Staff Profile


Publications
Journal(s)
TitleJournal NameYear
Langerin(+) Dermal Dendritic Cells Are Critical for CD8(+) T Cell Activation and IgH gamma-1 Class Switching in Response to Gene Gun Vaccines Journal of Immunology Vol 186 (1377-1383)  DOI   2011
Cell-to-Cell Interactions and Signals Involved in the Reconstitution of Peripheral CD8(+) T-CM and T-EM Cell Pools PLoS ONE Vol 6 (1377-1383)  DOI   2011
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration Development Vol 138 (3647-3656)  DOI   2011
Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells. European Journal of Immunology Vol 41(5) (1242-1248)  DOI 2011
The Role of Direct Presentation by Donor Dendritic Cells in Rejection of Minor Histocompatibility Antigen-Mismatched Skin and Hematopoietic Cell Grafts Transplantation Vol 91 (154-160)  DOI   2011
Development of atopic dermatitis-like inflammation is critically dependent on Langerhans cells in mice. Clinical & Experimental Dermatology Vol 19 (183-183)  2010
Langerhans Cells Prime IL-17-Producing T Cells and Dampen Genital Cytotoxic Responses following Mucosal Immunization Journal of Immunology Vol 184 (4842-4851)    2010
Vasodilator-Stimulated Phosphoprotein Regulates Inside-Out Signaling of beta(2) Integrins in Neutrophils Journal of Immunology Vol 184 (6575-6584)  DOI   2010
CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. The Journal of experimental medicine Vol 207(1) (189-206)  DOI   2010
Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes. Immunity Vol 32(2) (266-278)  DOI   2010
Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope. Journal of Immunology Vol 183(1) (430-437)  DOI 2009
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity Vol 31(2) (197-208)  DOI   2009
Peripheral Thy1+ lymphocytes rearranging TCR-gammadelta genes in LAT-deficient mice. European Journal of Immunology Vol 39(9) (2596-2605)  DOI 2009
Alloantigen-specific de novo-induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD. European Journal of Immunology Vol 39(11) (3091-3096)  DOI 2009
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. The Journal of experimental medicine Vol 206(13) (3089-3100)  DOI   2009
Langerhans cells are critical in the development of atopic dermatitis-like inflammation and symptoms in mice Journal of Cellular and Molecular Medicine Vol 13 (2658-2672)  DOI   2009
Priming of CD8(+) and CD4(+) T Cells in Experimental Leishmaniasis Is Initiated by Different Dendritic Cell Subtypes Journal of Immunology Vol 182(2) (774-783)    2009
Antigen-specific T-T interactions regulate CD4 T-cell expansion Blood Vol 112(4) (1249-1258)  2008
Insights into Langerhans Cell Function from LC Deficient Mice European Journal of Immunology Vol 38(9) (2369-2376)    2008
Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology. Immunity Vol 29(5) (782-794)  DOI 2008
Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk. Journal of Immunology Vol 180(7) (4361-4365)    2008
Langerin expressing cells promote skin immune responses under defined conditions. Journal of Immunology Vol 180(7) (4722-4727)    2008
ZAP-70 restoration in mice by in vivo thymic electroporation. PLoS ONE Vol 3(4) (e2059-e2059)  DOI   2008
Antigen specific T-T interactions regulate CD4 T cell expansion. Blood Vol Prepublished (0-0)  DOI   2008
Tumor immunotherapy by epicutaneous immunization requires langerhans cells. Journal of Immunology Vol 180(3) (1991-1998)    2008
Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. Journal of Immunology Vol 180(3) (1565-1575)    2008
The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. The Journal of experimental medicine Vol 204(13) (3119-3131)  DOI   2007
Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. The Journal of experimental medicine Vol 204(13) (3133-3146)  DOI   2007
Identification of a novel population of Langerin+ dendritic cells. The Journal of experimental medicine Vol 204(13) (3147-3156)  DOI   2007
Epidermal Langerhans Cells are Dispensable for Humoral and Cell-Mediated Immunity Elicited by Gene Gun Immunization. Journal of Immunology Vol 179(2) (886-893)    2007
Mature DC from skin and skin-draining LN retain the ability to acquire and efficiently present targeted antigen. European Journal of Immunology Vol 37(5) (1184-1193)  DOI   2007
Langerhans cells--revisiting the paradigm using genetically engineered mice. Trends in Immunology Vol 27(3) (132-139)  DOI   2006
Visualization of the earliest steps of gammadelta T cell development in the adult thymus. Nature Immunology Vol 7(9) (995-1003)  DOI   2006
Disruption of the langerin/CD207 Gene Abolishes Birbeck Granules without a Marked Loss of Langerhans Cell Function Molecular and Cellular Biology Vol 25(1) (88-99)  DOI   2005
Dynamics and Function of Langerhans Cells In Vivo: Dermal Dendritic Cells Colonize Lymph Node Areas Distinct from Slower Migrating Langerhans Cells Immunity Vol 22(5) (643-654)  DOI   2005
Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP European Journal of Immunology Vol 33(9) (2619-2629)    2003
Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues Journal of Immunology Vol 168(2) (782-792)    2002
The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. Immunogenetics Vol 52(1-2) (112-120)    2000
Conference Contribution(s)
TitleYear
SOCS are Essential for Macrophage Polarisation with Consequential Effects on Tumour Outcome 2011
The role of suppressor of cytokine signalling (SOCS)-2 in B cell development and function 2010
The role of SOCS2 and SOCS3 in macrophage plasticity and inflammation 2010
Function of lung langerin-positive dendritic cells in a model of respiratory viral infection 2010
Impact of SOCS2 on plasmacytoid DC biology and interferon response 2010
Function of lung langerin-positive dendritic cells in a model of respiratory viral infection 2009