Staff Profile

Dr. Ann McGinty - Queen's University Belfast Research Portal - Research Directory & Institutional Repository for QUB
Ann McGinty

Dr Ann McGinty

Lecturer

Phone: 028 90 632730

For media contact email comms.office@qub.ac.uk
or call +44(0)2890 973091.

Particulars

Research Statement

 

I have a recognised research profile in elucidating the physiological and pathophysiological roles of the inflammatory oncoprotein cyclooxygenase (Cox)-2. I was a member of one of the first groups to confirm the involvement of the Cox-2 in apoptosis inhibition and to elucidate the pathways involved in this phenomenon. I also have a long-standing research interest in the inflammatory axis of cardiometabolic disease including obesity, metabolic syndrome and type 2 diabetes.

 

Physiological and pathophysiological roles of cyclooxygenase (Cox)-2.

 

Throughout my career at QUB, by actively maintaining my research focus I have consistently produced high quality peer-reviewed outputs in internationally or nationally recognised journals. For example, while working in the area of neuroendocrine tumour biology I initiated and supervised studies investigating the utility of Cox-2 and Cox-2-dependent proteins as tissue-based biomarkers of malignant change in neuroendocrine tumours. I continue to investigate the mechanisms by which Cox-2 modulates cell function, in particular the pro-resolution functions of this enzyme. The role of Cox-2 and Cox-2 dependent gene products in adipose dysfunction is also a current area of research.

 

Mechanisms underlying the vascular complications of diabetes.

 

I have extended my research to incorporate population-based studies centred on studying the inflammatory mechanisms underlying the development of cardiovascular disease and Type 2 diabetes. I have secured DHSSPS R&D funding through the Diabetes, Nutrition and Metabolism Recognised Research Group (RRG) to investigate the importance of inflammatory pathways in obesity and the development of diabetes and cardiovascular disease. I have also secured DHSSPS R&D funding to investigate the molecular mechanisms of type 1 diabetic pre-eclampsia. Ongoing studies include investigations into the role of vitamin D metabolites in age related macular degeneration (AMD), pregnancy and ageing.  In addition, funding applications are centred on population-based studies into the molecular effects of dietary interventions in obesity/T2D. 

 

Other

Teaching

Frequent Journals

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Contribution to conference papers, events and activities

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