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Selected Publications

Books / editorial

"Antimicrobial peptides: utility players in innate immunity" (2012). Edited by Robinson, M.W., Hutchinson, A.T & Donnelly, S.  Frontiers in Molecular Innate Immunity.

"Cysteine Proteases of Pathogenic Organisms" (2011). Edited by Robinson, M.W. & Dalton, J.P.  Landes Bioscience Publishers, Austin, USA.

Book chapters / invited reviews

Robinson, M.W., Donnelly, S. & Dalton, J.P. (2013). Helminth defence molecules – immunomodulators designed by parasites!  Frontiers in Microbiology, 4 (Article 296): 1-4.

Dalton, J.P., Robinson, M.W., Mulcahy, G., O’neill, S.M. & Donnelly, S. (2013). Immunomodulatory Molecules of Fasciola hepatica: Candidates for Both Vaccine and Immunotherapeutic Development.  Veterinary Parasitology, 195(3-4): 272-285.

Robinson, M.W., Dalton, J.P., O’Brien, B.A. & Donnelly, S. (2013). Fasciola hepatica: the therapeutic potential of a worm secretome.  International Journal for Parasitology, 43 (3-4), 283-291.

Cotton, S., Donnelly, S., Robinson, M.W., Dalton, J.P. & Thivierge, K. (2012). Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?  Frontiers in Immunology, 3: (Article 269), 1-7.

Mcveigh, P., Maule, A.G. Dalton, J.P. & Robinson, M.W. (2012). Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective.  Microbes and Infection, 14: 301-310.

Robinson, M.W., Brindley, P.J., Mckerrow, J.H. & Dalton, J.P. (2011). Trematode cysteine endopeptidases. In "Handbook of Proteolytic Enzymes".  N.D. Rawlings & G. Salveson eds.  Elsevier Academic Press, London, UK.

Dalton, J.P., Robinson, M.W. & Brindley, P.J. (2011). Cathepsin W. In "Handbook of Proteolytic Enzymes".  N.D. Rawlings & G. Salveson eds.  Elsevier Academic Press, London, UK.

Robinson, M.W., Dalton, J.P., O'Neill, S.M. & Donnelly, S.M. (2011). Mechanisms of immune modulation by Fasciola hepatica: importance for vaccine development and for novel immunotherapeutics. In "Chemo- and Immuno-therapeutic Advances for Treatment and Control of Helminthic Infections".  C.R. Caffrey ed. Wiley, Hobroken, USA.

Donnelly, S., Dalton, J.P. & Robinson, M.W. (2011). How pathogen-derived cysteine proteases modulate host immune responses. In "Cysteine Proteases of Pathogenic Organisms".  M.W. Robinson & J.P. Dalton eds. Landes Bioscience, Austin, USA.

Stack, C.M., Dalton, J.P. & Robinson, M.W. (2011). The phylogeny, structure and function of trematode cysteine proteases, with particular emphasis on the Fasciola hepatica cathepsin L family. In "Cysteine Proteases of Pathogenic Organisms".  M.W. Robinson & J.P. Dalton eds. Landes Bioscience, Austin, USA.

Robinson, M.W., Hutchinson, A.T., Donnelly, S. & Dalton, J.P. (2010). Worm secretory proteins are causing alarm.  Trends in Parasitology, 26(8): 371-372.

Robinson, M.W., Hutchinson, A.T., Dalton, J.P. & Donnelly, S. (2010). Peroxiredoxin: a central player in immune modulation.  Parasite Immunology, 32(5): 305-313.

Trenholme, K.R., Brown, C.L., Skinner-Adams, T.S., Stack, C., Lowther, J.,To, J., Robinson, M.W., Donnelly, S.M., Dalton, J.P. & Gardiner, D.L. (2010). Aminopeptidases of malaria parasites: New targets for chemotherapy.  Infectious Disorders Drug Targets, 10(3): 217-225.

Robinson, M.W.& Dalton, J.P. (2009). Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases.  Philosophical Transactions of the Royal Society B, 364: 2763-2776.

Dalton, J.P., Brindley, P.J., Donnelly, S. & Robinson, M.W.(2009). The enigmatic asparaginyl endopeptidase of helminth parasites.  Trends in Parasitology, 25(2): 59-61.

Robinson, M.W., Dalton, J.P. & Donnelly, S. (2008). Helminth pathogen cathepsin proteases: it's a family affair.  Trends in Biochemical Sciences, 33(12): 601-608.

Brennan, G.P., Fairweather, I., Trudgett, A., Hoey, E., McCoy, M., McConville, M., Meaney, M., Robinson, M.W., McFerran, N., Ryan, L., Lanusse, C., Mottier, L., Alvarez, L., Solana, H., Virkel, G., & Brophy, P.M. (2007). Understanding triclabendazole resistance.  Experimental and Molecular Pathology, 82(2): 104-109.

