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Selected Publications

Villarreal-Chiu, J.F., Quinn, J.P.and McGrath, J.W. (2012). The genes and enzymes of phosphonate metabolism by bacteria and their distribution in the marine environment. Frontiers in Microbiology 3:19.

Temperton, B., Thomas, S., Tait, K., Parry, H., Emery, M., Allen, M., Quinn, J.P., McGrath, J.W. and Gilbert, J.A. (2011). Permanent draft genome sequence of Vibrio tubiashii strain NCIMB 1337 (ATCC 19106). Standards in Genomic Sciences 4, 183-190.

McGrath,J.W., Hammerschmidt, F., Kaehlig, H., Wuggenig, F., Lamprecht, G. and Quinn, J.P. (2011). Studies on the biodegradation of fosfomycin: synthesis of 13C-labelled intermediates, feeding experiments with Rhizobium huakuii PMY1, and isolation of labeled amino acids from cell mass by HPLC.  Chemistry: a European Journal, 17: 13341-1348.

Kulakova, A.N., Hobbs, D., Smithen, M., Pavlov, E., Gilbert, J.A., Quinn, J.P. and McGrath, J.W. (2011). Direct quantification of inorganic polyphosphate in microbial cells using 4'-6-diamidino-2-phenylindole (DAPI).  Environmental Science and Technology, 45: 7799-7803.

Larsen, P.E., Collart, F.R., Field, D., Meyer, F., Keegan, K.P., Henry, C.S., McGrath, J.W., Quinn, J.P. and Gilbert, J.A. (2011). Predicting relative metabolomic turnover (PRMT) from a coastal marine metagenomic dataset.  Microbial Informatics and Experimentation, 1: 4.

Kim, A., Benning, M.M., Oklee, S., Quinn, J.P., Martin, B.M., Holden, H.M. and Dunaway-Mariano, D.D. (2011). Divergence of chemical function in the alkaline phosphatase superfamily: structure and mechanism of the P-C bond cleaving enzyme phosphonoacetate hydrolase.  Biochemistry - US, 50: 3481-3494.

Cooley, N.A., Kulakova, A.N., Villarreal-Chiu, J.F., Gilbert, J.A., McGrath, J.W. and Quinn, J.P. (2011). Phosphonoacetate biosynthesis: in vitro detection of a novel NADP+-dependent phosphonoacetaldehyde-oxidizing activity in cell-extracts of a marine Roseobacter.  Microbiology, 80: 335-340.

Lai, M. W-Y, Kulakova, A.N., Quinn, J.P. and McGrath, J.W. (2011). Stimulation of phosphate uptake and polyphosphate accumulation by activated sludge microorganisms in response to sulfite addition.  Water Science and Technology, 63: 649-653.

Temperton, B., Gilbert, J.A., Quinn, J.P. and McGrath, J.W. (2011). Novel analysis of oceanic surface water metagenomes suggests importance of polyphosphate metabolism in oligotrophic environments.  PLoS One, 6: e16499.

Thomas, S., Burdett, H., Wick, R., Snelling, D., McGrath J.W., Quinn, J.P., Munn, C. and Gilbert, J.A. (2010). Evidence for phosphonate usage in the coral holobiont.  ISME Journal, 4: 459-461.

McGrath, J.W., Hammerschmidt, F., Preusser, W., Quinn, J.P. and Schweifer, A. (2009). Studies on the biodegradation of fosfomycin: growth of Rhizobium huakuii PMY1 on possible intermediates synthesised chemically.  Organic and Biomolecular Chemistry, 7: 1944-1953.

Kulakova, A.N., Kulakov, L., Villarreal-Chiu, J.F., McGrath, J.W. and Quinn, J.P. (2009). Expression of the phosphonoalanine-degradative gene cluster from Variovorax sp. Pal2 is induced by growth on phosphonoalanine and phosphonopyruvate.  FEMS Microbiology Letters, 292: 100-106.

Kulakova, A.N., Kulakov, L., McGrath J.W., and Quinn, J.P.. (2009). The construction of a whole-cell biosensor for phosphonoacetate, based on the LysR-like transcriptional regulator PhnR from Pseudomonas fluorescens 23F.  Microbial Biotechnology, 2: 234-240.

