Skip to main content


Eguaogie, O.,  Cooke, L.A.,  Martin, P.M.L.,  Ravalico, F.,  Conway, L.P., Hodgson, D.R.W., Law, C.J. & Vyle, J.S. (2015). Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill. Org. Biomol. Chem.(Accepted). DOI: 10.1039/c5ob02061a.

Alegre, K.O. & Law, C.J. (2015). Purification of a multidrug resistance transporter for crystallization studies. Antibiotics (special issue on "Multi-drug Efflux and Drug Permeation") 4(1): 113-135. PDF

Holdsworth, S.R. & Law, C.J. (2014). Measurement of the electrogenicity of bile salt/H+ antiport in Escherichia coli. Bio-protocol 4(21): e1279.

Holdsworth, S.R. & Law, C.J. (2014). Measurement of proton-driven antiport in Escherichia coli. Bio-protocol 4(21): e1278.

Alegre, K.O., Paul, S. & Law, C.J. (2014). Multidrug transporter proteins of the major facilitator superfamily: not only for drug efflux. In Prokaryotes: Physiology, Biochemistry and Cell Behavior. (Nisnevitch, M. ed), pp 55-76. Nova Science Publishers (New York).

*Paul, S., *Alegre, K.O., Holdsworth, S.R., Rice, M., Brown, J.A., McVeigh, P., Kelly, S.M. & Law, C.J. (2014). A single-component multidrug transporter of the major facilitator superfamily is part of a network that protects Escherichia coli from bile salt stress. Mol. Micro. 92, 872-884. *Joint first authors. PDF Supplementary material

Holdsworth, S.R. & Law, C.J. (2013). Multidrug resistance protein MdtM adds to the repertoire of antiporters involved in alkaline pH homeostasis in Escherichia coli. BMC Microbiology 13: 113.  PDF

Holdsworth, S.R. & Law, C.J. (2013). The major facilitator superfamily transporter MdtM contributes to the intrinsic resistance of Escherichia coli to quaternary ammonium compounds. J. Antimicrob. Chemother., 68: 831-839. (DOI: 10.1093/jac/dks491. Available online 5th December 2012). PDF  

Wilkinson, R., Law, C.J., Hoey, E.M., Fairweather, I., Brennan, G.P. & Trudgett, A. (2012).  An amino acid substitution in a Fasciola hepatica P-glycoprotein from triclabendazole-resistant and triclabendazole-susceptible populations. Mol. Biochem. Parasitol. 186: 69-72. PDF  

Holdsworth, S.R. & Law, C.J. (2012). Functional and biochemical characterisation of the Escherichia coli major facilitator superfamily multidrug transporter MdtM.  Biochimie 94: 1334-1346. PDF  

Law, C.J., Enkavi, G., Wang, D.-N. & Tajkhorshid, E. (2009). Structural basis of substrate selectivity in the glycerol-3-phosphate:phosphate antiporter GlpT.  Biophys. J., 97: 1346-1353. PDF  

Zhou, Z., Zhen, J., Karpowich, N., Law, C.J., Reith, M.E.A. & Wang, D-N. (2009). Antidepressant specificity of the serotonin transporter defined by three LeuT-SSRI structures.  Nat. Struct. Mol. Biol., 16: 652-657. PDF  

Law, C.J., Maloney, P.C & Wang, D-N. (2008). Ins and outs of major facilitator superfamily antiporters.  Annu. Rev. Microbiol., 62: 289-305. PDF  

Law, C.J., Almqvist, A., Bernstein, A., Goetz, R.M., Huang, Y., Soudant, C., Laaksonen, A., Hovmöller, S. & Wang, D-N. (2008). Salt bridge dynamics control substrate-induced conformational change in the membrane transporter GlpT.  J. Mol. Biol., 378: 826-837. PDF  

Law, C.J., Yang, Q., Soudant, C., Maloney, P.C. & Wang, D-N. (2007). Kinetic evidence is consistent with the rocker-switch mechanism of GlpT membrane transport.  Biochemistry, 46: 12190-12197. PDF  

Law, C.J. & Cogdell, R.J. (2007). The light-harvesting system of purple anoxygenic photosynthetic bacteria.  In: Primary Processes of Photosynthesis:Principles and Apparatus, Part 1 (Renger, G., ed), pp205-259. RSC Publishing, Cambridge, U.K.

Zhou, Z., Zhen, J., Karpowich, N., Goetz, R.M., Law, C.J., Reith, M.E.A. & Wang, D-N. (2007). LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.  Science, 317: 1390-1393. PDF   This article has received Faculty of 1000 recommendation.

