fibrosis Annals of Clinical Microbiology and Antimicrobials Vol 2 (8-8)  2004
Early detection of Pseudomonas aeruginosa - comparison of conventional versus molecular (PCR) detection directly from adult patients with cystic fibrosis (CF) Annals of Clinical Microbiology and Antimicrobials Vol 20 (21-21)  2004
Organisms isolated from adults with cystic fibrosis Annals of Clinical Microbiology and Antimicrobials Vol 3 (26-26)  2004
Energy balance in cystic fibrosis when stable and during respiratory exacerbation Clinical Nutrition Vol 23 (1405-1412)  2004
Reduction in neutrophil elastase concentration by recombinant alphal-antitrypsin (recAAT) does not alter bacterial loading in the sputum of cystic fibrosis patients. British Journal of Biomedical Science Vol 61(3) (146-147)  2004
Airway clearance in bronchiectasis: a randomized crossover trial of active cycle of breathing techniques (incorporating postural drainage and vibration) versus test of incremental respiratory endurance Chronic Respiratory Disease Vol 1(3) (127-130)  2004
Inflammatory markers in cystic fibrosis patients with transmissible Pseudomonas aeruginosa European Respiratory Journal Vol 22(3) (503-506)  DOI 2003
A comparison of pulmonary exacerbations with single and multiple organisms in patients with cystic fibrosis and chronic Burkholderia cepacia infection Journal of Infection Vol 46 (56-59)  2003
Bronchiectasis in secondary care: a comprehensive profile of a neglected disease European Journal of Internal Medicine Vol 14 (488-492)  2003
Development of a diagnostic PCR assay that targets a heat-shock protein gene (groES) for detection of Pseudomonas spp. in cystic fibrosis patients Journal of Medical Microbiology Vol 52 (759-763)  2003
Inflammatory markers in cystic fibrosis patients with transmissible Pseudomonas aeruginosa European Respiratory Journal Vol 22 (503-506)  2003
Incontinence in adult females with cystic fibrosis: A Northern Ireland survey International Journal of Clinical Practice Vol 57 (182-183)  2003
Development of a Gram-negative selective agar (GNSA) for the detection of Gram-negative microflora in sputa in patients with cystic fibrosis Journal of Applied Microbiology Vol 95 (160-166)  2003
Low incidence of Neisseria meningitis serogroups B and C in lower respiratory tract secretions in patients with Cystic Fibrosis Br J Biomed Sci Vol 60(4) (233-233)  2003
Correlation of cathepsin B-like activity with neutrophil elastase and other markers of inflammation in CF sputum Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Vol 2 (S27-S27)  2003
Comparison of sputum induction using high-output and low-output ultrasonic nebulizers in normal subjects and patients with COPD Chest Vol 122 (955-959)  2002
Perceived benefits of inhaled therapies in cystic fibrosis British Journal of Therapy and Rehabilitation Vol 9 (107-110)  2002
Burkholderia cepacia from a sink drain Journal of Hospital Infection Vol 50 (235-237)  2002
Incidence of Pseudomonas aeruginosa in recreational and hydrotherapy pools Communicable Disease and Public Health Vol 5 (23-26)  2002
Occurrence of Burkholderia cepacia in the hospital environment Irish Journal of Medical Science Vol 171 (131-133)  2002
Misidentification of a genomovar of Burkholderia cepacia by recA restriction fragment length polymorphism Journal of Clinical Pathology Vol 55 (309-311)  2002
Admissions with chronic obstructive pulmonary disease after publication of national guidelines Irish Journal of Medical Science Vol 171 (16-19)  2002
Improved molecular identification of Thermactinomyces spp. associated with mushroom worker's lun by 16S rDNA sequence typing Journal of Medical Microbiology Vol 51 (1117-1127)  2002
Pandoraea apista isolated from a patient wiht cystic fibrosis: problems associated with laboratory identification British Journal of Biomedical Science Vol 59 (164-166)  2002
Effect of high-termperature short-time (HTST) laboratory pasteurization on the survival of Burkholderia cepacia complex organisms in whole, low fat and skimmed milks Journal of Dairy Research Vol 69 (483-490)  2002
Pseudodextrocardia in bronchiectasis Hospital Medicine Vol 63 (304-305)  2002
Cytokine concentrations and neutrophil elastase activity in bronchoalveolar lavage and induced sputum from patients with cystic fibrosis, mild asthma and healthy volunteers. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Vol 1(4) (269-275)  2002
Improved molecular detection of Burkholderia cepacia genomoval III and Burkholderia multivorans directly from sputum of patients with cystic fibrosis Journal of Microbiological Methods Vol 49(2) (183-191)  2002
A comparison of inflammatory marker levels in clinically stable cystic fibrosis patients with chronic infection by unique and epidemic strains of Pseudomonas aeruginosa Thorax Vol 57(S3) (P108-P108)  2002
