Dr Simon Haughey
Senior Research Fellow/ASSET Technology Centre Manager
Postal Address:
Institute of Agri-Food & Land Use
Queen's University
David Keir Building
Stranmillis Road
Belfast BT9 5AG
Telephone: +44 (0)28 9097 6525
Fax: +44 (0)28 9097 6513
Email: s.a.haughey@qub.ac.uk
Profile
Simon obtained his BSc (Hons) in Pure and Applied Chemistry in 1992 and his PhD in Organic Synthetic Chemistry in 1996 from Queen's University Belfast. From 1996-1997 he was employed by the School of Chemistry at Queen's University Belfast researching and developing new methods for the synthesis of novel chiral organosulfur compounds, funded by an award obtained from the BBSRC under the direction of Prof. Derek Boyd. From 1997 to 2000 he was employed as a post-doctoral research fellow by Queen's University based at the Veterinary Sciences Division at Stormont to research and develop applications in the area of veterinary drug residue detection by SPR biosensors, sponsored by Biacore AB, Sweden, under direction of Prof. Chris Elliott. From 2000-2009, he was involved with the set up of a university spin out company, Xenosense Ltd, as a Senior Research Scientist/ Deputy Manager/ Health and Safety Officer. His role included development of novel sensor chip chemistries, kit development for vitamins, veterinary drugs and pathogens and mentoring and training staff.
At Xensoense he was also involved in the following EU research projects:
- SPIQ- European funded EUREKA project, addressing 3 major health hazards in pork production: Salmonella, Trichinella and Mycobacterium Avium spp. Avium
- EU 6th Framework Project - BioCop: New Technologies to Screen Multiple Chemical Contaminants in Foods
- EU 6th Framework Project - Detectox: Development of an SPR-based biosensor for the detection of lipophilic phycotoxins in shellfish residues
Simon joined IAFLU on May 1st 2009 as a Research Fellow under the direction of Prof. Chris Elliott. He is working as part of the ASSET group (sub strand 1, biosensor technology) looking at applications of biosensor technologies to monitor food safety and quality and also continuing work within the BioCop project. With over 12 years experience in the field of biosensors, Simon has gained expertise in sensor surface chemistries, assay validation, kit development and production, and technology transfer in the area of food quality and safety. He won an Innovators 2009 Award from Perkin Elmer to investigate the use of Raman Spectroscopy in the Animal Feed Industry.
Simon became a Senior Research Fellow and ASSET Technology Centre Manager in June 2011. His roles include project manager of the following projects: (i) EU FP7 project QSAFFE (ii) Invest NI funded FeedCheck project and (iii) FSA project (Development of the FoodRisk Alert Database and piloting Food Fingerprinting). He is also leader of ASSET substrand 3, Spectroscopic and Isotopic Techniques. He leads a team developing methods using Raman and Near Infrared Technologies for quality and safety applications for the food and animal feed sectors.
Publications
Simon A. Haughey, Christopher T. Elliott, Michalina Oplatowska, Linda D. Stewart, Caroline Frizzell, Lisa Connolly (2012). Production of a monoclonal antibody and its application in an optical biosensor based assay for the quantitative measurement of pantothenic acid (vitamin B5) in foodstuffs. Food Chemistry, 134: 540-545.
Simon A. Haughey, Stewart F. Graham, Emmanuelle Cancouët, Christopher T. Elliott (2012). The application of Near-Infrared Reflectance Spectroscopy (NIRS) to detect melamine adulteration of soya bean meal. Food Chemistry, published online, doi:10.1016/j.foodchem.2012.01.068.
Derek R. Boyd, Narain D. Sharma, Brian McMurray, Simon A. Haughey, Christopher C. R. Allen, John T. G. Hamilton, W. Colin McRoberts, Rory A. More O'Ferrall, Jasmina Nikodinovic-Runic, Lydie A. Coulombel and Kevin E. O'Connor (2012), Bacterial dioxygenase- and monooxygenase-catalysed sulfoxidation of benzo[b]thiophenes. Org. Biomol. Chem., 10: 782-790.
