Staff Profile




General Profile Information
Staff Name Dr Fionnuala Lundy
Job Title Senior Lecturer
Location H.S.B Block 10 MBC Site
Room Number 01.013
School School of Medicine, Dentistry and Biomedical Sciences
Contact Details
Telephone +44 (0)28 9097 5797
E-mail f.lundy@qub.ac.uk
Research Statement
My major research interest is innate immunity and inflammation.  I am particularly interested in the host response to pathogens including the expression and functionality of host defence peptides and in the contribution of the nervous system to the local inflammatory response (neurogenic inflammation).  I am also interested in the role of proteases in inflammation and their role in the degradation of host defence proteins and peptides.



Professional Qualifications

Visiting Assistant Professor, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, Texas, USA (June - July 2005)

Visiting Scholar, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, Texas, USA (Feb - March 1996)

Visiting Scholar, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, Texas, USA (May - June 1995)

External Assessor and Validator for the MRes Life and Health Sciences Programme, University of Ulster (2011)

External Examiner 2nd BDS Dentistry Univveristy of Dundee 2012-1015

External Examiner, PhD University of Ulster (2013)

External Examiner, PhD, University of Cardiff (2013)

External Examiner, PhD, King's College London (2011)

External Examiner, PhD, Universityof Birmingham (2011)

External Examiner, MSc, University of Ulster (2005)





Membership Of Other Societies / Professional Activities

Society Membership 

Member of the Biochemical Society

Member of the International Association for Dental Research

Member of the Society for Anaerobic Microbiology

 

Member of the Ulster Immunology Group

Chartered Biologist (CBiol) and full member of the Institute of Biology (MIBiol)

 

Professional activities associated with Learned Societies

President, Irish Division of the International Association for Dental Research (Oct 2011-Oct 2012) 

Treasurer, Irish Division of the International Association for Dental Research (2008-2011)

Council Member, Irish Division of the International Association for Dental Research (2000-2003)

 

Peer Review

Editorial Activity

 

I am a member of the Scientific Advisory Board of the Journal of Endodontics (Official Journal of the American Association of Endodontics)

 

I am a member of the Editorial Advisory Board of Archives of Oral Sciences and Research

 

Manuscript Review

 

I review manuscripts regularly for the following journals:

Journal of Dental Research

European Journal of Oral Sciences

Journal of Mass Spectrometry

Anti-infective Agents in Medicinal Chemistry

Mini-Reviews in Medicinal Chemistry

Journal of Endodontics

Archives of Oral Biology

Clinical Oral Investigations 

Journal of Dentistry

Journal of the Irish Dental Association

Medical Science Monitor

Journal of Periodontal Research

Journal of Periodontology

Oral Diseases

Inflammation Research

Peptides

Disease Models and Mechanisms

Journal of Anatomy

BMC Immunol

PLoS One

Current Pharmaceutical Design

 

Grant Review

I review grants for the Health Research Board (Ireland), the Medical Research Council, the Biotechnology & Biological Sciences Research Council and the IRCSET (Irish Research Council for Science, Engineering and Technology)

 

Conference Organisation

International Conference organisation

- Member of the Local Organising Committee for REGPEP2010, 18th International Symposium  on Regulatory Peptides, held in Belfast in September 2010.

- Oral session chair 18th Annual International Symposium on Regulatory Peptides (REGPEP Society), Belfast, September 2010

- Oral session chair 88th Annual International Conference of IADR (International Association for Dental Research), Barcelona July 2010

- Poster Discussion session chair IADR 88th Annual International Conference of IADR, Barcelona July 2010

 

National Conference organisation 

- Judge, Royal College of Surgeons in Ireland (RCSI) sponsored Research Prize IADR Dublin, 2011

- Member of the Local Organising Committee for the Irish Division of Dental Research Dublin meeting 2011

- Judge, Postgraduate Poster Prize IADR Dublin, 2010

- Oral Session Chair IADR Dublin meeting 2011

- Judge, Postgraduate Poster Prize IADR Limerick, 2009

            - Member of the Local Organising Committee for the Irish Division of Dental Research Limerick meeting 2009

- Oral Session Chair IADR Limerick meeting 2009

- Oral session Chair IADR Cork meeting 2007

 

 

Invited Lectures, Interviews and Editorials

Inited Speaker: Tissue Enginering Research Group, Univeristy of Cardiff. 'TRP and FALL...in the oral cavity' June 2013

 

Invited Speaker: American Cough Conference, New York  'A novel model of human neural function in cough' June 2011  

 

Keynote Speaker: Medical and Health Sciences Board, Graduate College, University of Khartoum, 'Antimicrobial Peptides - Potential therapeutic agants?' February 2011 

 

Invited Speaker: School of Biological Sciences QUB, Seminar Programme  'Antimicrobial Peptides - Lessons from nature' February 2011

 

