Resistance to all anti-cancer therapies is a major problem. Mechanisms of resistance frequently involve activation of survival pathways, ineffective induction of cell death, defective DNA damage repair pathways, epigenetic reprogramming, altered metabolism and ineffective tumour recognition and elimination by the immune system.
DNA Damage Signalling
Dysregulation of DNA damage signalling plays a significant role in cancer biology, leading to genomic instability. Our aim is to identify and understand the mechanisms and consequences of altered DNA damage signalling in cancer development and treatment.
Tumour Microenvironment Biology
The development of a complex tumour microenvironment by tumour cells and co-opted immune and stromal cells represent a key determinant of cancer progression and response to therapy. Moreover, the microenvironmental communication networks are instrumental in the development of metastasis.
Tumour Epidemiology and Early Detection
There are numerous genetic risk factors which can significantly alter a person’s risk of developing cancer. Our research in this area brings together multidisciplinary researchers with expertise in genetics, pathology (including molecular pathology) and molecular biological research methods to better understand these risks.