'FROM DISCOVERY TO RECOVERY'
For more information on Denise Fitzergerald's research use the link below
My current research is firmly focused on inflammatory demyelinating disorders of the CNS with an emphasis on immune-mediated pathology. My ongoing work in murine and human immune models, is investigating the fundamental biology of IL-27 and its therapeutic potential in inflammatory/autoimmune disease, with particular focus on Th1 and Th17 mediated inflammatory responses. My previous research has encompassed the role of TLRs in autoimmune inflammation and mucosal immunology. I am also currently developing the basis for a research program on mechanisms of repair in the CNS and how the immune system and ageing may modulate such mechanisms.
Peer review Activities
Grant Review Panel: National Mutiple Sclerosis Society (UK), (2012-present, renewed for second term)
Editorial Board Member: American Journal of Clinical and Experimental Immunology (2013-present), Frontiers in Neuro-opthalmology (2011-present).
Advisory board: Transverse Myelitis Association Medical and Scientific Board, (2012-present)
Manuscript reviewer: Journal of Immunology, European Journal of Immunology, Acta Neuropathologica Communications, Immunology, Glia, Journal of Neuroimmune Pharmacology, Cytokine, Microbes and Infection, Biomaterials, Molecular Medicine.
Grant reviewer: The Wellcome Trust, Medical Research Council (UK), Biotechnology and Biological Sciences Research Council (BBSRC), The Cunningham Trust, Neurological Foundation of New Zealand and Arthritis Research UK, Poland National Science Centre.
External examiner for PhD thesis, Mr. Shane Russell, Department of Clinical Medicine, School of Medicine, Trinity College, Dublin 8, Ireland; Viva voce examination Nov 2013
External Examiner for PhD thesis, Ms. Laura Carney, School of Cellular and Molecular Medicine, University of Bristol, UK, Viva voce examination July 2014
Upcoming: Received PhD Thesis of Helen Mohan, University College Dublin, viva in Apring 2016.
Senior author on over 40 accepted oral and poster presentations by my PhD students and PDRAs at national and international scientific meetings from 2010-2016
Regulatory T cells produce CCN3 and directly promote myelin regeneration in the CNS. Invited Platform presentation at the 8th International Workshop on the CCN Family of Genes, Nice, France, Nov 2015.
Regulatory T cells directly promote myelin regeneration in the Central Nervous system. Invited Platform presentation at Euroglia, Bilbao July 2015
Hungry macrophages lose their appetite with age. Invited Oral Presentation at Fraser Research Symposium, Belfast, Apr 2015.
Neural Stem Cells and the Central Nervous System. Invited Oral Presentation at European-wide UNISTEM day, March 2015
Emerging regenerative functions of T cells in the central nervous system. Invited Oral Presentation at University of Cambridge, Nov 2014.
Harnessing T cells to Remyelinate the Central Nervous System. Invited Oral Presentation at Beaumont Hospital, Dublin, Oct 2014.
Harnessing T cells to Remyelinate the Central Nervous System. Invited Oral Presentation at University College Dublin, Dublin, Oct 2014.
Regenerative influences of T cells in the central nervous system. Invited Platform Presentation at Irish Society for Immunology Annual Meeting, Dublin, Sep 2014.
Harnessing the immune system to repair the brain. Invited Oral Presentation at REMERGE Annual Symposium 2014, Riddel Hall, QUB, Belfast, Northern Ireland, July 2014
Regenerating myelin in the central nervous system; the next frontier in MS therapy? Invited Oral Presentation at Neurology Registrar Training Day, Royal Victoria Hospital and MS Society (Northern Ireland Branch), Annadale Embankment. Belfast April 2014.
Regenerating myelin in the CNS; the next frontier in Multiple Sclerosis therapy? Invited Oral Presentation at National University of Ireland Galway, April 2014.
Harnessing the immune system to repair the CNS. Invited Oral Presentationat Neuropathology Grand Rounds, Royal Victoria Hospital Belfast, Dec 2013.
Immunoregulatory mechanisms of IL-27; implications for CNS inflammation. Invited Oral Presentation at National University of Ireland, Maynooth, October 2012.
Autoimmune Inflammation and Remyelination in the Central Nervous System. Invited Oral Presentation at University of Newcastle, Australia, December 2011.
Suppression of GM-CSF in murine and human T cells by IL-27. Invited Oral Presentation at Australasian Society for Immunology Annual Meeting, Adelaide, December 2011
Inflammatory Demyelination and Remyelination in the Central Nervous System; In pursuit of novel treatments for REPAIR. Invited Oral Presentation at NMO and TM Patient Support Group meeting, Antrim, Northern Ireland, June 2011.
Inflammatory Demyelination and Remyelination in the Central Nervous System; In pursuit of novel targets for Multiple Sclerosis. Invited Oral Presentation at School of Biological Sciences Seminar Series, QUB, Northern Ireland, March 2011.
Rodent models of MS; Paradoxes and (some) resolutions in EAE. Invited Oral Presentation at ‘Multiple Sclerosis Immunology: A foundation for current and future treatments’ at University of Nottingham, Nov 2010
Autoimmune Inflammation and remyelination in the Central Nervous System. Invited Oral Presentation at National University of Ireland Maynooth, July 2010
Current and future MS research at QUB. Invited oral presentation, MS Society Pritchard Lecture Research Symposium, Belfast, Northern Ireland, May 2010.
