Staff Profile




General Profile Information
Staff Name Professor Madeleine Ennis
Job Title Professor
Location H.S.B Block 10 MBC Site
Room Number 03.024
School School of Medicine, Dentistry and Biomedical Sciences
Contact Details
Telephone +44 (0)28 9097 2672
E-mail m.ennis@qub.ac.uk
Membership Of Other Societies / Professional Activities

I apologize for the varying font sizes but all text was the same font size when I pasted it into this box.

 

Other Committee Appointments

Research and Development Office, Northern Ireland

Member, Research and Development Office, Northern Ireland Health and Social Services, Central Services Agency Ad Hoc Group for the Award of Studentships (2009-2001)

 

EU Work (2009-20012)

Evaluator for Stage 1 of the Innovative Medicines Initiative Joint Undertaking (IMI JU)  which is a public-private partnership between the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA). This involved evaluating the Expressions of Interest submitted by Applicant Consortia (i.e. consortia formed from academia, SMEs, patient organisations, non EFPIA industry, etc). The aim was to select the best Expression of Interest in order to join a pre-established Consortium of member companies of EFPIA (industry).

 

Selected evaluator for Stage 2 of the Innovative Medicines Initiative Joint Undertaking, which involved evaluating the Full Project Proposals from the successful Applicant Consortium and the pre-established Consortium of member companies of EFPIA (industry).

 

Rapporteur for the  Interim Review of U-BIOPRED Project: “Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome”.  The role of the Rapporteur  was to consolidate the consensus Review Report with the input from the other Reviewers, after a hearing meeting in Brussels.  I was selected from the original panel of evaluators (from Stage 2). The other members of the review group were from the Scientific Committee of the IMI Joint Undertaking (IMI JU). I was the only person selected from the original evaluators to review the progress of the project.

 

Evaluator for Stage 1 of the FP7-HEALTH-2012-Innovation 1 applications in Systems Medicine.  In this first stage, short proposals (5 pages) were submitted and evaluators selected the best ones. Selected proposals were then invited to submit a full proposal.

 

Evaluator for Stage 2 of the FP7-HEALTH-2012-Innovation 1 applications in Systems Medicine for the topic 2.1-2-2 "Systems medicine: Applying systems biology approaches for understanding multifactorial human diseases and their co-morbidities."

 

Scientific Expert for German Government (2010-2011)

 

In a unique effort to establish six National Centres for Research in the fields of the most common diseases a National Centre for Lung Research was planned. The German Federal Ministry of Education and Research (BMBF) spending on this centre is of the order of more than 100 million Euro over the first 5 years.  The aim of the BMBF was to develop a centrally coordinated research hub for this important research area in Germany. I was selected as one of the review panel of internationally renowned experts in the field.  This work entailed: firstly evaluating all the proposals from potential centre partners and the pre-selection of 12 partners to submit to the second stage; secondly evaluating the second stage applications which included also hearing them present their proposals which resulted in the selection of the partners  for the centre and thirdly reviewing the joint proposal developed by the partners specifically for its scientific and structural integrity, the long-term strategy and sustainability as well as and most importantly, the added value for the area of lung research in Germany. This work entailed reviewing at home as well as 3 trips to Germany for the meetings. 

 

Review of manuscripts for journals

I serve as a referee for the following journals: Allergy, American Journal of Respiratory and Critical Care Medicine, Biochemical Pharmacology, British Journal of Pharmacology, Clinical and Experimental Allergy, European Journal of Pharmacology, European Respiratory Journal, Immunopharmacology, Inflammation Research,  Journal of Leukocyte Biology, Journal of Pharmacy and Pharmacology, Life Sciences, Pediatric Allergy and Immunology, Pediatric Pulmonology, Pulmonary Pharmacology & Therapeutics, Thorax.

 

Membership of Professional Bodies

 (i)         British Pharmacological Society

(ii)         British Society for Immunology

(iii)        British Society for Allergy and Clinical Immunology

(iv)        British Thoracic Society  (Member of Council and the Research and Scientific Committee 2010 onwards)

(v)        European Academy of Allergy and Clinical Immunology

(vi)        European Cystic Fibrosis Society

(vii)       European Histamine Research Society (Past President of Society)

(viii)      European Respiratory Society

(ix)        Irish Thoracic Society

(x)        Ulster Immunology Group 

 

Conference Organisation

I have been an active  member of the organising committees of the annual European Histamine Research Society meetings since 1998. 

