RETINAL IMAGING- CONFOCAL SCANNING LASER OPHTHALMOSCOPE (CSLO)

Heidelberg Retinal Angiograph II (HRA2), (Heidelberg Engineering http://www.heidelbergengineering.co.uk). It features a variable lens (15-30 degrees) for imaging to provide wide views of the retina in either angiography modes or non-invasive imaging modes.

FUNCTIONS: This machine has the capability for looking at infrared (IR), sodium fluorescein (NaF) and indocyanin green (ICG) dye wavelengths. It provides images of both the retina and choroid and enables analysis of various pathologies. The system is setup specifically for rodent eye imaging. 

 

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IN VIVO OPHTHALMIC LASER SYSTEM

Haag Streit slit lamp + a portable laser system (hgm ELITE –solid State 532 nm Litechnica: www.litechnica.co.uk).

FUNCTIONS: This system has been used for development of neovascularisation (CNV) and branch retinal vein occlusion (BRVO) models in rodents. It can produce pulsed or single beam irradiances to produce retinal burns ranging from 10-200 mm in size.

SERVICE: Currently several CVVS members of staff are trained in the operation of both units and training can be given if necessary. It would be anticipated that booking sessions for use of the equipment would be confined to half days at most with at least five working days notice (preferably at least two weeks’ notice). Appropriate materials will also be provided at cost, sourced and priced on application.

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CONTACT: In all cases potential users will have to complete appropriate centre based laser safety training (CD-ROM based) in addition to operational training.

The contact person in both cases is Dr Josephine Glenn (j.v.glenn@qub.ac.uk : CVVS Laser Safety Officer). We are more than happy to offer advice and suggestions re appropriate applications on request.

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Spectralis Animal Imaging:

Spectralis OCT Plus: We have recently acquired the Spectralis OCT Plus from Heidelberg Engineering (http://www.heidelbergengineering.com/us/products/spectralis-models/). The system combines the confocal scanning laser fundus imaging and Spectral-Domain OCT, which allows the OCT scan to be conducted in real-time under the guidance of infrared fundu Spectralis OCT Plus s image.

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Visualsonics Vevo 770 High-Resolution In Vivo Micro-Imaging System

Applications: Currently used for serial assessment of cardiac structure, function and blood flow in mice. May also be used in rats for both cardiovascular and cancer applications although additional hardware would be required. The system has a maximum resolution of 30 microns and frame rate of up to 240 per second.

   

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Scisense ADVantageTM Pressure-Volume System

Applications: Comprehensive invasive assessment of cardiac function using high-fidelity pressure-volume catheters and state-of-the-art acquisition hardware.

   

 

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ADInstruments ML125/M NIBP System

Applications: Non-invasive blood pressure measurement in rats and mice by tail-cuff plethysmography.