Dr Burrows’s research team identify and characterise proteases which potentially represent targets for drug discovery.
A current focus is USP17, a deubiquitinase overexpressed in multiple cancers and required for tumour growth and metastases. Dr Burrows has been at the forefront of studies characterising its biological role and assessing its credentials as a therapeutic target.
Dr Burrows also has an interest in bacterial proteases which subvert the host immune response, with the aim of identifying potential antimicrobial targets.Find out more
Open to PhD applications in the field of the biology, characterisation and therapeutic targeting of mammalian and microbial proteases.
PUBLIC OUTREACH AND KEY ACHIEVEMENTS
PhD Title: Design, synthesis and anti-tumour potency evaluation of pyrimidines as cyclin dependent kinase inhibitors
Name: Mr Jia Lin
Years of Study: 2016-2019
PhD Title: The role of USP17 in EGFR signaling and as a potential novel target for therapy in colorectal cancer
Name: Mr Aidan McCann
Years of Study: 2015-2018
Country: Northern Ireland
PhD Title: Therapeutic evaluation of an immunomodulatory nanoparticle in Acute Respiratory Distress Syndrome
Years of Study: 2011-2015
Country: United Kingdom
Current position: Postdoctoral Fellow, School of Pharmacy, Queen’s University Belfast
PhD Title: The role of the deubiquitinating enzyme USP17 in endocytosis and the regulation of Ras converting enzyme 1 activity.
Years of Study: 2010-2013
Current position: Principal Scientist, Immunocore Ltd, Oxford, UK
PhD Title: The effect of USP17 on GTPase trafficking and cell migration
Years of Study: 2007-2009
Current position: Leader Instructor and Research Scientist, Health Sciences Academy, London, UK
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