Scarlett is a final year PhD student whose studies focus on the purification and functional characterisation of MdtM, a 12-transmembrane spanning segment major facilitator superfamily multidrug efflux protein from Escherichia coli.
You can watch a short movie of our homology model of MdtM in an occluded conformation here. The model used the crystal structure of the homologous MFS multidrug efflux protein EmrD as the template. In the movie the periplasmic side of the transporter is at the top and the cytoplasmic side at the bottom. The movie was produced using PyMOL.
You can read some of Scarlett's published work on MdtM here.
Scarlett also plays hockey for Armagh.
Matthew will join the lab in early summer of 2013 to work on the transport kinetics of monovalent ion transport by MdtM.
Christopher spent summer of 2012 studying the role of an MFS transporter in protecting E. coli from the noxious effects of bile salts. Christopher was supported by a research bursary from The Physiological Society.