 

 

This year the meeting will be held for the first time in the island of Ireland and I am responsible for organisation. See my conference website (www.qub.ac.uk/EHRS2012).   Although nominally European, this year the delegates are from 29 countries including USA, Japan, Argentina and Mexico as well as European Countries. 

 

In my role as member of the Science and Research Committee of the British Thoracic Society, I am responsible for helping to organise the Annual Winter Meeting. In 2011, I was responsible for 1 symposium and for 2012 I have organised 3 symposia. 

 

I organised and chaired a workshop entitled “Therapeutic potential of histamine H4 receptor compounds”  which was held during the European Academy of Allergy and Clinical Immunology (EAACI) 2010 Meeting.

 

  






Publications
Journal(s)
TitleJournal NameYear
Comparison of nasal and bronchial epithelial cells obtained from patients with COPD PLoS ONE Vol 7 (3) e32924  DOI 2012
Anti-inflammatory effects of DX-890, a human neutrophil elastase inhibitor Journal of Cystic Fibrosis Vol epub  DOI   2012
EFFECT OF HISTAMINE ON HUMAN NEUTROPHILS Inflammation Research Vol 60 (S335-S335)  2011
Population structure and characterization of viridans group streptococci (VGS) including Streptococcus pneumoniae isolated from adult patients with cystic fibrosis (CF) Journal of Cystic Fibrosis Vol 10 (133-139)  DOI   2011
Comparative repeatability of two handheld fractional exhaled nitric oxide monitors. Pediatric Pulmonology Vol epub (133-139)  DOI   2011
Effect of Aspergillus fumigatus and Candida albicans on pro-inflammatory response in cystic fibrosis epithelium. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Vol in press (133-139)  DOI   2011
LUNG CLEARANCE INDEX IS A REPRODUCIBLE AND SENSITIVE MEASURE OF AIRWAYS DISEASE IN BRONCHIECTASIS Thorax Vol 66 (A121-A121)  DOI 2011
Basophil models of homeopathy: a sceptical view Homeopathy Vol 99 (51-56)  DOI   2010
IDENTIFICATION OF H-3 AND H-4 HISTAMINE RECEPTORS ON NORMAL AND CYSTIC FIBROSIS EPITHELIAL CELLS Inflammation Research Vol 59 (S343-S343)  2010
SELDI-TOF analysis of induced sputum from patients with lung cancer, 'at risk' control subjects and healthy control subjects Lung Cancer Vol 60 (S8-S8)  2008
Frequency of cytokine gene promoter polymorphisms in the Northern Ireland Cystic Fibrosis population Journal of Cystic Fibrosis Vol 6 (363-365)  DOI   2007
Neutrophil cell death, activation and bacterial infection in cystic fibrosis Thorax Vol 60(8) (659-664)  DOI 2005
Mast cell degranulation after endobronchial adenosine challenge - Reply Journal of Allergy and Clinical Immunology Vol 115 (1098-1099)  DOI 2005
Adverse reactions to drugs: in vitro studies with isolated cells Inflammation Research Vol 53 (S105-S108)  DOI   2004
Mast cell mediator release in nonasthmatic subjects after endobronchial adenosine challenge Journal of Allergy and Clinical Immunology Vol 114 (34-39)  DOI   2004
Adenosine, inflammation and asthma - a review Inflammation Research Vol 53 (171-178)  DOI   2004
Histamine dilutions modulate basophil activation Inflammation Research Vol 53 (181-188)  DOI   2004
The effect of nicotine on basophil histamine release Inflammation Research Vol 53 (211-214)  DOI   2004
Possible association between passive smoking and lower exhaled nitric oxide in asthmatic children Archives of environmental health Vol 58 (613-616)    2003
