Staff Profile




General Profile Information
Staff Name Professor Liam Heaney
Job Title Clinical Professor (Cons) (JA)
Location H.S.B Block 10 MBC Site
Room Number 02.021
School School of Medicine, Dentistry and Biomedical Sciences
Contact Details
Telephone +44 (0)28 9097 5850
E-mail l.heaney@qub.ac.uk
Research Statement

My principal research interests are as follows:

 

1. Clinical assessment and mechanisms of difficult asthma including identification and management of poor adherence.

Difficult asthma represents 5 - 10% of adult asthmatics but this group utilises ca 60% of NHS asthma spend, with repeated unscheduled healthcare contact. Our initial programme of research developed and validated a multi-disciplinary systematic assessment / management model for difficult asthmatics, and defined best practice in this area.

 

I founded and now co-ordinate the BTS UK Severe Asthma Network and National Registry on Difficult Asthma (see above). The Registry, as well as standardising UK specialist clinical services, facilitates research into the assessment and clinical management of difficult asthma.

My non-adherence research programme has defined, for the first time, the significant scale of this problem in difficult asthma (30 - 50% of subjects) and my Research Nurse, Dr Gamble PhD was awarded Royal College of Nursing Research Nurse of the Year 2010, received a Special Research Award from Asthma UK and was awarded the JD Williamson prize 2010 for best doctoral research in QUB.

My group's current research is developing methods to better identify and manage this problem in the clinic and we have recently developed a novel clinical test using exhaled nitric oxide suppression, and for this work, my Clinical Fellow, Dr McNicholl, won an American Thoracic Society 2010 Travel Award, the UK Respiration Forum Young Investigator Award 2009, and the 2010 Research Medal, NICHS 6th Research Conference.

In collaboration with Genentech, we are developing clinical biomarkers for steroid resistance and exposure and validating the latter as a clinical test for non-adherence. We are developing important collaborations with Professors Rob Horne (University of London) & Professor Paul Cullinan (Imperial) in this area. 

We are also examining the role of managing co-morbidity e.g. depressive illness, hyperventilation in this difficult asthma patient group.

 

2. Epithelial / environmental interactions and onset of wheezing in childhood.

I have pioneered non-bronchoscopic sampling of paediatric airways and have established important in vitro cell models, including a differentiated paediatric epithelial cell model. My group has identified important fundamental differences in the paediatric asthmatic epithelium and our current focus is to examine the mechanism of these abnormalities at transcriptional and translational level. This work has won a number of Research prizes, including the Young Investigator Prize at the British Thoracic Society Winter Meeting 2009.

We have also developed a differentiated nasal epithelial model and have demonstrated using this differentiated system that the nasal response is different and not representative of the bronchial system (manuscript in preparation). With colleagues, I am currently examining opportunities to expand this model to a co-culture system with bronchial smooth cells and differentiated neuronal cells.

In addition, using our paediatric epithelial cell culture model, we have developed a programme with a long-term goal of developing a Respiratory Syncytial Virus vaccine (with Dr U Power, QUB), and we are currently in a programme defining a genetic signature of severe RSV disease.

 

 

3. Mechanistic studies in refractory asthma.

The hallmark of refractory asthma is relative steroid resistance and the precise mechanism of this remains unclear; we have recently demonstrated that 2 favoured mechanisms, specifically downregulation of HDAC2 / upregulation of GR-b (dominant negative isoform of glucocorticoid receptor) expression are not as relevant in refractory asthma as previously thought (manuscript under review). My current research strategy, in separate collaborations with Industrial partners [Genentech Inc and Medimmune] is to utilise whole genome expression profiling in bronchial biopsies and epithelial cell brushings to examine other steroid resistance pathways in this refractory group.

Any Translational Medical strategy must utilise early ‘proof of concept' studies and subsequent larger multi-Centre clinical trials. I have substantial experience of interaction with the Pharmaceutical Industry in Phase II / III clinical trials in including study concept and design, establishment of methodology, final protocol review and data analysis.





Professional Qualifications

Vice Chairman Northern Ireland Medical Academic Specialist Committee - 2002 - 2007

NI Medical Academic Specialist Committee Representative to Northern Ireland Council 2002 - 2007

NI Medical Academic Specialist Committee negotiator to NI Consultants and Specialists Committee - 2002 - 2007

Royal College of Physicians Tutor for Medical Senior House Officers, Belfast City Hospital Trust, 2002 - 2005

Member of Royal College of Physicians

Member of British Medical Association, British Thoracic Society, Royal College of Physicians of London, Ulster Thoracic Society, Irish Thoracic Society, European Respiratory Society,

Member of Clinical Management Group, Northern Ireland Clinical Trials Network, 2007 - current.

