Skip to main content

Selected Publications

Cray, Jonathan; Russell, John T., Timson, David; Singhal, Rekha S., Hallsworth, John. (2013). A universal measure of chaotropicity and kosmotropicity.  Environmental Microbiology, 15(1): 287-296.

Banford, Samantha; Drysdale, Orla; Hoey, Elizabeth M., Trudgett, Alan; Timson, David J. (2013). FhCaBP3 : A Fasciola hepatica calcium binding protein with EF-hand and dynein light chain domains.  Biochimie, 95(4): 751–758.

McLean, Denise T.F., Lundy, Fionnuala T., Timson, David J. (2013). IQ-motif peptides as novel anti-microbial agents.  Biochimie, 95(4): 875-80.

Bell, Andrew N.W.; Magill, Emma; Hallsworth, John E.; Timson, David J. (2013). Effects of Alcohols and Compatible Solutes on the Activity of β-Galactosidase.  Applied Biochemistry and Biotechnology, 169(3): 2013786-94.

Cray, Jonathan A., Bell, Andrew N.W., Bhaganna, Prashanth; Mswaka, Allen Y., Timson, David J., Hallsworth, John E. (2013). The biology of habitat dominance; can microbes behave as weeds?.  Microbial Biotechnology,6: 453-492.

Zinsser, Veronika L., Moore, Catherine M., Hoey, Elizabeth M., Trudgett, Alan; Timson, David J. (2013). Citrate synthase from the liver fluke Fasciola hepatica.  Parasitology Research,112:2413-2417.

McCorvie, Thomas J., Gleason, Tyler J., Fridovich-Keil, Judith L., Timson, David J. (2013). Misfolding of galactose 1-phosphate uridylyltransferase can result in type I galactosemia.  Biochimica et biophysica acta, 1832(8): 1279-1293.

Kavanagh, J.N., Currell, F.J., Timson, D.J., Savage, K.I., Richard, D.J., McMahon, S.J., Hartley, O., Cirrone, G.A.P., Romano, F., Prise, K. M., Bassler, N., Holzscheiter, M, H., Schettino, G. (2013). Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest.  Nature Scientific Reports, 3: 1770, 1-10.

Duffy, Martin J.; Kelly, Orla; Calvert, Christopher R., King, Raymond B., Belshaw, Louise; Kelly, Thomas J., Costello, John T., Timson, David J., Bryan, William A; Kierspel, Thomas; Turcu, I C Edmond; Cacho, Cephise M; Springate, Emma; Williams, Ian D; Greenwood, Jason B. (2013). Fragmentation of Neutral Amino Acids and Small Peptides by Intense, Femtosecond Laser Pulses.  Journal of The American Society for Mass Spectrometry, 24(9): 1366-75.

Huang, Meilan; Li, Xiaozhou; Zou, Jian-Wei; Timson, David J. (2013). The Role of Arg228 in the phosphorylation of galactokinase: The mechanism of GHMP kinases by QM/MM studies.  Biochemistry, 52(28): 4858.

McCorvie, Thomas J.; Timson, David J. (2013). In silico prediction of the effects of mutations in the human UDP-galactose 4'-epimerase gene : Towards a predictive framework for type III galactosemia.  Gene, 524(2): 95-104.

Timson, David J, Lindert, Steffen. (2013). Comparison of dynamics of wildtype and V94M human UDP-galactose 4-epimerase-A computational perspective on severe epimerase-deficiency galactosemia.  Gene, 525: 318-324.

Zinsser, Veronika L., Farnell, Edward; Dunne, David W., Timson, David J. (2013). Triose phosphate isomerase from the blood fluke Schistosoma mansoni : Biochemical characterisation of a potential drug and vaccine target.  FEBS Letters, 587(21): 3422-3427.

Zinsser, Veronika L., Hoey, Elizabeth M., Trudgett, Alan; Timson, David J. (2013). Biochemical characterisation of triose phosphate isomerase from the liver fluke Fasciola hepatica.  Biochimie, 95: 2182-2189.

Fuchs, Marc-Aurel; Ryan, Louise A; Chambers, Emma L., Moore, Catherine M., Fairweather, Ian; Trudgett, Alan; Timson, David J., Brennan, Gerard; Hoey, Elizabeth M. (2013). Differential expression of liver fluke β-tubulin isotypes at selected life cycle stages.  International Journal for Parasitology, doi: 10.1016/j.ijpara.2013.08.007.

