Research themes and areas of activity
Resistance to all anti-cancer therapies is a major problem. Mechanisms of resistance frequently involve activation of survival pathways, ineffective induction of cell death, defective DNA damage repair pathways, epigenetic reprogramming, altered metabolism and ineffective tumour recognition and elimination by the immune system.
Genomic instability plays a strategic role in cancer biology. Our aim is to identify and understand the causes, mechanisms and consequences of genome instability.
The development of a complex tumour microenvironment by tumour cells and co-opted immune and stromal cells represent a key determinant of cancer progression and response to therapy. Moreover, the microenvironmental communication networks are instrumental in the development of metastasis.
Tumour Epidemiology and Early Detection
The Tumour Epidemiology and Early Detection focus group brings together multidisciplinary researchers with expertise in the application of genetics, pathology (including molecular pathology) and molecular biological research methods.