Interleukin-4 and interleukin-4 soluble receptor a levels in bronchoalveolar lavage from children with asthma ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY Vol 90 (429-433)    2003
Neutrophil apoptosis and bacterial infection in cystic fibrosis Thorax Vol 57 (429-433)  2002
The repeatability of nonbronchoscopic bronchoalveolar lavage differential cell counts The European respiratory journal : official journal of the European Society for Clinical Respiratory Vol 18 (1009-1012)    2001
Oxidative stress and increased type-IV collagenase levels in bronchoalveolar lavage fluid from newborn babies Pediatric Research Vol 50 (29-33)    2001
Oxidative stress in lavage fluid of preterm infants at risk of chronic lung disease AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY Vol 281 (L1386-L1391)    2001
Chronic cough in children: bronchoalveolar lavage findings European Respiratory Journal Vol 16 (1109-1114)    2000
Is there an association between angiotensin-converting enzyme gene variants and chronic nonproductive cough? Chest Vol 118 (1091-1094)    2000
Sensory neuropeptides induce histamine release from bronchoalveolar lavage cells in both nonasthmatic coughers and cough variant asthmatics Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 30 (225-232)    2000
Clinical consequences of mast cell heterogeneity Inflammation Research Vol 49 (147-154)    2000
Serum eosinophilic cationic protein and blood eosinophil counts for the prediction of the presence of airways inflammation in children with wheezing Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 29 (1382-1389)    1999
Adenosine induces histamine release from human bronchoalveolar lavage mast cells Clinical Science Vol 96 (349-355)    1999
Inflammatory mediators in bronchoalveolar lavage samples from children with and without asthma Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 29 (362-366)    1999
Bronchoalveolar lavage findings in patients with chronic nonproductive cough European Respiratory Journal Vol 13 (59-65)    1999
Adenosine, mast cells and asthma Inflammation Research Vol 48 (301-307)    1999
Pharmacological regulation of mediator release from human mast cells Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 28 (1171-1173)  1998
In vitro effects of the pyrethroid S-bioallethrin on lymphocytes and basophils from atopic and nonatopic subjects Allergy Vol 53 (1052-1059)    1998
Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol Thorax Vol 53 (738-743)    1998
Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fluid in normal and asthmatic subjects Thorax Vol 53 (357-362)    1998
Histamine release from bronchoalveolar lavage cells from asthmatic subjects after allergen challenge and relationship to the late asthmatic response Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 28 (196-204)    1998
Bronchoalveolar lavage findings suggest two different forms of childhood asthma Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 27 (1027-1035)    1997
Histamine release from human bronchoalveolar lavage mast cells by neurokinin A and bradykinin Inflammation Research Vol 46 (306-309)    1997
A comparison of three standard methods of identifying mast cells in endobronchial biopsies in normal and asthmatic subjects Allergy Vol 52 (836-843)    1997
Structure activity studies of mast cell activation and hypotension induced by neuropeptide Y (NPY), centrally truncated and C-terminal NPY analogues British Journal of Pharmacology Vol 117 (325-332)    1996
