Intellectual Property

Light activated infection-resistant biomaterial

Light activated infection-resistant biomaterial

Researchers at QUB have developed methods to incorporate compounds at the surface of medical materials which show a sustained ability to resist infection.

Description

Benefits

  • Low cost technology offers distinct advantages over competing drug-eluting and silver-based technologies.
  • Spectrum of activity is very broad, including activity against MRSA, and other problem organisms
  • There is no leaching of the sensitizer from the device surface Persistence of activity has been demonstrated beyond 3 weeks, with no reduction in efficacy
  • Developed methods to incorporate surface layers in several classes of polymer, including hydrogels, PVC and silicones.

Background

In the hospital sector, hospital acquired infections (HAI) are a major concern, with HAI deaths running into several thousands a year in the UK alone. Evidence is emerging that organisms such as MRSA can survive on the fabric of a building. This is a significant discovery as ceilings and walls in medical environments tend to be cleaned less frequently than floors. A wide variety of businesses such as direct food handling, pharmaceutical manufacture, hospitals, leisure centres and the animal handling industry require a high level of cleanliness to ensure that micro-organisms do not multiply and contaminate products or effect human health. Surfaces must not only be easy to clean, and where necessary, to disinfect, but also prevent the build-up of dirt, shedding of particles and condensation.

Innovation

Researchers at QUB have invented a unique technology uses photosensitising molecules, of the same class used in photodynamic therapy for the treatment of various cancers. When exposed to visible light, these molecules generate reactive oxygen species, predominantly singlet oxygen, which is indiscriminately cytotoxic. The technology is aimed at killing bacteria which adhere to medical devices and biomaterials after implantation. The process is catalytic, so the sensitizer can give a prolonged protection, unlike conventional drug-incorporation strategies.

The sensitizers can be incorporated into a range of materials in a straightforward and inexpensive process and is based on clinically-approved compounds.

The principal areas for this technology are for devices where the surface can be readily addressed by light, such as ophthalmic biomaterials (intraocular and contact lenses), wound dressings, urinary and central venous catheters, and endotracheal tubes. The biomaterial could also be used in industrial applications such as plastic packaging and plastic consumables.

Market Opportunity

In the US, the total revenue from the antimicrobial paints and coatings market (specifically for lowering infection or contamination) was $175.4 million in 2005 and is estimated to grow to $488.9 million in 2012, demonstrating a high growth opportunity. In the US paints and coatings market, the two market segments showing the largest increase in sales are the medical devices and the antimicrobial agent coatings markets which is the core target market for the QUB Photodynamic antimicrobial paints & varnishes technology

Inventors

Sean Gorman, David Jones, Colin McCoy, Steven Bell

Patent Status

This technology is the subject of an international patent application with International Publication Number WO2007088392

Acknowledgements

Project part financed by the European Regional Development Fund under the European Sustainable Competitiveness Programme for Northern Ireland.

Funding

We have access to a range of potential funding mechanisms to support your business engage and exploit this IP including.

boosting-business Boosting Business through R&D is designed to help you ensure your business remains competitive and grows its market share. With support, you can invest in new products, services and processes, use design to improve your business performance, gain a better understanding of the technical, legislative and intellectual property issues you may face and access collaborative networks to access new business opportunities that might otherwise be beyond your reach. www.boostingbusinessni.com/research-and-development/
ktp Knowledge Transfer Partnerships are based on partnerships between academic groups and companies who need access to skills and knowledge in order to innovate. The academic and industrial partners jointly devise and manage a two or three year programme to achieve the advances the company needs. This programme of work is carried out in the company by a KTP Associate and the resulting relationship can be very challenging and rewarding to all parties www.ktponline.org.uk
qub-innovation-fund The Queen's University Belfast Innovation Fund (QUBIF) is a £1 million venture capital fund, set-up to invest in post Proof of Concept, pre-commercialisation spin-out companies. Funding rounds will be typically in the range of £50k to £200k and investments must be strongly related to the QUB research base. www.nispofunds.com/queensfund.html

Project Number

P44371 POC40A
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