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Selected Publications

Atkinson, L.E., Stevenson, M., McCoy, C.J., Marks, N.J., Fleming, C., Zamanian, M., Day, T.A., Kimber, M.J, Maule, A.G., Mousley, A. (2013). Flp-32 Ligand/receptor silencing phenocopy faster plant pathogenic nematodes.  PLoS Pathog., 2013 Feb;9(2):e1003169. doi: 10.1371/journal.ppat.1003169.

McVeigh, P., Maule, A.G., Dalton, J.P., Robinson, M.W. (2012). Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective.  Microbes and Infections, 14(4): 301-10.  doi: 10.1016/j.micinf.2011.11.012.

Morphew, R.M., Eccleston, N., Wilkinson, T.J., McGarry, J., Perally, S., Prescott, M., Ward, D., Williams, D., Paterson, S., Raman, M., Ravikumar, G., Khalid,Saifullah, M., Abbas Abidi, S.M., McVeigh, P., Maule, A.G., Brophy, P.M., LaCourse, E.J. (2012). Proteomics and in silico approaches to extend understanding of the glutathione transferase superfamily of the tropical liver fluke Fasciola gigantica.  Journal of Proteome Research, 11(12): 5876-89.  doi: 10.1021/pr300654w.

Dalzell, J.J., Warnock, N.D., McVeigh, P., Marks, N.J., Mousley, A., Atkinson, L.E. & Maule, A.G. (2012). Considering RNAi experimental design in parasitic helminths.  Parasitology epub, 1-16.

Ashby, J.A., Stevenson, C.E.M., Jarvis, G.E., Lawson, D.M., Maule, A.G. (2011) Structure-based mutational analysis of eIF4E in relation to sbm1 resistance to peas seed-borne mosaic virus in pea.  PLos ONE, 6.

Maule, A.G., McVeigh P., Dalzell J.J., Atkinson, L., Mousley A., Marks N.J. (2011) An eye on RNAi in nematode parasites.  Trends in Parasitology, 27: 505-513.

Zamanian M., Kimber M., McVeigh P., Carlson M., Maule, A.G.. Day, T.A. (2011) The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea.  BMC Genomics, 12: 596-602.

McVeigh P., Mair G.M., Novozhilova, E., Day, A., Zamanian, M., Marks, N.J., Kimber, M.J., Day, T.A., Maule, A.G. (2011). Schistosome I/Lamides - A New Family of Bioactive Helminth Neuropeptides.  International Journal for Parasitology, 41: 905-13.

Dalzell, J.J., McVeigh, P., Warnock, N.D., Mitreva, M., Bird, D. McK., Abad, P. Fleming, C.C., Day, T.A., Mousley, A., Marks, N.J., Maule, A.G. (2011). RNAi effector diversity in nematodes.  PLoS Neglected Tropical Diseases, 5: e1176.

Pierson, L., Mousley, A., Divine, L., Day, T.A., Marks, N.J., Maule, A.G. (2010). RNA interference in a cestode reveals specific silencing of selected highly expressed gene transcripts.  International Journal for Parasitology, 40: 605-615.

Novozhilova, E., Kimber, M.J., McVeigh, P., Zamanian, M., Maule, A.G., Day, T.A. (2010). FMRFamide-like peptides (FLPs) enhance voltage-gated calcium currents to elicit muscle contraction in the human parasite Schistosoma mansoni.  PLoS Neglected Tropical Diseases, 4(8): e790.

Dalzell, J.J., Warnock, N.D., Stevenson, M.A., Mousley, A., Fleming, C.C., Maule, A.G. (2010). Short interfering RNA-mediated knockdown of drosha and pasha in undifferentiated Meloidogyne incognita eggs leads to irregular growth and embryonic lethality.  International Journal for Parasitology, 40: 1303-10.

Dalzell, J.J., McMaster, S., Fleming, C.C., Maule, A.G. (2010). siRNA-mediated gene silencing in Globodera pallida and Meloidogyne incognita infective stage juveniles.  International Journal for Parasitology, 40: 91-100.

McVeigh, P., Mair, G., Atkinson, L., Zamanian, M., Ladurner, P., Novozhilova, E., Marks, N.J., Day, T.A., Maule, A.G. (2009). Discovery of multiple neuropeptide families in phylum Platyhelminthes.  International Journal for Parasitology, 39: 1243-52.

Dalzell, J.J., McMaster, S., Johnston, M.J., Kerr, R., Fleming, C.C., Maule, A.G. (2009). Non-nematode-derived double stranded RNAs induce profound phenotypic changes in Meloidogyne incognita and Globodera pallida infective juveniles.  International Journal for Parasitology, 39: 1503-16.