Timson, David. (2012). N-acetylgalactosamine kinase: a naturally promiscuous small molecule kinase.  Applied Biochemistry and Biotechnology, 166(1): 57-63.

Elliott, Sarah; Allen, George; Timson, David. (2012). Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42.  World Journal of Biological Chemistry, 3(3): 53-60.

Calvert, Chris; Belshaw, Louise; Duffy, Martin; Kelly, Orla; King, Raymond; Smyth, Ashley; Kelly, T.J. Costello, J.T., Timson, David; Bryan, W.A., Kierspel, T., Rice, P., Turcu, I.C.E.; Cacho, C.M., Springate, E., Williams, Ian; Greenwood, Jason. (2012). LIAD-fs scheme for studies of ultrafast laser interactions with gas phase biomolecules.  Physical Chemistry Chemical Physics, 14(18): 6289-6297.

Russell, Sean L; McFerran, Neil V; Moore, Catherine M., Tsang, Yvonne; Glass, Peter; Hoey, Elizabeth M., Trudgett, Alan; Timson, David J. (2012). (2012). A novel calmodulin-like protein from the liver fluke, Fasciola hepatica.  Biochimie, 94(11): 2398-2406.

Orr, Rebecca; Kinkead, Ruth; Newman, Richard; Anderson, Lindsay; Hoey, Elizabeth M., Trudgett, Alan; Timson, David J. (2012).  FhCaBP4 : a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains.  Parasitology Research, 111(4): 1707-13

Moore, Catherine M., Hoey, Elizabeth M., Trudgett, Alan; Timson, David J. (2012). A plasma membrane Ca 2+ -ATPase (PMCA) from the liver fluke, Fasciola hepatica.  International Journal for Parasitology, 42(9): 851-8.

McCorvie, Thomas J., Liu, Ying; Frazer, Andrew; Gleason, Tyler J., Fridovich-Keil, Judith L., Timson, David J. (2012). Altered cofactor binding affects stability and activity of human UDP-galactose 4'-epimerase: Implications for type III galactosemia.  Biochimica et biophysica acta, 1822(10): 1516-26.

Andrews, William J., Bradley, Conor A., Hamilton, Elaine; Daly, Clare; Mallon, Thérèse; Timson, David J. (2012). A calcium-dependent interaction between calmodulin and the calponin homology domain of human IQGAP1.  Molecular and Cellular Biochemistry, 371(1-2): 217-23

Friedman, Aaron J., Durrant, Jacob D., Pierce, Levi C.T., McCorvie, Thomas J., Timson, David J., McCammon, J. Andrew. (2012). The molecular dynamics of Trypanosoma brucei UDP-galactose 4'-epimerase : a drug target for African sleeping sickness.  Chemical Biology & Drug Design, 80(2): 173-81.

Merrigan, Tony L; Timson, David J., Hunniford, C. Adam; Catney, Martin; McCullough, Robert W. (2012). Plume characteristics and dynamics of UV and IR laser-desorbed oligonucleotides.  International journal of biological macromolecules, 50(4): 1081-90.

Timson, David J., Kavanagh, Joy N., Currell, Frederick J., Schettino, Giuseppe. (2012). Breaking DNA and killing cells with exotic types of radiation.  International Journal of Molecular Medicine, 30: S12-S12.

Kristiansson, Helena; Timson, David. (2012). Galactokinases: potential biotechnological applications as biocatalysts.  Current Biotechnology, 1: 148-154.

McCorvie, Thomas J.; Wasilenko, Jamie; Liu, Ying; Fridovich-Keil, Judith L., Timson, David J. (2011). In vivo and in vitro function of human UDP-galactose 4 '-epimerase variants.  Biochimie, 93(10), 1747-1754.

McCorvie, T.J., Timson, David. (2011). The Structural and Molecular Biology of Type I Galactosemia: Enzymology of Galactose 1-phosphate Uridylyltransferase.  IUBMB life, 63(9): 694-700.

Kristiansson, H., Timson, David. (2011). Increased Promiscuity of Human Galactokinase Following Alteration of a Single Amino Acid Residue Distant from the Active Site.  ChemBioChem, 12(13): 2081-2087.

Barnard, Emma; Timson, David. (2011). The GAL genetic switch: visualisation of the interacting proteins by split-EGFP bimolecular fluorescence complementation.  Journal of Basic Microbiology, 51(3): 312-317.