Fankem, H., Ngo Nko, L., Deubel, A., Quinn, J.P., Merbach, W., Etoa, F-X. and Nwagad, D. (2008). Solubilization of inorganic phosphates and plant growth promotion by strains of Pseudomonas fluorescens isolated from acidic soils in Cameroon.  African Journal of Microbiology Research, 2: 171-178.

Gilbert, J.A., Thomas, S., Cooley, N.A. Kulakova, A.N., McGrath, J.W., Quinn, J.P. and Joint, I. (2009). Potential for phosphonate utilization by marine bacteria in temperate coastal waters.  Environmental Microbiology, 11: 111-125.

Buchberger, W., Ahrer, W., McGrath, J.W., Hammerschmidt, F., Preusser, W., and Quinn, J.P. (2008). Studies on the biodegradation of fosfomycin: growth of Rhizobium huakuii on possible intermediates synthesized chemically (submitted)

Quinn, J.P., Kulakova, A.N., Cooley, N.A. & McGrath, J.W. (2007). New ways to break an old bond: the bacterial carbon-phosphorus hydrolases and their role in biogeochemical phosphorus cycling.  Environmental Microbiology, 9: 2392-2400.

Quinn, J.P. (2007). Uncharted route for antibiotics.  Nature, 448: 415-416.

McNicholl, B.P., McGrath, J.W. & Quinn, J.P. (2007). Development and application of a resazurin-based biomass activity test for activated sludge plant management.  Water Research, 41: 127-133.

Tobin, K.M., McGrath, J.W., Mullan, A.M., Quinn, J.P. & O'Connor, K.E. (2007). Polyphosphate accumulation by Pseudomonas putida CA-3 and other medium chain length polyhydroxyalkanoate-accumulating bacteria under aerobic growth conditions.  Applied and Environmental Microbiology, 73: 1383-1387.

Moriarty, T.F., Mullan, A., McGrath, J.W., Quinn, J.P., Elborn, J.S. & Tunney, M.M. (2006). Effect of reduced pH on inorganic polyphosphate accumulation by Burkholderia cepacia complex isolates.  Letters in Applied Microbiology, 42: 617-623.

Chen, C.C.H., Han, Y., Niu, W., Kulakova, A.N., Howard, A., Quinn, J.P., Dunaway-Mariano, D. & Herzberg, O. (2006). Structure and kinetics of phosphonopyruvate hydrolase from Variovorax sp. Pal2: new insight into the divergence of catalysis within the PEP mutase/isocitrate lyase superfamily.  Biochemistry-US, 45: 11491-11504.

Mullan, A., Quinn, J.P. & McGrath, J.W. (2006). The application of low pH- inducible polyphosphate accumulation by environmental microorganisms to biological phosphate removal from wastewaters: a field study. (Environmental Science and Technology: in press)

McGrath, J.W., Kulakova, A.N., Kulakov, L.A. & Quinn, J.P. (2005). In vitro detection and characterization of a polyphosphate-synthesizing activity in the yeast Candida humicola G1.  Research in Microbiology, 156: 485-491.

McCluskey, C., Quinn, J.P. and McGrath, J.W. (2004). An evaluation of three 'new-generation' tetrazolium salts for the measurement of respiratory activity in activated sludge microorganisms.  Microbial Ecology, 49: 379-387.

McGrath, J.W. and Quinn, J.P. (2004). Biological Phosphorus Removal. In Phosphorus in Environmental Technology pp. 272-286 Ed Valsami-Jones, E. IWA Publishing.

Kulakova, A.N., Wisdom, G.B., Kulakov, L. and Quinn, J.P. (2003). The purification and characterization of phosphonopyruvate hydrolase, a novel carbon-phosphorus bond cleavage enzyme from Variovorax sp. Pal2. Journal of Biological Chemistry, 278: 23426 - 23431.

McGrath, J.W. and Quinn, J.P. (2003). Microbial Phosphate Removal and Polyphosphate Production from Wastewaters. Advances in Applied Microbiology, Vol 52: 75 - 100.