Stewart Francis Graham, Simon Anthony Haughey, Robert Marc Ervin, Emmanuelle Cancouët, Steven Bell and Christopher Trevor Elliott (2012). The Application of Near-Infrared (NIR) and Raman Spectroscopy to detect adulteration of oil used in animal feed production. Food Chemistry, 132: 1614-1619.
Hongtao Lei, Gang Xue, Chunfai Yu, Simon A. Haughey, Sergei A. Eremin, Yuanming Sun, Zhanhui Wang, Zhenlin Xu, Hong Wang, Yudong Shen and Qing Wu (2011). Fluorescence polarization as a tool for the detection of a widely used herbicide, butachlor, in polluted waters. Anal. Methods, 3: 2334-2340.
Hongtao Lei, Jin Liu, Lijun Song, Yudong Shen, Simon A. Haughey, Haoxian Guo , Jinyi Yang, Zhenlin Xu, Yueming Jiang and Yuanming Sun (2011). Development of a Highly Sensitive and Specific Immunoassay for Determining Chrysoidine, A Banned Dye, in Soybean Milk Film. Molecules, 16: 7043-7057.
Hongtao Lei, Rui Su, Simon A. Haughey, Qiang Wang, Jinyi Yang, Zhenlin Xu, Yudong Shen, Hong Wang, Yuming Jiang , Yuanming Sun (2011). Development of a Specifically Enhanced Enzyme-linked Immunosorbent Assay for the Detection of Melamine in Milk. Molecules, 16: 5591-5603.
Terence L. Fodey, Colin S. Thompson, Imelda M. Traynor, Simon A. Haughey, D. Glenn Kennedy, and Steven R. H. Crooks (2011). Development of an Optical Biosensor Based Immunoassay to Screen Infant Formula Milk Samples for Adulteration with Melamine. Analytical Chemistry, 83(12): 5012-5016.
Hester J. van den Top, Christopher T. Elliott, Simon A. Haughey, Natalia Vilarino, Hans P. van Egmond, Luis M. Botana, and Katrina Campbell (2011). Surface Plasmon Resonance Biosensor Screening Method for Paralytic Shellfish Poisoning Toxins: A Pilot Interlaboratory Study. Analytical Chemistry, 83(11): 4206-4213.
Simon A. Haughey, Katrina Campbell, Betsy J. Yakes, Samantha M. Prezioso, Stacey L. DeGrasse, Kentaro Kawatsu and Christopher T. Elliott (2011). Comparison of biosensor platforms for surface plasmon resonance based detection of paralytic shellfish toxins. Talanta, 85(1): 519-526.
Betsy Jean Yakes , Samantha Prezioso, Simon A. Haughey, Katrina Campbell, Christopher T. Elliott, and Stacey L. DeGrasse (2011). An Improved Immunoassay for Detection of Saxitoxin by Surface Plasmon Resonance Biosensors. Sensors and Actuators B: Chemical, 156: 805-811.
Tatiana Vinogradova, Martin Danaher, Andrew Baxter, Mary Moloney, Danielle Victory, Simon A. Haughey (2011). Rapid surface plasmon resonance immunobiosensor assay for microcystin toxins in blue-green algae food supplements. Talanta, 84(3): 638-643.
Qiang Wang, Simon A. Haughey, Yuan-Ming Sun, Sergei A. Eremin, Zhen-Feng Li, Hui Liu, Zhen Lin Xu, Yu-Dong Shen, Hong-Tao Lei, Development of a Fluorescence Polarization Immunoassay for the Detection of Melamine in Milk and Milk Powder. Anal. Bioanal. Chem., 399: 2275-2284.
Anne-Catherine Huet, Terry Fodey, Simon A. Haughey, Stefan Weigel, Christopher Elliott, Philippe Delahaut (2010). Advances in biosensor-based analysis for antimicrobial residues in foods. Trends in Analytical Chemistry, 29(11): 1281-1294.
Chou Srey, Simon A. Haughey, Lisa Connolly, Maria Dolores del Castillo, Jennifer M. Ames, and Christopher T. Elliott (2010). Immunochemical and Mass Spectrometric Analysis of Nε-(Carboxymethyl)lysine content of AGE-BSA Systems Prepared with and without Selected Antiglycation Agents. J. Agric. Food Chem., 58: 11955-11961.
