Other Renal Genetics Projects

Utilising samples from the MRC-KRUK glomerulonephritis DNA Bank (n>2,000 individuals) we have comprehensively examined two chromosome regions for genetic risk factors using a combination of microsatellite, tag (proxy) SNP, and potentially functional SNP approaches.  Our primary interest involves common, complex renal disorders, but the genetics of renal conditions with a more typical Mendelian inheritance pattern are also considered, along with renal cell cancer.  We developed a genetics resource that merges diverse datasets for renal disease; this site includes annotated chromosome maps combining data from linkage, genome-wide association scans and complex chromosomal abnormalities.  A candidate gene directory highlights published gene or variant-based association studies with further pages focused on epigenetics, copy number variation and the mitochondrial genome.