Mullan, A., Quinn, J.P. and McGrath, J.W. (2002). A non-radioactive method for the assay of polyphosphate kinase activity and its application in the study of polyphosphate metabolism in Burkholderia cepacia.  Analytical Biochemistry, 308: 294-299.

Mullan, A., Quinn J.P. and McGrath, J.W. (2002). Enhanced phosphate uptake and polyphosphate accumulation in Burkholderia cepacia grown under low pH conditions. Microbial Ecology, 44(1): 69-77.

Mullan, A., Quinn, J.P. and McGrath, J.W. (2002). Phosphate Removal from Wastewaters: A Novel Approach. Chemical Engineering and Technology (Engineering in Life Sciences), 2: 63-66.

McGrath, J W, Cleary S, Mullan A, and Quinn, J.P. (2001). Acid-stimulated phosphate uptake by activated sludge microorganisms under aerobic laboratory conditions. Water Research, 35(18): 4317 - 4322.

Mullan, A., Quinn, J.P. and McGrath, J.W. (2001). Phosphate removal from wastewaters. In Removal of Phosphorus and Recovery from Sludge (Horan N.J. ed.) Aqua Enviro Technology Transfer, Leeds, UK.

Kulakova, A.N., Kulakov, L., Akulenko, N.V., Ksenzenko, V.N., Hamilton, J.T.G., and Quinn, J.P. (2001). Structural and functional analysis of the phosphonoacetate hydrolase gene region in Pseudomonas fluorescens 23F. Journal of Bacteriology, 183: 3268-75.

McGrath, J.W. and Quinn, J.P. (2000). Intracellular accumulation of polyphosphate by the yeast Candida humicola G-1 in response to acid pH. Applied and Environmental Microbiology, 66: 4068 - 4073.

Ternan, N.G., Hamilton, J.T.G. and Quinn, J.P. (2000). Initial in vitro characterization of phosphonopyruvate hydrolase, a novel phosphate starvation-independent carbon-phosphorus bond cleavage enzyme in Burkholderia cepacia Pal6. Archives of Microbiology, 173: 35-41.

McGrath J. W., Kulakova, A.N. and Quinn, J.P. (1999). A comparison of three bacterial phosphonoacetate hydrolases from different environmental sources. Journal of Applied Microbiology, 86: 834-840.

Ternan, N. G., McGrath, J.W. and Quinn, J.P. (1998). Phosphoenolpyruvate phosphomutase activity in an L-phosphonoalanine mineralizing strain of Burkholderia cepacia.  Applied and Environmental Microbiology, 64: 2291-2294.

McGrath, J.W., Hammerschmidt, F. and Quinn, J.P. (1998). Biodegradation of phosphonomycin by Rhizobium huakuii PMY1. Applied and Environmental Microbiology, 64: 356-358.

Ternan, N. G., McGrath, J.W., McMullan G. and Quinn, J.P. (1998). Organophosphonates: occurrence, synthesis and biodegradation by microorganisms. World Journal of Microbiology and Biotechnology, 14: 635-647.

McGrath, J.W., Ternan, N. G. and Quinn, J.P. (1997). Utilization of organophosphonates by environmental microorganisms. Letters in Applied Microbiology, 24: 69-73.

McGrath, J.W., Wisdom, G. B., McMullan, G., Larkin, M.J. and Quinn, J.P. (1995). The purification and properties of phosphonoacetate hydrolase, a novel carbon-phosphorus bond-cleaving enzyme from Pseudomonas fluorescens 23F. European Journal of Biochemistry, 234: 225-230.

McGrath, J.W. and Quinn, J.P. (1995). A plate assay for the detection of organophosphonate mineralisation by environmental bacteria and its modification as an activity stain for identification of the carbon-phosphorus bond cleaving enzyme phosphonoacetate hydrolase. Biotechnology Techniques, 9: 497-502.

Conference Presentations

Quinn, J.P., Kulakova, A.N., Cooley, N.A. and McGrath, J.W. (2008). New ways to break an old bond: the role of the carbon-phosphorus hydrolases in biogeochemical phosphorus cycling. Society of General Microbiology, Edinburgh.

Kulakova, A.N., McAreavy, O.R., McGrath, J.W. and Quinn, J.P. (2007). Use of a GFP-based whole-cell biosensor to detect organophosphonate residues in the environment. Society for General Microbiology, Belfast.

