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The Patrick G Johnston Centre for Cancer Research

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  • Home
  • Our Science
    • Tumour Specialisms and Clinical Trials
    • Disciplinary Strengths
    • Technology Specialisms
    • Major Research Programmes
  • Education
    • Clinical Academic Training
    • Postgraduate Research
    • Postgraduate Taught
    • Princess Margaret Cancer Centre
    • Summer Research Programme
    • Undergraduate
  • Impact
    • Videos
    • Seminars and Events
    • Research Engagement
    • Industry and Innovations
    • Bulletins and Annual Reports
  • Cancer Digest
    • Blood Cancer
    • Breast Cancer
    • Colorectal Cancer
    • Prostate Cancer
    • Radiotherapy
  • Opportunities
    • Academic Posts
    • Postdoctoral
    • PhD Opportunities
  • Contact Us
    • Academic Staff
    • Administrative Staff
    • Clinical Academic Training Programme
    • Clinical Research Fellows
    • Honorary Staff
    • Research Staff
    • Technical Staff
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In This Section
  • Therapy Resistance
  • DNA Damage Signalling
  • Tumour Microenvironment Biology
  • Tumour Epidemiology and Early Detection

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  • The Patrick G Johnston Centre for Cancer Research
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  • Disciplinary Strengths

Disciplinary Strengths

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Our Science
Disciplinary strengths

Therapy Resistance


Resistance to all anti-cancer therapies is a major problem. Mechanisms of resistance frequently involve activation of survival pathways, ineffective induction of cell death, defective DNA damage repair pathways, epigenetic reprogramming, altered metabolism and ineffective tumour recognition and elimination by the immune system.

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DNA Damage Signalling


Dysregulation of DNA damage signalling plays a significant role in cancer biology, leading to genomic instability. Our aim is to identify and understand the mechanisms and consequences of altered DNA damage signalling in cancer development and treatment.

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Tumour Microenvironment Biology


The development of a complex tumour microenvironment by tumour cells and co-opted immune and stromal cells represent a key determinant of cancer progression and response to therapy. Moreover, the microenvironmental communication networks are instrumental in the development of metastasis.

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Tumour Epidemiology and Early Detection 


There are numerous genetic risk factors which can significantly alter a person’s risk of developing cancer. Our research in this area brings together multidisciplinary researchers with expertise in genetics, pathology (including molecular pathology) and molecular biological research methods to better understand these risks.

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Disciplinary Strengths
  • Our Science
  • Therapy Resistance
  • DNA Damage Signalling
  • Tumour Microenvironment Biology
  • Tumour Epidemiology and Early Detection
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Contact Us

The Patrick G Johnston Centre for Cancer Research

Queen's University Belfast
97 Lisburn Road
Belfast
BT9 7AE

Phone: +44 (0) 28 9097 2760
Email: pgjccr@qub.ac.uk  
Fax: +44 (0) 28 9097 2776

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