Publications

The following lists recent publications and the links below open pdf files with clickable links to papers. REMERGE PIs are highlighted in bold.

2015
2014
2013
2013-2015 collated

 

2015

Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice

McVicar, C. M., Ward, M., Colhoun, L. M., Guduric-Fuchs, J., Bierhaus, A., Fleming , T., Schlotterer, A., Kolibabka, M., Hammes , H-P., Chen, M. & Stitt, A. W. May 2015 In : Diabetologia. 58, 5, p. 1129-37

 

Effect of membrane stiffness and cytoskeletal element density on mechanical stimuli within cells: an analysis of the consequences of ageing in cells

Xue, F., Lennon, A. B., McKayed, K. K., Campbell, V. A. & Prendergast, P. J. 2015 In : Computer Methods in Biomechanics and Biomedical Engineering. 18, 5, p. 468-476    

 

MicroRNA-199b Modulates Vascular Cell Fate During iPS Cell Differentiation by Targeting the Notch Ligand Jagged1 and Enhancing VEGF Signaling

Chen, T., Margariti, A., Kelaini, S., Cochrane, A., Guha, S. T., Hu, Y., Stitt, A. W., Zhang, L. & Xu, Q. May 2015 In : Stem Cells. 33, 5, p. 1405-1418

 

Mesenchymal stromal cells for treatment of the acute respiratory distress syndrome: The beginning of the story

Morrison, T., McAuley, D. F. & Krasnodembskaya, A. 2015 In : Journal of the Intensive Care Society.

 

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome

Li, J. T., Melton, A. C., Su, G., Hamm, D. E., LaFemina, M., Howard, J., Fang, X., Bhat, S., Huynh, K-M., O'Kane, C., Ingram, R. J., Muir, R. R.,McAuley, D. F., Matthay, M. A. & Sheppard, D. Jul 2015 In : Journal of immunology. 195, 1, p. 87-95

 

Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis  

Boyle, A. J., Di Gangi, S., Hamid, U. I., Mottram, L-J., McNamee, L., White, G., Cross, L. J. M., McNamee, J. J., O'Kane, C. M. & McAuley, D. F. 23 Mar 2015 In : Critical Care. 19, 109. , 109

 

A Functional Variant of Elafin With Improved Anti-inflammatory Activity for Pulmonary Inflammation  

Small, D. M., Zani, M. L., Quinn, D. J., Dallet-Choisy, S., Glasgow, A. M. A., O'Kane, C., Mcauley, D. F., Mcnally, P., Weldon, S., Moreau, T. &Taggart, C. C. Jan 2015 In : Molecular therapy : the journal of the American Society of Gene Therapy. 23, 1, p. 24-31

 

Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia

 McAuley, D. F. , McMullan, R. , O'Kane, C. M. & 27 others Jan 2015 In : Thorax. 70, 1, p. 41-47

 

Antimicrobial efficacy of tobramycin polymeric nanoparticles for Pseudomonas aeruginosa infections in cystic fibrosis: Formulation, characterisation and functionalisation with dornase alfa (DNase)

 Deacon, J., Abdelghany, S. M., Quinn, D. J., Schmid, D., Megaw, J., Donnelly, R. F., Jones, D. S., Kissenpfennig, A., Elborn, J. S., Gilmore, B. F., Taggart, C. C. & Scott, C. J. 28 Jan 2015 In : Journal of Controlled Release. 198, p. 55-61

 

A Functional Variant of Elafin With Improved Anti-inflammatory Activity for Pulmonary Inflammation

 Small, D. M., Zani, M. L., Quinn, D. J., Dallet-Choisy, S., Glasgow, A. M. A., O'Kane, C., Mcauley, D. F., Mcnally, P., Weldon, S., Moreau, T. &Taggart, C. C. Jan 2015 In : Molecular therapy : the journal of the American Society of Gene Therapy. 23, 1, p. 24-31

 

Type-I interferons induce lung protease responses following respiratory syncytial virus infection via RIG-I-like receptors

 Foronjy, R. F., Taggart, C. C., Dabo, A. J., Weldon, S., Cummins, N. & Geraghty, P. Jan 2015 In : Mucosal Immunology. 8, p. 161-175

 

Secretory Leukocyte Protease Inhibitor Decreases Apoptosis in Monocytes via a Mechanism independent of its Protease Inhibition Activity

 McGarry, N., Greene, C. M., McElvaney, N. G., Weldon, S. & Taggart, C. C. 2015 In : Journal of Immunology Research.2015,

