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Research


Endothelial cells stained with fluorescent Ab against 67LR

Angiogenesis and the high affinity 67 kiloDalton laminin receptor (67LR)

In my lab, we have investigated the effects of synthetic peptide ligands of 67LR in both in vitro and in vivo models of angiogenesis.  Using our 67LR antibodies we have shown that the receptor is selectively expressed by activated endothelial cells and that this angiogenic target can be blocked using small peptides with resulting improvement in the progress of retinopathy.

 

Alpha-Defensins

With colleagues in the Royal Victoria School of Dentistry, I have begun an investigation of the cytotoxic effects of defensins with the aim of:

  1. identifying the active core
  2. producing conformationally constrained analogues using bend-forming amino acid mimetics
  3. tailoring the resulting sequences to target tumour cells

 

EGF receptor

Currently we are using cell-permeant peptide delivery to 'interrogate' the EGF receptor's signal transduction pathways in live cells.  We are especially interested in the pathway leading to cell death in EGFR-overexpressors.  The peptides are designed to contain sequences that interfere with signals involving protein kinase enzymes and phosphotyrosine recognition by proteins containing SH2 and PDB domains.