Consultant for MDS Pharma [Multi-national Contract Research Organisation], Phase IIa Respiratory Clinical Trial Programme, 2003 - 2005 - the major focus was the development of a Phase IIa Respiratory Clinical Trial programme in collaboration with Pharmaceutical companies. In this capacity, I have been involved in study concept and design, establishment of methodology, final protocol review and data analysis.





Membership Of Other Societies / Professional Activities

Chairman of the British Thoracic Society National Registry of Difficult Asthma which has a number of ongoing service development initiatives and research projects - examples include:

-      AUGOSA study (in collaboration with Professor Ian Hall, University of Nottingham) - genome wide UK severe asthma study - funded by Asthma UK and using the Registry as the phenotyping dataset;

-        Defining the heterogeneity of severe asthma: a BTS severe asthma network pilot study (in collaboration with Professor John Thompson, University of Leicester) - funded by Asthma UK this will use the Registry and biostatistical techniques to examine heterogeneity in refractory asthma;

-        Health Economics analysis of refractory asthma - supported by GSK (in collaboration with Professor Ciaran O'Neill University of Galway, ROI).

-        Work Package Lead to AirPROM (WP1) - an FP7 application using a systems biology approach to analyse airway morphology and geometry in refractory asthma and its relationship to physiological and inflammatory indices.

 

UK Chief Investigator for 2 multi-centre pivotal clinical trials - Lebrikizumab oral steroid sparing study in refractory asthma (2012) and BOBCAT study [Bronchoscopic Exploratory Research Study Biomarkers in Corticosteroid-Refractory Asthma], Genentech Inc, US (2010 - bronchoscopic / sputum study in refractory asthma). 

Principal Investigator for Phase 3 Asthma Clinical Trials, Belfast Trust (2000 - current).

Consultant for Phase II / III new Clinical Trials - Medimmune, GSK, Genentech - current.

 

Conference Organisation

Difficult Asthma: past, present and future, Belfast 26th / 27th March 2009 - International meeting of academic and clinical leaders in difficult asthma

Co-Chair American Thoracic Society / European Respiratory Society Task Force meeting, European Society Congress, Barcelona September 2010

British Thoracic Society Winter Meeting 2010 - Session Chair - Clinical and experimental studies in asthma

British Thoracic Society Winter Meeting 2011 - Session Chair - Severe asthma in adults and children

British Thoracic Society Summer Meeting 2012 - Session Chair - Asthma - beyond the airways

 

INVITED LECTURES / MEEETINGS

1.    Invited International Expert to Translational Immunology Summit, Genentech Inc., December 14 - 16, 2011, San Diego, California.

2.      European Respiratory Annual Congress 2011 - Glaxo Smith Kline - Pro-Con debate with Professor Ian Pavord, University of Leicester - The majority of asthmatics can be well controlled with optimal use of existing medications."

3.      Genentech Key Opinion Lecture, San Francisco "Difficult Asthma: a clinical perspective", July 2011.

4.       Respiratory Connections Education Programme - Cheshire, Milton Keynes, Leeds, September - November 2011 -  ‘How to personalise treatment in airways disease- rather than one size fits all' - joint symposium with Professor Wisia Wedzicha, University College London.

5.      National Respiratory Meeting, Novartis UK, Birmingham June 2011"Non-adherence in difficult asthma"

6.      Co-Chair American Thoracic Society / European Respiratory Society Task Force meeting, European Society Congress, Barcelona September 2010.

7.      Genentech Advisory Board, San Francisco, US - November 4th - 5th November 2010.

8.      Advances in Respiratory Therapeutics Forum, Rome June 2010 - Assessing adherence in difficult to control asthma.

9.      Invited Major Symposium Speaker BTS Winter meeting December 2010 - Symposium - ‘Assessing and modifying adherence in difficult asthma.

10.   Scottish Thoracic Society April 2010, Perthshire - Assessment and management of Difficult Asthma - plenary lecture.

