Staff Profile

Dr. Amy Jayne McKnight - Queen's University Belfast Research Portal - Research Directory & Institutional Repository for QUB
Amy Jayne McKnight

Dr Amy Jayne McKnight

Senior Lecturer

Phone: RGH 90632681 / BCH 90638460

For media contact email
or call +44(0)2890 973091.

Research Statement

Research is focused on genetic and epigenetic factors that influence renal disease, in particular diabetic nephropathy and end stage renal disease. We conduct studies on candidate genes, prioritised genetic regions, genome-wide and epigenome-wide screens, along with whole exome/genome sequencing with specific emphasis on MHC, telomere and mitochondrial influences.  Data is derived from individuals recruited as part of multi-centre collections including Warren 3, Genetics of Kidneys in Diabetes (GoKinD UK), Medical Research Council and National Kidney Research Fund DNA bank, and the Wellcome Trust Case Control Consortium. We also launched an international renal genetics initiative, creating the first chromosome-based maps for renal disease and a contributor-driven database for genes and complex chromosome abnormalities consistently demonstrating renal involvement.

Our laboratories are well equipped for genetic studies, including scanners and next generation sequencing machines.  This enables me to facilitate projects for many other teams looking at different diseases within and outside QUB.  Whole exome sequencing, whole genome sequencing, RNA-seq and ChIP-Seq for rare and complex disorders, plus bacterial whole genome sequencing are regularly performed.  We hold several registries and are actively engaged in making maximal use of complex genetic information.

Research Interests

Bioinformatics, Genetics, Epigenetics, DNA Methylation, Kidney Disease, Registries, Renal

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Frequent Journals

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Contribution to conference papers, events and activities

ID: 31642