Campbell, K, Haughey, S.A., van den Top, H., van Egmond, H. Vilarino, N., Botana, L.M. and Elliott, C.T. (2010). Single Laboratory Validation of a Surface Plasmon Resonance Biosensor Screening method for Paralytic Shellfish Poisoning Toxins. Anal Chem, 82: 2977-2988.
Hongtao Lei, Yudong Shena, Lijun Songa, Jinyi Yanga, Olivier P. Chevallier, Simon A. Haughey, Hong Wanga, Yuanming Suna, Christopher T. Elliott. (2010). Hapten synthesis and antibody production for the development of a melamine immunoassay. Analytica Chimica Acta, 665: 84-90.
Campbell, K., Haughey, S.A., van den Top, H., van Egmond, H., Vilarino, N., Botana, L.M. and Elliott, C.T. (2010). Single Laboratory Validation of a Surface Plasmon Resonance Biosensor Screening method for Paralytic Shellfish Poisoning Toxins. Anal Chem, 82: 2977-2988.
T. McGrath, S. Haughey, A. Baxter, A. James, N. Martinez-Llamas (2008). Detection of Total Tylosin Residues by SPR Biosensor. In Proceedings of EuroResidue VI, 1335-1340.
Colin S. Thompson, Simon A. Haughey, Imelda M. Traynor, Terence L. Fodey, Christopher T. Elliott, Jean-Philippe Antignac, Bruno Le Bizec and Steven R.H. Crooks. (2008). Effective Monitoring for Ractopamine residues in samples of animal origin by SPR biosensor and mass spectrometry. Anal. Chim. Acta, 608: 217-225.
Eva S. Fonfira, Natalia Vilarino, Katrina Campbell, Chris Elliott, Simon A. Haughey, Begona Ben-Gigirey, Juan M. Vietes, Kentaro Kawatsu and Luis M. Botana. (2007). Paralytic Shellfish Poisoning Detection by Surface Resonance-Based Biosensors in Shellfish Matrices. Anal. Chem., 79: 6303-6311.
Katrina Campbell, Linda D. Stewart, Gregory J. Doucette, Terence L. Fodey, Simon A. Haughey, Natalia Vilarino, Kentaro Kawatsu and Christopher T. Elliott. (2007). Assessment of Specific Binding Proteins Suitable for the Detection of Paralytic Shellfish Poisons Using Optical Biosensor Technology. Anal. Chem., 79: 5906-5914.
Lisa Connolly, Colin S. Thompson, Simon A. Haughey, Imelda M. Traynor, Sheryl Tittlemeier and Christopher T. Elliott. (2007). The development of a multi-nitroimidazole residue analysis by optical biosensor via a proof of concept project to develop and assess a prototype test kit. Anal. Chim. Acta, 598: 155-161.
Simon A. Haughey and G. Andrew Baxter (2006). Biosensor Screening for Veterinary Drug Residues in Foodstuffs. J. AOAC International, 89(3): 862-867.
Derek R. Boyd, Narain D. Sharma, Ian N. Brannigan, Simon A. Haughey, John F. Malone, David A. Clarke and Howard Dalton (2006). Dioxygenase-catalysed formation of cis/trans-dihydrodiol metabolites of mono- and bi-cyclic heteroarenes. J. Chem. Soc., Chem. Commun., 2361-2362.
Lynsey Dunne, Stephen Daly, Andrew Baxter, Simon Haughey and Richard O'Kennedy (2005). Surface Plasmon Resonance-Based Immunoassay for the Detection of Aflatoxin B1 using Single-Chain Antibody Fragments. Spect. Letts., 38(3): 229-245.
Simon A. Haughey (2005). Multi-Analyte Screening of Veterinary Drug Residues. Biacore Journal, 5(1): 19-21.
Terry McGrath, Andrew Baxter, Julie Ferguson, Simon Haughey and Peter Bjurling (2005). Multi sulfonamide screening in porcine muscle using a surface plasmon resonance biosensor. Anal. Chim. Acta, 529: 123-127.