11.  Difficult Asthma - major symposium, British Thoracic Society Summer meeting, Bournemouth 2009.

12.  Difficult Asthma; psychology or pathology - major symposium, British Thoracic Society Winter meeting London 2008.

13.  Severe Asthma; a Clinical Update (International Expert Consensus meeting) Leuven, Belgium, March 2007.

14.  The role of anti-TNF in severe asthma - major symposium, British Thoracic Society Winter meeting 2007.

15.  Assessment of Difficult Asthma - University of Aberdeen - June 2007

16.  European Academy of Allergy and Immunology, Vienna June 2006. Neurogenic inflammation in asthma.

17.  ARENA Post-graduate Teaching Symposium, Glasgow, Difficult Asthma. April 2006.

18.  University of Leicester, Update in assessment and management of Difficult Asthma, October 2006.

19.  Royal Society of Medicine, Difficult Asthma Symposium - Assessment and adherence, Wythenshawe Hospital, Manchester, 28th February 2006

20.  British Thoracic Society Working Group on Difficult Asthma - Assessment of difficult asthma, Leicester 15th November 2005

21.  Northern Ireland Centre for Postgraduate Pharmaceutical Education and Training - Keynote  Lecture - Asthma (2002 and 2005)

22.  Respiratory Education Training Centre Meeting 2004. Difficult asthma or Difficult patients

23.  British Thoracic Society Annual Summer Meeting Manchester June 2004. Protocolised assessment of difficult asthma.

24.  Ninewells Hospital Dundee January 2004. Assessment of Difficult Asthma

25.  University of Aberdeen / Aberdeen Royal Infirmary January 2004. Predictors of therapy resistant asthma.

26.  Irish Respiratory Specialist Registrar Training Day, Beaumont Hospital, Dublin Feb 2004. Assessment of Difficult Asthma.

27.  All-Ireland Institute of Psychiatrists (Joint Meeting of the Royal College of Psychiatrists / Irish College of Psychiatrists) November 2004. Psychiatric and psychological disorders in asthma.

28.  The Breathing Club, Lyons, France September 2003. Acute COPD - what to do and why?

29.  Institute of Molecular Pharmacology, Berlin, Germany May 1993. Neuropeptides, mast cells and asthma.

30.  Royal College of Physicians of Edinburgh Annual Symposium November 2000. Difficult Asthma.

31.  Respiratory Specialist Registrar Symposium, Irish Thoracic Society November 1999. Assessment of difficult asthma.

32.  Clinical Allergy Symposium. National Heart and Lung Institute, London April 1998. Non-bronchoscopic lavage - a gateway to understanding paediatric asthma.

I regularly lecture at Postgraduate meetings for GP's and specialist nurses and medical colleagues

 

Academic Collaborations

University of Nottingham, (Professor Ian Hall) AUGOSA study - genome wide UK severe asthma study - funded by Asthma UK and using the BTS Registry as the phenotyping dataset;

University of Leicester (Professor John Thompson) - Defining the heterogeneity of severe asthma: a BTS severe asthma network pilot study - funded by Asthma UK.

AirPROM (FP7 - WP1) - an Work Package Lead to using a systems biology approach to analyse airway morphology and geometry in refractory asthma and its relationship to physiological and inflammatory indices.

University of Galway (Professor Ciaran O'Neill) - Health Economics analysis of refractory asthma - supported by GSK.

Imperial College (Professor Paul Cullinan) - Asthma exacerbations and prescribed treatment: an exploration of the THIN database (CSD EPIC).

University of London (Professor Rob Horne) - Non-adherence in Difficult Asthma.

Genentech Inc (USA) - genome wide expression analysis in severe asthma (DEL/CAST funded PhD studentship and Project Grant). UK Chief Investigator for BOBCAT study [Bronchoscopic Exploratory Research Study Biomarkers in Corticosteroid-Refractory Asthma], Genentech Inc, US - bronchoscopic / sputum study in refractory asthma. Project grant - Biomarkers for steroid resistance in refractory asthma.

 

Presentations

I have over 200 presentations and published abstracts presented at Local, National and International meetings including:

      European Respiratory Society

      American Thoracic Society

      British Thoracic Society

      American Academy of Asthma, Allergy and Immunology

      European Histamine Research Society

      European Academy of Allergy and Clinical Immunology

      British Society of Allergy and Clinical Immunology

      Irish Thoracic Society





Awards And Honours/major Prizes

Appointment to National / International Expert Advisory Bodies

Invited member of National Expert Asthma UK Advisory Panel to define their research strategy for the next 10 years 2011.

