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Selected Publications

Meaney, M., Savage, J., Brennan, G.P., Hoey, E., Trudgett, A., Fairweather, I. (2013). Increased susceptibility of a triclabendazole (TCBZ)-resistant isolate of Fasciola hepatica to TCBZ following co-incubation in vitro with the P-glycoprotein inhibitor, R(+)-verapamil.  Parasitology, 12: 1-17.

Savage, J., Meaney, M., Brennan, G.P., Hoey, E., Trudgett, A., Fairweather, I. (2013). Effect of the P-glycoprotein inhibitor, R(+)-verapamil on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica.  Veterinary Parasitology, 195: 72-86.

Hanna, R.E., Forster, F.I., Brennan, G.P., Fairweather, I. (2013). Fasciola hepatica: histological demonstration of apoptosis in the reproductive organs of flukes of triclabendazole-sensitive and triclabendazole-resistant isolates, and in field-derived flukes from triclabendazole-treated hosts, using in situ hybridisation to visualise endonuclease-generated DNA strand breaks.  Veterinary Parasitology, 191: 240-51.

Walker, S.M., Demiaszkiewicz, A.W., Kozak, M., Wedrychowicz, H., Teofanova, D., Prodöhl, P., Brennan, G., Fairweather, I., Hoey, E.M., Trudgett, A. (2013). Mitochondrial DNA haplotype analysis of liver fluke in bison from Bialowieza Primaeval Forest indicates domestic cattle as the likely source of infection.  Veterinary Parasitology, 191: 161-4.

Kajugu, P.E., Hanna, R.E., Edgar, H.W., Forster, F.I., Malone, F.E., Brennan, G.P., Fairweather, I. (2012). Specificity of a coproantigen ELISA test for fasciolosis: lack of cross-reactivity with Paramphistomum cervi and Taenia hydatigena.  Veterinary Record, 171: 502.

McConville, M., Hanna, R.E., Brennan, G.P., Edgar, H.W., McConnell, S., McCoy, M., Castillo, R., Hernández-Campos, A., Fairweather, I. (2012). Impact of compound alpha treatment in vivo on egg production by the liver fluke, Fasciola hepatica.  Veterinary Parasitology, 187: 183–95.

Hanna, R.E., Moffett, D., Brennan, G.P., Fairweather, I. (2012). Fasciola hepatica: a light and electron microscope study of sustentacular tissue and heterophagy in the testis.  Veterinary Parasitology, 187: 168-82.

Wilkinson, R., Law, C.J., Hoey, E.M., Fairweather, I., Brennan, G.P., Trudgett, A. 2012). An amino acid substitution in Fasciola hepatica P-glycoprotein from triclabendazole-resistant and triclabendazole-susceptible populations.  Molecular Biochemical Parasitology, 186: 69-72.

Walker, S.M., Prodöhl, P.A., Hoey, E.M., Fairweather, I., Hanna, R.E., Brennan, G., Trudgett, A. (2012). Substantial genetic divergence between morphologically indistinguishable populations of Fasciola suggests the possibility of cryptic speciation.  International Journal of Parasitology, 42: 1193-9.

Fairweather, I., McShane, D.D., Shaw, L., Ellison, S.E., O'Hagan, N.T., York, E.A., Trudgett, A., Brennan, G.P. (2012). Development of an egg hatch assay for the diagnosis of triclabendazole resistance in Fasciola hepatica: proof of concept.  Veterinary Parasitology, 183: 249-59.

Toner, E., Brennan, G.P., Hanna, R.E.B., Edgar, H.W.J., Fairweather, I. (2011a). Disruption of 880 egg formation by Fasciola hepatica following treatment in vivo with triclabendazole in the sheep host.  Vet. Parasitol., 177: 79-89.

Toner, E., Brennan, G.P., Hanna, R.E.B., Edgar, H.W.J., Fairweather, I. (2011b). Fasciola hepatica: time-dependent disruption of spermatogenesis following in vivo treatment with triclabendazole.  Parasitol. Res.(in press).

Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I. (2011a). Piperonyl butoxide enhances triclabendazole action against triclabendazole-resistant Fasciola hepatica.  Parasitology, 138: 224-236.

Flanagan, A.M., Edgar, H.W.J., Forster, F., Gordon, A., Hanna, R.E.B., McCoy, M., Brennan, G.P., Fairweather, I. (2011a) Standardisation of a coproantigen reduction test (CRT) protocol for the diagnosis of resistance to triclabendazole in Fasciola hepatica.  Vet. Parasito, 176: 34-42.

