School of Biological Sciences

Scarlett Holdsworth, PhD student

Scarlett is a final year PhD student whose studies focus on the purification and functional characterisation of MdtM, a 12-transmembrane spanning segment major facilitator superfamily multidrug efflux protein from Escherichia coli.

You can watch a short movie of our homology model of MdtM in an occluded conformation here. The model used the crystal structure of the homologous MFS multidrug efflux protein EmrD as the template. In the movie the periplasmic side of the transporter is at the top and the cytoplasmic side at the bottom. The movie was produced using PyMOL.

You can read some of Scarlett's published work on MdtM here.

Scarlett also plays hockey for Armagh.

Matthew Rice, MSc student (2013)

Matthew will join the lab in early summer of 2013 to work on the transport kinetics of monovalent ion transport by MdtM.

Christopher Wooster, summer student (2012)

Christopher spent summer of 2012 studying the role of an MFS transporter in protecting E. coli from the noxious effects of bile salts. Christopher was supported by a research bursary from The Physiological Society.

Tim Little, work placement student (2012)

Tim spent time in the lab during May 2012 as part of his work placement experience learning how to culture E. coli cells and performing transport assays on inverted vesicles.