Microbes & Pathogen Biology
The primary focus of the Microbe and Pathogen Biology research group is the study of fundamental biological processes in cells, microbes and parasites as well as applied processes in environmental microbiology, parasitology and disease control. The group provides a broad platform of fundamental and applied expertise in the biosciences, including: molecular biology; cell biology and cell signalling; microbial biochemistry and genomics; stress metabolism; bioremediation; parasite biology, physiology and therapeutics; protein biochemistry, expression and engineering; peptide/protein modelling and synthesis; nucleic acid structure and function; bioimaging.
This diverse array of interests, ranging from protein modelling, through microbiology to parasite control, is linked by common approaches within the molecular biosciences that are aimed at exploiting the ongoing genomic, transcriptomic/proteomic revolution. The molecular microbiology component is heavily involved with QUESTOR, a successful International Industry/University Co-operative Research Centre. The food safety and nutritional research elements are linked with the Institute for Global Food Security which aims to exploit cutting-edge technologies to drive a competitive and sustainable agricultural sector. The group has a wide range of strong international links across Europe, Asia and North America.
Research staff
Professor Chris Allen
Prokaryote biochemistry, biocatalysis and biotransformation.
Prokaryote biochemistry, biocatalysis and biotransformation.
Pathogen biology, parasite functional genomics, bioinformatics.
Host-microbiome interactions with a focus on early life nutrition and human milk profiling using mass spectrometry.
Microbial nutrient cycling, particularly of phosphorus and nitrogen, and how these drive biogeochemistry and can be used for biotechnology.
Method development and applications in quantitative proteomics, analysis of protein interaction networks and protein complexes, host-pathogen biology with a focus on Mycobacterium tuberculosis.
Computational biology with an interest in applying ecological and evolutionary principles to microbial communities, especially those associated with animal hosts.
Professor Tim Geary
Genomic and proteomic analysis of the host-parasite interface, especially filarial and gastrointestinal nematode infections.
Genomic and proteomic analysis of the host-parasite interface, especially filarial and gastrointestinal nematode infections.
Helminth biology: schistosome calcium homeostasis and drug design, microbiomes and helminths, schistosome-induced hepatic disease, helminth tegumental structure/function.
Proteomics and chemical biology in host pathogen interactions.
Cell signalling, proteomics, the immunomodulatory response.
Professor Irene Grant
Microbiological food safety, novel detection methods, emerging pathogens.
Microbiological food safety, novel detection methods, emerging pathogens.
Dr John Hallsworth
Stress mechanisms and responses in microbial cells and ecosystems.
Stress mechanisms and responses in microbial cells and ecosystems.
Microbiomes, rumen, ruminants, "omic" technologies.
Dr Edel Hyland
Adaptation and molecular evolution of infectious yeast, histone post-translational modifications.
Adaptation and molecular evolution of infectious yeast, histone post-translational modifications.
Professor Ilias Kyriazakis
Consequences of animal management on performance, ability to cope with pathogens and environmental impact.
Consequences of animal management on performance, ability to cope with pathogens and environmental impact.
Dr Chris Law
Structure and function of integral membrane proteins.
Structure and function of integral membrane proteins.
Dr Fuquan Liu
Dynamics, regulatory mechanisms and functions of co-transcriptional RNA processing in plants.
Dynamics, regulatory mechanisms and functions of co-transcriptional RNA processing in plants.
Professor Nikki Marks
Parasite biochemistry, endectocide target discovery, neurobiology.
Parasite biochemistry, endectocide target discovery, neurobiology.
Professor Aaron Maule
Molecular parasitology, drug target discovery and validation.
Molecular parasitology, drug target discovery and validation.
Professor John McGrath
Molecular microbiology and bioremediation, microbial ecology.
Molecular microbiology and bioremediation, microbial ecology.
Microbial biochemistry and physiology with a focus on bacterial systems biology.
Using molecular methods to develop improved diagnostic tools for helminth parasite infections.
Microbiomes, fundamental and molecular biology of the domain Archaea.
Sustainable control of parasites of veterinary importance under climate change.
Dr Angela Mousley
Helminth neuropeptide signalling systems.
Helminth neuropeptide signalling systems.
Dr Kostya Panov
Pol I transcription, molecular and cellular mechanisms involved in the regulation of rRNA transcription.
Pol I transcription, molecular and cellular mechanisms involved in the regulation of rRNA transcription.
Dr Mark Robinson
Parasite proteomics, pathogen proteases and immunomodulators.
Parasite proteomics, pathogen proteases and immunomodulators.
Bacterial cell surface mapping and rapid diagnostics.