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Dr F. Liu

PhD Plant Molecular Biology,
Peking University, 1998.

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Contact Information
Tel:  +44 (0)28 9097 2477 (Direct line)
Fax:  +44 (0)28 9097 5877
Email:  f.liu@qub.ac.uk
Room:  Medical Biology Centre - 01.445.

Research Interests

Expression of eukaryotic genes is an integrated process of transcription and co-transcriptional RNA processing in the dynamic context of chromatin.  Every step of transcription is intimately coupled with co-transcriptional RNA processing-capping, splicing and 3' formation/polyadenylation.  Co-transcriptional RNA processing is now recognized as one of the major steps of gene expression regulation in all eukaryotic cells.  Recent evidence also hints the vital role of co-transcriptional processing of non-coding RNA in chromatin modification and epigenetic regulation of gene expression.  My research interest focuses on dynamics, regulatory mechanisms and functions of co-transcriptional RNA processing in plants, especially in response to abiotic stresses.

Publications

Liu, Fuquan; Bakht, Saleha; Dean, Caroline. (2012). Cotranscriptional role for Arabidopsis DICER-LIKE 4 in transcription termination.  Science, 335(6076): 1621-1623.

Liu, F., Marquardt, S. and Dean, C. (2010). Targeted RNA 3' processing of antisense RNA triggers chromatin silencing of FLC.  Science, 327: 94-97.

Swiezewski, S., Liu, F., Magusin, A. and Dean, C. (2009). Cold-induced silencing by long antisense transcripts of an Arabidopsis Polycomb target FLC.  Nature, 62: 799-802.

Manzano, D., Marquardt, S., Jones, A., Bäurle, I., Liu, F. and Dean, C. (2009). Altered interactions within FY/AtCPSF complexes required for Arabidopsis FCA-mediated chromatin silencing.  Proc. Natl. Acad. Sci. U.S.A., 106: 8772-8777.

Liu, F., Quesada, V., Crevillén, .P, Bäurle, I., Swiezewski, S. and Dean, C. (2007). The Arabidopsis RNA-binding protein FCA requires a lysine-specific demethylase 1 homolog to downregulate FLC.  Molecular Cell, 28: 398-407.

Swiezewski, S., Crevillen, P., Liu, F., Ecker, J.R., Jerzmanowski, A. and Dean, C. (2007). Small RNA-mediated chromatin silencing directed to the 3' region of the Arabidopsis gene encoding the developmental regulator, FLC.  Proc. Natl. Acad. Sci. U.S.A., 104: 3633-8.

Henderson, I., Liu, F., Drea, S., Simpson, G. and Dean, C. (2005). An allelic series reveals essential roles for FY in plant development in addition to flowering-time control.  Development, 132: 3597-607.

Xiao, S., Dai, L., Liu, F., Wang, Z., Peng, W. and Xie, D. (2004). COS1: an Arabidopsis coronatine insensitive1 suppressor essential for regulation of jasmonate-mediated plant defense and senescence.  Plant Cell, 16: 1132-42.

Liu, F., Ni, W., Griffith, M., Huang, Z., Chang, C., Peng, W., Ma, H. and Xie, D. (2004). The ASK1 and ASK2 genes are essential for Arabidopsis early development.  Plant Cell, 16: 5-20.

Xu, L., Liu, F., Lechner, E., Genschik, P., Crosby, W., Ma, H., Peng, W. and Xie, D. (2002), The SCFCOI1 ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis.  Plant Cell, 14: 1919-35.

Xu, L., Liu, F., Wang, Z., Peng, W., Huang, R., Huang, D. and Xie, D. (2001). An Arabidopsis mutant cex1 exhibits constant accumulation of jasmonate-regulated AtVSP, Thi2.1 and PDF1.2.  FEBS Letters, 494: 161-4.

Yang, L., Chen, M., Liu, F., Geng, Y., Chen, C., Li, Y., Cao, Z., Xu, Z. and Bai, S. (2000). Carpel of cucumber (cucumis sativas. L) male flowers maintains early characteristics during organ development.  Chinese Science Bulletin, 45: 729-733.

Liu, F., Zhu, G., Luo, D., Wu, X. and Xu, Z. (1999). Cloning and analysis of CFL, a LFY-like gene from cucumber.  Acta Botanica Sinica, 41: 813-819.