Investigating paediatric airways by non-bronchoscopic lavage: Normal cellular data Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 26 (799-806)    1996
Influence of alpha-helicity, amphipathicity and D-amino acid incorporation on the peptide-induced mast cell activation EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION Vol 291 (291-300)    1995
EFFECT OF IN-VIVO AND IN-VITRO LOVASTATIN TREATMENT ON MAST-CELL ACTIVATION International Archives of Allergy and Immunology Vol 108 (240-246)    1995
MODULATORY ACTION OF HELICOBACTER-PYLORI ON HISTAMINE-RELEASE FROM MAST-CELLS AND BASOPHILS IN-VITRO Journal of Medical Microbiology Vol 42 (386-393)    1995
SUBSTANCE-P INDUCES HISTAMINE-RELEASE FROM HUMAN PULMONARY MAST-CELLS Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Vol 25 (179-186)    1995
ELECTRONIC CELL COUNTING TO MEASURE TOTAL CELL NUMBERS IN BRONCHOALVEOLAR LAVAGE FLUID European Respiratory Journal Vol 7 (1527-1531)    1994
ROLE OF INTRACELLULAR AND EXTRACELLULAR CALCIUM IN HISTAMINE-RELEASE FROM RAT PERITONEAL MAST-CELLS Agents and actions Vol 43 (144-148)    1994
INCIDENCE AND CLINICAL IMPORTANCE OF PERIOPERATIVE HISTAMINE-RELEASE - RANDOMIZED STUDY OF VOLUME LOADING AND ANTIHISTAMINES AFTER INDUCTION OF ANESTHESIA Lancet Vol 343 (933-940)    1994
INTRAVASCULAR ANTI-IGE CHALLENGE IN PERFUSED LUNGS - MEDIATOR RELEASE AND VASCULAR PRESSOR-RESPONSE Journal of Applied Physiology Vol 71 (2499-2506)    1991
HISTAMINE-RELEASE INDUCED BY RADIOGRAPHIC CONTRAST-MEDIA - COMPARISON BETWEEN PULMONARY AND PERITONEAL MAST-CELLS DERIVED FROM NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS International archives of allergy and applied immunology Vol 92 (203-208)  1990
HISTAMINE-RELEASE FROM CANINE LUNG AND LIVER MAST-CELLS INDUCED BY RADIOGRAPHIC CONTRAST-MEDIA Agents and actions Vol 27 (101-103)  1989
RADIOGRAPHIC CONTRAST MEDIA-INDUCED HISTAMINE-RELEASE - A COMPARATIVE-STUDY WITH MAST-CELLS FROM DIFFERENT SPECIES Agents and actions Vol 27 (104-106)  1989
THE EFFECT OF SERINE ESTERASE INHIBITORS ON IONOPHORE-INDUCED HISTAMINE-RELEASE FROM HUMAN PULMONARY MAST-CELLS Agents and actions Vol 23 (198-200)  1988
PREDICTION OF RISK FOR PSEUDOALLERGIC REACTIONS AND HISTAMINE-RELEASE IN PATIENTS UNDERGOING ANESTHESIA AND SURGERY - A COMPUTER-AIDED MODEL USING INDEPENDENCE-BAYES Agents and actions Vol 23 (366-369)  1988
ISOLATION OF MAST-CELLS FROM RABBIT LUNG AND LIVER - COMPARISON OF HISTAMINE-RELEASE INDUCED BY THE HYPNOTICS ALTHESIN AND PROPANIDID Agents and actions Vol 20 (219-222)  1987
MODULATION OF HISTAMINE-RELEASE FROM RAT PERITONEAL MAST-CELLS BY NONCYTOTOXIC CONCENTRATIONS OF THE DETERGENTS CREMOPHOR EL (OXETHYLATED CASTOR-OIL) AND TRITON X100 - A POSSIBLE EXPLANATION FOR UNEXPECTED ADVERSE DRUG-REACTIONS Agents and actions Vol 18 (235-238)  1986
COMPARISON OF THE HISTAMINE-RELEASING ACTIVITY OF CREMOPHOR EL AND SOME OF ITS DERIVATIVES IN 2 EXPERIMENTAL-MODELS - THE INVIVO ANESTHETIZED DOG AND INVITRO RAT PERITONEAL MAST-CELLS Agents and actions Vol 16 (265-268)  1985
HISTAMINE-RELEASE IN ANESTHESIA AND SURGERY - A SYSTEMATIC-APPROACH TO RISK IN THE PERIOPERATIVE PERIOD International anesthesiology clinics Vol 23 (41-66)  1985
FUNCTIONAL-CHARACTERISTICS OF MUCOSAL AND CONNECTIVE-TISSUE MAST-CELLS OF MAN, THE RAT AND OTHER ANIMALS International archives of allergy and applied immunology Vol 77 (274-276)  1985
MEASUREMENT OF PROSTAGLANDIN-D2 AND IDENTIFICATION OF METABOLITES IN HUMAN-PLASMA DURING INTRAVENOUS-INFUSION Prostaglandins Vol 28 (743-754)  1984
