'FROM DISCOVERY TO RECOVERY'
For more information on Denise Fitzergerald's research use the link below
My current research is firmly focused on inflammatory demyelinating disorders of the CNS with an emphasis on immune-mediated pathology. My ongoing work in murine and human immune models, is investigating the fundamental biology of IL-27 and its therapeutic potential in inflammatory/autoimmune disease, with particular focus on Th1 and Th17 mediated inflammatory responses. My previous research has encompassed the role of TLRs in autoimmune inflammation and mucosal immunology. I am also currently developing the basis for a research program on mechanisms of repair in the CNS and how the immune system and ageing may modulate such mechanisms.
Peer review Activities
Grant Review Panel: National Mutiple Sclerosis Society (UK), (2013-present)
Editorial Board Member: American Journal of Clinical and Experimental Immunology (2013-present), Frontiers in Neuro-opthalmology (2011-present).
Advisory board: Transverse Myelitis Association Medical and Scientific Board, (2012-present)
Manuscript reviewer: Journal of Immunology, Glia, Journal of Neuroimmune Pharmacology, Cytokine, Immunology
Grant reviewer: Wellcome Trust, Medical Research Council, The Cunningham Trust and Arthritis Research UK
External examiner for PhD thesis, Mr. Shane Russell, Department of Clinical Medicine, School of Medicine, Trinity College, Dublin 8, Ireland; Viva voce examination scheduled for Nov 2013
** indicates abstracts on topics of postdoctoral development
Senior author on over 25 accepted oral and poster presentations by my PhD students and PDRAs at national and international scientific meetings from 2010-2013
Denise C. Fitzgerald. Immunoregulatory mechanisms of IL-27; implications for CNS inflammation. Invited Oral Presentation at National University of Ireland, Maynooth, October 2012.
Denise C. Fitzgerald. Autoimmune Inflammation and Remyelination in the Central Nervous System. Invited Oral Presentation at University of Newcastle, Australia, December 2011.
Denise C. Fitzgerald. Suppression of GM-CSF in murine and human T cells by IL-27. Invited Oral Presentation at Australasian Society for Immunology Annual Meeting, Adelaide, December 2011
Denise C. Fitzgerald. Inflammatory Demyelination and Remyelination in the Central Nervous System; In pursuit of novel treatments for REPAIR. Invited Oral Presentation at NMO and TM Patient Support Group meeting, Antrim, Northern Ireland, June 2011.
Denise C. Fitzgerald. Inflammatory Demyelination and Remyelination in the Central Nervous System; In pursuit of novel targets for Multiple Sclerosis. Invited Oral Presentation at School of Biological Sciences Seminar Series, QUB, Northern Ireland, March 2011.
Denise C. Fitzgerald. Rodent models of MS; Paradoxes and (some) resolutions in EAE. Invited Oral Presentation at ‘Multiple Sclerosis Immunology: A foundation for current and future treatments’ at University of Nottingham, Nov 2010
Denise C. Fitzgerald. Autoimmune Inflammation and remyelination in the Central Nervous System. Invited Oral Presentation at National University of Ireland Maynooth, July 2010
Denise C. Fitzgerald. Current and future MS research at QUB. Invited oral presentation, MS Society Pritchard Lecture Research Symposium, Belfast, Northern Ireland, May 2010.
Denise C. Fitzgerald. Autoimmune Inflammation and remyelination in the Central Nervous System. Invited Oral Presentation at Trinity College Dublin, Ireland, April 2010
Denise C. Fitzgerald. Multiple Sclerosis Research in the Centre for Infection and Immunity (CII), QUB. Invited Oral Presentation at Neuropathology Grand Rounds, RVH, Belfast, Northern Ireland, March 2010
Denise C. Fitzgerald. The role of interleukin-27 in CNS autoimmune inflammation; Invited oral presentation, Neuroimmunology Seminar Series, Johns Hopkins University, Baltimore, USA, Feb 09.
Denise C. Fitzgerald. Immunomodulatory properties of human IL-27. Invited oral presentation, Joint Irish society for Immunology/Ulster Immunology Group meeting, Belfast, June 2009.
Denise C. Fitzgerald, Zoe Fonseca-Kelly, Abdolmohamad Rostami. Immunomodulatory functions of human IL-27. Poster presentation. Keystone Symposium (Multiple Sclerosis), Santa Fe, Jan 2009.