Simon A. Haughey, Anthony A. O'Kane, G. Andrew Baxter, Andras Kalman, Marie-Jose Trisconi, Harvey E. Indyk and Gaylene A. Watene (2005). Determination of Pantothenic Acid in Foods by Optical Biosensor Immunoassay. J. AOAC International, 88(4): 1008-1014.
Andras Kalman, Isabelle Caelen, M.-J. Trisconi, Anthony O'Kane, Simon Haughey and Lennart Wahlstrom (2004). Quantitative analysis of Vitamin B2. New Food, 26-31.
Derek R. Boyd, Narain D. Sharma, Briege E. Byrne, Simon A. Haughey, Martina A. Kennedy and Christopher C.R. Allen (2004). Dioxygenase-catalysed oxidation of alkylaryl sulfides: sulfoxidation versus cis-dihydrodiol formation. Org. Biomol. Chem., 2: 2530-2537.
Derek R. Boyd, Narain D. Sharma, Simon A. Haughey, Martina A. Kennedy, John F. Malone, Steven D. Shepherd, Christopher C.R. Allen and Howard Dalton (2004). Dioxygenase-catalysed sulfoxidation of bicyclic alkylaryl sulfides and chemoenzymatic synthesis of acyclic disulfoxides. Tetrahedron, 60: 549-559.
Simon A. Haughey (2003). SPR Biosensor Detection of Ractopamine Residues in Food. Food Technology International.
Boyd, D.R., Sharma, N.D., Guarantne, N., Haughey, S.A., Kennedy, M.A., Malone, J.F., Allen. C.C. and Dalton, H. (2003). Dioxygenase-catalysed oxidation of monosubstituted thiophenes: sulfoxidation versus dihydrodiol formation. Org. Biomol. Chem., 1(6): 984-994.
Boyd, D.R., Sharma, N.D., Haughey, S.A., Malone, J.F., King, A.W.T., McMurray, B.T., Alves-Areias, A., Allen, C.C.R., Holt, R., Dalton, H. (2001). Dioxygenase-catalysed mono-, di-, and tri-oxygenation of dialkyl sulfides and thioacetals: chemoenzymatic synthesis of enantiopure cis-diol sulfoxides. J. Chem. Soc., Perkin Trans. 1, 24: 3288-3296.
Simon A. Haughey, G. Andrew Baxter, Christopher T. Elliott, Bjorn Persson, Carin Jonson and Peter Bjurling (2001). Determination of Clenbuterol Residues in Bovine Urine by Optical Immunobiosensor Assay. J. AOAC International, 84(4): 1025-1030.
G. Andrew Baxter, Mary C. O'Connor, Simon A. Haughey, Steven R.H. Crooks and Christopher T. Elliott (1999). Evaluation of an immunobiosensor for the on-site testing of veterinary drug residues at an abattoir. Screening for sulfamethazine in pigs. Analyst, 124: 1315-1318.
Derek R. Boyd, Narain D. Sharma, Simon A. Haughey, Martina A. Kennedy, Brian T. McMurray, Gary N. Sheldrake, Christopher C.R. Allen, Howard Dalton and Kenneth Sproule (1998). Toluene and naphthalene dioxygenase-catalysed sulfoxidation of alkyl aryl sulfides. J. Chem. Soc., Perkin Trans. 1, 1929-1933.
Derek R. Boyd, Narain D. Sharma, Simon A. Haughey, John F. Malone, Brian T. McMurray, Gary N. Sheldrake, Christopher C.R. Allen and Howard Dalton (1996). Enantioselective dioxygenase-catalysed formation and thermal racemisation of chiral thiophene sulfoxides. J. Chem. Soc., Chem. Commun., 2363-2364.
Christopher C.R. Allen, Derek R. Boyd, H. Dalton, Narain D. Sharma, Simon A. Haughey, R. Austin S. McMordie, Brian T. McMurray, Gary N. Sheldrake and Kenneth Sproule (1995). Sulfoxides of High Enantiopurity from Bacterial Dioxygenase-catalysed Oxidation. J. Chem. Soc., Chem. Commun., 119-120.
