Researchers

Dr Derek Brazil

Dr Derek Brazil

The Brazil Group is studying the role of vascular stem cells in tissue repair, with a focus on:

  • Signalling pathways activated by hypoxia in endothelial progenitor cells (EPCs)
  • Bone morphogenetic protein (BMP) and Gremlin regulation of EPC-mediated angiogenesis
  • Placental-like growth factor (PlGF) and EPC function in ischaemic/diabetic retina and kidney

 Dr Brazil's Research Portal profile can be viewed here.

 

Dr Denise FitzgeraldDr Denise Fitzgerald

The Fitzgerald Group has a particular focus on Multiple Sclerosis (MS), an immune-mediated, demyelinating disorder of the Central Nervous System (CNS). The central goal of our research is to identify new strategies to treat MS and other inflammatory and demyelinating disorders. We are particularly interested in:

  • the process of remyelination. We aim to identify novel therapeutic targets to promote remyelination in MS.
  • the pathogenesis of autoimmune inflammation. This programme mainly focuses on T cell biology with a view to identifying strategies to reduce disease activity in MS and other immune-mediated diseases.

Dr Fitzgerald's Research Portal profile can be accessed here.

 

Dr David Grieve

Dr David GrieveThe Grieve Group is researching the mechanisms underlying cardiovascular remodelling, with a particular focus on:

  • Stem cells for vascular repair in cardiovascular disease
  • Oxidative stress and reactive oxygen species in tissue remodelling
  • Therapeutic potential of novel peptide hormones

Dr Grieve's Research Portal profile can be accessed here.

 

 

Dr Anna Krasnodembskaya

Dr Anna Krasnodembskaya

The Krasnodembskaya Group in the Centre for Infection and Immunity is researching:
  • Mesenchymal Stem/Stromal Cells (MSC) for the therapy of Acute Respiratory Distress Syndrome (ARDS)
  • Understanding mechanisms mediating MSC effects in ARDS
  • MSC effects on macrophage polarization

Dr Krasnodembskaya's Research Portal Profile can be viewed here.

 

Dr Andriana Margariti

Dr Andriana Margariti

The Margariti Group's research focuses on stem cells, somatic cell reprogramming, cell signaling and vascular cell biology, particularly:

  • Generation of induced pluripotent stem cells from blood cells based on novel methods
  • Elucidation of the mechanisms of vascular cell differentiation
  • Establishing robust direct reprogramming approaches towards vascular cell lineages
  • Regenerative Medicine; testing the functional properties of the reprogrammed vascular cells in vivo, and proposing potential therapeutic strategies to treat vascular diseases

Dr Margariti's Research Portal profile is available here.

 

Professor Danny McAuley

Professor Danny McAuleyProfessor McAuley is Professor and Consultant in Intensive Care Medicine at the Royal Victoria Hospital and Queen’s University of Belfast. He is Co-Director of Research for the Intensive Care Society and Chair of the Irish Critical Care Trials Group. His major research area is acute lung injury (ALI).

 His group are investigating:

  • potential therapeutic agents for ALI
  • ion channel function in the clearance of pulmonary oedema in ALI
  • the pathophysiological role of matrix metalloproteinases, oncostatin M and receptor for advanced glycation endproducts (RAGE) in ALI
  • vascular reactivity in critical illness, delirium in critical illness and nosocomial MRSA and fungal infection.

Professor McAuley's Reseach Portal profile can be viewed here.

 

Dr Sandra McAllisterDr Sandra McAllister

Dr McAllister is a clinical academic trainee in plastic surgery. Her group are studying wounde healing, with a focus on the therapeutic potential of endothelial progenitor cells:

  • the role of endothelial progenitor cells in skin graft revascularisation
  • the effects of ageing and co-morbidities on endothelial progenitor cell function
  • the use of negative pressure wound therapy on complex wounds.

Dr McAllister's Research Portal profile can be viewed here.

 

Dr Reinhold Medina

Dr Reinhold Medina

The Medina Group is investigating the role of endothelial progenitor stem cells in a range of conditions, including diabetic retinopathy, and wound healing. Dr Medina's Research Portal profile can be accessed here.

 

 

 

 

Dr Cecilia O'Kane

Dr Cecilia O'KaneThe O'Kane Group focuses largely on the processes that mediate inflammation and repair in inflammatory lung disease, with a particular interest in:

  • the role of matrix metalloproteinases (MMPs) in both initiating and perpetuating the process of tissue damage, but also mediating a reparative process allowing recovery
  • profiling the expression of these proteases at different stages of disease and identify which initiate the damage and which regulate the repair process at the given time points
  • clinical application of research findings, expecially in tuberculosis and cystic fibrosis.

Dr O'Kane's Research Portal profile can be viewed here.

 

Dr Fionnuala Lundy

Dr Fionnuala Lundy

The Lundy Group in the Centre for Infection and Immunity is investigating the role of dental pulp stem cells in tissue repair:
  • Biology and differentiation of dental pulp stem cells
  • Dental pulp stem cell response to infection and inflammation
  • Reparative potential of dental pulp stem cells
Dr Lundy's Research Portal profile can be accessed here.

 

 

Professor Alan Stitt

Professor Alan Stitt

Professor Stitt is the Director of the Centre for Experimental Medicine. The research interests of his group include:

  • The pathogenic role of advanced glycation endproducts (AGEs) and RAGE in diabetic retinopathy
  • Retinal angiogenesis including harnessing the regenerative potential of endothelial progenitor cells for ischaemic retinopathies
  • The pathobiology of age-related retinal dysfunction and RPE biology

Professor Stitt's Research Portal profile is available here.

 

Dr Alexander Thompson

Dr Alex ThompsonThe Thompson Group's research focuses on:

  • Malignant and non-malignant haematopoiesis molecular biology
  • Self-renewal capacity of Haematopoietic stem cells (HSCs)
  • Normal and malignant HSC functional response to anti-cancer therapies
  • Genetic and epigenetic modification of HSCs for ex vivo expansion
  • The role of HOX genes in HSC malignancy and stem cell function.

Dr Thompson's Research Portal profile can be viewed here.

 

Professor Heping Xu

Professor Heping Xu

The Xu Group in the Centre for Experimental Medicine is researching retinal repair and regeneration, with a focus on:

  • Macrophages in post-inflammation retinal repair and remodelling.
  • Macrophages in retinal repair and remodelling following degeneration.
  • Regeneration of retinal pigment epithelial cells.

Professor Xu's Research Portal profile can be accessed here.

 

 

 

Dr Yvonne Dombrowski

Dr. Dombrowski’s research focuses on innate immune mechanisms in brain repair. Inflammasomes are multiprotein complexes in a cell that are activated by danger signals. Inflammasome activation leads to cleavage and release of IL-1beta and IL-18. We are particularly interested in the role of inflammasomes in myelin regeneration.

  • Identification of inflammasomes in demyelinated CNS lesions
  • Uncovering the function of inflammasomes in myelin regeneration
  • Elucidation of inflammasomes as targets in Multiple Sclerosis therapy

 

Dr. Dombrowski’s Research Portal profile can be found here

 

‌‌Dr Ikhlas El Karim

Dr Ikhlas El Karim's main area of research interest is  inflammation and regeneration in orofacial tissues.

Current research focus:

  • Investigating the role of Ion channels in mediating dental pain, inflammation and regeneration
  • Exploring potential mechanisms and strategies for optimising neurogenic and osteogenic lineage commitment of dental pulp stem cells.
  • Identify inflammatory signalling pathways that impact the regenerative potential of dental pulp stem cells.

Dr Karim's research portal profile can be found here.