Chairman of the British Thoracic Society (BTS) Asthma Specialist Advisory Group (SAG) 2011 - (member of Asthma Specialist Advisory Group 2008 - 2010).

Invited member of British Lung Foundation National Advisory and Implementation Group 2011.

National Institute of Clinical Excellence UK Bronchial Thermoplasty Registry - appointed Co‑ordinator 2011

Peer nominated member of Association of Physicians of Great Britain and Ireland 2010.

Asthma UK Research Committee 2007 - 2010 (3 year tenure).

International Reviewer of World Health Organisation Statement on Severe Asthma 2009.

National Expert (Royal College of Physicians) to nominate key topics for National Audit of Asthma Care 2009

Co-ordinator / Founder of the British Thoracic Society National Registry in Difficult Asthma 2007 - current

Respiratory Framework for Northern Ireland - Lead author - Adult Asthma Section 2007.

Member of UK Steering Committee for British Thoracic Society & Scottish Intercollegiate Guideline Network Guidelines on Asthma Management - 2006 - current

Chairman of Evidence Review Group for Difficult Asthma on behalf of British Thoracic Society & Scottish Intercollegiate Guideline Network Guidelines on Asthma Management - 2006 - current

Member of British Thoracic Society Research Committee - 2006 - 2009.

Chairman of British Thoracic Society Research sub-committee on Difficult Asthma 2005 - 2007

Participant of British Thoracic Society UK Experts "Attitudes and assessment of Difficult Asthma" London December 2004

 

Honorary Appointments

Adjunctive Professor, School of Business and Economics (Health Economics), University of Galway 2011.

 

Academic Prizes

My clinical Fellows have won a number of important prizes in recognition of the high quality of their work:

Dr Gamble - JD Williamson prize 2010, Royal College of Nursing Research Nurse of the Year 2010, Special Research Award from Asthma UK 2010.

Dr McNicholl - American Thoracic Society 2010 Travel Award, UK Respiration Forum Young Investigator Award 2009, Research Medal, NICHS 6th Research Conference 2010 .

Dr Thavagnanam - Young Investigator Prize, British Thoracic Society Winter Meeting 2009.

 

Editorial Boards

International Editorial Board Primary Care Respiratory Journal.

Editorial Board Scientific World Journal - Pulmonology Domain  (http://www.tswj.com)

 

Journal Review

In the past 10 years I have reviewed over 100 manuscripts in the field of respiratory medicine for major journals including the American Journal of Respiratory and Critical Care Medicine, American Journal of Respiratory Cell and Molecular Biology, British Medical Journal, Journal of Allergy and Clinical Immunology, Thorax, Chest, Journal of Leucocyte Biology, Primary Care Respiratory Journal, Neuropharmacology, Journal of Allergy and Clinical Immunology, Treatments in Respiratory Medicine, Trends in Molecular Medicine

Grant Review

I regularly review for the Medical Research Council (Project Grants and Training Fellowships), Chief Scientist's Office (Scotland) and for a number of National Bodies and Charities e.g. Asthma UK, Action Medical Research, Central Commissioning Facility [RfPB Competition] etc.