Houston, D.F.; Timson, David. (2011). Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change.  Molecular and Cellular Biochemistry, 348(1-2), 109-115.

Moore, C.M., Hoey, Elizabeth; Trudgett, Alan; Timson, David. (2011). Artemisinins act through at least two targets in a yeast model.  FEMS Yeast Research, 11(2): 233-237.

Megarity, C.F., Huang, Meilan; Warnock, C., Timson, David. (2011). The role of the active site residues in human galactokinase: implications for the mechanisms of GHMP kinases.  Bioorganic Chemistry, 39(3): 120-126.

McCorvie, T.J., Timson, David. (2011). Structural and Molecular Biology of Type I Galactosemia: Disease-associated Mutations.  IUBMB life, 63(11): 949-954.

Atcheson, E., Hamilton, E., Pathmanathan, Sevvel; Greer, Brett; Harriott, Patrick; Timson, David. (2011). IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain.  Bioscience Reports, 31(5): 371-379.

Liu, Weiru; Yue, Anbu; Timson, David. (2010). A Ligand predication tool based on modeling and reasoning with imprecise probabilistic knowledge.  Computer Methods and Programs in Biomedicine, 98(1): 45-54.

Chambers, E., Hoey, E.M., Trudgett, A., Fairweather, I. & Timson, D.J. (2010). Binding of serum albumin to the anthelmintic drugs albendazole, triclabendazole and their sulphoxides.  Veterinary Parasitology.  Accepted for publication (25th February 2010).

Bouteldja, N. & Timson, D.J. (2010). The biochemical basis of hereditary fructose intolerance.  Journal of Inherited Metabolic Disease, 33: 105-112.

Barnard, E. & Timson, D.J. (2010). Split-GFP screens for the detection and localization of protein-protein interactions in living yeast cells.  In: Molecular and Cell Biology Methods for Fungi.  Methods in Molecular Biology, 638: 303-317.

Yue, A., Lui, W., & Timson, D.J. (2010). A ligand predication tool based on modeling and reasoning with imprecise probabilistic knowledge.  Computer Methods and Programs in Biomedicine, 98: 45-54.

Agnew, A. & Timson, D.J. (2010). Mechanistic studies on human N-acetylgalactosamine kinase.  Journal of Enzyme Inhibition and Medicinal Chemistry, 25: 370-376.

Fatehullah, A., Doherty, C., Pivato, G., Allen, G., Devine, L., Nelson, J. & Timson, D.J. (2010). Interactions between the 67 kDa laminin receptor and its precursor with laminin.  Bioscience Reports, 30: 73-79.

Timson, D.J. (2010). The IQGAP-myosin light chain interaction:  what is its function?  in Cytoskeleton: Cell Movement, Cytokinesis and Organelles Organization.  Nova Science Publishers, (New York).

Merrigan, T.L., Hunniford, C.A., Timson, D.J., Catney, M. & McCullough, R.W. (2009). Development of a novel mass spectrometric technique for studying DNA damage.  Biochemical Society Transactions, 37: 905-909.

Hunniford, C.A., McCullough, R.W., Davies, R.H.J. & Timson, D.J. (2009). DNA damage by low energy ions.  Biochemical Society Transactions, 37: 893-896.

Bouteldja, N. & Timson, D.J. (2009). Serine proteases in bone disease.  Current Rheumatology Reviews, 5: 141-147.

McCammick, E.M., Gomase, V.S., Timson, D.J. & Hallsworth JE (2009). Water-hydrophobic compound interactions with the microbial cell in  Handbook of Hydrocarbon and Lipid Microbiology, Springer-Verlag (Germany).

McCrudden, M.T.C., Ryan, L.A., Turkington, P.T. & Timson, D.J. (2009). The contribution of key hydrophobic residues in ecotin to enzyme-inhibitor complex stability.  Journal of Enzyme Inhibition and Medicinal Chemistry, 24: 1207-1210.

Timson, D.J., Reece, R.J., Thoden, J.B. & Holden, H.M. (2009). Galactokinase deficiency in Encyclopedic Reference of Molecular Mechanisms of Disease, Lang F (Ed), Springer (Germany).

Merrigan, T.L., Hunniford, C.A., Timson, D.J., Catney, M. & McCullough, R.W. (2008). Plume Image Profiling of UV Laser Desorbed Biomolecules.  AIP Conference Proceedings 1080, 176-181.