FUNCTIONAL-HETEROGENEITY OF MAST-CELLS, WITH SPECIAL REFERENCE TO THE GASTROINTESTINAL-TRACT ALLERGOLOGIE Vol 7 (276-281)  1984
PROSTAGLANDIN AND HISTAMINE-RELEASE FROM STIMULATED RAT PERITONEAL MAST-CELLS Agents and actions Vol 14 (397-400)  1984
ACTION OF 3-ISOBUTYL-1-METHYLXANTHINE AND PROSTAGLANDIN-D2 AND PROSTAGLANDIN-E1 ON HISTAMINE-RELEASE FROM RAT AND GUINEA-PIG MAST-CELLS International archives of allergy and applied immunology Vol 72 (289-293)  1983
DO ANTI-ALLERGIC AGENTS PREVENT HISTAMINE-RELEASE FROM MAST-CELLS BY ACTING ON RECEPTOR-MEDIATED CALCIUM CHANNELS Monographs in allergy Vol 18 (220-222)  1983
MAST-CELLS ISOLATED FROM GUINEA-PIG LUNG - CHARACTERIZATION AND STUDIES ON HISTAMINE-SECRETION Agents and actions Vol 13 (122-126)  1983
CALCIUM-ANTAGONISTS AND HISTAMINE-SECRETION FROM RAT PERITONEAL MAST-CELLS Agents and actions Vol 13 (144-148)  1983
SOME CHARACTERISTICS OF HISTAMINE-SECRETION FROM MAST-CELLS TREATED WITH IONOMYCIN International archives of allergy and applied immunology Vol 69 (86-88)  1982
ANALYSIS OF PICOMOLAR CONCENTRATIONS OF 6-OXO-PROSTAGLANDIN F1-ALPHA IN BIOLOGICAL-FLUIDS Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences Vol 239 (71-80)  1982
HISTAMINE-RELEASE - HISTAMINE-RELEASE FROM HUMAN PULMONARY MAST-CELLS Agents and actions Vol 12 (60-63)  1982
LECTIN-INDUCED HISTAMINE-SECRETION FROM ISOLATED RAT AND GUINEA-PIG MAST-CELLS Biochemical Pharmacology Vol 30 (2179-2181)  1981
ROLE OF INTRACELLULAR AND EXTRACELLULAR CALCIUM IN HISTAMINE-RELEASE FROM RAT PERITONEAL MAST-CELLS Agents and actions Vol 11 (51-54)  1981
INHIBITION OF HISTAMINE-SECRETION FROM MAST-CELLS Nature Vol 289 (186-187)  1981
DIFFERENTIAL REACTIVITY OF ISOLATED MAST-CELLS FROM THE RAT AND GUINEA-PIG European Journal of Pharmacology Vol 66 (339-345)  1980
SOME STUDIES ON THE RELEASE OF HISTAMINE FROM MAST-CELLS STIMULATED WITH POLYLYSINE British Journal of Pharmacology Vol 70 (329-334)  1980
BOUND CALCIUM IN HISTAMINE-RELEASE FROM MAST-CELLS CELL BIOLOGY INTERNATIONAL REPORTS Vol 4 (745-745)  1980
CALCIUM POOLS INVOLVED IN HISTAMINE-RELEASE FROM RAT MAST-CELLS International archives of allergy and applied immunology Vol 62 (467-471)  1980
INHIBITION OF HISTAMINE-RELEASE INDUCED BY COMPOUND 48-80 AND PEPTIDE-401 IN THE PRESENCE AND ABSENCE OF CALCIUM - IMPLICATIONS FOR THE MODE OF ACTION OF ANTI-ALLERGIC COMPOUNDS Agents and actions Vol 10 (222-228)  1980
ISOLATION AND SOME PROPERTIES OF MAST-CELLS FROM THE MESENTERY OF THE RAT AND GUINEA-PIG Agents and actions Vol 10 (124-131)  1980
EFFECT OF CYCLIC-AMP ON HISTAMINE-RELEASE INDUCED BY COMPOUND 48-80 International archives of allergy and applied immunology Vol 60 (461-464)  1979
SOME STUDIES ON THE MECHANISM OF ACTION OF ANTIBODIES TO NERVE GROWTH-FACTOR Neuroscience Vol 4 (1391-1398)  1979
STUDIES ON HISTAMINE-RELEASE INDUCED BY COMPOUND-48-80 AND PEPTIDE-401 Agents and actions Vol 9 (63-64)  1979
MECHANISM OF IMMUNOSYMPATHECTOMY EXPERIENTIA Vol 34 (1371-1372)  1978
Conference Contribution(s)
TitleYear
Flow-cytometric analysis of basophil activation: inhibition by histamine at conventional and homeopathic concentrations 2001
Inhibition of human basophil degranulation by successive histamine dilutions: Results of a European multi-centre trial 1999
The modulatory effects of WE-14 on histamine release from rat peritoneal mast cells 1997
NEUROPEPTIDE Y-INDUCED MAST-CELL ACTIVATION 1994