McGonigle, L., Mousley, A., Marks, N.J., Brennan, G.P., Dalton, J.P., Spithill, T.W., Day, T.A., Maule, A.G. (2008). The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference.  International Journal for Parasitology, 38(2): 149-155.

Abad, P., Aury, J-M., Castagnone-Sereno, P., Danchin, E.G.J., Deleury, E., Gouzy, J., Anthouard, V., Artiguenave, F., Blok, V.C., Caillaud, M-C., Coutinho, P.M., Dasilva, C., De Luca, F., Deau, F., Esquibet, M., Favery, B., Flutre, T., Goldstone, J.V., Hamamouch, N., Hewezi, T., Jaillon, O., Jubin, C., Leonetti, P., Magliano, M., Maier, T.R., Markov, G., McVeigh, P., Perfus-Barbeoch, L., Pesole, G., Poulain, J., Robinson-Rechavi, M., Rosso, M-N., Sallet, E., Ségurens, B., Smant, G., Steinbach, D., Tytgat, T., Ugarte, E., van Ghelder, C., Veronico, P., Baum, T.J., Blaxter, M., Bleve-Zacheo, T., Davis, E.L., Ewbank, J.J., Grenier, E., Henrissat, B., Jones, J.T., Laudet, V., Maule, A.G., Quesneville, H., Schiex, T., Weissenbach, J. and Wincker, P. (2008). Plant parasitism in metazoans: insight from the Meloidogyne incognita nematode genome.  Nature Biotechnology, 26(8): 909-915.

Kreshchenko, N., Sedelnikov, Z., Sheiman, I.M., Reuter, M., Maule, A.G., Gustafsson, M.K. (2008). Effects of neuropeptide F on regeneration in Girardia tigrina (Platyhelminthes).  Cell and Tissue Research, 331: 739-50.

McVeigh, P., Alexander-Bowman, S., Kidd, E., Mousley, A., Marks, N.J., Maule, A.G. (2008). Neuropeptide-like protein diversity in phylum Nematoda.  International Journal for Parasitology, 38(13): 1493-1503.

Kimber, M.J., McKinney, S., McMaster, S.M., Day, T.A., Fleming, C.C. and Maule, A.G. (2007). flp Gene disruption in a parasitic nematode reveals motor dysfunction and neuronal sensitivity to RNA interference.  FASEB Journal, 21(4): 1233-43.

McVeigh, P., Leech, S., Marks, N.J., Geary, T.G. and Maule, A.G. (2006). Gene expression and pharmacology of nematode NLP-12 neuropeptides.  International Journal for Parasitology, 36: 633-40.

Mousley, A., Marks, N.J. and Maule, A.G. (2006). Parasitic Nematode Peptides.  In: Handbook of Biologically Active Peptides. Elsevier.

McVeigh, P., Geary, T.G., Marks, N.J. and Maule, A.G. (2006). The FLP-side of nematodes.  Trends in Parasitology, 22: 385-96.

McVeigh, P., Leech, S., Mair, G.R., Marks, N.J., Geary, T.G. and Maule, A.G. (2005). Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda.  International Journal for Parasitology, 35: 1043-1060.

Mousley, A., Moffett, C.L., Duve, H., Thorpe, A., Halton, D.W., Geary, T.G., Thompson, D.P., Maule, A.G. and Marks, N.J. (2005). Expression and bioactivity of allatostatin-like neuropeptides in helminths.  International Journal for Parasitology, 35: 1557-67.

Mousley, A., Maule, A.G., Halton, D.W. and Marks, N.J. (2005). Inter-phyla studies on neuropeptides: the potential for broad spectrum anthelmintic and/or endectocide discovery.  Parasitology, 131: S143-67.

Maule, A.G., Marks, N.J. and Day, T.A. (2005). Signalling Molecules and Nerve-Muscle Function.  In: Parasitic Flatworms: Molecular Biology, Biochemistry, Immunology and Physiology.  CABI Publishing.

Mousley, A., Marks, N.J., Maule, A.G. (2004). Neuropeptide signalling: A repository of targets for novel endectocides?  Trends in Parasitology, 20: 482-7.

Humphries, J.E., Kimber, M.J., Barton, E., Hsu, W., Marks, N.J., Greer, B., Harriott, P., Maule, A.G., Day, T.A. (2004). Structure and bioactivity of neuropeptide F from the human parasites Schistosoma mansoni and Schistosoma japonicum.  The Journal of Biological Chemistry, 279: 39880-5.

Mousley, A., Marks, N.J., Halton, D.W., Geary, T.G., Thompson, D.P., Maule, A.G. (2004). Arthropod FMRFamide-related peptide modulate muscle activity in helminths.  International Journal for Parasitology, 34: 755-768.

