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Dr A. Mousley

Dr. Angela Mousley
Dr. Angela Mousley Lecturer in Biology

BSc (Hons) Biological Science, 1998;
PhD Parasitology, 2001,
Queen's University Belfast.

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Contact Information
Tel:  +44 (0)28 9097 2118 (Direct line)
Fax:  +44 (0)28 9097 5877
Email:  a.mousley@qub.ac.uk
Room:  Medical Biology Centre - OG.418

Research Interests

  • Parasitology: Structural and functional characterisation of novel endectocide targets for parasite/pest control including neuropeptides, G-protein coupled receptors, signalling pathways (FMRFamide-like peptides, neuropeptide-like proteins, neuropeptide F, allatostatins, myokinins, leucokinins, tachykinins), and signal termination peptidases (cysteine endoproteases of the papain family)
  • Neurobiology: Molecular and pharmacological characterization, and comparative expression analyses of vertebrate neuropeptide signalling molecules and cognate receptors; NPY, Y receptors, RFamides (PQRFamides, LPxRFamides, prolactin-releasing peptides, metastatins)
  • Research Relevance: The current control strategies for parasites of humans and animals relies on only a few frontline drugs [benzimidazoles, levamisole, macrocyclic lactones] that have been overused and misused since entering the market.  Consequently there is now global resistance in parasites to all available chemical classes of drugs such that sustained control in the future will ultimately depend on the discovery/development of anthelmintics with novel modes of action.  Structural, physiological and expression data are emerging that point to aspects of the neuropeptide signalling system as strong drug target candidates

Other Information

Member of: British Society for Parasitology, Society of Neuroscience, Higher Education Academy