Publications
Edited Book(s)
TitlePublisherYear
Difficult Asthma Jaypee Brothers Medical Publishers 2011
Chapter(s)
TitleBook TitleYear
Inflammation in chronic obstructive pulmonary disease: Implications for new treatment strategies Inflammatory Diseases 2011
Difficult Asthma Asthma 2011
Refractory Asthma – the patient’s perspective Difficult Asthma 2011
Non-adherence in Difficult Asthma Difficult Asthma 2011
Difficult Asthma Asthma 2008
Journal(s)
TitleJournal NameYear
Increased expression of immunoreactive thymic stromal lymphopoetin in severe asthma Journal of Allergy and Clinical Immunology Vol epub October 2011  2012
Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells. Virology journal Vol 8 (43-  DOI   2011
A study of a multi-level intervention to improve non-adherence in difficult to control asthma. Respiratory Medicine Vol 105(9) (1308-1315)  DOI 2011
Non-adherence in difficult asthma: time to take it seriously. Thorax Vol epub (1308-1315)  DOI 2011
The Utility of Cardiopulmonary Exercise Testing in Difficult Asthma. Chest Vol 139(5) (1117-1123)  DOI 2011
The impact of non-adherence to inhaled long-acting β2-agonist / steroid combination therapy on healthcare costs in difficult to control asthma Pharmaceutical Medicine Vol in press (1117-1123)  2011
Effects of interleukin-13 on mucociliary differentiation of paediatric asthmatic bronchial cells. Pediatric Research Vol 69 (2) (95-100)  DOI   2011
Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma. Thorax Vol ePub (95-100)  DOI 2011
Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry. Thorax Vol 65(9) (787-794)  DOI   2010
The safety of bisphosphonate use in pre-menopausal women on corticosteroids. Current Drug Safety Vol 5(2) (182-187)  2010
Respiratory viral infection in lower airways of asymptomatic children. Acta paediatrica (Oslo, Norway : 1992) Vol 99(3) (394-398)  DOI   2010
Cytopathogenesis of Sendai virus in well-differentiated primary pediatric bronchial epithelial cells. Journal of Virology Vol 84 (11718-11728)  DOI   2010
A Large-Scale, Consortium-Based Genomewide Association Study of Asthma New England Journal of Medicine Vol 363(13) (1211-1221)  2010
A 3-D well differentiated model of pediatric bronchial epithelium demonstrates unstimulated morphological differences between asthmatic and nonasthmatic cells Pediatric Research Vol 67 (17-22)  DOI   2010
Difficult to treat asthma in adults British Medical Journal Vol 24 (338-b494)  DOI 2009
The prevalence of nonadherence in difficult asthma American Journal Respiratory Critical Care Medicine Vol 180 (817-822)  DOI   2009
Omalizumab: the evidence for its place in the treatment of allergic asthma. Core Evidence Vol 3(1) (55-66)  DOI   2008
Impact of cough across different chronic respiratory diseases: comparison of two cough-specific health-related quality of life questionnaires Chest Vol 134 (2) (295-302)  DOI   2008
Neurogenic inflammation in asthma Current Drug Targets. Inflammation and Allergy Vol 6(2) (127-132)  2007
Difficult asthma: people's perspectives on taking corticosteroid therapy Journal of Clinical Nursing Vol 16(3A) (59-67)  2007
Acute and latent adenovirus in COPD Respiratory Medicine Vol 101(10) (2084-2090)  2007
Airway expression of calcitonin-gene related peptide in T-cell peptide induced late asthmatic reactions in atopics Allergy Vol 62(5) (495-503)  2007
Inflammation in chronic obstructive pulmonary disease - implications for new treatment strategies Current Medical Chemistry Vol 14(7) (787-796)  2007
Assessment of impairment in health-related quality of life in patients with difficult asthma: psychometric performance of the asthma quality of life questionnaire Respirology Vol 12(2) (227-233)  2007
Increased tachykinin levels in induced sputum from asthmatic and cough patients with acid reflux Thorax Vol 62 (491-495)  DOI 2007
A cross-sectional study evaluating the relationship between cortisol suppression and asthma control in patients with difficult asthma British Journal of Clinical Pharmacology Vol 63(1) (110-115)  DOI 2007
Prevalence of psychomorbidity among patients with chronic cough Cough (London, England) Vol 16 (2(1)-4)  2006
A comparison of direct medical care costs among COPD and asthma patients living in the community in Northern Ireland Treatments in Respiratory Medicine Vol 5(6) (495-501)  2006
Severe asthma treatment: need for characterising patients The Lancet Vol 365(9463) (974-976)  DOI 2005
Prevalence of gastroesophageal reflux in difficult asthma - Relationship to asthma outcome Chest Vol 127(4) (1227-1231)  DOI 2005
Prevalence of psychiatric morbidity in a difficult asthma population: Relationship to asthma outcome Respiratory Medicine Vol 99 (1152-1159)  2005
Short burst oxygen therapy in chronic obstructive pulmonary disease: a patient survey and cost analysis International Journal of Clinical Practice Vol 59 (751-753)  2005
Relationship between lung function and asthma symptoms in patients with difficult to control asthma Journal of Asthma Vol 42 (859-864)  2005
Endobronchial adenosine monophosphate challenge causes tachykinin release in the human airway Journal of Allergy and Clinical Immunology Vol 116(2) (312-317)  DOI 2005