Pathmanathan, S., Elliott, S.F., McSwiggan, S., Greer, B., Harriott, P., Irvine, G.B. & Timson, D.J. (2008). IQ-motif selectivity in human IQGAP1: binding of myosin light chain and S100B.  Molecular and Cellular Biochemistry, 318: 43-51.

Pathmanathan, S., Barnard, E., & Timson, D.J. (2008). Interactions between the budding yeast IQGAP homologue Iqg1p and its targets revealed by a split-EGFP bimolecular fluorescence complementation assay.  Cell Biology International, 32: 1318-1322.

Ryan, L., Hoey, E., Trudgett, A., Fairweather, I., Fuchs, M., Robinson, M.W., Chambers, E., Timson, D.J., Ryan, E., Feltwell, T., Ivens, A., Bentley, G. & Johnston, D. (2008). Fasciola hepatica expresses multiple α- and β-tubulin isotypes.  Molecular and Biochemical Parasitology, 159: 73-78.

Barnard, E., McFerran, N.V., Trudgett, A., Nelson, J. & Timson, D.J. (2008). Development and implementation of split-GFP based bimolecular fluorescence complementation (BiFC) assays in yeast.  Biochemical Society Transactions, 36: 479-482.

McCrudden, M.T.C., Dafforn, T.R., Houston, D.F., Turkington, P.T. & Timson, D.J. (2008). Functional domains of the human epididymal protease inhibitor, eppin.  FEBS Journal, 275: 1742-1750.

Barnard, E., McFerran, N.V., Trudgett, A., Nelson, J. & Timson, D.J. (2008). Detection and localisation of protein-protein interactions in Saccharomyces cerevisiae using a split-GFP method.  Fungal Genetics & Biology, 45: 597-604.

Nelson, J., Pivato, G., Chambers, E., Doherty, C., Steele, D. & Timson, D.J. (2008). The 67 kDa laminin receptor: structure, function and role in disease.  Bioscience Reports, 28: 33-48.

Chhay, J.S., Vargas, C.A., McCorvie, T.J., Fridovich-Keil, J.L. & Timson, D.J. (2008). Analysis of UDP-galactose 4'-epimerase mutations associated with the intermediate form of type III galactosemia.  Journal of Inherited Metabolic Disease, 31: 108-116.

Timson, D.J., Reece, R.J., Thoden, J.B. & Holden, H.M. (2008). Galactokinase deficiency in Encyclopedic Reference of Molecular Mechanisms of Disease Lang F (Ed), Springer (Germany).

Merrigan, T.L., Hunniford, C.A., Timson, D.J., Morrow, T. & McCullough, R.W. (2008). Formation of gas phase macromolecular targets by laser desorption from surfaces.  Journal of Physics: Conference Series, 101: 012016.

Hunniford, C.A., Timson, D.J., Davies, R.J.H. & McCullough, R.W. (2008). Effects of low energy carbon ions on plasmid DNA.  Journal of Physics: Conference Series, 101: 012012.

Nolan, K.A., Zhao, H., Faulder, P.F., Timson, D.J., Siegel, D., Ross, D., Burke, Jr T.R., Stratford, I.J., Bryce, R.A. (2007). Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.  Journal of Medicinal Chemistry, 50: 6316-6325.

Barnard, E., McFerran, N.V., Nelson, J. & Timson, D.J. (2007). Detection of protein-protein interactions using protein-fragment complementation assays (PCA).  Current Proteomics, 4: 17-27.

Russell, S.L., McFerran, N.V., Hoey, E.M., Trudgett, A. & Timson, D.J. (2007). Characterisation of two calmodulin-like proteins from the liver fluke Fasciola hepatica.  Biological Chemistry, 388: 593-599.

Hunniford, C.A., Timson, D.J., Davies, R.J.H. & McCullough, R.W. (2007). Damage to plasmid DNA induced by low keV carbon ions.  Physics in Medicine and Biology, 52: 3729-3740.

Timson, D.J. (2007). Galactose metabolism in Saccharomyces cerevisiae.  Dynamic Biochemistry, Process Biotechnology and Molecular Biology.

Scott, A. & Timson, D.J. (2007). Characterisation of the Saccharomyces cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein, Gal10p.  FEMS Yeast Research, 7: 366-371.