Collins, P.R., Stack, C.N., O'Neill, S.M., Doyle, S., Ryan, T., Brennan, G.P., Mousley, A., Stewart, M, Maule, A.G., Dalton, J.P., Donnelly, S. (2004). Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells.  The Journal of Biological Chemistry, 279: 17038-46.

Halton, D.W. and Maule, A.G. (2004). Flatworm nerve and muscle: structural and functional analysis.  Canadian Journal of Zoology, 82: 316-333.

Mair, G.R., Niciu, M.J., Stewart, M.T., Brennan, G., Omar, H., Halton, D.W., Mains, R., Eipper, B.A., Maule, A.G. and Day, T.A. (2004). A functionally atypical amidating enzyme from the human parasite Schistosoma mansoni.  The FSAEB Journal, 18(1): 114-21.

McCarthy, E., Stack, C., Donnelly, S.M., Doyle, S., Mann, V.H., Brindley, P.J., Stewart, M., Day, T.A., Maule, A.G. and Dalton, J.P. (2004). Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum.  International Journal for Parasitology, 34: 703-13.

Hrckova, G., Velebný, S., Halton, D.W., Day, T.A. and Maule, A.G. (2004). Pharmacological characterisation of neuropeptide F (NPF)-induced effects on the motility of Mesocestoides corti (syn. M. vogae) larvae.  International Journal for Parasitology, 34(1): 83-93.

Raikova, O.I., Reuter, M., Gustafsson, M.K.S., Maule, A.G., Halton, D.W., Jondelius, U. (2004). Basiepidermal system in Nemertoderma westbladi (Nemertodermatida): GYIRFamide immunoreactivity.  Zoology, 107: 75-86.

Zurawski, T.H., Mair, G.R., Maule, A.G., Gelnar, M. and Halton, D.W. (2003). Microscopical evaluation of neural connectivity between paired stages of Eudiplozoon nipponicum (Monogenea: Diplozoidae).  Journal of Parasitology, 89: 198-200.

Curry, W.J., McCollum, A.P., Brockbank, S., Gardiner, T.A., Maule, A.G. and Stitt, A.W. (2003). Characterisation of WE-14 in porcine ocular tissue.  Regulatory Peptides, 113: 41-47.

Zurawski, T.H., Mousley, A., Maule, A.G., Gelnar, M. and Halton, D.W. (2003). Cytochemical studies of the neuromuscular systems of the diporpa and juvenile stages of Eudiplozoon nipponicum (Monogenea: Diplozoidea).  Parasitology, 126: 349-57.

Dalton, J.P., O'Neill, S., Stack, C., Collins, P., Walsh, A., Sekiya, M., Doyle, S., Mulcahy, G., Hoyle, D., Khaznadji, E., Moiré N, Brennan, G., Mousley, A., Kreshchenko, N., Maule, A.G. and Donnelly, S.M. (2003). Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines.  International Journal for Parasitology, 33: 1173-81.

Mair, G.R., Maule, A.G., Fried, B., Day, T.A. and Halton, D.W. (2003). Organization of the musculature of schistosome cercariae.  Journal of Parasitology, 89: 623-625.

Moffett, C.L., Beckett, A.M., Mousley, A., Marks, N.J., Thompson, D.P., Geary, T.G., Halton, D.W. and Maule, A.G. (2003). The ovijector of Ascaris suum: multiple response types revealed by C. elegans FMRFamide-related peptides.  International Journal for Parasitology, 33: 859-876.

Maule, A.G., Mousley, A., Marks, N.J., Day, T.A., Thompson, D.P., Geary, T.G. and Halton, D.W. (2002). Neuropeptide Signaling Systems - Potential Drug Targets for Parasite and Pest Control.  Current Topics in Medicinal Chemistry, 2(7): 733-758.

Hrckova, G., Maule, A.G., Velebný, S. and Halton, D.W. (2002). Mesocestoides corti (syn. M. vogae): modulation of larval motility by neuropeptides, serotonin and acetylcholine.  Parasitology, 124: 409-421.

Kimber, M.J., Fleming, C.C., Prior, A., Jones, J.T., Halton, D.W. and Maule, A.G. (2002). Localisation of Globodera pallida FMRFamide-related peptide encoding genes using in situ hybridization.  International Journal for Parasitology, 32: 1095-105.

Dougan, P.M., Mair, G.R., Halton, D.W., Curry, W.J., Day, T.A. and Maule, A.G. (2002). Gene organization and expression of a neuropeptide Y homolog from the land planarian, Arthurdendyus triangulatus.  The Journal of Comparative Neurology, 454: 58-64.

