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Research Focus

Our research group specialise in the application of advanced manufacturing technologies to the production of drug eluting devices, with a particular focus on additive manufacturing (AM), injection molding (IM) and reaction injection molding (RIM).

Our expertise in additive manufacturing focuses on Fused Deposition Modelling (FDM) and Arburg Plastic Freeforming (APF) to produce multi- material

Our research team have world-leading knowledge and expertise in the formulation, testing and manufacture of controlled release implantable drug delivery devices, particularly vaginal rings for HIV prevention and contraception.

Current project sponsors include: The International Partnership for Microbicides (IPM), World Health Organization (WHO); Wellcome Trust; Medical Research Council (MRC); The Population Council; and various pharmaceutical and polymer supply companies.

Professor Gavin Andrews’ research sits at the interface between pharmaceutical sciences and chemical engineering with the aim of challenging the traditional methods commonly used to manufacture oral dosage forms.

The group have a strong interest in solubility enhancement of poorly soluble therapeutics and the use of advanced technologies for manufacture of multi-drug therapies. The group aims to explore the capabilities of innovative continuous processes and to build an understanding of the interrelation between formulation and processing factors and the impact these have upon end product performance.

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Research Areas

  • Pharmaceutical Materials Science and Formulation
  • Drug Delivery and Biomaterials 

Public Outreach

Karl's research group has worked closely with The International Partnership for Microbicides to help develop the first vaginal ring offering sustained release of the antiretroviral microbicide dapivirine for prevention of sexual transmission of HIV. The dapivirine ring has recently completed Phase III clinical testing, and subject to review by regulatory bodies, will likely be available to users in 2018. Second generation ring devices for HIV prevention and contraception are currently in early state clinical testing.

Research Students

PhD title: Development of 3D Printed Drug Delivery Devices

Name: Nicole Welsh

Years of Study: 2015 - 2018

Country: United Kingdom

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