Invited Speaker: University of Glasgow, Dental School Seminar Programme 'Innate immunity, host defence peptides and protection of the oral cavity' June 2010  

 

Keynote Speaker: Pan European Federation meeting of the International Association for Dental Research, London ‘Proteomic analysis of disease markers in gingival crevicular fluid' September 2008

 

Invited Reviewer Wrigley Oral Healthcare Programme (WOHP) September 2008

 

Keynote Speaker: Inaugural meeting of the Sudanese section of the International Association for Dental Research, Univeristy of Khartoum ‘Proteins, peptides and oral disease', March 2008

 

Invited Speaker: Postgraduate research symposium, University of Khartoum ‘Research ethics', March 2008

 

Interview: ‘Researcher awarded for enzyme discovery'. Interview by Dental Product Report Europe, Dentistry's only Pan-European dental products publication as winner of the IADR/GSK Innovation in Oral Care Award (2007), Interview published in May 2007 

 

Invited EditorialDental Products Report Europe ‘The nervous connection' October 2007

 

Invited Referee  Invited peer reviewer of abstracts for the Pan European Federation of the International Association of Dental Research Meeting in Dublin, September 2006

 

Invited Speaker: Baylor College of Dentistry, Dallas, Texas USA ‘Neuropeptides and neurogenic mechanisms in oral and periodontal disease', July 2005

 

Invited article: Plaque Prevention, Launchpad (2003) 10(2), 33-34. Launchpad is a British Dental Association magazine for dental  students and recent graduates throughout the UK

 

Invited Speaker: British Electrophoresis Society (Silver Jubilee Meeting) Maidstone ‘Reactivation of proteases after SDS-PAGE', July 1995

 





Awards And Honours/major Prizes

 

2011     Joint Winner of the International Association for Dental Research (IADR)/ GlaxoSmithKline (GSK) Innovation in Oral Care Award. ($75,000, The IADR's most prestigious monetary prize)

 

2007     Winner of the International Association for Dental Research (IADR)/ GlaxoSmithKline (GSK) Innovation in Oral Care Award. ($75,000, The IADR's most prestigious monetary prize)

 

1999     Winner of the Sir Wilfred Fish Research Prize (The British Society of Periodontology's most prestigious research prize)