Timson, D.J. (2007) GHMP kinases - structures, mechanisms and potential for therapeutically relevant inhibition.  Current Enzyme Inhibition, 3: 77-94.

Nolan, K.A., Timson, D.J., Stratford, I.J. & Bryce, R.A. (2006). In silico identification and biochemical characterisation of novel substrates and inhibitors of NQO1.  Bioorganic and Medicinal Chemistry Letters, 16: 6246-6254.

Timson, D.J. (2006). The structural and molecular biology of type III galactosemia.  IUBMB Life, 58: 83-89.

Thoden, J.B., Sellick, C.A., Timson, D.J., Reece, R.J. & Holden, H.M.(2005). Molecular structure of Saccharomyces cerevisiae Gal1p - a bifunctional galactokinase and transcriptional inducer.  Journal of Biological Chemistry, 280: 36905-36911.

Timson, D.J. (2005). Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase.  FEBS Journal, 272: 6170-6177.

Timson, D.J., Reece, R.J., Thoden, J.B. & Holden, H.M. (2005). Galactokinase deficiency in Encyclopedic Reference of Molecular Mechanisms of Disease Lang F (Ed), Springer (Germany).

Thoden, J.B., Timson, D.J., Reece, R.J. & Holden, H.M. (2004). Molecular structure of human galactose mutarotase.  Journal of Biological Chemistry, 279: 23431-23437.

Holden, H.M., Thoden, J.B., Timson, D.J. & Reece, R.J. (2004). Galactokinase - structure, function and role in type II galactosemia.  Cellular and Molecular Life Sciences, 61: 2471-2484.

Hartley, A., Glynn, S.E., Barynin, V., Baker, P.J., Sedelnikova, S.E., Verhees, C., de Geus, D., van der Oost, J., Timson D.J., Reece, R.J. & Rice, D.W. (2004). Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase.  Journal of Molecular Biology, 337: 387-398.

Timson, D.J. & Reece, R.J. (2003). Functional analysis of disease-causing mutations in human galactokinase.  European Journal of Biochemistry, 270: 1767-1774.

Timson, D.J. & Reece, R,J, (2003). Identification and characterisation of human aldose 1-epimerase.  FEBS Letters, 543: 21-24.

Timson, D.J. (2003). Fine tuning the myosin motor: the role of the essential light chain.  Biochimie, 85: 639-645.

Timson, D.J. & Reece, R.J. (2003). Sugar recognition by human galactokinase.  BMC Biochemistry, 4: 16.

Timson, D.J., Ross, H.C. & Reece, R.J. (2002). Gal3p and Gal1p interact with the transcriptional repressor Gal80p to form a complex of 1:1 stoichiometry.  Biochem. J., 363: 515-520.

Timson, D.J. & Reece, R.J. (2002). Kinetic analysis of yeast galactokinase: Implications for transcriptional activation of the GAL genes.  Biochimie., 84: 265-272.

Timson, D.J., Singleton, M.R. & Wigley, D.B. (2000). DNA ligases in the repair and replication of DNA.  Mutation Research (DNA Repair), 460: 301-318.

Brannigan, J.A., Ashford, S.R., Doherty, A.J., Timson, D.J. & Wigley, D.B. (1999). Nucleotide sequence, heterologous expression and novel purification of DNA ligase from Bacillus stearothermophilus.  Biochimica et Biophysica Acta (Protein Structure and Molecular Enzymology) 1432, 413-418.

Singleton, M.R., Håkansson, K., Timson, D.J. & Wigley, D.B. (1999). Structure of the adenylation domain of an NAD+-dependent DNA ligase.  Structure, 7: 35-42.

Timson, D.J. & Wigley, D.B. (1999). Functional domains of an NAD+-dependent DNA ligase.  Journal of Molecular Biology, 285: 73-83.

Timson, D.J., Trayer, H.R., Smith, K.J. & Trayer, I.P. (1999). Size and charge requirements for kinetic modulation and actin binding by alkali 1-type myosin essential light chains.  J. Biol. Chem., 274: 18271-18277.

Timson, D.J., Trayer, H.R. & Trayer, I.P. (1998). The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function.  European Journal of Biochemistry, 255: 654-662.

Timson, D.J. & Trayer, I.P. (1997). The rôle of the proline-rich region in A1-type myosin essential light chains: implications for information transmission in the acto-myosin complex.  FEBS Letters, 400: 31-36.