Cogdell, R.J., Southall, J., Gardiner, A.T., Law, C.J., Gall, A., Roszak, A. & Isaacs, N.W. (2006). How purple photosynthetic bacteria harvest solar energy.  C.R. Chimie, 9: 201-206. PDF  

Law, C.J., Gardiner A.T., Southall, J., Roszak, A.W., Howard, T.D., Isaacs, N.W. (2005). How purple bacteria harvest light energy.  In: Energy Harvesting Materials, (Andrews, D., ed), pp65-95. World Scientific Publishing Co.

Cogdell, R.J., Gardiner, A.T., Roszak, A., Law, C.J., Southall, J. & Isaacs, N.W. (2004). Rings, ellipses and horseshoes: How purple bacteria harvest solar energy.  Photosynth. Res., 81: 207-214.

Law, C.J., Roszak, A.W., Southall, J., Gardiner, A.T., Isaacs, N.W. & Cogdell, R.J. (2004). The structure and function of bacterial light-harvesting complexes.  Mol. Memb. Biol., 21: 183-191. PDF  

Parkes-Loach, P.S., Majeed, A.P., Law, C.J. & Loach, P.A. (2004). Interactions stabilizing the structure of the core light-harvesting complex (LH1) of photosynthetic bacteria and its subunit (B820).  Biochemistry, 43: 7003-7016. PDF  

Roszak, A.W., Howard, T.D., Southall, J., Gardiner, A.T., Law, C.J., Isaacs, N.W. and Cogdell, R.J. (2003). Crystal structure of the RC-LH1 core complex from Rhodopseudomonas palustris.  Science, 302: 1969-1975. PDF  

Law, C.J., Penfold, C.N., Walker, D.C., Moore, G.R., James, R. and Kleanthous, C. (2003). OmpF enhances the ability of BtuB to protect susceptible Escherichia coli cells from colicin E9 cytotoxicity.  FEBS Letts., 545: 127-132. PDF  

Law, C.J, Chen, J., Parkes-Loach, P.S. & Loach, P.A. (2003). Interaction of bacteriochlorophyll with the LH1 and PufX polypeptides of photosynthetic bacteria: use of chemically synthesized analogs and covalently attached fluorescent probes.  Photosynth. Res., 75: 193-210. PDF  

Parkes-Loach, P.S., Law, C.J., Recchia, P.A., Kehoe, J., Nehrlich, S., Chen, J. & Loach, P.A. (2001). Role of the core region of the PufX protein in inhibition of reconstitution of the core light-harvesting complexes of Rhodobacter sphaeroides and Rhodobacter capsulatus.  Biochemistry, 19: 5593-5601. PDF  

Trissl, H-W., Law, C.J. & Cogdell, R.J. (1999). Uphill energy transfer in LH2-containing purple bacteria at room temperature.  Biochim. Biophys. Acta Bioenergetics, 1412: 149-172. PDF  

Trissl, H-W., Law, C.J. & Cogdell, R.J. (1998).  In Proceedings of the XIth International Congress on Photosynthesis, (Garab, G & Pusztai, J, eds.), Vol. 1: pp 65-68. Kluwer Academic Publishers, The Netherlands.

Law, C.J. & Cogdell, R.J. (1998). The effect of chemical oxidation on the fluorescence of the LH1 (B880) complex from the purple bacterium Rhodobium marinum. FEBS Letts., 432 (1-2), 27-30. PDF  

Cogdell, R.J., Fyfe, P., Fraser, N., Law, C., Howard, T., McLuskey, K., Prince, S., Freer, A. & Isaacs, N. (1998) Photosynthetic Light Harvesting.  In Microbial responses to light and time, (Caddick, M.X et al., eds), pp 143-158. Cambridge University Press

Law, C.J., Prince, S.M. & Cogdell, R.J. (1998). Crystallising the LH1-RC "core" complex of purple bacteria.  Biochem. Soc. Trans., 26(2): S160. PDF  

Alden, R.G., Johnson, E., Nagaragan, V., Parson, W.W., Law, C.J. & Cogdell, R.J. (1997). Calculations of spectroscopic properties of the LH2 bacteriochlorophyll-protein antenna complex from Rhodopseudomonas acidophila. J. Phys. Chem. B, 101: 4667-4680. PDF  

Law, C.J., Cogdell, R.J. & Trissl, H.-W. (1997). Antenna organisation in the purple bacterium Rhodopseudomonas acidophila studied by fluorescence induction.  Photosynthesis Research, 52: 157-165. PDF  

Law, C.J. & Price, N.C. (1996). The accessibility of proteins in protein-SDS complexes.  Biochem. Soc. Trans., 24(2): 323S. PDF