Research papers

Lund, M.E., O'Brien, B.A., Hutchinson, A.T., Robinson, M.W., Simpson, A.M., Dalton, J.P. & Donnelly, S. (2013). Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouse.  PLoS One, 9(1): e86289.

Thivierge, K., Cotton, S., Schaefer, D.A., Riggs, M.W., To, J., Lund, M.E., Robinson, M.W., Dalton, J.P. & Donnelly, S. (2013). Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation.  PLoS Neglected Tropical Diseases, 7(7): e2307.

Robinson, M.W., Buchtmann, K.A., Jenkins, C., Tacchi, J.L., Raymond, B.A., To, J., Chowdhury, P.R., Woolley, L.K., Labbate, M., Turnbull, L., Whitchurch, C.B., Padula, M., & Djordjevic, S. (2013). MHJ_0125 is a M42 glutamyl aminopeptidase that moonlights as a multifunctional adhesin on the surface of Mycoplasma hyopneumoniae.  Open Biology, 3: 130017.

Robinson, M.W., Alvarado, R., To, J., Hutchinson, A.T., Dowdell, S.N., Lund, M., Turnbull, L., Whitchurch, C.B., O`Brien, B.A., Dalton, J.P. & Donnelly, S. (2012). A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase.  The FASEB Journal, 26 (11): 4614-4627.

Jones, P.M., Robinson, M.W., Dalton, J.P. & George, A.M. (2011). The Plasmodium falciparum malaria M1 alanyl aminopeptidase (PfA-M1): insights of catalytic mechanism and function from MD simulations.  PLoS One, 6(12): e28589.

Sripa, J., Pinlaor, P., Brindley, P.J., Sripa, B., Kaewkes, S., Robinson, M.W., Young, N.D., Gasser, R.B., Loukas, A. & Laha, T. (2011). RNA interference targeting cathepsin B of the carcinogenic liver fluke, Opisthorchis viverrini.  Parasitology International, 60(3): 283-288.

Robinson, M.W., Donnelly, S., Hutchinson, A.T., To, J., Taylor, N.L., Norton, R.S., Perugini, M.A. & Dalton, J.P. (2011). A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides.  PLoS Pathogens, 7(5): e1002042.

Robinson, M.W., Corvo, I., Jones, P.M., George, A.M., Padula, M.P., To, J., Cancela, M., Rinaldi, G., Tort, J.F., Roche, L. & Dalton, J.P. (2011). Collagenolytic activities of the major secreted cathepsin L proteases involved in the virulence of the helminth pathogen, Fasciola hepatica.  PLoS Neglected Tropical Diseases, 5(4): e1012.

Sripa, J., Laha, T., To, J., Brindley, P.J., Sripa, B., Kaewkes, S., Dalton, J.P. & Robinson, M.W. (2010). Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B.  Cellular Microbiology, 12(6): 781-795.

Donnelly, S., O'Neill, S.M., Stack, C.M., Robinson, M.W., Turnbull, L., Whitchurch, C. & Dalton, J.P. (2010). Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3.  Journal of Biological Chemistry, 285(5) 3383-3392.

Maric, S., Donnelly, S., Robinson, M.W., Stack, C.M., Trenholme, K.R., Gardiner, D.L., Dalton, J.P. & Lowther, J. (2009). The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: the importance of active site metal ions in the binding of substrates and inhibitors.  Biochemistry, 48(23): 5435-5439.

Robinson, M.W., Menon, R., Donnelly, S.M., Dalton, J.P. & Ranganathan, S. (2009). An integrated transcriptomic and proteomic analysis of the secretome of the helminth pathogen, Fasciola hepatica: proteins associated with invasion and infection of the mammalian host.  Molecular and Cellular Proteomics, 8(8): 1891-1907.

Pinlaor, P., Kaewpitoon, N., Laha, T., Sripa, B., Kaewkes, S., Morales, M.E., Mann, V.H., Parriott, S.K., Suttiprapa, S., Robinson, M.W., To, J., Dalton, J.P., Loukas, A. & Brindley, P.J. (2009). Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini.  PLoS Neglected Tropical Diseases, 3(3): e398.

Bolas-Fernández, F., Dea-Ayuela, M.A., Connolly, B. & Robinson, M.W. (2009). Micro-environmental conditions modulate protein secretion and infectivity of the Trichinella spiralis L1 larva.  Veterinary Parasitology, 159(3-4): 236-239.