A comparison of neutrophil elastase and cathepsin S levels in CF sputum Pediatric Pulmonology Vol Suppl 24 (274-274)  2002
Improved cultural detection of Burkholderia cepacia from sputum in patients with cystic fibrosis Journal of Clinical Pathology Vol 54 (803-805)  2001
Total energy expenditure in stable patients with cystic fibrosis Clinical Nutrition Vol 20 (235-241)  2001
Long-term preservation of strains of Burkholderia cepacia, Pseudomonas spp. and Stenotrophomonas maltophilia isolated from patients with cystic fibrosis Letters in Applied Microbiology Vol 33 (82-83)  2001
Occurrence of Burkholderia cepacia in foods and waters: Clinical implications for patients with cystic fibrosis Journal of Food Protection Vol 64 (1076-1078)  2001
Clinical outcome after acquisition of Burkholderia cepacia in patients with cystic fibrosis Irish Journal of Medical Science Vol 170 (28-31)  2001
Rapid characterization of teh genomovars of the Burkholderio cepacia complex by PCR-single-stranded conformational polymorphism (PCR-SSCP) analysis Journal of Hospital Infection Vol 48 (129-134)  2001
PCR-based detection and identification of Burkholderia cepacia complex pathogens in sputum from cystic fibrosis patients Journal of Clinical Microbiology Vol 39 (4247-4255)  2001
Antibiotic resistance in Burkholderia cepacia at two regional cystic fibrosis centres in Northern Ireland: is there a need for synergy testing? Journal of Antimicrobial Chemotherapy Vol 48 (319-321)  2001
Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis The Lancet Vol 358(9295) (1780-1781)  DOI 2001
Individuals with cystic fibrosis do not display impaired endothelial function or evidence of oxidative damage in endothelial cells exposed to serum Clinical Science (London) Vol 101 (507-513)  2001
Nasal septal perforation and oxygen cannulae Hospital Medicine Vol 62 (248-248)  2001
PCR-based detection and identification of Burkholderia cepacia complex pathogens in sputum from cystic fibrosis patients. Journal of Clinical Microbiology Vol 39(12) (4247-4255)  DOI 2001
Pulmonary function, inflammation, exercise capacity and quality of life in cystic fibrosis European Respiratory Journal Vol 17(4) (712-715)  2001
Lung transplantation for cystic fibrosis: the effect of B cepacia genomovars on post transplant lung outcomes Journal of Heart and Lung Transplantation Vol 20(2) (158-158)  2001
Neutrophils migrating to CF sputum sol preferentially employ the CD-18 independent transendothelial route Thorax Vol 56 (S3) (44-44)  2001
Elective versus symptomatic antibiotic treatment in cystic fibrosis patients with chronic Pseudomonas infection of the lungs Thorax Vol 55 (355-358)  2000
Breath isoprene during acute respiratory exacerbation in cystic fibrosis European Respiratory Journal Vol 16 (1065-1069)  2000
Reliability, repeatability and sensitivity of the modified shuttle test in adult cystic fibrosis Chest Vol 117 (1666-1671)  2000
Clinical features associated with a delayed diagnosis of cystic fibrosis Respiration Vol 67 (402-407)  2000
Metabolic and inflammatory responses to pulmonary exacerbation in adults with cystic fibrosis European Journal of Clinical Investigation Vol 30 (553-559)  2000
Antibody response to Burkholderia cepacia in patients with cystic fibrosis colonized with Burkholderia cepacia and Pseudomonas aeruginosa Journal of Infection Vol 40 (164-170)  2000
Pulmonary function, serum markers of inflammation, and IgG antibodies to core lipopolysaccharide of Bhrkholderia cepacia in adults with cystic fibrosis, following coloonization with Burkholderia cepacia Pediatric Pulmonology Vol 29 (8-10)  2000
Disease progression and fat-soluble micronutrients in cystic fibrosis patients with and without Burkholderia cepacia. Proceedings of the Nutrition Society Vol 59 (160A-160A)  2000
The relationship of outcome to Burkholderia cepacia, lung function and inflammatory markers in stable patients with cystic fibrosis Thorax Vol 54 (S3) (S10-S10)  1999
Phase II trial to assess the biochemical efficacy of transgenic alpha(1)-anti-trypsin as an effective treatment of cystic fibrosis Thorax Vol 54 (3) (A3-A3)  1999
Comparison of mediator concentrations in BAL and induced sputum from patients with cystic fibrosis, mild asthma and healthy volunteers. Thorax Vol 54 (A57-A57)  1999
Safety and tolerability of four ascending single doses of transgenic sheep derived human alpha-1-antitrypsin (tg-hAAT) administered by a nebuliser to patients with cystic fibrosis(CF). American Journal of Respiratory and Critical Care Medicine Vol 159 (3) (A191-A191)  1999
Improved protease inhibition for storage and analysis of CF sputum Pediatric Pulmonology Vol 26 (S17) (382-383)  1998