Autoimmune Inflammation and remyelination in the Central Nervous System. Invited Oral Presentation at Trinity College Dublin, Ireland, April 2010
Multiple Sclerosis Research in the Centre for Infection and Immunity (CII), QUB. Invited Oral Presentation at Neuropathology Grand Rounds, RVH, Belfast, Northern Ireland, March 2010
The role of interleukin-27 in CNS autoimmune inflammation; Invited oral presentation, Neuroimmunology Seminar Series, Johns Hopkins University, Baltimore, USA, Feb 09.
Immunomodulatory properties of human IL-27. Invited oral presentation, Joint Irish society for Immunology/Ulster Immunology Group meeting, Belfast, June 2009.
Immunomodulatory functions of human IL-27. Poster presentation. Keystone Symposium (Multiple Sclerosis), Santa Fe, Jan 2009.
Regulation of autoimmune inflammation by IL-27;Invited oral presentation, Mucosal Inflammation Program Seminar, University of Colorado School of Medicine, Denver, Nov 08
Interleukin-27 in CNS Autoimmune Inflammation;Invited oral presentation; Irish Society for Immunology Annual Meeting, Dublin, Sep 2008
IL-27 upregulates IL-10 production by IFN-γ+ T-bet+ Foxp3- effector T cells and suppresses ongoing experimental autoimmune encephalomyelitis. Irish Society for Immunology Annual Meeting, Dublin, Sep 2007. Oral Presentation. Also poster presentation at Cytokines 2007, San Francisco, Oct 2007 and Jefferson Postdoctoral Research Symposium, Philadelphia, 2008.
Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis (EAE). Jefferson Postdoctoral Research Symposium, Philadelphia, June 2007. Oral Presentation First Prize
The National Postdoctoral Association (NPA) Model In Action. NPA Annual Meeting, UC Berkeley, CA, USA, March 2007. Poster Presentation
Effect of TLR4 stimulation in EAE.MedImmune, Gaithersburg, MD, USA, Oct 2006. Oral Presentation,
Stimulation of TLR4 Delays The Onset Of Chronic Experimental Autoimmune Encephalomyelitis (EAE).Rare Neuroimmunological Disorders Symposium, Baltimore, July 2006. Oral Presentation. Also Poster Presentation at International Congress of Neuroimmunology (2006), American Association of Immunology (2005), Irish Society of Immunology (2005), ECTRIMS (2005)
Identification of Pertinent Local Postdoctoral Issues and Subsequent Development of an Action Plan, National Postdoctoral Association Meeting, NIH, Bethesda, MD, USA, April 2006. Poster presentation
IL-8 release from bovine mammary epithelial cells in response to pro- and anti-inflammatory stimuli. AVTRW Spring meeting, Dublin, March 2003. Oral presentation.
Flamin' mammaries! The role of teat sinus epithelium in mastitis Faculty of Veterinary Medicine Seminar Series, UCD, December 2002. Oral presentation.
TNF-α induces IL-8 release from bovine mammary mucosa in vitro. 2nd Conway Festival of Research, Dublin September 2003. Poster presentation.
British Society of Immunology Neuroimmunology Affinity Group 2013-present
British Society of Immunology Young Immunologist Forum Co-Chair 2012, 2014
Irish Society of Immunology, 2014-present
Ulster Immunology Group 2011-present
Infection and Immunity TRG 2011-present
Pritchard Lecture Research Symposium 2010
Laboratory Hosting of Visiting Researchers and Students at QUB since 2010
Ms. Natasha Boylan, Intercalating MRes student 2015/2016
Mr. Daniel Crooks, Honours project student, 2015
Mr. Calum McDonald, Honours project student, 2015
Ms. Rachel Forkin, Cii Summer Studentship, 2015
Ms. Hannah Ware, Nuffield Summer Studentship 2015
Dr. Andrew Young, Visiting Research Fellow, 2015
Mr. John Falconer. Visiting Research Associate, 2014-present
Mrs. Jill Moffatt, Visiting Research Associate, 2014-present
Rachel Smyth, Honours project student, 2014
Jason Hurson, Honours project student, 2014
Samara Fleville, Summer studentship, 2014
Maeve Moore, Summer studentship, 2014
Andre Borba, Summer studentship, 2014
Malik Hasson, Summer studentship, 2014
Anna Grant, Honours project student, 2013
Katie Harrison, Honours project student, 2013
Seanna Meehan, Honours project student, 2013
Samara Fleville, Summer studentship, 2013
Yixi Bi, Visiting research associate, 2013
Paul Denver, Visiting research associate, 2012-2013
Rachel Snoddy, Honours project student, 2012
James McGuinness, Honours project student, 2012
Caitlin Milliken, Nuffield summer student, 2012
Aideen Carroll, Summer studentship, 2012
Thomas O'Hagan, Honours project student, 2011-12
Jessica Huddleson, Honours project student, 2011-12
Romain Davaze, MRes Student (France), 2011
Brendan Wright, MRes Student (QUB), 2011
Anindita Banerjee, visiting researcher 2010
Tanuja Chahal, visiting researcher 2010
Janine Crawford, summer student 2010
Cliona Johnston, summer student, 2010
Enda Shevlin, rotating PhD student (HRB Immunology Scholars programme), 2010