 

The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung

 Twigg, M. S., Brockbank, S., Lowry, P., FitzGerald, S. P., Taggart, C. & Weldon, S. 2015 In : Mediators of Inflammation. 2015,293053. , 293053

 

Rapid detection of health-care-associated bloodstream infection in critical care using multipathogen real-time polymerase chain reaction technology: a diagnostic accuracy study and systematic review

 Warhurst, G., Dunn, G., Chadwick, P., Blackwood, B., McAuley, D., Perkins, G. D., McMullan, R., Gates, S., Bentley, A., Young, D., Carlson, G. L. & Dark, P. May 2015 In : Health Technology Assessment. 19, 35,

 

Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children: a cochrane systematic review and meta-analysis

 Rose, L., Schultz, M. J., Cardwell, C. R., Jouvet, P., McAuley, D. F. & Blackwood, B. 24 Feb 2015 In : Critical Care. 19, 48,

 

Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia

McAuley, D. F. , McMullan, R. , O'Kane, C. M. & 27 others Jan 2015 In : Thorax. 70, 1, p. 41-47

 

Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial

 Casarin, A., McAuley, D. F., Alce, T. M., Zhao, X., Ely, E. W., Jackson, J. C., McDowell, C., Agus, A., Murphy, L. & Page, V. J. 2015 In : Trials. 16, 218,

 

Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix

Robinson, E., Cassidy, R. S., Tate, M., Zhao, Y., Lockhart, S., Calderwood, D., Church, R., McGahon, M. K., Brazil, D. P., McDermott, B. J., Green, B. D. & Grieve, D. J. 01 Mar 2015 In : Basic Research in Cardiology. 110, 2,

 

Chronic PEGylated obestatin treatment prevents the onset of high fat diet induced hypertension and endothelial dysfunction in the absence of metabolic actions

 Burch, K., Cowan, E., Agnew, A., Green, B. & Grieve, D. Mar 2015

 

Chronic treatment with a stable obestatin analogue curbs insulin desensitisation in high fat fed mice

 Cowan, E., Burch, K., Greer, B., McClune, D., Scantlebury, D., Grieve, D. & Green, B. Mar 2015

 

Selective targeting of glucagon-like peptide-1 signalling as a novel therapeutic approach for cardiovascular disease in diabetes

Tate, M., Chong, A., Robinson, E., Green, B. D. & Grieve, D. J. Feb 2015 In : British Journal of Pharmacology. 172, 3, p. 721-736

 

Solvent induced phase inversion-based in situ forming controlled release drug delivery implants

 Thakur, R. & Jones, D. 26 Jul 2015

 

Punctal plug: a medical device to treat dry eye syndrome and for sustained drug delivery to the eye

 Yellepeddi, V. K., Sheshala, R., McMillan, H., Gujral, C., Jones, D. & Singh, T. R. R. Jul 2015 In : Drug Discovery Today. 20, 7, p. 884-889

 

Antimicrobial efficacy of an innovative emulsion of medium chain triglycerides against canine and feline periodontopathogens

Laverty, G., Gilmore, B. F., Jones, D. S., Coyle, L., Folan, M. & Breathnach, R. Apr 2015 In : Journal of Small Animal Practice. 56, 4, p. 253-263

 

Quantification of singlet oxygen generation from photodynamic hydrogels

 Craig, R. A., McCoy, C. P., De Baroid, A. T., Andrews, G. P., Gorman, S. P. & Jones, D. S. Feb 2015 In : Reactive and Functional Polymers.87, p. 1-6

 

Ageing and the immune system: focus on macrophages

 Linehan, E. & Fitzgerald, D. C. 2015 In : European Journal of Microbiology and Immunology. 5, 1, p. 14-24

 

BMP signalling: agony and antagony in the family

 Brazil, D. P., Church, R. H., Surae, S., Godson, C. & Martin, F. May 2015 In : Trends in Cell Biology. 25, 5, p. 249-264

 

Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix

Robinson, E., Cassidy, R. S., Tate, M., Zhao, Y., Lockhart, S., Calderwood, D., Church, R., McGahon, M. K., Brazil, D. P., McDermott, B. J., Green, B. D. & Grieve, D. J. 01 Mar 2015 In : Basic Research in Cardiology. 110, 2,

 

Gremlin1 preferentially binds to Bone Morphogenetic Protein-2 (BMP-2) and BMP-4 over BMP-7