Publications
Chapter(s)
TitleBook TitleYear
Biomarkers of Periodontal Disease: Past, Present and Future Challenges Periodontal Disease: Symptoms, Treatment and Prevention 2011
Journal(s)
TitleJournal NameYear
Human odontoblasts express functional thermo-sensitive TRP channels: Implications for dentin sensitivity Pain Vol 152(10) (2211-2223)  DOI   2011
Human Dental Pulp Fibroblasts Express the “Cold-sensing” Transient Receptor Potential Channels TRPA1 and TRPM8 Journal of Endodontics Vol 37(4) (473-478)  DOI   2011
Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y. International Endodontic Journal Vol 43(10) (835-842)  DOI 2010
PAR-2 Regulates Dental Pulp Inflammation Associated with Caries. Journal of Dental Research Vol 89 (684-688)  DOI   2010
Quantification of secretory leucocyte protease inhibitor in exudates from leg ulcers of patients with diabetes Regulatory Peptides Vol 164 (31-32)  DOI 2010
Antimicrobial activity of LL-37 and three truncated derivatives against Gram positive and Gram negative bacteria Regulatory Peptides Vol 164 (49-49)  DOI 2010
The antimicrobial activity of interlukin-8 derived peptide is influenced by glucose Regulatory Peptides Vol 164 (49-50)  DOI 2010
Substance P expression by human dental pulp fibroblasts:a potential role in neurogenic inflammation Journal of Endodontics Vol 35 (73-77)  2009
Neuropeptides Regulate Expression of Angiogenic Growth Factors in Human Dental Pulp Fibroblasts Journal of Endodontics Vol 35 (829-833)  DOI   2009
Neuropeptide Y (NPY) and NPY Y1 receptor in periodontal health and disease Archives of Oral Biology Vol 54 (258-262)  DOI   2009
Antimicrobial activity of truncated alpha-defensin (human neutrophil peptide (HNP)-1) analogues without disulphide bridges. Molecular Immunology Vol 45 (1) (190-193)  DOI   2008
Neuropeptide YY1 receptor in human dental pulp cells of noncarious and carious teeth International Endodontic Journal Vol 41 (850-855)  DOI   2008
Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites Journal of Neuroimmunology Vol 200 (11-16)  DOI   2008
Matrix Metalloproteinase-3 Differences in Oral and Skin Fibroblasts Journal of Dental Research Vol 86(5) (457-462)  2007
Caries-induced changes in the expression of pulpal neuropeptide Y. European Journal of Oral Sciences Vol 114(2) (133-137)  DOI 2006
Vasoactive intestinal polypeptide (VIP) and VPAC1 receptor in adult human dental pulp in relation to caries. Archives of Oral Biology Vol 51(10) (849-855)  DOI 2006
Phenotypic differences between oral and skin fibroblasts in wound contraction and growth factor expression Wound Repair and Regeneration Vol 14(2) (172-178)  DOI 2006
The Cytotoxic Effects of Human Neutrophil Peptide-1 (HNP1) and Lactoferrin on Oral Squamous Cell Carcinoma (OSCC) in vitro Oral Oncology Vol 42(7) (685-690)  DOI 2006
Radioimmunoassay quantification of adrenomedullin in gingival crevicular fluid Archives of Oral Biology Vol 51(4) (334-338)  DOI 2006
Detection of individual human neutrophil α-defensins (human neutrophil peptides 1,2 and 3) in unfractionated gingival crevicular fluid - a MALDI-MS approach Molecular Immunology Vol 42(5) (575-579)  DOI 2005
NEUROPEPTIDES AND NEUROGENIC MECHANISMS IN ORAL AND PERIODONTAL INFLAMMATION. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Vol 15(2) (82-98)  2004
Sjögren's syndrome: a condition with features of chronic graft-versus-host disease: does duct cell adhesion or permeability play a role in pathogenesis? Medical Hypotheses Vol 62(5) (825-829)  DOI 2004
Identification and overexpression of human neutrophil ά defensins (human neutrophil peptides 1, 2 and 3) in squamous cell carcinomas of the human tongue Oral Oncology Vol 40(2) (139-144)  DOI 2004
Extraction and radioimmunoassay quantitation of neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP) from human dental pulp tissue Archives of Oral Biology Vol 48(3) (249-254)  DOI 2003
Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in pulp tissue from painful and healthy human teeth International Endodontic Journal Vol 35(1) (30-36)  DOI 2002
Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in gingival crevicular fluid associated with painful human teeth European Journal of Oral Sciences Vol 110(3) (185-191)  DOI 2002
Changes in vasoactive intestinal peptide in gingival crevicular fluid in response to periodontal treatment Journal Of Clinical Periodontology Vol 29(6) (484-489)  DOI 2002
Quantitative analysis of MRP-8 in gingival crevicular fluid in periodontal health and disease using microbore HPLC. Journal Of Clinical Periodontology Vol 28(12) (1172-1177)  DOI 2001
Bcl-2 expression in sequential biopsies of potentially malignant oral mucosal lesions assessed by immunocytochemistry Oral Diseases Vol 6 (5) (318-326)    2000
Changes in substance P and neurokinin A in gingival crevicular fluid in response to periodontal treatment Journal Of Clinical Periodontology Vol 27 (7) (526-530)    2000
Carboxypeptidase-mediated metabolism of calcitonin gene-related peptide in human gingival crevicular fluid - a role in periodontal inflammation? Journal Of Clinical Periodontology Vol 27 (7) (499-505)    2000
Identification of MRP-8 (calgranulin A) as a major responsive protein in chronic periodontitis The Journal of Pathology Vol 192 (4) (540-544)    2000
A comparison of four extraction methods for substance P, neurokinin A and calcitonin gene-related peptide from human dental pulp tissue Archives of Oral Biology Vol 44 (12) (999-1004)    1999
An antibody-lectin sandwich assay for quantifying protein glycoforms. Molecular biotechnology Vol 12(2) (203-206)  DOI   1999
Calcitonin gene-related peptide in gingival crevicular fluid in periodontal health and disease. Journal Of Clinical Periodontology Vol 26(4) (212-216)  1999
TFF1 gene expression in human medullary thyroid carcinoma. The Journal of Pathology Vol 184(4) (408-413)  DOI 1998
Substance P and neurokinin A in gingival crevicular fluid in periodontal health and disease. Journal Of Clinical Periodontology Vol 24(11) (799-803)  1997
Evaluation of major parotid glycoproteins in patients with burning mouth syndrome. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics Vol 83(2) (252-258)  1997
Cross-reactivity of antibodies raised to Pseudomonas fluorescens protease with extracellular proteins produced by meat-spoiling pseudomonads. The Journal of applied bacteriology Vol 81(1) (1-6)  1996
Sample handling techniques for analysis of neurokinin A in human saliva. Biochemical Society Transactions Vol 24(2) (336S-6)  1996
Alcohol intake in patients admitted acutely to a general medical unit. The Ulster Medical Journal Vol 64(2) (157-163)  1995
The recovery of proteolytic activity using the Salivette system. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies Vol 33(7) (443-444)  1995
A new method for the detection of proteolytic activity in Pseudomonas lundensis after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. ELECTROPHORESIS Vol 16(1) (43-45)  DOI 1995
The determination of asialoglycoforms of serum glycoproteins by lectin blotting with Ricinus communis agglutinin Clinica Chimica Acta Vol 205 (3) (187-195)  DOI   1992