Children with stable asthma have reduced airway matrix metalloproteinase-9 and matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio Clinical & Experimental Allergy Vol 35(9) (1168-1174)  DOI   2005
The prevalence of obstructive lung disease in a general population sample: the NICECOPD study European Journal of Epidemiology Vol 20 (443-453)  2005
Mass cell mediator release in non-asthmatic subjects after endobronchial adenosine challenge Journal of Allergy and Clinical Immunology Vol 114(1) (34-39)  2004
Adenosine, inflammation and asthma - a review Inflammation research : official journal of the European Histamine Research Society ... [et al.] Vol 53(5) (171-178)  2004
A possible case of pneumoconiosis in a limestone quarry worker Occupational Medicine - Oxford Vol 54 (497-499)  2004
Oesophageal pH monitoring is of limited value in the diagnosis of European Respiratory Journal Vol 24 (724-727)  2004
Prescribing practice for intermittent oxygen therapy: a GP survey Chronic Respiratory Disease Vol 1 (139-142)  2004
Psychogenic cough in a schoolboy: Evaluation using an ambulatory cough recorder Pediatric Pulmonology Vol 36 (73-75)  2003
Predictors of therapy resistant asthma: outcome of a systematic evaluation protocol Thorax Vol 58(7) (561-566)  DOI 2003
Simple liquid chromatography method for the rapid simultaneous determintion of prednisolone and cortisol in plasma and urine using hydrophilic lipophilic balanced solid phase extraction cartridges Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences Vol 798 (193-201)  2003
Non-bronchoscopic sampling and culture of bronchial epithelial cells in children Clinical & Experimental Allergy Vol 33(9) (1221-1225)  DOI 2003
Nasal septal perforation and oxygen cannulae Hospital Medicine Vol 62 (248-248)  2001
Progressive breathlessness in an 18 year old male - idiopathic pulmonary emphysema Postgraduate Medical Journal Vol 76 (307-307)  2000
Eosinophilic bronchitis is an important cause of chronic cough American Journal of Respiratory Critical Care Medicine Vol 161 (1763-1764)  2000
Sensory neuropeptides induce histamine release from bronchoalveolar lavage cells in both nonasthmatic coughers and cough variant asthmatics Clinical & Experimental Allergy Vol 30 (225-232)  2000
Is there an association between angiotensin-converting enzyme gene variants and chronic nonproductive cough Chest Vol 118 (1091-1094)  2000
Adenosine stimulates histamine release from human bronchoalveolar lavage cells Clinical Science Vol 96 (349-355)  1999
Inflammatory mediators in bronchoalveolar lavage samples from children with and without asthma Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 29 (362-366)  1999
Domicilary Oxygen Provision - are the drug tariff prescribing guidelines cost effective British Medical Journal Vol 319(7201) (19-23)  1999
A retrospective survey of diagnosis and management of patients presenting with chronic cough to a general chest clinic. International Journal of Clinical Practice Vol 52(3) (158-161)  1998
Histamine release from bronchoalveolar lavage cells from asthmatic subjects after allergen challenge and relationship to development of a late asthmatic response Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 1998 (196-204)  1998
Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fluid in normal and asthmatic subjects Thorax Vol 53 (357-362)  1998
Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol Thorax Vol 53 (738-743)  1998
Evidence for ongoing airways inflammation in the subjects with chronic non-productive cough European Respiratory Journal Vol 13 (59-65)  1998
Neurokinin A and bradykinin stimulate human pulmonary mast cells Inflammation research : official journal of the European Histamine Research Society ... [et al.] Vol 46 (304-309)  1997
Bronchoalveolar lavage findings suggest two different forms of childhood asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 27(9) (1027-1035)  1997
A comparison of three standard methods of identifying mast cells in endobronchial biopsies in normal and asthmatic subjects. Allergy Vol 52(8) (836-843)  1997
Dyspnoea, anorexia and weight loss in a 74 year old man. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Vol 10(6) (1412-1414)  1997
Brewer's asthma due to malt contamination. Occupational medicine (Oxford, England) Vol 47(7) (397-400)  1997
Prescription of oxygen concentrators and survival in Northern Ireland. The Ulster Medical Journal Vol 66(2) (86-91)  1997
Further characterisation of SP-induced histamine release from human bronchoalveolar lavage cells Inflammation Research Vol 45 (11-13)  1996
Investigating paediatric airways by non-bronchoscopic lavage: normal cellular data. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 26(7) (799-806)  1996
Substance P causes histamine release from bronchoalveolar lavage mast cells Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 25 (179-186)  1995
Electronic cell counting to assess cell numbers in bronchoalveolar lavage fluid European Respiratory Journal Vol 7 (1527-1531)  1994
Differential reactivity of bronchial lavage mast cells to substance P Agents and actions Vol 41 (19-21)  1993