Recent Publications

2013

  1. Chen M, Luo C, Penalva R, Xu H. Paraquat-induced retinal degeneration is exaggerated in CX3CR1 deficient mice and is associated with increased retinal inflammation. Invest Ophthalmol Vis Sci. 2013. 54(1):682-690. [PubMed]

2012  

  1. Forrester JV and Xu H. Good news – bad news: the Yin and Yang of immune privilege in the eye. Front Immun. 2012,3:338. Doi:10.3389/fimmu.2012.00338 [PubMed]  
  2. Serra AM, Waddell J, Mannivannan A, Xu H, Cotter M, Forrester JV. CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in the mouse and express high levels of CCR5 in the circulation. Am J Pathol. 2012;181(2):719-727.
  3. Luo C, Chen M, Madden A. Xu H. Expression of complement components and regulators by different subsets of bone marrow-derived macrophages. Inflammation. 2012; 35(4):1448-1461. [Pubmed]
  4. Chen M, Luo C, Zhao J, Pandi SP, Penalva R, Fitzgerald D, Xu H. Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole body irradiation is CCL2 dependent. Glia. 2012;60(5):833-842. [PubMed]
  5. Chen M, Zhao J, Luo C, Pandi SP, Penalva R, Fitzgerald D, Xu H. Para-inflammation mediates retinal recruitment of bone marrow myeloid derived cells following whole body irradiation. Glia. 2012, Feb. 23. (Epub ahead of print). [PubMed]
  6. Chen M, Copland DA, Zhao J, Liu J, Forrester JV, Dick AD, Xu H. Persistent inflammation subverts thrombospondin-1 induced regulation of retinal angiogenesis, and is driven by CCR2 ligation. Am J Pathol.  2012;180(1):235-245. [PubMed]
  7. Glenn JV, Mahaffy H, Pawlak A, Dasari S, Oliver M, Boulton ME, Chen M, Xu H, Curry WJ, Stitt AW. Proteomic profiling of human retinal pigment epithelium exposed to an advanced glycation-modified substrate.  Graefes Archive for Clinical and Experimental Ophthalmology. 2012;250:349-359. [PubMed]
  8. Chen M & Xu H. Inflammation in Age-related Macular Degeneration-Implication for Therapy. In “ Inflammatory Disease: Immunopathology, Clinical and Pharmacological Bases ”. ISBN 978-953-307-911-0. Mahin Khatami (Editor). InTech. 2012 . Chapter 6, P129-150.

 2011 

  1. Luo C, Chen M, Xu H. Complement Gene Expression and Regulation In Mouse Retina and RPE/Choroid. Mol Vis. 2011;17:1588-97. [PubMed]
  2. Xu X, Luhmann U, Aleman TS, Barker SE, Lennon A, Tulloch B, Chen M, Xu H, Jacobson SG, Ali R, Wright A. Characterisation of C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration. PloS One. 2011;6(11)e27433. [PubMed]
  3. Chen M, Forrester JV, Xu H. Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PloS One. 2011; 6(8):e22818. [PubMed]
  4. Xu H, Chen M, Forrester JV, Lois N. Cataract surgery induces pro-inflammatory gene expression and protein secretion. Invest Ophthalmol Vis Sci. 2011; 52(1):249-255. [PubMed]
  5. Ganesan PB, He S, Xu H. Development of an image-based model for capillary vasculature of retina. Computer Methods & Programs in Biomedicine. 2011;102:35-46. [PubMed]
  6. Ganesan PB, He S, Xu H. Modelling of pulsatile blood flow in arterial trees of retinal vasculature. Med Eng Phy. 2011;33:810-823. [PubMed]
  7. Xu H, Liversidge J. Quantitative in situ analysis of cludin expression at the blood-retinal barrier. Methods Mol Biol. 2011;762:321-331. [PubMed]

