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Recent Publications

Walker, S.M., Johnston, C, Hoey, E.M., Fairweather, I., Borgsteede, F., Gaasenbeek, C., Prodöhl, P.A., Trudgett, A. (2011). Population dynamics of the liver fluke, Fasciola hepatica: the effect of time and spatial separation on the genetic diversity of fluke populations in the Netherlands.  Parasitology, 138: 215-23.

Teofanova, D., Kantzoura, V., Walker, S., Radoslavov, G., Hristov, P., Theodoropoulos, G., Bankov, I., Trudgett, A. (2011). Genetic diversity of liver flukes (Fasciola hepatica) from Eastern Europe.  Infect Genet Evol., 11: 109-15.

Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I. (2011). Piperonyl butoxide enhances triclabendazole action against triclabendazole-resistant Fasciola hepatica.  Parasitology, 138: 224-36.

Králová-Hromadová, I., Bazsalovicsová, E., Stefka, J., Spakulová, M., Vávrová, S., Szemes, T., Tkach, V., Trudgett, A., Pybus, M. (2011). Multiple origins of European populations of the giant liver fluke Fascioloides magna (Trematoda: Fasciolidae), a liver parasite of ruminants.  Int J Parasitol., 41: 373-83.

Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I. (2011). Enhancement of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica by co-treatment with ketoconazole.  Vet Parasitol., 177: 305-15.

Walker, S.M., Johnston, C., Hoey, E.M., Fairweather, I., Borgsteede, F.H., Gaasenbeek, C.P., Prodohl, P.A., Trudgett, A. (2011). Potential role of hares in the spread of liver fluke in the Netherlands.  Vet Parasitol., 177:179-81.

Moore, C.M., Hoey, E.M., Trudgett, A., Timson, D.J. (2011). Artemisinins act through at least two targets in a yeast model.  FEMS Yeast Res., 11: 233-7.

Chambers, E., Hoey, E.M., Trudgett, A., Fairweather, I., Timson, D.J. (2011). Binding of serum albumin to the anthelmintic drugs albendazole, triclabendazole and their sulphoxides.  Vet Parasitol., 171: 172-5.

Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I. (2010). Enhancement of the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica using the metabolic inhibitor ketoconazole.  Parasitol Res. 107: 337-53.

Chambers, E., Ryan, L.A., Hoey, E.M., Trudgett, A., McFerran, N.V., Fairweather, I., Timson, D.J. (2010). Liver fluke β-tubulin isotype 2 binds albendazole and is thus a probable target of this drug.  Parasitol Res., 107: 1257-64.

Chemale, G., Perally, S., LaCourse, E.J., Prescott, M.C., Jones, L.M., Ward, D., Meaney, M., Hoey, E., Brennan, G.P., Fairweather, I., Trudgett, A., Brophy, P.M. (2010). Comparative proteomic analysis of triclabendazole response in the liver fluke Fasciola hepatica.  J Proteome Res., 9: 4940-51.

Devine C, Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I. (2010). Inhibition of cytochrome P450-mediated metabolism enhances ex vivo susceptibility of Fasciola hepatica to triclabendazole.  Parasitology, 137: 871-80.

Sotillo, J., Trudgett, A., Halferty, L., Marcilla, A., Esteban, J.G., Toledo, R. (2010). Echinostoma caproni: differential tegumental responses to growth in compatible and less compatible hosts.  Exp Parasitol., 125: 304-9.

Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I. (2010). Potentiation of triclabendazole sulphoxide-induced tegumental disruption by methimazole in a triclabendazole-resistant isolate of Fasciola hepatica.  Parasitol Res., 106: 1351-63.

Halferty, L., Brennan, G.P., Trudgett, A., Hoey, L., Fairweather, I. (2009). Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica.  Vet Parasitol, 159: 126-38.

Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I. (2009). Effect of the metabolic inhibitor, methimazole on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica.  Parasitology, 136: 183-92.

