Staff

• Dr. C.C.R. Allen
• Dr. J.H. Bothwell
• Dr. G.P. Brennan
• Dr. D. Campbell
• Dr. K. Campbell
• Dr. L. Connolly
• Dr. R.T. Cunningham
• Dr. M. Dean
• Dr. J.T.A. Dick
• Professor M.J. Dring
• Professor C.T. Elliott
• Professor R.W. Elwood
• Professor I. Fairweather
• Dr. K.D. Farnsworth
• Dr. H.L. Fletcher
• Dr. A. Galkin
• Dr. I.R. Grant
• Dr. B.D. Green
• Dr. J.E. Hallsworth
• Dr. Pat Harriott
• Dr. C. Harrod
• Dr. E.M. Hoey
• Dr. J.D.R. Houghton
• Professor W.G. Hutchinson
• Dr. K. King
• Dr. L. A. Kulakov
• Dr. H.P. Kunc
• Professor M.J. Larkin
• Dr. C.J. Law
• Dr. A. Longo
• Professor C.A. Maggs
• Dr. N.J. Marks
• Professor A.G. Maule
• Dr. J.W. McGrath
• Professor W.I. Montgomery
• Dr. M.H. Mooney
• Dr A. Mousley
• Dr. J. Nelson
• Dr. N.E. O'Connell
• Dr. K. Panov
• Dr. R.J. Paxton
• Dr. P. A. Prodöhl
• Dr. Jim Provan
• Dr. J.P. Quinn
• Dr. D. Roberts
• Dr. G. Savidge
• Dr. D. M. Scantlebury
• Dr. J.D. Sigwart
• Dr. C. Situ
• Dr. L.D. Stewart
• Dr. D.J. Timson
• Dr. A. Trudgett

BSc (Hons) Biochemistry, University of Stirling, 1995;
PhD Biochemistry & Molecular Biology
University of Glasgow, 1999.

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Contact Information
Tel:  +44 (0)28 9097 2071 (Direct line)
Fax:  +44 (0)28 9097 5877
Email:  c.law@qub.ac.uk
Room:  Medical Biology Centre - 185

Research Interests

My research focuses on the structure and function of integral membrane proteins, with emphasis on inner membrane transporter proteins involved in sugar-phosphate uptake and drug efflux in prokaryotes such as Escherichia coli, and those involved in metal ion uptake in pathogenic spirochaete bacteria.  I am also interested in the structures, mechanisms and membrane targeting processes of apicoplast membrane transporters from malaria-causing parasites of the genus Plasmodium.

My laboratory utilises a comprehensive range of state-of-the-art techniques to answer important questions pertaining to the structure and mechanism of membrane transporter proteins.  These include X-ray crystallography, isothermal titration calorimetry, fluorescence spectroscopy and transport assays of protein reconstituted into proteoliposomes.

Positions available

Enquiries from post graduates/post docs who have independent funding or fellowships, and who have a desire to work at the cutting edge of membrane protein biology, are welcome.

Publications

Law, C.J., Enkavi, G., Wang, D.-N. & Tajkhorshid, E. (2009). Structural basis of substrate selectivity in the glycerol-3-phosphate:phosphate antiporter GlpT.  Biophys. J., In press.

Zhou, Z., Zhen, J., Karpowich, N., Law, C.J., Reith, M.E.A. & Wang, D-N. (2009). Antidepressant specificity of the serotonin transporter defined by three LeuT-SSRI structures.  Nat. Struct. Mol. Biol., 16: 652-657.

Law, C.J., Maloney, P.C & Wang, D-N. (2008). Ins and outs of major facilitator superfamily antiporters.  Annu. Rev. Microbiol., 62: 289-305.

Law, C.J., Almqvist, A., Bernstein, A., Goetz, R.M., Huang, Y., Soudant, C., Laaksonen, A., Hovmöller, S. & Wang, D-N. (2008). Salt bridge dynamics control substrate-induced conformational change in the membrane transporter GlpT.  J. Mol. Biol., 378: 826-837.

Law, C.J., Yang, Q., Soudant, C., Maloney, P.C. & Wang, D-N. (2007). Kinetic evidence is consistent with the rocker-switch mechanism of GlpT membrane transport.  Biochemistry, 46: 12190-12197.

Law, C.J. & Cogdell, R.J. (2007). The light-harvesting system of purple anoxygenic photosynthetic bacteria.  In: Primary Processes of Photosynthesis:Principles and Apparatus, Part 1 (Renger, G., ed), pp205-259. RSC Publishing, Cambridge, U.K.

