Wednesday 28 May 2008 @ 12.30pm

Tracking Disease Spread in Juvenile Arthritis by Proteome Signatures

Dr David S Gibson PhD
Research Fellow
Arthritis Research Group, QUB  

Seminar Rooms 3 & 4, Mulhouse

Everyone Welcome

Bring Your Lunch - Tea/Coffee Complimentary on 2nd Floor Landing

Background


Juvenile idiopathic arthritis (JIA) comprises a group of chronic autoimmune diseases with variable clinical presentations and outcomes. Predicting the progression and consequence of JIA inflammatory pathology is vital to achieve optimal clinical management. Synovial fluid (SF) is a potential source of novel biomarkers for many arthritic disorders involving joint inflammation, including JIA.

We first compared the distinctive protein ‘fingerprints’ of local joint inflammation in SF with systemic profiles within matched plasma samples. Investigations were performed into whether the synovial proteome could be used to monitor disease spread to previously uninvolved joints and establish expression patterns across multiple inflamed joints. 

Localized and systemic aspects of this disease can been differentiated, using proteomics. The proteins identified may play a specific role in the determining the spread of joint inflammation. Definition of these protein profiles may act as reliable criteria to identify those children more likely to suffer disease spread from a single joint to multiple joints. This could enable earlier and more appropriate therapeutic intervention.

Wednesday 8 May 2008 @ 16.00hrs


Jane Blazeby
Professor of Surgery and Consultant Upper GI Surgery
Department of Social Medicine and Clinical Sciences University of Bristol and Bristol Royal Infirmary

'Quality of Life in Clinical Trials - Measurement, Methods and Decision Making'

Seminar Room 5, Mulhouse, RVH

Everyone Welcome!

Tea/Coffee will be available on the 2nd Floor Landing

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Wednesday 28 May 2008 @ 12.30pm

Tracking Disease Spread in Juvenile Arthritis by Proteome Signatures

Dr David S Gibson PhD
Research Fellow
Arthritis Research Group, QUB  

Seminar Rooms 3 & 4, Mulhouse

Everyone Welcome

Bring Your Lunch - Tea/Coffee Complimentary on 2nd Floor Landing

Background


Juvenile idiopathic arthritis (JIA) comprises a group of chronic autoimmune diseases with variable clinical presentations and outcomes. Predicting the progression and consequence of JIA inflammatory pathology is vital to achieve optimal clinical management. Synovial fluid (SF) is a potential source of novel biomarkers for many arthritic disorders involving joint inflammation, including JIA.

We first compared the distinctive protein ‘fingerprints’ of local joint inflammation in SF with systemic profiles within matched plasma samples. Investigations were performed into whether the synovial proteome could be used to monitor disease spread to previously uninvolved joints and establish expression patterns across multiple inflamed joints. 

Localized and systemic aspects of this disease can been differentiated, using proteomics. The proteins identified may play a specific role in the determining the spread of joint inflammation. Definition of these protein profiles may act as reliable criteria to identify those children more likely to suffer disease spread from a single joint to multiple joints. This could enable earlier and more appropriate therapeutic intervention.

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