Hanna, R.E., Edgar, H., Moffett, D., McConnell, S., Fairweather, I., Brennan, G.P., Trudgett, A., Hoey, E.M., Cromie, L., Taylor, S.M., Daniel, R. (2008). Fasciola hepatica: Histology of the testis in egg-producing adults of several laboratory-maintained isolates of flukes grown to maturity in cattle and sheep and in flukes from naturally infected hosts.  Vet Parasitol., 157: 222-34.

Fennell, B.J., Naughton, J.A., Barlow, J., Brennan, G., Fairweather, I., Hoey, E., McFerran, N., Trudgett, A. and Bell, A. (2008). Microtubules as antiparasitic drug targets.  Expert Opinion on Drug Discovery, 3: 501-518.

Halferty, L., Brennan, G.P., Hanna, R.E.B., Edgar, H.W., Meaney, M.M., McConville, M., Trudgett, A., Hoey, L., Fairweather, I. (2008). Tegumental surface changes in juvenile Fasciola hepatica in response to treatment in vivo with triclabendazole.  Veterinary Parasitology, 155: 49-58.

Barnard, E., McFerran, N.V., Trudgett, A., Nelson, J., Timson, D.J. (2008). Development and implementation of split-GFP-based bimolecular fluorescence complementation (BiFC) assays in yeast.  Biochemical Society Transactions, 36: 479-82.

Ryan, L.A., Hoey, E., Trudgett, A., Fairweather, I., Fuchs, M., Robinson, M.W., Chambers, E., Timson, D.J., Ryan, E., Feltwell, T., Ivens, A., Bentley, G., Johnston, D. (2008). Fasciola hepatica expresses multiple alpha- and beta-tubulin isotypes.  Molecular and Biochemical Parasitology, 159: 73-78.

Barnard, E., McFerran, N.V., Trudgett, A., Nelson, J., Timson, D.J. (2008). Detection and localisation of protein-protein interactions in Saccharomyces cerevisiae using a split-GFP method.  Fungal Genetics and Biology, 45: 597-604.

Walker, S.M., Makundi, A.E., Namuba, F.V., Kassuku, A.A., Keyyu, J., Hoey, E.M., Prödohl, P., Stothard, J.R., Trudgett, A. (2008). The distribution of Fasciola hepatica and Fasciola gigantica within southern Tanzania--constraints associated with the intermediate host.  Parasitology, 135: 495-503.

Brennan, G.P., Fairweather, I., Trudgett, A., Hoey, E.M., McCoy, M., McConville, M., Meaney, M., Robinson, M.W., McFerran, N.V., Ryan, L., Lanusse, C., Mottier, L., Alvarez, L., Solana, H., Virkel, G. and Brophy, P.M. (2007). Understanding triclabendazole resistance.  Experimental and Molecular Pathology, 82: 104-109.

Russell, S.L., McFerran, N.V., Hoey, E.M., Trudgett, A. and Timson, D.J. (2007). Characterisation of two calmodulin-like proteins from the liver fluke, Fasciola hepatica.  Biological Chemistry, 388 593-599.

Walker, S.M., Prodöhl, P.A., Fletcher, H.L., Hanna, R.E.B., Kantzoura, V., Hoey, E.M. and Trudgett, A. (2007). Evidence for multiple mitochondrial lineages of Fasciola hepatica (liver fluke) within infrapopulations from cattle and sheep.  Parasitology Research, 101: 117-125.

Walker, S.M., Hoey, E.M., Fletcher, H., Brennan, G., Fairweather, I. and Trudgett, A. (2006). Stage-specific differences in fecundity over the lifecycle of two characterised isolates of the liver fluke, Fasciola hepatica.  Parasitology, 133: 209-216.

Dosay-Akbulut, M., Trudgett, A. and Stanhope, M. (2005). Understanding genetic diversity of the liver fluke Fasciola hepatica.  Zeitschrift fur Natürforschung, 60c: 774-778.