Zhou, Z., Zhen, J., Karpowich, N., Goetz, R.M., Law, C.J., Reith, M.E.A. & Wang, D-N. (2007). LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.  Science, 317: 1390-1393.

Cogdell, R.J., Southall, J., Gardiner, A.T., Law, C.J., Gall, A., Roszak, A. & Isaacs, N.W. (2006). How purple photosynthetic bacteria harvest solar energy.  C.R. Chimie, 9: 201-206.

Law, C.J., Gardiner A.T., Southall, J., Roszak, A.W., Howard, T.D., Isaacs, N.W. (2005). How purple bacteria harvest light energy.  In: Energy Harvesting Materials, (Andrews, D., ed), pp65-95. World Scientific Publishing Co.

Cogdell, R.J., Gardiner, A.T., Roszak, A., Law, C.J., Southall, J. & Isaacs, N.W. (2004). Rings, ellipses and horseshoes: How purple bacteria harvest solar energy.  Photosynth. Res., 81: 207-214.

Law, C.J., Roszak, A.W., Southall, J., Gardiner, A.T., Isaacs, N.W. & Cogdell, R.J. (2004). The structure and function of bacterial light-harvesting complexes.  Mol. Memb. Biol., 21: 183-191.

Parkes-Loach, P.S., Majeed, A.P., Law, C.J. & Loach, P.A. (2004). Interactions stabilizing the structure of the core light-harvesting complex (LH1) of photosynthetic bacteria and its subunit (B820).  Biochemistry, 43: 7003-7016.

Roszak, A.W., Howard, T.D., Southall, J., Gardiner, A.T., Law, C.J., Isaacs, N.W. and Cogdell, R.J. (2003). Crystal structure of the RC-LH1 core complex from Rhodopseudomonas palustris.  Science, 302: 1969-1975.

Law, C.J., Penfold, C.N., Walker, D.C., Moore, G.R., James, R. and Kleanthous, C. (2003). OmpF enhances the ability of BtuB to protect susceptible Escherichia coli cells from colicin E9 cytotoxicity.  FEBS Letts., 545: 127-132.

Law, C.J, Chen, J., Parkes-Loach, P.S. & Loach, P.A. (2003). Interaction of bacteriochlorophyll with the LH1 and PufX polypeptides of photosynthetic bacteria: use of chemically synthesized analogs and covalently attached fluorescent probes.  Photosynth. Res., 75: 193-210.

Parkes-Loach, P.S., Law, C.J., Recchia, P.A., Kehoe, J., Nehrlich, S., Chen, J. & Loach, P.A. (2001). Role of the core region of the PufX protein in inhibition of reconstitution of the core light-harvesting complexes of Rhodobacter sphaeroides and Rhodobacter capsulatus.  Biochemistry, 19: 5593-5601.

Trissl, H-W., Law, C.J. & Cogdell, R.J. (1999). Uphill energy transfer in LH2-containing purple bacteria at room temperature.  Biochim. Biophys. Acta Bioenergetics, 1412: 149-172.

Trissl, H-W., Law, C.J. & Cogdell, R.J. (1998).  In Proceedings of the XIth International Congress on Photosynthesis, (Garab, G & Pusztai, J, eds.), Vol. 1: pp 65-68. Kluwer Academic Publishers, The Netherlands.

Law, C.J. & Cogdell, R.J. (1998). The effect of chemical oxidation on the fluorescence of the LH1 (B880) complex from the purple bacterium Rhodobium marinum. FEBS Letts., 432 (1-2), 27-30.

Cogdell, R.J., Fyfe, P., Fraser, N., Law, C., Howard, T., McLuskey, K., Prince, S., Freer, A. & Isaacs, N. (1998) Photosynthetic Light Harvesting.  In Microbial responses to light and time, (Caddick, M.X et al., eds), pp 143-158. Cambridge University Press

Law, C.J., Prince, S.M. & Cogdell, R.J. (1998). Crystallising the LH1-RC "core" complex of purple bacteria.  Biochem. Soc. Trans., 26(2): S160.

Alden, R.G., Johnson, E., Nagaragan, V., Parson, W.W., Law, C.J. & Cogdell, R.J. (1997). Calculations of spectroscopic properties of the LH2 bacteriochlorophyll-protein antenna complex from Rhodopseudomonas acidophila. J. Phys. Chem. B, 101: 4667-4680.

Law, C.J., Cogdell, R.J. & Trissl, H.-W. (1997). Antenna organisation in the purple bacterium Rhodopseudomonas acidophila studied by fluorescence induction.  Photosynthesis Research, 52: 157-165.

Law, C.J. & Price, N.C. (1996). The accessibility of proteins in protein-SDS complexes.  Biochem. Soc. Trans., 24(2): 323S.