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RESEARCH FOCUS

Dr Burden’s research team are focused on dissecting the role of proteases in the cellular microenvironment and the mechanisms by which proteases mediate inflammation in cancer, cardiovascular disease and as a result of particulate matter exposure.

Of particular interest, is the role of proteases in chemokine regulation, invasion, immune cell recruitment and angiogenesis.

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RESEARCH OPPORTUNITIES

Open to PhD applications in the fields of protease biology and inhibitor development (small molecule and biological inhibitors). 

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DR ROBERTA BURDEN

School of Pharmacy

Roberta Burden

Dr Roberta Burden (PI) 

 

PUBLIC OUTREACH and key achievements

Dr Burden was strategically involved in the development and characterisation of a therapeutic monoclonal antibody targeting the cysteine protease Cathepsin S. She was involved in conception of the compound, in vitro/in vivo characterisation and pre-clinical analysis. This work resulted in numerous publications and patents. Furthermore, her analysis of the molecular involvement of proteases in the disease microenvironment resulted in seminal findings identifying Cathepsin S as a transcriptional regulator of proinflammatory chemokines such as CCL2 and a mediator of macrophage recruitment.

Alumni: where are they now?

Dr Robyn Foster


PhD Title: Cathepsin S as a therapeutic target in radioresistant glioblastoma

Years of Study: 2012 - 2015
Country: UK
Current position: Medical Writer at 2theNth

Dr Richard Wilkinson


PhD Title: Evaluating Cathepsin S as a target and a biomarker in cancer

Years of Study: 2012-2015
Country: UK
Current position: Post doctoral Research Fellow, Queen's University Belfast

Dr Sinead Magorrian


PhD Title: Elucidating the role of CD74 in cancer

Years of Study: 2012-2016
Country: UK
Current position: Medical Information Officer at ProPharma

Research at Queen's

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