Solvents, move aside – scientists achieve dry multicomponent synthesis in a single step with twisting screws
A team of researchers led by Prof. Stuart James and Dr Deborah Crawford have adapted a technique more commonly used for making crisps and mixing polymers so that it can perform complex multi-component organic reactions in a single step without the need for a solvent.
Fine chemicals such as drugs, food additives and fragrances are typically made through complex processes with many intricate reaction steps. These steps can be time-consuming and expensive, and often require solvents that are harmful to the environment. But mechanochemistry, where mechanical forces initiate chemical reactions, could side-step such problems.