Dr Panagiotis Manesiotis

Developing novel polymerisable building blocks for Molecular Imprinting for applications in bioanalysis, affinity separations, sensors, catalysis, and polymeric sorbents for environmental clean-up. Dr Panagiotis Manesiotis
Reader in Analytical Chemistry
Office: DKB 0G.415 I Tel: +44 (0)28 9097 4515 I @pmanesiotis
- Director of Education
- Programme co-ordinator for MSc in Pharmaceutical Analysis
- Head of PGT in Chemistry
Research
Molecularly Imprinted Polymers (MIPs)
The principle idea behind Molecularly Imprinted Polymer (MIP) synthesis is the generation of solution state complexes between the template ligand in hand and appropriate functional monomers, followed by subsequent "freezing" of these complexes by co-polymerisation of the above with an excess of a cross-linking monomer. These monomer – template complexes are stabilised by non-covalent interactions, reversible covalent interactions or metal ion mediated interactions. The types of interactions that are usually exploited in molecular imprinting are: a) hydrogen bonds, b) π-π interactions, c) ionic forces, d) hydrophobic interactions, e) van der Waals forces, f) metal-ligand bonds, g) cleavable covalent bonds.
The non-covalent or "self-assembly" approach is the most widely applied mode in molecular imprinting. The template is mixed with monomers and cross-linkers in an appropriate solvent. In this pre-polymerisation mixture, complexes of the template with the monomers are formed as a result of polar interactions such as hydrogen bonds, ionic interactions, Van der Waals forces etc. The strength of these interactions and the resulting complexes is of vital importance for the templating effect in the final polymer.

Our research focuses on the development and application of Molecularly Imprinted Polymers targeting compounds of environmental, pharmaceutical and biological interest, using custom synthesised functional monomers. Such monomers exhibit superior complementarity to the compounds of interest, enabling us to access materials able to achieve selective compound extraction from competitive media and complicated samples.
Depending on the desired application, MIPs can be formulated as amorphous broadly sized particles (SPE, CSPs), narrowly dispersed spherical beads (HPLC), monoliths, membranes (filtration), or thin films (sensors).
Polymerisable molecular recognition elements and optical sensors
We are interested in the development of novel, polymerisable receptors tailored to the recognition of specific target compounds. Thus, we have developed a range of custom functional monomers with selectivity for imides, carboxylic acids, carboxylate anions and ureas, among others. Apart from superior selectivity and affintiy, customisation of our recognition elements enables sensing applications of the resulting MIPs, which are able to signal the binding event by a change in colour, fluorescence or electrical properties. Recently, our group reported on the first example of polymersable squaramides and demostrated their potential in the binding and sension of anionic species.
This work resulted in P_Sense, a project aiming to develop and commercialise an optical sensor for phosphate. You can find out more about this project at the project website or follow us on Twitter @P_Sense_.
Recognition of whole cells and micro-organisms
We have recently started working on the application of custom functional monomers for the capture of whole cells and micro-organisms. In particular we are interested in the development of materials and surfaces complementary to Circulating Tumour Cells (CTCs). More information about this exciting area of research within the group can be found in our recent review in Advanced Materials.

Recovery and recycling of valuable resources from waste streams
Working in collaboration with Dr John McGrath from the School of Biological Sciences and Prof. Vincent O' Flaherty from NUI Galway, we are developing novel sorbents for the recovery and recycling of valuable chemical compounds from waste-water streams and anaerobic digestion systems using renewable biopolymers as starting materials. This work is funded by Invest NI, SFI-DEL, DPTC and the EPA.
Research Group
Post-Doctoral Researchers | PhD Students |
Niall Corry | |
Andrew McClure | |
Joshua O'Hagan |
Work with us
PhD Position Available
Apart from our advertised research positions, we strongly encourage potential co-workers to secure their own research funds. Potential funding sources include:
- Royal Society of Chemistry
- Newton International Fellowships
- Leverhulme Trust
- EPSRC Postdoctoral Fellowships
- BBSRC Fellowships
- Marie Sklodowska-Curie Research Fellowships
If you are interested in preparing a research application, please contact Dr P. Manesiotis directly to discuss.
Recent Publications
"Rapid photocatalytic degradation of MCPA using low-power UV LED irradiation: investigation of the reaction mechanism and the role of pH"
J. Kelly, G. Morrison, N. Skillen, P. Manesiotis, P. Robertson, Chem. Eng. J. 2019 359, 112-118.
"Preparation and Characterization of Beclomethasone Dipropionate Solvates"
C. Weiss, P. McLoughlin, P. Manesiotis, L. Redington and H. Cathcart, Crys. Chrowth. Des. 2018 18(10), 5832-5844.
"Molecular ‘traps’ for sulfonylureas prepared using polymerisable ion-pair receptors"
F. Pessagno, A. Nur Hasanah, P. Manesiotis, RSC Adv. 2018, 8, 14212-14220 (Open Access).
"Evolutionary clade affects resistance of Clostridium difficile spores to Cold Atmospheric Plasma"
M. Connor, P. Flynn, D. Fairley, N. Marks, P. Manesiotis, W. Graham, B. Gilmore and J. W. McGrath Sci. Rep. 2017, Article 41814.
"Biological phosphorus removal during high-rate, low-temperature, anaerobic digestion of wastewater"
C. Keating, J.P. Chin, D. Hughes, P. Manesiotis, D. Cysneiros, T. Mahony, C.J. Smith, J.W. McGrath, V. O'Flaherty, Frontiers in Microbiology 2016, 7, Article 226 (Open Access).
"Chromatography: High Performance Liquid Chromatography”
H. Gika, G. Kaklamanos, P. Manesiotis and G. Theodoridis, in Encyclopedia of Food and Health, 93-99, Elsevier 2016.
"Advanced materials for recognition and capture of whole cells and microorganisms"
A. Bole and P. Manesiotis, Adv. Mater. 2016 28(27), 5349-5366.
"Stoichiometric Molecularly Imprinted Polymers for the Recognition of Anti-Cancer Pro-drug Tegafur"
P. Mattos dos Santos, A. J. Hall and P. Manesiotis, J. Chromatogr. B 2016 1021, 197-203.