An MRC-funded postdoctoral position is available to work on a project entitled: Investigating the role of mitochondrial Complex I in cellular response to hypoxia.
Mitochondrial Complex I plays a critical role in the regulation of energy generation in the cell. The activity of this enzyme can be modulated by oxygen availability thereby mediating ischaemia/reperfusion injury. This project aims to unravel the role of mitochondrial Complex I in hypoxia and experiments will be conducted on preparations of isolated mitochondria and cultured cells. Techniques which will be utilised during the project include: isolation and functional assays on mitochondria and cells; enzyme kinetics; basic molecular biology; cell culture; fluorescence imaging techniques.
Highly qualified and motivated candidates with a PhD or in process of submitting their thesis in a relevant subject area (Biochemistry / Cell biology / Molecular biology) are encouraged to submit their application. Preference will be given to candidates with a proven track record in bioenergetics/mitochondrial physiology and enzymology. Experience in in vivo imaging and immunochemistry techniques is desirable. Proficiency in English and excellent communication and social skills are required.
Project on mitochondrial Complex I studies is available for individuals with self arranged funding. Enquiries from motivated post graduates/post docs who have independent funding or fellowships, and who have a desire to work at the forefront of mitochondrial physiology are always welcome.