Flanagan, A., Edgar, H.W.J., Gordon, A., Hanna, R.E.B., Brennan, G.P., Fairweather, I. (2011b). Comparison of two assays, a faecal egg count reduction test (FECRT) and a coproantigen reduction test (CRT), for the diagnosis of resistance to triclabendazole in Fasciola hepatica in sheep.  Vet. Parasitol., 176: 170-176.

Hanna, R.E.B., Gordon, A.W., Moffett, D., Edgar, H.W.J., Oliver, L.F., McConnell, S., Shaw, L., Brennan, G.P., Fairweather, I. (2011). Fasciola hepatica: Comparative effects of host resistance and parasite intra-specific interactions on size and reproductive histology in flukes from rats infected with isolates differing in triclabendazole sensitivity.  Vet. Parasitol., 178: 251-263.

Hanna, R.E.B., Edgar, H.W.J., McConnell, S., Toner, E., McConville, M., Brennan, G.P., Devine, C., Flanagan, A., Halferty, L., Meaney, M., Shaw, L., Moffett, D., McCoy, M., Fairweather, I. (2010). Fasciola hepatica: histological changes in the reproductive structures of triclabendazole (TCBZ)-sensitive and TCBZ-resistant flukes collected from experimentally infected sheep one to four days after treatment in vivo with TCBZ and the related benzimidazole derivative, Compound Alpha.  Vet. Parasitol., 168: 240-254.

Toner, E., McConvery, F., Brennan, G.P., Meaney, M., Fairweather, I. (2010). A transmission electron microscope study on the route of entry of triclabendazole into the liver fluke, Fasciola hepatica.  Parasitology, 137: 855-870.

Toner, E., Brennan, G.P., Hanna, R.E.B., Edgar, H.W., Fairweather, I. (2010a). Tegumental surface changes in adult Fasciola hepatica in response to treatment in vivo with triclabendazole in the sheep host.  Vet. Parasitol., 172: 238-248.

Toner, E., Brennan, G.P., Hanna, R.E.B., Edgar, H.W.J., Fairweather, I. (2010b). Time-dependent changes to the tegumental system and gastrodermis of adult Fasciola hepatica following treatment in vivo with triclabendazole in the sheep host.  Vet. Parasitol., 174: 218-227.

Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I. (2010a). Inhibition of cytochrome P450-mediated metabolism enhances ex vivo susceptibility of Fasciola hepatica to triclabendazole.  Parasitology, 137: 871-880.

Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I. (2010b). Potentiation of triclabendazole sulphoxide induced tegumental disruption by methimazole in a triclabendazole- resistant isolate of Fasciola hepatica. Parasitol Res., 106: 1351-1363.

Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I. (2010c). Enhancement of the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica using the metabolic inhibitor ketoconazole.  Parasitol Res., 107: 337-353.

Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I. (2009). Effect of the metabolic inhibitor, methimazole on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica.  Parasitology, 136: 183-192.

Toner, E., McConvery, F., Brennan, G.P., Meaney, M., Fairweather, I. (2009). A scanning electron microscope study on the route of entry of triclabendazole into the liver fluke, Fasciola hepatica.  Parasitology, 136: 523-535.

Halferty, L., Brennan, G.P., Trudgett, A., Hoey, E.M., Fairweather, I. (2009). The relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica.  Vet Parasitol., 159: 126-138.

McConville, M., Brennan, G.P., Flanagan, A., Edgar, H.W.J., Hanna, R.E.B., McCoy, M., Gordon, A.W., Castillo, R., Hernández-Campos, A., Fairweather, I. (2009). An evaluation of the efficacy of compound alpha and triclabendazole against two isolates of Fasciola hepatica. Vet. Parasitol., 162: 75-88.

McConville, M., Brennan, G.P., Flanagan, A., Hanna, R.E.B., Edgar, H.W.J., Castillo, R., Hernández-Campos, A., Fairweather, I. (2009a). Surface changes in adult Fasciola hepatica following treatment in vivo with the experimental fasciolicide, compound alpha.  Parasitol Res., 105: 757-767.

McConville, M., Hanna, R.E.B., Brennan, G.P., McCoy, M., Edgar, H.W.J., McConnell, S., Castillo, R., Hernández-Campos, A., Fairweather, I. (2009b). Fasciola hepatica: disruption of spermatogenesis by the fasciolicide compound alpha.  Parasitol. Res., 106: 311-323.