 2010 

  1. Chen M, Muckerise E, Forrester JV, Xu H. Immune activation in retinal aging: a gene expression study. Invest Ophthalmol Vis Sci. 2010. 51(11):5888-5896. [PubMed]
  2. Chen M, Muckersie E, Forrester JV, Xu H. Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis. Eur J Immunol. 2010. 40: 2870-2881. [PubMed]
  3. Motulsky E, Koch P, Janssens S, Liénart M, Vanbellinghen A, Bolaky N, Chan CC, Caspers L, Martin-Martinez M, Xu H, Delporte C, and Willermain F. Aquaporins expression on blood retinal barrier cells during experimental autoimmune uveitis. Mol Vis. 2010. Apri 3 ; 16 :602-10.  [PubMed]
  4. Ganesan PB, He S, Xu H. Analysis of retinal circulation using an image-based network model of retinal vasculature. Microvasc Res. 2010, 80(1):99-109. [PubMed]
  5. Ganesan PB, He S, Xu H. Development of an image-based network model of retinal vasculature. Ann Biomed Eng. 2010,38(4):1566-85. [PubMed]
  6. Forrester JV, Xu H, Kuffova L, McMenamin P, Dick AD. (Review) Dendritic cell physiology and function in the Eye. Immunol Rev. 2010. 234(1)282-304. [PubMed]
  7. Copland DA, Hussain K, Baalasubramanian S, Hughes TR, Morgan BP, Xu H, Dick AD, Nicholson LB. Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis. Clin Exp Immunol. 2010. 159:303-314. [PubMed]

 2009

  1. Xu H, Chen M, Forrester JV. (Review) Para-inflammation in the aging retina. Prog Retin Eye Res. 2009. 28(5):348-368. [PubMed]
  2. Dagkalis A, Wallace C, Xu H, Liebau S, Manivannan A, Stone M, Mack M, Liversidge J, Crane IJ. Development of experimental autoimmune uveitis with efficient recruitment of monocytes is independent of CCR2. Invest Ophthalmol Vis Sci. 2009, 50(9):4288-4294. [PubMed]
  3. Xu H, Forrester JV (2009). Chapter 7 “Inflammation in age-related macular degeneration: what is the evidence?” in “Essentials in Ophthalmology”. Uwe Pleyer and John V Forrester (Editors). Springer. Pages 61-71.
  4. Xu H (2009). Chapter “Lipofuscin and aurofluorescence in experimental models”. In “Fundus Autofluorescence”. Dr Noemi Lois and JV Forrester (Editors). Lippincott. Pages 38-47.

 2008 

  1. Forrester JV, Xu H, Lambe T, Cornall R, (Review). Immune privilege or privileged immunity? Muscosal Immunol. 2008,1(5):372-381. [PubMed]
  2. Chen M, Muckersie E, Robertson M, Forrester JV, Xu H. Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina. Exp Eye Res. 2008, 87(6):543-440. [PubMed]
  3. Xu H, Koch P, Chen M, Lau A, Reid DM, Forrester JV. A Clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images. Exp Eye Res. 2008, 87(4):319-326. [PubMed]
  4. Chen M, Muckersie E, Roberston M, Fraczek M, Forrester JV, Xu H. Characterization of a mouse retinal pigment epithelial cell line: B6-RPE07. Invest Ophthalmol Vis Sci. 2008, 49(8):3699-3706. [PubMed]
  5. Xu H, Manivannan A, Crane IJ, Dawson R, Liversidge J. Critical but divergent roles for CD62L and CD44 in directing monocyte trafficking in vivo during inflammation. Blood. 2008, 112(4):1166-74. [PubMed]
  6. Kezic J, Xu H, Chinnery HR, Murphy C, McMenamin PG. Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their homing and distribution. Invest Ophthalmol Vis Sci. 2008. 49;1599-608. [PubMed]
  7. Xu H, Chen M, Manivannan A, Lois N, Forrester JV. Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell. 2008. 7; 58-68. [PubMed]