Denise C. Fitzgerald. Regulation of autoimmune inflammation by IL-27;Invited oral presentation, Mucosal Inflammation Program Seminar, University of Colorado School of Medicine, Denver, Nov 08
Denise C. Fitzgerald. Interleukin-27 in CNS Autoimmune Inflammation
Invited oral presentation; Irish Society for Immunology Annual Meeting, Dublin, Sep 2008
Denise C. Fitzgerald, Guang-Xian Zhang, Mohamed Elbehi, Hongmei Li, Christiaan J. Saris, Bruno Gran, Bogoljub Ciric, Abdolmohamad Rostami. IL-27 upregulates IL-10 production by IFN-γ+ T-bet+ Foxp3- effector T cells and suppresses ongoing experimental autoimmune encephalomyelitis. Irish Society for Immunology Annual Meeting, Dublin, Sep 2007. Oral Presentation. Also poster presentation at Cytokines 2007, San Francisco, Oct 2007 and Jefferson Postdoctoral Research Symposium, Philadelphia, 2008.
Denise C. Fitzgerald*, Bogoljub Ciric, Tarik Touil, Jayasri Das Sarma, Bruno Gran, Guang-Xian Zhang, Abdolmohamad Rostami. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis (EAE). Jefferson Postdoctoral Research Symposium, Philadelphia, June 2007. Oral Presentation
**Denise C. Fitzgerald, Georgia Anyatonwu, R. Mark Jones, Lisa Kozlowski. The National Postdoctoral Association (NPA) Model In Action. NPA Annual Meeting, UC Berkeley, CA, USA, March 2007. Poster Presentation
Denise C. Fitzgerald, Tarik Touil, Abdolmohamad Rostami, Bruno Gran. Effect of TLR4 stimulation in EAE.MedImmune, Gaithersburg, MD, USA, Oct 2006. Oral Presentation,
Denise C. Fitzgerald, Tarik Touil, Abdolmohamad Rostami, Bruno Gran. Stimulation of TLR4 Delays The Onset Of Chronic Experimental Autoimmune Encephalomyelitis (EAE).Rare Neuroimmunological Disorders Symposium, Baltimore, July 2006. Oral Presentation. Also Poster Presentation at International Congress of Neuroimmunology (2006), American Association of Immunology (2005), Irish Society of Immunology (2005), ECTRIMS (2005)
**Denise C. Fitzgerald, Adam Hardy, Ahmad B. Naim. Identification of Pertinent Local Postdoctoral Issues and Subsequent Development of an Action Plan, National Postdoctoral Association Meeting, NIH, Bethesda, MD, USA, April 2006. Poster presentation
Denise C. Fitzgerald, Alan W. Baird. IL-8 release from bovine mammary epithelial cells in response to pro- and anti-inflammatory stimuli. AVTRW Spring meeting, Dublin, March 2003. Oral presentation.
Denise Fitzgerald, Alan W. Baird. Flamin' mammaries! The role of teat sinus epithelium in mastitis Faculty of Veterinary Medicine Seminar Series, UCD, December 2002. Oral presentation.
Denise Fitzgerald, Alan W. Baird. TNF-α induces IL-8 release from bovine mammary mucosa in vitro. 2nd Conway Festival of Research, Dublin September 2003. Poster presentation.
BSI Neuroimmunology Affinity Group 2013-present
QUB REMERGE (Regenerative Medicine Research Groups) 2013-presentPostgraduate Education and Training (Cii) 2011-present (Deputy Chair)
Ulster Immunology Group 2011-present
Infection and Immunity TRG 2011-present
Pritchard Lecture Research Symposium 2010
School Website Committee (SMDB) 2011-present
QUB Coordinator, HRB Immunology Scholars Programme 2010
Laboratory Hosting of Visiting Researchers and Students at QUB since 2010
Anna Grant, Honours project student, 2013
Katie Harrison, Honours project student, 2013Seanna Meehan, Honours project student, 2013Samara Fleville, Summer studentship, 2013Yixi Bi, Visiting research associate, 2013Paul Denver, Visiting research associate, 2012-2013Rachel Snoddy, Honours project student, 2012James McGuinness, Honours project student, 2012
Caitlin Milliken, Nuffield summer student, 2012Aideen Carroll, Summer studentship, 2012
Thomas O'Hagan, Honours project student, 2011-12
Jessica Huddleson, Honours project student, 2011-12
Romain Davaze, MRes Student (France), 2011
Brendan Wright, MRes Student (QUB), 2011
Anindita Banerjee, visiting researcher 2010
Tanuja Chahal, visiting researcher 2010
Janine Crawford, summer student 2010
Cliona Johnston, summer student, 2010
Enda Shevlin, rotating PhD student (HRB Immunology Scholars programme), 2010