Publications

Publications

Ageing and the immune system: focus on macrophages.
Linehan E, Fitzgerald DC.
Eur J Microbiol Immunol (Bp). 2015 Mar;5(1):14-24

Interferon regulatory factor (IRF) 3 is critical for the development of experimental autoimmune encephalomyelitis.
Fitzgerald DC*, O Brien K, Young A, Fonseca-Kelly Z, Rostami A, Gran B*.
J Neuroinflammation. 2014 Jul 28;11(1):130. [Epub ahead of print]
*joint-corresponding authors

Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis.
Linehan E, Dombrowski Y, Snoddy R, Fallon PG, Kissenpfennig A, Fitzgerald DC.
Aging Cell. 2014 Aug;13(4):699-708. doi: 10.1111/acel.12223. Epub 2014 May 12.

Independent and interdependent immunoregulatory effects of IL-27, IFN-β, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis.
Fitzgerald DC*, Fonseca-Kelly Z, Cullimore ML, Safabakhsh P, Saris CJ, Zhang GX, Rostami A*.
J Immunol. 2013 Apr 1;190(7):3225-34. doi: 10.4049/jimmunol.1200141. Epub 2013 Mar 1.
*joint-corresponding authors

Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.
Knosp CA, Schiering C, Spence S, Carroll HP, Nel HJ, Osbourn M, Jackson R, Lyubomska O, Malissen B, Ingram R, Fitzgerald DC, Powrie F, Fallon PG, Johnston JA, Kissenpfennig A.
J Immunol
. 2013 Apr 1;190(7):3235-45. doi: 10.4049/jimmunol.1201396. Epub 2013 Mar 1.

Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.
Spence S, Fitzsimons A, Boyd CR, Kessler J, Fitzgerald D, Elliott J, Gabhann JN, Smith S, Sica A, Hams E, Saunders SP, Jefferies CA, Fallon PG, McAuley DF, Kissenpfennig A, Johnston JA.
Immunity
. 2013 Jan 24;38(1):66-78. doi: 10.1016/j.immuni.2012.09.013. Epub 2012 Nov 21.

Cutting Edge: Suppression of GM-CSF Expression in Murine and Human T Cells by IL-27.
Young A, Linehan E,
Hams E, O'Hara Hall AC, McClurg A, Johnston JA, Hunter CA, Fallon PG, Fitzgerald DC.
J Immunol
. 2012 Sep 1;189(5):2079-83. Epub 2012 Jul 25.

Intravenous tolerance effectively overcomes enhanced pro-inflammatory responses and experimental autoimmune encephalomyelitis severity in the absence of IL-12 receptor signaling.
Fitzgerald DC
, Zhang GX, Yu S, Cullimore ML, Zhao Z, Rostami A.
J Neuroimmunol
. 2012 Jun 15;247(1-2):32-7. Epub 2012 Apr 21.

A robust co-localisation measurement utilising z-stack image intensity similarities for biological studies.
Wang Y, Ledgerwood C, Grills C, Fitzgerald DC, Hamilton PW.
PLoS One
. 2012;7(2):e30632. Epub 2012 Feb 17.

Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent.
Chen M, Zhao J, Luo C, Pandi SP, Penalva RG, Fitzgerald DC, Xu H.
Glia
. 2012 May;60(5):833-42. doi: 10.1002/glia.22315. Epub 2012 Feb 23.

Altered Toll-like receptor 2-mediated endotoxin tolerance is related to diminished interferon beta production.
Zaric SS, Coulter WA, Shelburne CE, Fulton CR, Zaric MS, Scott A, Lappin MJ, Fitzgerald DC, Irwin CR, Taggart CC.
J Biol Chem
. 2011 Aug 26;286(34):29492-500. Epub 2011 Jun 24.

SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
Knosp CA, Carroll HP, Elliott J, Saunders SP, Nel HJ, Amu S, Pratt JC, Spence S, Doran E, Cooke N, Jackson R, Swift J, Fitzgerald DC, Heaney LG, Fallon PG, Kissenpfennig A, Johnston JA.
J Exp Med
. 2011 Jul 4;208(7):1523-31. Epub 2011 Jun 6.

Oral resveratrol reduces neuronal damage in a model of multiple sclerosis.
Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC, Rostami A.
J Neuroophthalmol
. 2010 Dec;30(4):328-39.

Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes.
Liu H, Fitzgerald D, Gran B, Leong JM, Alugupalli KR.
J Immunol
. 2010 May 15;184(10):5859-64. Epub 2010 Apr 9.

The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis.
O'Brien K, Fitzgerald D, Rostami A, Gran B.
J Neuroimmunol
. 2010 Apr 15;221(1-2):107-11. Epub 2010 Feb 6.

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis.
Yang J, Jiang Z, Fitzgerald DC, Ma C, Yu S, Li H, Zhao Z, Li Y, Ciric B, Curtis M, Rostami A, Zhang GX.
J Clin Invest
. 2009 Dec;119(12):3678-91. doi: 10.1172/JCI37914. Epub 2009 Nov 2.

Differential effect of IL-27 on developing versus committed Th17 cells.
El-behi M, Ciric B, Yu S, Zhang GX, Fitzgerald DC, Rostami A.
J Immunol
. 2009 Oct 15;183(8):4957-67. Epub 2009 Sep 28.

Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis.
Das Sarma J, Ciric B, Marek R, Sadhukhan S, Caruso ML, Shafagh J, Fitzgerald DC, Shindler KS, Rostami A.
J Neuroinflammation
. 2009 Apr 28;6:14.

Therapeutic potential of IL-27 in multiple sclerosis?
Fitzgerald DC
, Rostami A.
Expert Opin Biol Ther
. 2009 Feb;9(2):149-60. Review.

Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells.
Fitzgerald DC
, Zhang GX, El-Behi M, Fonseca-Kelly Z, Li H, Yu S, Saris CJ, Gran B, Ciric B, Rostami A.
Nat Immunol
. 2007 Dec;8(12):1372-9. Epub 2007 Nov 11. Erratum in: Nat Immunol. 2008 Jan;9(1):105.

Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis.
Fitzgerald DC
, Ciric B, Touil T, Harle H, Grammatikopolou J, Das Sarma J, Gran B, Zhang GX, Rostami A.
J Immunol
. 2007 Sep 1;179(5):3268-75.

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