Cwiklinski, K., Meskill, D., Robinson, M.W., Pozio, E., Appleton, J.A. & Connolly, B. (2009). Cloning and analysis of a Trichinella pseudospiralis muscle larva secreted serine protease gene.  Veterinary Parasitology, 159(3-4): 268-271.

Lowther, J., Robinson, M.W., Donnelly, S.M., Xu, W., Stack, C.M., Matthews, J.M. & Dalton. J.P. (2009). The importance of pH in regulating the function of Fasciola hepatica cathepsin L1 cysteine protease.  PLoS Neglected Tropical Diseases, 3(1): e369.

Robinson, M.W., Tort, J.F., Wong, E., Donnelly, S.M., Lowther, J., Xu, W., Stack, C.M., Padula, M., Herbert, B. & Dalton, J.P. (2008). Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen, Fasciola hepatica: expansion of a repertoire of virulence-associated factors.  Molecular and Cellular Proteomics, 7(6): 1111-1123.

Stack, C.M., Caffrey, C.R., Donnelly, S.M., Seshaadri, A., Lowther, J., Tort, J.F., Collins, P.R., Robinson, M.W., Xu, W., Mckerrow, J.H., Geiger, S., Marion, R., Brinen, L.S. & Dalton, J.P. (2008). Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica.  Journal of Biological Chemistry, 283(15): 9896-9908.

Ryan, L., Hoey, E.M., Trudgett, A., Fairweather, I., Fuchs, M., Robinson, M.W., Chambers, E., Timson, D., Ryan, E., Feltwell, T., Ivans, A., Bentley, G. & Johnston, D. (2008). Fasciola hepatica expresses multiple α- and β-tubulin isotypes.  Molecular and Biochemical Parasitology, 159(1): 73-78.

Robinson, M.W., Massie, D., & Connolly, B. (2007). Secretion and post-translational processing of a novel multi-domain cystatin-like protein by intracellular stages of Trichinella spiralis.  Molecular and Biochemical Parasitology, 151(1): 9-17.

Robinson, M.W., Greig, R., Beattie, K., Lamont, D. & Connolly, B. (2007). Comparative analysis of the excretory-secretory proteome of the muscle larva of Trichinella pseudospiralis and Trichinella spiralis.  International Journal for Parasitology, 37(2): 139-148.

Robinson, M.W. & Connolly, B. (2005). Proteomic analysis of the excretory-secretory proteins of the Trichinella spiralis L1 larva, a nematode parasite of skeletal muscle.  Proteomics, 5(17): 4525-4532.

Robinson, M.W., Gare, D. & Connolly, B. (2005). Profiling excretory-secretory proteins of Trichinella muscle larvae by 2-dimensional gel electrophoresis and mass spectrometry.  Veterinary Parasitology, 132(1-2): 37-41.

Robinson, M.W., McFerran, N., Trudgett, A., Hoey, L., Fairweather, I. (2004). A possible model of benzimidazole binding to beta-tubulin disclosed by invoking an inter-domain movement.  Journal of Molecular Graphics and Modelling, 23(3): 275-284.

Fletcher, H.L., Hoey, E.M., Orr, N., Trudgett, A., Fairweather, I. & Robinson, M.W. (2004). The occurrence and significance of triploidy in the liver fluke, Fasciola hepatica.  Parasitology, 128(1): 1-4.

Robinson, M.W., Lawson, J., Trudgett, A., Hoey, E.M. & Fairweather, I. (2003). The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica.  Parasitology Research, 92(3): 205-210.

Robinson, M.W., Trudgett, A., Hoey, E.M. & Fairweather, I. (2003). The effect of the microtubule inhibitor tubulozole-C on the tegument of triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica.  Parasitology Research, 91(2): 117-129.

Robinson, M.W., Trudgett, A., Fairweather, I. & McFerran, N. (2002). Benzimidazole binding to Haemonchus contortus tubulin: a question of structure.  Trends in Parasitology, 18(4): 153-154.

Robinson, M.W., Trudgett, A., Hoey, E.M. & Fairweather, I. (2002). Triclabendazole-resistant Fasciola hepatica: β-tubulin and response to in vitro treatment with triclabendazole.  Parasitology, 124: 325-338.

Robinson, M.W., Colhoun, L.M., Fairweather, I., Brennan, G.P. & Waite, J.H. (2001). Development of the vitellaria of the liver fluke, Fasciola hepatica in the rat host.  Parasitology, 123: 509-518.

Robinson, M.W., Hoey, E.M., Fairweather, I., Dalton, J.P., Mcgonigle, S. & Trudgett, A. (2001). Characterisation of a β-tubulin gene from the liver fluke, Fasciola hepatica.  International Journal for Parasitology, 31(11): 1264-1268.