Plasma medicine is an emerging field that combines elements of plasma physics, biological sciences and clinical medicine to generate novel therapeutics.
Plasmas generated in air produce:
|Charged particles:||electrons and ions|
|Radicals:||eg., N, O, NO, OH, H2O2, O3|
|Metastables:||eg., N2*, O2*|
|Light:||IR, Visible, UV, VUV|
These products can react either individually or synergistically with biological material.
The Plasma Medicine team at Queen’s is an interdisciplinary group led by:
The group is focused on the optimization of a in-house built, kHz-driven plasma source for the control and prevention of hospital acquired infections, especially biofilm-mediated infections and those caused by a group of organisms termed the ESKAPE pathogens. They are particularly interested in investigating the cellular targets of plasma and in understanding its mechanism of action.
Eradication of marine biofilms by atmospheric pressure nonthermal plasma: A potential approach to control biofouling?
Alkawareek, M., Gormam, S., Graham, B. & Gilmore, B. 2014 International Biodeterioration & Biodegradation 86(A):14-18
Atmospheric pressure, nonthermal plasma inactivation of MS2 bacteriophage: effect of oxygen concentration on virucidal activity.
Alshraiedeh, N., Alkawareek, M.Y., Gorman, S. P., Graham, B. & Gilmore, B.F. 2013 Journal of Applied Microbiology 115(6):1420-1426
Potential cellular targets and antibacterial efficacy of atmospheric pressure nonthermal plasma.
Alkawareek, M. Y., Gorman, S.P., Graham, W. & Gilmore, B. F. 2013 International Journal of Antimicrobial Agents 43(2):154-160
Eradication of Pseudomonas aeruginosa biofilms by atmospheric pressure nonthermal plasma.
Alkawareek, M. Y., Algwari, Q. T., Laverty, G., Gorman, S., Graham, B. & Gilmore, B. F. 2013 PLoS ONE 7(8):1-8 e44289.
Application of atmospheric pressure nonthermal plasma for the in vitro eradication of bacterial biofilms.
Alkawareek, M. Y., Algwari, Q. T., Gorman, S., Graham, B. & Gilmore, B. F. 2012 FEMS Immunology and Medical Microbiology 65(2):381-384