Church, R. H., Krishnakumar, A., Urbanek, A., Geschwinder, S., Meneely, J., Bianchi, A., Basta, B., Monaghan, S., Elliott, C., Stromstedt, M., Ferguson, N., Martin, F. & Brazil, D. P. 15 Feb 2015 In : Biochemical Journal. 466, 1, p. 55-68

 

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung

Glasgow, A. M. A., Small, D. M., Scott, A., McLean, D. T., Camper, N., Hamid, U., Hegarty, S., Parekh, D., O'Kane, C., Lundy, F. T., McNally, P., Elborn, J. S., McAuley, D. F., Weldon, S. & Taggart, C. C. May 2015 In : Thorax. 70, 5, p. 426-32

 

Replication of the association of GLT6D1 with aggressive periodontitis in a Sudanese population

Hashim, N. T., Linden, G. J., Ibrahim, M. E., Gismalla, B. G., Lundy, F. T., Hughes, F. J. & El Karim, I. A. Apr 2015 In : Journal Of Clinical Periodontology. 42, 4, p. 319-324

 

Optical Coherence Tomography for the Monitoring of Neovascular Age-Related Macular Degeneration : A Systematic Review

Castillo, M. M., Mowatt, G., Elders, A., Lois, N., Fraser, C., Hernández, R., Amoaku, W., Burr, J. M., Lotery, A., Ramsay, C. R. & Azuara-Blanco, A. Feb 2015 In : Ophthalmology. 122, 2, p. 399-406

 

Natural cutaneous anthrax infection, but not vaccination, induces a CD4+ T cell response involving diverse cytokines

Ingram, R. J., Ascough, S., Reynolds, C. J., Metan , G., Doganay , M., Baillie, L., Williamson, D. E., Robinson, J. H., Maillere, B., Boyton, R. J. & Altmann, D. M. 26 Apr 2015 In : Cell & Bioscience . 5, 20. , 20

 

Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

De Majumdar, S., Yu, J., Fookes, M., McAteer, S. P., Llobet, E., Finn, S., Spence, S., Monaghan, A., Kissenpfennig, A.,Ingram, R. J., Bengoechea, J., Gally, D. L., Fanning, S., Elborn, J. S. & Schneiders, T. 29 Jan 2015 In : PLoS Pathogens. 11,1, 1004627. , 1004627

 

Dissolving Microneedle Delivery of Nanoparticle-Encapsulated Antigen Elicits Efficient Cross-Priming and Th1 Immune Responses by Murine Langerhans Cells

Zaric, M., Lyubomska, O., Poux, C., Hanna, M. L., McCrudden, M. T., Malissen, B., Ingram, R. J., Power, U. F., Scott, C. J., Donnelly, R. F. &Kissenpfennig, A. 2015 In : Journal of Investigative Dermatology. 135, p. 425–434

 

Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications

Rajasekar, P., O'Neill, C. L., Eeles, L., Stitt, A. W. & Medina, R. J. 2015 In : Journal of Diabetes Research. 2015, 436879. , 436879

 

Predictors of adherence to treatment in bronchiectasis

McCullough, A. R., Tunney, M. M., Elborn, J. S., Bradley, J. M. & Hughes, C. M. Jul 2015 In : Respiratory Medicine. 109, 7, p. 838-845

 

Reduced Bacterial Colony Count of Anaerobic Bacteria Is Associated with a Worsening in Lung Clearance Index and Inflammation in Cystic Fibrosis

O'Neill, K., Bradley, J. M., Johnston, E., McGrath, S., McIlreavey, L., Rowan, S., Reid, A., Bradbury, I., Einarsson, G., Elborn, J. S. & Tunney, M. M. 20 May 2015 In : PloS one. 10, 5, e0126980. , e0126980

 

Sedentary behaviour and physical activity in bronchiectasis: a cross-sectional study

Bradley, J. M., Wilson, J. J., Hayes, K., Kent, L., McDonough, S., Tully, M. A., Bradbury, I., Kirk, A., Cosgrove, D., Convery, R., Kelly, M., Elborn, J. S. & O'Neill, B. 13 May 2015 In : BMC Pulmonary Medicine. 15, 1, p. 61

 

Efficacy response in CF patients treated with ivacaftor: Post-hoc analysis

Konstan, M. W., Plant, B. J., Elborn, J. S., Rodriguez, S., Munck, A., Ahrens, R. & Johnson, C. May 2015 In : Pediatric Pulmonology. 50, 5, p. 447-455

 

Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

De Majumdar, S., Yu, J., Fookes, M., McAteer, S. P., Llobet, E., Finn, S., Spence, S., Monaghan, A., Kissenpfennig, A.,Ingram, R. J., Bengoechea, J., Gally, D. L., Fanning, S., Elborn, J. S. & Schneiders, T. 29 Jan 2015 In : PLoS Pathogens. 11,1, 1004627. , 1004627

 

 Comparison of Microbiomes from Different Niches of Upper and Lower Airways in Children and Adolescents with Cystic Fibrosis

Boutin, S., Graeber, S. Y., Weitnauer, M., Panitz, J., Stahl, M., Clausznitzer, D., Kaderali, L., Einarsson, G., Tunney, M. M.,Elborn, J. S., Mall, M. A. & Dalpke, A. H. 28 Jan 2015 In : PloS one. 10, 1, e0116029. , e0116029

 

Do veterinary antibiotics have efficacy against highly resistant Gram-negative pathogens from patients with cystic fibrosis?

Moore, J. E., Alcorn, M., Ara, W., Millar, B. C., McCaughan, J., Rendall, J. C., McNeilly, J., Kuribayashi, T., Yamamoto, S., Matsuda, M., Goldsmith, C. E., Elborn, J. S. & Downey, D. G. Jan 2015 In : International journal of antimicrobial agents. 45, 1, p. 93-95

 

‘All illness is personal to that individual’: a qualitative study of patients’ perspectives on treatment adherence in bronchiectasis

Mccullough, A. R., Tunney, M. M., Elborn, J. S., Bradley, J. M. & Hughes, C. M. 2015 In : Health Expectations.

 

Cystic Fibrosis Foundation and European Cystic Fibrosis Society Survey of cystic fibrosis mental health care delivery

Abbott, J., Elborn, J. S., Georgiopoulos, A. M., Goldbeck, L., Marshall, B. C., Sabadosa, K. A., Smith, B. A. & Quittner, A. L. 2015 In : Journal of Cystic Fibrosis.

 

Reclaiming the name ‘bronchiectasis’

Chalmers, J. D. & Elborn, J. S. 2015 In : Thorax. 70, 5, p. 399-400

 

Tiotropium Respimat® in cystic fibrosis: Phase 3 and Pooled phase 2/3 randomized trials

Ratjen, F., Koker, P., Geller, D. E., Langellier-Cocteaux, B., Le Maulf, F., Kattenbeck, S., Moroni-Zentgraf, P. & Elborn, J. S. 2015 In : Journal of Cystic Fibrosis

 

2014

 

Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony–forming cells

O'Neill, C. L. , Medina, R. J. , Stitt, A. W. & 21 others Nov 2014 In : Nature Biotechnology. 32, 11, p. 1151-1157

 

Angiogenic Potential of Vitreous from Proliferative Diabetic Retinopathy and Eales' Disease Patients

Murugeswari, P., Shukla, D., Kim, R., Namperumalsamy, P., Stitt, A. W. & Muthukkaruppan, V. 13 Oct 2014 In : PloS one. 9,10, p. e107551

 

RAGE Regulates Immune Cell Infiltration and Angiogenesis in Choroidal Neovascularization

Chen, M., Glenn, J. V., Dasari, S., McVicar, C., Ward, M., Colhoun, L., Quinn, M., Bierhaus, A., Xu, H. & Stitt, A. W. 26 Feb 2014 In : PloS one. 9, 2, e89548. , e89548

 

Peripheral neuropathy may be a potential risk of cardiovascular disease in diabetes mellitus

Margariti, A. Dec 2014 In : Heart (British Cardiac Society). 100, 23, p. 1823-1824

 

Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3*

Martin, D., Li, Y., Yang, J., Wang, G., Margariti, A., Jiang, Z., Yu, H., Zampetaki, A., Hu, Y., Xu, Q. & Zeng, L. 04 Sep 2014 In :Journal of Biological Chemistry. 289, p. 30625-30634

 

Macrophages Control Vascular Stem/Progenitor Cell Plasticity Through Tumor Necrosis Factor-α–Mediated Nuclear Factor-κB Activation

Wong, M. M., Chen, Y., Margariti, A., Winkler, B., Campagnolo, P., Potter, C., Hu, Y. & Xu, Q. Mar 2014 In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 3, p. 635-643

 

Direct reprogramming of adult cells: avoiding the pluripotent state

Kelaini, S., Cochrane, A. & Margariti, A. Feb 2014 In : Stem cells and cloning : advances and applications. 7, p. 19-29