MacCombe, D. Mullan, A. Cooper, S.J. Quinn, J.P. and McGrath, J.W. (2007). Biological phosphate removal from wastewaters: a pilot plant study of a novel approach. Society for General Microbiology, Belfast.

MacCombe, D., Mullan, A. Cooper, S.J. Quinn, J.P. and McGrath, J.W. (2007). Low pH-induced phosphate removal and polyphosphate accumulation in microorganisms. Society for General Microbiology, Belfast.

MacCombe, D., Mullan, A., Cooper, S.J., Quinn, J.P. and McGrath, J.W. (2004). Low pH-induced polyphosphate accumulation in microorganisms. 10th International Symposium on Microbial Ecology, Cancun, Mexico.

MacCombe, D., Mullan, A., Cooper, S.J., Quinn, J.P. and J. W. McGrath (2004). Biological phosphate removal from wastewaters: 10th International Symposium on Microbial Ecology, Cancun, Mexico.

Mullan, A., Cooper, S.J., Quinn, J.P. and McGrath, J.W. (2004). Low pH-induced phosphate removaland polyphosphate accumulation in microorganisms. 5th UK Meeting IWA UK Young Researchers Conference.

Mullan, A., Cooper, S.J., Quinn, J.P. and McGrath, J.W. (2004). Biological Phosphate Removal from Wastewaters: a pilot plant study of a novel approach. 5th UK Meeting IWA UK Young Researchers Conference.

Mullan, A., Cooper, S.J., Quinn, J.P. and McGrath, J.W. (2003). Low pH-induced polyphosphate accumulation in environmental microorganisms. 11th European Congress on Biotechnology, Basel, Switzerland.

Kulakova, A.N. Wisdom, G.B. and Quinn, J.P. (2003). Phosphonopyruvate hydrolase - a novel bacterial carbon-phosphorus bond cleavage enzyme. Society for General Microbiology, University of Warwick.

Mullan, A., Cooper, S.J., Quinn, J.P. and McGrath, J.W. (2003). Biological phosphate removal from wastewaters: a pilot plant study (2003) 11th European Congress on Biotechnology, Basel, Switzerland.

McGrath, J.W., Quinn, J.P., and Hammerschmidt, F. (2002). Use of stable isotopes for the biosynthesis and biodegradation of phosphonomycin, International Isotope Society, Germany.

Mullan, A., Quinn, J.P. and McGrath, J.W. (2001). Enhanced phosphate removal and polyphosphate accumulation in Burkholderia cepacia during growth at low pH. American Society for Microbiology San Juan, Puerto Rico.

McGrath, J.W. and Quinn, J.P. (2000). Phosphate removal from wasewaters. American Society for Microbiology, Los Angeles, California.

Quinn, J.P. (1998). Carbon-phosphorus and carbon-arsenic bond cleavage activities in environmental pseudomonads. Society for General Microbiology Symposium, University of East Anglia.

McGrath, J.W. and Quinn, J.P. (1997). Regulation of C-P Bond Cleavage in Environmental Bacteria, Society for General Microbiology Symposium, University College Dublin.

King, J.E. and Quinn, J.P. (1997). Carbon-sulphur bond cleavage by environmental bacteria Society for General Microbiology Symposium, University College Dublin.

Quinn, J.P. and McMullan, G. (1997). The biodegradation of organoarsenicals by an environmental bacterial isolate. Society for General Microbiology Symposium, University College Dublin.

Ternan, N.G., McGrath, J.W. and Quinn, J.P (1997). Metabolism of phosphonoalanine by Burkholderia cepacia. Society for General Microbiology Symposium, University College Dublin.

McGrath, J.W. and Quinn, J.P. (1997). Carbon-Phosphorus Bond Cleavage - A Novel Mechanism of Bacterial Resistance to the Organophosphonate Antibiotic Phosphonomycin, Society for General Microbiology Symposium, University of Limerick.

McGrath, J.W. and Quinn, J.P. (1995). A Comparison of the Phosphonoacetate Hydrolase Activities From Three Environmental Bacterial, American Society for Microbiology / Society for General Microbiology Joint Symposium, Aberdeen.