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Position available



An MRC-funded postdoctoral position is available to work on a project entitled: Investigating the role of mitochondrial Complex I in cellular response to hypoxia.


Mitochondrial Complex I plays a critical role in the regulation of energy generation in the cell.  The activity of this enzyme  can be modulated by oxygen availability thereby mediating ischaemia/reperfusion injury. This project aims to unravel the role of mitochondrial Complex I in hypoxia and experiments will be conducted on preparations of isolated mitochondria and cultured cells. Techniques which will be utilised during the project include: isolation and functional assays on mitochondria and cells; enzyme kinetics; basic molecular biology; cell culture; fluorescence imaging techniques.


Highly qualified and motivated candidates with a PhD or in process of submitting their thesis in a relevant subject area (Biochemistry / Cell biology / Molecular biology) are encouraged to submit their application. Preference will be given to candidates with a proven track record in bioenergetics/mitochondrial physiology and enzymology. Experience in in vivo imaging and immunochemistry techniques is desirable. Proficiency in English and excellent communication and social skills are required.


Relevant publications:

Galkin, A.,  Abramov, A., Frakich, N., Duchen, M., Moncada, S. (2009) Lack of oxygen deactivates  mitochondrial complex I: Implications for ischemic injury? J.Biol.Chem., 284: 36055-36061.  PMID: 19861410.
Galkin, A., Meyer, B., Wittig, I., Karas, M., Schägger H., Vinogradov, A., Brandt, U. (2008). Identification of the mitochondrial complex I ND3 subunit as a structural component involved in the active/de-active enzyme transition.  J.Biol.Chem., 283: 20907-20913.  PMID: 18502755.
Galkin, A. and Moncada, S. (2007). Nitrosation of mitochondrial complex I.  J.Biol.Chem., 282: 37448-37453. PMID: 17956863.

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Project on mitochondrial Complex I studies is available for individuals with self arranged funding. Enquiries from motivated  post graduates/post docs who have independent funding or fellowships, and who have a desire to work at the forefront of mitochondrial physiology are always welcome.


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