 

Expression pattern of arenicins—the antimicrobial peptides of polychaete Arenicola marina

 Maltseva, A., Kotenko, O., Kokryakov, V., Starunov, I. & Krasnodembskaya, A. 19 Dec 2014 In : Frontiers in Physiology.120063. , 120063

 

Simvastatin in the Acute Respiratory Distress Syndrome

McAuley, D. F., Laffey, J. G., O'Kane, C. M., Perkins, G. D., Mullan, B., Trinder, T. J., Johnston, P., Hopkins, P. A., Johnston, A. J., McDowell, C., McNally, C. & the HARP-2 Investigators, for the Irish Critical Care Trials Group 30 Oct 2014 In : New England Journal of Medicine. 371, p. 1695-1703

 

SMAD inhibition attenuates epithelial to mesenchymal transition by primary keratinocytes in vitro

O'Kane, D., Jackson, M. V., Kissenpfennig, A., Spence, S., Damkat-Thomas, L., Tolland, J. P., Smyth, A. E., Denton, C. P., Elborn, J. S., McAuley, D. F.O'Kane, C. M. Jul 2014 In : Experimental dermatology. 23, 7, p. 497-503

 

Respiratory Infections Cause the Release of Extracellular Vesicles: Implications in Exacerbation of Asthma/COPD

 Eltom, S., Dale, N., Raemdonck, K. R. G., Stevenson, C. S., Snelgrove, R. J., Sacitharan, P. K., Recchi, C., Wavre-Shapton, S., McAuley, D. F., O'Kane, C., Belvisi, M. G. & Birrell, M. A. Jun 2014 In : PloS one. 9, 6, e101087. , e101087

 

miR-31 Dysregulation in Cystic Fibrosis Airways Contributes to Increased Pulmonary Cathepsin S Production

Weldon, S., McNally, P., McAuley, D. F., Oglesby, I. K., Wohlford-Lenane, C. L., Bartlett, J. A., Scott, C. J., McElvaney, N. G., Greene, C. M., McCray, P. B. & Taggart, C. C. 15 Jul 2014 In : American Journal of Respiratory and Critical Care Medicine. 190, 2, p. 165-174

 

Keratinocyte Growth Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury

Shyamsundar, M., McAuley, D. F., Ingram, R. J., Gibson, D. S., O'Kane, D., McKeown, S. T., Edwards, A., Taggart, C., Elborn, J. S., Calfee, C. S., Matthay, M. A. & O'Kane, C. M. 15 Jun 2014 In : American Journal of Respiratory and Critical Care Medicine. 189, 12, p. 1520-1529

 

Respiratory Syncytial Virus Infections Enhance Cigarette Smoke Induced COPD in Mice

 Foronjy, R. F., Dabo, A. J., Taggart, C. C., Weldon, S. & Geraghty, P. 28 Feb 2014 In : PLoS ONE. 9, 2, e90567. , e90567

 

Accuracy of LightCycler® SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis

 Dark, P., Blackwood, B., Gates, S., McAuley, D., Perkins, G. D., McMullan, R., Wilson, C., Graham, D., Timms, K. & Warhurst, G. Nov 2014 In : Intensive Care Medicine. 41, 1, p. 21-33

 

Academic medicine - revolution, evolution or extinction?

 Irwin, G. W., Spence, R. A. J., McAuley, D. F., Kennedy, R. D., Gardiner, K. R. & Elborn, J. S. Sep 2014 In : The Ulster Medical Journal. 83, 3,p. 141-5

 

Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children

Rose, L., Schultz, M. J., Cardwell, C., Jouvet, P., McAuley, D. F. & Blackwood, B. 10 Jun 2014 In : The Cochrane Library. 6

 

An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial

 L'E Orme, R. M., Perkins, G. D., McAuley, D. F., Liu, K. D., Mason, A. J., Morelli, A., Singer, M., Ashby, D. & Gordon, A. C. 02 Jun 2014 In : Trials. 15, 1, 199. , 199

 

The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility Index ?

 Walsh, M., Srinathan, S. K., McAuley, D. F., Mrkobrada, M., Levine, O., Ribic, C., Molnar, A. O., Dattani, N. D., Burke, A., Guyatt, G., Thabane, L., Walter, S. D., Pogue, J. & Devereaux, P. J. 01 Jun 2014 In : Journal of Clinical Epidemiology. 67, 6,p. 622-628