Bowman, J.W., Friedman, A.R., Thompson, D.P., Maule, A.G., Alexander-Bowman, S. and Geary, T.G. (2002). Structure-activity relationships of an inhibitory nematode FMRFamide-related peptide, SDPNFLRFamide (PF1), on Ascaris suum muscle.  International Journal for Parasitology, 32: 1765-72.

Gustafsson, M.K.S., Terenina, N.B., Kreshchenko, N.D., Reuter, M., Maule, A.G. and Halton, D.W. (2001). Comparative study of the spatial relationship between nicotinamide adeninedinucleotide phosphate-diaphorase activity, serotonin immunoreactivity, GYIRFamide immunoreactivity and the musculature of the adult liver fluke Fasciola hepatica (Digenea, Fasciolidae).  Journal of Comparative Neurology, 429: 71-79.

Moneypenny, C.G., Kreshchenko, N., Moffett, C.L., Halton, D.W., Day, T.A. and Maule, A.G. (2001). Physiological effects of FMRFamide-related peptides and classical transmitters on dispersed muscle fibres of the turbellarian, Procerodes littoralis.  Parasitology, 122: 447-455.

Zurawski, T.H., Mousley, A., Mair, G., Brennan, G.P., Maule, A.G., Gelnar, M. and Halton, D.W. (2001). Immunomicroscopical observations on the nervous system of adult Eudiplozoon nipponicum (Monogenea: Diplozoidae).  International Journal for Parasitology, 31: 783-792.

Reuter, M., Raikova, O.I., Jondelius, U., Gustafsson, M.K.S., Maule, A.G. and Halton, D.W. (2001). Organisation of the nervous system in the Acoela: an immunocytochemical study.  Tissue and Cell, 33: 119-128.

Kimber, M.J., Fleming, C.C., Bjourson, A.J., Halton, D.W. and Maule, A.G. (2001). FMRFamide-related peptides in potato cyst nematodes.  Molecular and Biochemical Parasitology, 116: 199-208.

Norlen, P., Curry, W.J., Bjorkqvist, M., Maule, A.G., Cunningham, R.T., Hogg, R.B., Harriott, P., Johnston, C.F., Hutton,,J.C., Hakanson, R. (2001). Cell-specific processing of chromogranin A in endocrine cells of the rat stomach.  Journal of Histochemistry and Cytochemistry, 49: 9-18.

Marks, N.J., Shaw, C., Halton, D.W., Li, C., Thompson, D.P., Geary, T.G. and Maule, A.G. (2001). Isolation and pharmacology of AADGAPLIRFamide and SVPGVLRFamide from Caenorhabditis elegans.  Biochemical and Biophysical Research Communications, 286: 1170-1176.

Skelly, P.J., Dougan, P.M., Maule, A.G., Day, T.A. and Shoemaker, C.B. (2001). Cloning and characterization of a muscle isoform of a sodium potassium ATPase alpha subunit (SnaK1) from Schistosoma mansoni.  Parasitology, 123: 277-284.

Fellowes, RA, Maule, A.G., Marks, N.J. Geary, T.G., Thompson, D.P. and Halton, DW (2000). Nematode neuropeptide modulation of the vagina vera of Ascaris suum: in vitro effects of PF1, PF2, PF4 AF3 and AF4.  Parasitology, 120: 79-89.

Mair, G.R., Halton, D.W., Shaw, C. and Maule, A.G. (2000). The neuropeptide F (NPF) encoding gene from the cestode, Moniezia expansa.  Parasitology, 120: 71-77.

Day, T.A., Haithcock, J., Kimber, M. and Maule, A.G. (2000). Functional ryanodine receptor channels in flatworm muscle fibres.  Parasitology, 120: 417-422.

Mair, G.R., Maule, A.G., Day, T.A. and Halton, D.W. (2000). A confocal microscopical study of the musculature of adult Schistosoma mansoni.  Parasitology, 121: 163-170.

Fellowes, R.A., Maule, A.G., Martin, R.J., Geary, T.G., Thompson, D.P., Kimber, M.J., Marks, N.J. and Halton, D.W. (2000). Classical neurotransmitters in the ovijector of Ascaris suum: localisation and modulation of muscle activity.  Parasitology, 121: 325-336.

Biserova, N.M., Ducicheva, V.A., Terenina, N.B., Reuter, M., Halton, D.W., Maule, A.G. and Gustafsson, M.K. (2000). The nervous system of Amphilina foliacea (Platyhelminthes, Amphilina) an immunocytochemical, ultrastructural and spectrofluorometric study.  Parasitology, 121: 441-453.